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ONTOLOGY REPORT - ANNOTATIONS


Term:protein sumoylation
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Accession:GO:0016925 term browser browse the term
Definition:The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
Synonyms:exact_synonym: SUMO-protein conjugation;   protein sumolation;   small ubiquitin-related protein 1 conjugation;   sumoylation
 alt_id: GO:0006485;   GO:0016927
 xref: Wikipedia:SUMO_protein


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protein sumoylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07034657.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr11:82,813,691...82,814,017 JBrowse link
G AABR07045341.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr20:43,929,592...43,932,361 JBrowse link
G Bcl11a BAF chromatin remodeling complex subunit BCL11A ISO (MGI:MGI:3820475|PMID:18681895) RGD PMID:18681895 MGI:MGI:3820475 NCBI chr14:108,826,717...108,921,197
Ensembl chr14:108,826,831...108,921,669
JBrowse link
G Cbx4 chromobox 4 ISO (MGI:MGI:4461078|PMID:20176810) RGD PMID:20176810 MGI:MGI:4461078 NCBI chr10:108,190,947...108,196,455
Ensembl chr10:108,190,995...108,196,217
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Egr2 early growth response 2 IEA
ISO
GO_REF:0000041
(MGI:MGI:5508720|PMID:21836637)
UniProt
RGD
PMID:21836637 GO_REF:0000041, MGI:MGI:5508720 NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025
JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 ISO
IEA
(MGI:MGI:3663824|PMID:16990542)
GO_REF:0000107
RGD
Ensembl
PMID:16990542 GO_REF:0000107, MGI:MGI:3663824 NCBI chr 5:4,275,728...4,495,525
Ensembl chr 5:4,373,626...4,513,142
JBrowse link
G Hdac4 histone deacetylase 4 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 9:99,052,945...99,299,715
Ensembl chr 9:99,057,089...99,299,715
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 ISO (PMID:21156324) RGD PMID:21156324 NCBI chr 3:48,557,696...48,604,097
Ensembl chr 3:48,557,696...48,604,097
JBrowse link
G LOC102553386 SUMO-conjugating enzyme UBC9-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:72,147,680...72,148,784
Ensembl chr10:72,147,816...72,148,783
JBrowse link
G Mdm2 MDM2 proto-oncogene IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:156,855,105...156,864,517
Ensembl chr 5:156,850,206...156,864,517
JBrowse link
G Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 7:99,677,295...99,900,765
Ensembl chr 7:99,677,290...99,900,764
JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 ISO
IEA
IBA
(PMID:18579533)
GO_REF:0000041
PMID:21873635
(MGI:MGI:5487503|PMID:22406621), (MGI:MGI:5619430|PMID:24061474)
RGD
UniProt
PMID:18579533, PMID:22406621, PMID:24061474, PMID:21873635 GO_REF:0000041, MGI:MGI:5487503, MGI:MGI:5619430, RGD:13792537 NCBI chr 8:67,771,720...67,869,015
Ensembl chr 8:67,771,720...67,869,019
JBrowse link
G Pias2 protein inhibitor of activated STAT, 2 ISO
IBA
ISS
IEA
(MGI:MGI:3575864|PMID:15767674)
PMID:21873635
(PMID:20408817), (PMID:22406621)
GO_REF:0000024
GO_REF:0000041
RGD
UniProt
PMID:15767674, PMID:20408817, PMID:22406621, PMID:21873635 GO_REF:0000024, GO_REF:0000041, MGI:MGI:3575864, RGD:13792537 NCBI chr18:73,479,863...73,524,956
Ensembl chr18:73,378,662...73,524,956
JBrowse link
G Pias3 protein inhibitor of activated STAT, 3 IEA
IBA
ISS
ISO
GO_REF:0000041
PMID:21873635
GO_REF:0000024
(MGI:MGI:3575864|PMID:15767674)
UniProt
RGD
PMID:15767674, PMID:21873635 GO_REF:0000024, GO_REF:0000041, MGI:MGI:3575864, RGD:13792537 NCBI chr 2:198,821,377...198,831,533
Ensembl chr 2:198,823,366...198,836,372
JBrowse link
G Pias4 protein inhibitor of activated STAT, 4 ISO
IEA
IBA
(PMID:18579533), (PMID:22508508)
GO_REF:0000041
PMID:21873635
(MGI:MGI:2154657|PMID:11731474), (MGI:MGI:4887534|PMID:19955185)
RGD
UniProt
PMID:11731474, PMID:18579533, PMID:19955185, PMID:22508508, PMID:21873635 GO_REF:0000041, MGI:MGI:2154657, MGI:MGI:4887534, RGD:13792537 NCBI chr 7:11,414,565...11,428,090
Ensembl chr 7:11,414,446...11,428,552
