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ONTOLOGY REPORT - ANNOTATIONS


Term:plasma membrane phospholipid scrambling
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Accession:GO:0017121 term browser browse the term
Definition:The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE).
Comment:Note that this term describes the trans-bilayer motion of a population of phospholipid molecules, and should not be confused with 'phospholipid translocation ; GO:0045332'.
Synonyms:exact_synonym: PL scrambling
 related_synonym: phospholipid scrambling


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plasma membrane phospholipid scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano1 anoctamin 1 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:217,754,349...217,902,540
Ensembl chr 1:217,754,336...217,902,473
JBrowse link
G Ano10 anoctamin 10 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 8:130,812,941...130,931,021
Ensembl chr 8:130,813,214...130,930,990
JBrowse link
G Ano2 anoctamin 2 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 4:158,222,650...158,577,595
Ensembl chr 4:158,224,000...158,576,978
JBrowse link
G Ano5 anoctamin 5 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:106,873,580...106,971,769
Ensembl chr 1:106,896,790...106,968,885
JBrowse link
G Ano6 anoctamin 6 ISO (MGI:MGI:5440105|PMID:23021219)
(PMID:25651887), (PMID:30700552)
RGD PMID:23021219, PMID:25651887, PMID:30700552 MGI:MGI:5440105 NCBI chr 7:137,142,063...137,335,208
Ensembl chr 7:137,142,170...137,335,208
JBrowse link
G Ano8 anoctamin 8 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr16:19,884,661...19,894,608
Ensembl chr16:19,886,051...19,894,591
JBrowse link
G LOC102551265 phospholipid scramblase 1-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:99,740,031...99,783,260
Ensembl chr 8:99,680,406...99,783,327
JBrowse link
G P2rx7 purinergic receptor P2X 7 ISO
IEA
(PMID:25651887)
GO_REF:0000107
RGD
Ensembl
PMID:25651887 GO_REF:0000107 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G Plscr1 phospholipid scramblase 1 IMP
IBA
IEA
ISO
PMID:17712045
PMID:21873635
GO_REF:0000002
(PMID:10770950), (PMID:18629440), (PMID:9218461)
(MGI:MGI:5284813|PMID:12509439)
InterPro
RGD
PMID:9218461, PMID:10770950, PMID:12509439, PMID:18629440, PMID:17712045, PMID:21873635 GO_REF:0000002, MGI:MGI:5284813, RGD:8553758, RGD:13792537 NCBI chr 8:99,625,523...99,645,882
Ensembl chr 8:99,625,545...99,725,217
JBrowse link
G Plscr2 phospholipid scramblase 2 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:99,650,351...99,725,514
Ensembl chr 8:99,625,545...99,725,217
JBrowse link
G Plscr3 phospholipid scramblase 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:56,452,632...56,458,390
Ensembl chr10:56,453,877...56,458,390
JBrowse link
G Plscr4 phospholipid scramblase 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:99,880,073...99,917,733
Ensembl chr 8:99,880,073...99,918,825
JBrowse link
G Plscr5 phospholipid scramblase family, member 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:99,558,279...99,579,791
Ensembl chr 8:99,568,958...99,579,255
JBrowse link
G Slc4a1 solute carrier family 4 member 1 (Diego blood group) IEA
ISO
GO_REF:0000107
MGI:MGI:1857140 (MGI:MGI:3619187|PMID:9716609)
Ensembl
RGD
PMID:9716609 GO_REF:0000107, MGI:MGI:3619187 NCBI chr10:90,296,144...90,312,401
Ensembl chr10:90,296,141...90,312,386
JBrowse link
calcium activated galactosylceramide scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano3 anoctamin 3 ISO (MGI:MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:MGI:5496475 NCBI chr 3:101,843,516...102,203,368
Ensembl chr 3:101,840,630...102,151,489
JBrowse link
G Ano4 anoctamin 4 ISO (MGI:MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:MGI:5496475 NCBI chr 7:29,492,017...30,025,587
