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ONTOLOGY REPORT - ANNOTATIONS


Term:aminoacyl-tRNA synthetase multienzyme complex
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Accession:GO:0017101 term browser browse the term
Definition:A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates.
Synonyms:exact_synonym: aminoacyl-tRNA synthetase complex;   multisynthetase complex


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aminoacyl-tRNA synthetase multienzyme complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 JBrowse link 2 237,727,782 237,751,327 RGD:1624291
G Aimp2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 JBrowse link 12 12,738,784 12,748,345 RGD:12793003
RGD:1600115
RGD:1624291
G Dars aspartyl-tRNA synthetase JBrowse link 13 45,074,067 45,127,815 RGD:631931
RGD:13792537
RGD:1600115
RGD:1624291
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 JBrowse link 17 26,785,017 26,795,723 RGD:1624291
G Eprs glutamyl-prolyl-tRNA synthetase JBrowse link 13 103,300,911 103,371,651 RGD:1624291
RGD:13792537
G Iars1 isoleucyl-tRNA synthetase 1 JBrowse link 17 15,356,016 15,402,680 RGD:1624291
G Kars lysyl-tRNA synthetase JBrowse link 19 44,212,205 44,231,209 RGD:2303393
RGD:13792537
RGD:1624291
RGD:12793003
RGD:2303394
RGD:2303396
G Lars1 leucyl-tRNA synthetase 1 JBrowse link 18 36,524,013 36,579,471 RGD:1624291
G LOC100911132 glutamine--tRNA ligase-like RGD:13792537
G Mars1 methionyl-tRNA synthetase 1 JBrowse link 7 70,585,011 70,602,425 RGD:12793003
RGD:1624291
G Qars1 glutaminyl-tRNA synthetase 1 JBrowse link 8 117,297,670 117,305,708 RGD:1624291
RGD:13792537
RGD:1600115
G Rars1 arginyl-tRNA synthetase 1 JBrowse link 10 20,633,630 20,658,074 RGD:2303394
RGD:1624291
RGD:12793003
G Rpl5 ribosomal protein L5 JBrowse link 14 2,860,963 2,867,397 RGD:2316859

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  cellular_component 19843
    protein-containing complex 5779
      aminoacyl-tRNA synthetase multienzyme complex 13
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.