JBrowse link
G Ranbp2 RAN binding protein 2 ISO (PMID:17264123), (PMID:22155184) RGD PMID:17264123, PMID:22155184 NCBI chr20:28,027,054...28,076,664
NCBI chr20:28,365,538...28,375,676
Ensembl chr20:28,027,054...28,076,664
Ensembl chr20:28,027,054...28,076,664
JBrowse link
G Rnf212 ring finger protein 212 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:1,959,148...1,998,077
Ensembl chr14:1,959,610...1,998,102
JBrowse link
G Sae1 SUMO1 activating enzyme subunit 1 IEA
IBA
ISO
ISS
GO_REF:0000041
PMID:21873635
(PMID:15660128), (PMID:20164921), (PMID:21968017)
GO_REF:0000024
UniProt
RGD
PMID:15660128, PMID:20164921, PMID:21968017, PMID:21873635 GO_REF:0000024, GO_REF:0000041, RGD:13792537 NCBI chr 1:78,277,524...78,333,281
Ensembl chr 1:78,277,515...78,333,321
JBrowse link
G Stx1a syntaxin 1A ISO (PMID:26635000) RGD PMID:26635000 NCBI chr12:24,682,050...24,710,002
Ensembl chr12:24,682,041...24,710,019
JBrowse link
G Sumo1 small ubiquitin-like modifier 1 ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:11889051), (PMID:14752048), (PMID:15572661), (PMID:15637059), (PMID:15959518), (PMID:17081986), (PMID:17696781), (PMID:18538659), (PMID:19223394), (PMID:21965678), (PMID:24651376), (PMID:25210186), (PMID:27068747), (PMID:9885291)
MGI:MGI:3819343 (MGI:MGI:3575864|PMID:15767674), (MGI:MGI:3813414|PMID:18644859), (MGI:MGI:3819151|PMID:19033381), (MGI:MGI:5616325|PMID:15023536)
UniProt
RGD
AgBase
PMID:9885291, PMID:11889051, PMID:14752048, PMID:15023536, PMID:15572661, PMID:15637059, PMID:15767674, PMID:15959518, PMID:17081986, PMID:17696781, PMID:18538659, PMID:18644859, PMID:19033381, PMID:19223394, PMID:21965678, PMID:24651376, PMID:25210186, PMID:27068747, PMID:21873635 GO_REF:0000024, MGI:MGI:3575864, MGI:MGI:3813414, MGI:MGI:3819151, MGI:MGI:5616325, RGD:13792537 NCBI chr 9:66,453,428...66,483,614
Ensembl chr 9:66,453,438...66,483,614
JBrowse link
G Sumo2 small ubiquitin-like modifier 2 IDA
IBA
ISO
PMID:19850744
PMID:21873635
(PMID:17081986), (PMID:17696781), (PMID:21965678), (PMID:24105744), (PMID:27068747)
(MGI:MGI:3575864|PMID:15767674), (MGI:MGI:3813414|PMID:18644859)
RGD PMID:15767674, PMID:17081986, PMID:17696781, PMID:18644859, PMID:21965678, PMID:24105744, PMID:27068747, PMID:19850744, PMID:21873635 MGI:MGI:3575864, MGI:MGI:3813414, RGD:8553529, RGD:13792537 NCBI chr10:104,085,401...104,097,983
Ensembl chr10:104,086,002...104,097,812
JBrowse link
G Sumo3 small ubiquitin-like modifier 3 ISO
IBA
(MGI:MGI:3575864|PMID:15767674), (MGI:MGI:3813414|PMID:18644859)
PMID:21873635
(PMID:11889051), (PMID:16626738), (PMID:17696781), (PMID:18538659), (PMID:19050011), (PMID:21965678), (PMID:24105744), (PMID:27068747)
RGD PMID:11889051, PMID:15767674, PMID:16626738, PMID:17696781, PMID:18538659, PMID:18644859, PMID:19050011, PMID:21965678, PMID:24105744, PMID:27068747, PMID:21873635 MGI:MGI:3575864, MGI:MGI:3813414, RGD:13792537 NCBI chr20:11,726,488...11,737,050
Ensembl chr20:11,726,497...11,737,050
JBrowse link
G Sumo4 small ubiquitin-like modifier 4 ISO
IBA
(PMID:15247916), (PMID:16236267), (PMID:18708028)
PMID:21873635
RGD PMID:15247916, PMID:16236267, PMID:18708028, PMID:21873635 RGD:13792537 NCBI chr 5:14,983,382...14,984,134
Ensembl chr 5:14,983,371...14,984,364
JBrowse link
G Topors TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase ISO
IBA
(PMID:17803295), (PMID:20188669)
PMID:21873635
RGD PMID:17803295, PMID:20188669, PMID:21873635 RGD:13792537 NCBI chr 5:56,554,956...56,566,503
Ensembl chr 5:56,554,969...56,567,320
JBrowse link
G Trim28 tripartite motif-containing 28 IEA
IBA
ISO
GO_REF:0000041
PMID:21873635
(PMID:18082607)
UniProt
RGD
PMID:18082607, PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 1:65,544,369...65,551,043
Ensembl chr 1:65,544,373...65,551,043
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:19726882)
Ensembl
UniProt
RGD
PMID:19726882 GO_REF:0000024, GO_REF:0000107 NCBI chr 1:101,293,300...101,323,484
Ensembl chr 1:101,293,409...101,323,960
JBrowse link
G Uba2 ubiquitin-like modifier activating enzyme 2 ISO
IBA
IEA
(PMID:15660128), (PMID:20164921), (PMID:21968017)
PMID:21873635
GO_REF:0000041
RGD
UniProt
PMID:15660128, PMID:20164921, PMID:21968017, PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 1:90,010,681...90,035,522
Ensembl chr 1:90,011,306...90,035,522
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I IDA
IBA
ISO
IEA
PMID:21873635
(PMID:15660128), (PMID:19955185), (PMID:21968017), (PMID:26620705)
GO_REF:0000041
RGD
UniProt
PMID:15660128, PMID:19955185, PMID:21968017, PMID:26620705, PMID:11812797, PMID:21873635 GO_REF:0000041, RGD:2301354, RGD:13792537 NCBI chr10:14,618,615...14,639,274
Ensembl chr10:14,620,531...14,630,151
JBrowse link
G Zfp451 zinc finger protein 451 ISO (PMID:26524494) RGD PMID:26524494 NCBI chr 9:38,395,464...38,451,585
Ensembl chr 9:38,396,449...38,451,656
JBrowse link
negative regulation of protein sumoylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Capn3 calpain 3 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:20694146)
Ensembl
UniProt
RGD
PMID:20694146 GO_REF:0000024, GO_REF:0000107 NCBI chr 3:112,227,486...112,278,408
Ensembl chr 3:112,228,720...112,278,408
JBrowse link
G Ctnnb1 catenin beta 1 ISO
IEA
ISS
(PMID:22155184)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:22155184 GO_REF:0000024, GO_REF:0000107 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Fscb fibrous sheath CABYR binding protein ISO
ISS
(MGI:MGI:5908510|PMID:27398160)
GO_REF:0000024
RGD
UniProt
PMID:27398160 GO_REF:0000024, MGI:MGI:5908510 NCBI chr 6:86,220,260...86,223,052
Ensembl chr 6:86,220,260...86,223,052
JBrowse link
G Gnl3l G protein nucleolar 3 like ISO (PMID:22641345) RGD PMID:22641345 NCBI chr  X:20,037,558...20,070,505
Ensembl chr  X:20,034,882...20,070,578
JBrowse link
G Hmg20a high mobility group 20A ISO (MGI:MGI:5426297|PMID:22570500) RGD PMID:22570500 MGI:MGI:5426297 NCBI chr 8:61,080,103...61,157,613
Ensembl chr 8:61,080,103...61,157,611
JBrowse link
G Hmg20b high mobility group 20 B ISO (MGI:MGI:5426297|PMID:22570500) RGD PMID:22570500 MGI:MGI:5426297 NCBI chr 7:11,238,594...11,243,312
Ensembl chr 7:11,238,630...11,243,310
JBrowse link
G Park7 Parkinsonism associated deglycase ISO
IEA
ISS
(PMID:16731528)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
ParkinsonsUK-UCL
PMID:16731528 GO_REF:0000024, GO_REF:0000107 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Pias3 protein inhibitor of activated STAT, 3 ISO
ISS
(PMID:24651376)
GO_REF:0000024
RGD
UniProt
PMID:24651376 GO_REF:0000024 NCBI chr 2:198,821,377...198,831,533
Ensembl chr 2:198,823,366...198,836,372
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO (MGI:MGI:5905546|PMID:25152367) RGD PMID:25152367 MGI:MGI:5905546 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rnf4 ring finger protein 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:81,658,400...81,679,756
Ensembl chr14:81,660,354...81,679,082
JBrowse link
positive regulation of protein sumoylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahrr aryl-hydrocarbon receptor repressor ISO (MGI:MGI:4359338|PMID:19251700) RGD PMID:19251700 MGI:MGI:4359338 NCBI chr 1:31,603,297...31,698,329
Ensembl chr 1:31,603,297...31,698,329
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator ISO
IEA
(MGI:MGI:4359338|PMID:19251700)
GO_REF:0000107
RGD
Ensembl
PMID:19251700 GO_REF:0000107, MGI:MGI:4359338 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A ISO (PMID:19057511) RGD PMID:19057511 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Gnl3 G protein nucleolar 3 ISO (PMID:22641345) RGD PMID:22641345 NCBI chr16:7,097,580...7,103,518
Ensembl chr16:7,097,507...7,103,604
JBrowse link
G Hdac4 histone deacetylase 4 ISO (PMID:17696781) RGD PMID:17696781 NCBI chr 9:99,052,945...99,299,715
Ensembl chr 9:99,057,089...99,299,715
JBrowse link
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 ISO (PMID:19407830) RGD PMID:19407830 NCBI chr 5:156,855,105...156,864,517
Ensembl chr 5:156,850,206...156,864,517
JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 IMP
ISO
(PMID:17696781), (PMID:21965678) RGD PMID:17696781, PMID:21965678, PMID:25031400 RGD:10059390 NCBI chr 8:67,771,720...67,869,015
Ensembl chr 8:67,771,720...67,869,019
JBrowse link
G Pias3 protein inhibitor of activated STAT, 3 ISO (PMID:17696781), (PMID:21965678) RGD PMID:17696781, PMID:21965678 NCBI chr 2:198,821,377...198,831,533
Ensembl chr 2:198,823,366...198,836,372
JBrowse link
G Pias4 protein inhibitor of activated STAT, 4 ISO (PMID:17696781), (PMID:21965678) RGD PMID:17696781, PMID:21965678 NCBI chr 7:11,414,565...11,428,090
Ensembl chr 7:11,414,446...11,428,552
JBrowse link
G Rasd2 RASD family, member 2 IDA PMID:19498170 UniProt PMID:19498170 RGD:8554673 NCBI chr19:14,653,198...14,663,914
Ensembl chr19:14,653,198...14,663,914
JBrowse link
G Rwdd3 RWD domain containing 3 ISO
IBA
ISS
(PMID:23469069)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:23469069, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 2:224,710,351...224,723,136
Ensembl chr 2:224,710,348...224,723,112
JBrowse link
G Sae1 SUMO1 activating enzyme subunit 1 ISO (PMID:10187858) RGD PMID:10187858 NCBI chr 1:78,277,524...78,333,281
Ensembl chr 1:78,277,515...78,333,321
JBrowse link
G Sumo2 small ubiquitin-like modifier 2 IDA RGD PMID:19850744 RGD:8553529 NCBI chr10:104,085,401...104,097,983
Ensembl chr10:104,086,002...104,097,812
JBrowse link
G Tollip toll interacting protein IDA RGD PMID:19198660 RGD:5508208 NCBI chr 1:214,823,993...214,844,861
Ensembl chr 1:214,823,978...214,844,858
JBrowse link
G Traf7 TNF receptor associated factor 7 ISO (MGI:MGI:3620307|PMID:16162816) RGD PMID:16162816 MGI:MGI:3620307 NCBI chr10:13,874,444...13,893,090
Ensembl chr10:13,874,456...13,892,997
JBrowse link
G Uba2 ubiquitin-like modifier activating enzyme 2 ISO (PMID:10187858) RGD PMID:10187858 NCBI chr 1:90,010,681...90,035,522
Ensembl chr 1:90,011,306...90,035,522
JBrowse link
positive regulation of SUMO transferase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ube2i ubiquitin-conjugating enzyme E2I ISO (PMID:19955185) RGD PMID:19955185 NCBI chr10:14,618,615...14,639,274
Ensembl chr10:14,620,531...14,630,151
JBrowse link
regulation of protein sumoylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egr1 early growth response 1 ISO
IEA
(PMID:19057511)
GO_REF:0000107
RGD
Ensembl
PMID:19057511 GO_REF:0000107 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Zmiz1 zinc finger, MIZ-type containing 1 ISO (PMID:14609956) RGD PMID:14609956 NCBI chr16:1,749,191...1,954,633
Ensembl chr16:1,749,191...1,954,614
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20017
    metabolic process 12256
      primary metabolic process 10901
        protein metabolic process 6214
          protein modification process 3937
            cellular protein modification process 3937
              peptidyl-amino acid modification 1316
                peptidyl-lysine modification 414
                  protein sumoylation 49
                    negative regulation of protein sumoylation + 10
                    positive regulation of protein sumoylation + 17
                    protein autosumoylation 0
                    regulation of protein sumoylation + 28
Path 2
Term Annotations click to browse term
  biological_process 20017
    metabolic process 12256
      organic substance metabolic process 11636
        macromolecule metabolic process 10081
          protein metabolic process 6214
            protein modification process 3937
              cellular protein modification process 3937
                peptidyl-amino acid modification 1316
                  peptidyl-lysine modification 414
                    protein sumoylation 49
                      negative regulation of protein sumoylation + 10
                      positive regulation of protein sumoylation + 17
                      protein autosumoylation 0
                      regulation of protein sumoylation + 28
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.