Ensembl chr 7:29,492,016...29,701,721
JBrowse link
G Ano6 anoctamin 6 ISO (MGI:MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:MGI:5496475 NCBI chr 7:137,142,063...137,335,208
Ensembl chr 7:137,142,170...137,335,208
JBrowse link
G Ano7 anoctamin 7 ISO (MGI:MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:MGI:5496475 NCBI chr 9:100,511,610...100,551,798
Ensembl chr 9:100,511,610...100,551,798
JBrowse link
G Ano9 anoctamin 9 ISO (MGI:MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:MGI:5496475 NCBI chr 1:213,908,389...213,929,291
Ensembl chr 1:213,908,982...213,921,208
JBrowse link
calcium activated phosphatidylcholine scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano3 anoctamin 3 ISO (MGI:MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:MGI:5496475 NCBI chr 3:101,843,516...102,203,368
Ensembl chr 3:101,840,630...102,151,489
JBrowse link
G Ano4 anoctamin 4 ISO (MGI:MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:MGI:5496475 NCBI chr 7:29,492,017...30,025,587
Ensembl chr 7:29,492,016...29,701,721
JBrowse link
G Ano6 anoctamin 6 ISO
IBA
(MGI:MGI:5496475|PMID:23532839)
PMID:21873635
RGD PMID:23532839, PMID:21873635 MGI:MGI:5496475, RGD:13792537 NCBI chr 7:137,142,063...137,335,208
Ensembl chr 7:137,142,170...137,335,208
JBrowse link
G Ano7 anoctamin 7 ISO (MGI:MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:MGI:5496475 NCBI chr 9:100,511,610...100,551,798
Ensembl chr 9:100,511,610...100,551,798
JBrowse link
G Ano9 anoctamin 9 ISO (MGI:MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:MGI:5496475 NCBI chr 1:213,908,389...213,929,291
Ensembl chr 1:213,908,982...213,921,208
JBrowse link
calcium activated phosphatidylserine scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano4 anoctamin 4 ISO (MGI:MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:MGI:5496475 NCBI chr 7:29,492,017...30,025,587
Ensembl chr 7:29,492,016...29,701,721
JBrowse link
G Ano6 anoctamin 6 ISO
IBA
(MGI:MGI:5496475|PMID:23532839)
PMID:21873635
RGD PMID:23532839, PMID:21873635 MGI:MGI:5496475, RGD:13792537 NCBI chr 7:137,142,063...137,335,208
Ensembl chr 7:137,142,170...137,335,208
JBrowse link
G Ano7 anoctamin 7 ISO (MGI:MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:MGI:5496475 NCBI chr 9:100,511,610...100,551,798
Ensembl chr 9:100,511,610...100,551,798
JBrowse link
G Ano9 anoctamin 9 ISO (MGI:MGI:5496475|PMID:23532839) RGD PMID:23532839 MGI:MGI:5496475 NCBI chr 1:213,908,389...213,929,291
Ensembl chr 1:213,908,982...213,921,208
JBrowse link
calcium activated phospholipid scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano6 anoctamin 6 ISO MGI:MGI:4127698 (MGI:MGI:5486117|PMID:22936354), (MGI:MGI:5496475|PMID:23532839) RGD PMID:22936354, PMID:23532839 MGI:MGI:5486117, MGI:MGI:5496475 NCBI chr 7:137,142,063...137,335,208
Ensembl chr 7:137,142,170...137,335,208
JBrowse link
G Ano7 anoctamin 7 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:100,511,610...100,551,798
Ensembl chr 9:100,511,610...100,551,798
JBrowse link
phosphatidylserine exposure on apoptotic cell surface term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano6 anoctamin 6 NOT ISO MGI:MGI:4127698 (MGI:MGI:5486117|PMID:22936354), (MGI:MGI:5496475|PMID:23532839) RGD PMID:22936354, PMID:23532839 MGI:MGI:5486117, MGI:MGI:5496475 NCBI chr 7:137,142,063...137,335,208
Ensembl chr 7:137,142,170...137,335,208
JBrowse link
G Plscr1 phospholipid scramblase 1 IEA
ISO
ISS
IBA
GO_REF:0000107
(MGI:MGI:5284813|PMID:12509439), (MGI:MGI:6450314|PMID:32110987)
GO_REF:0000024
(PMID:32110987)
PMID:21873635
Ensembl
RGD
UniProt
PMID:12509439, PMID:32110987, PMID:21873635 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5284813, MGI:MGI:6450314, RGD:13792537 NCBI chr 8:99,625,523...99,645,882
Ensembl chr 8:99,625,545...99,725,217
JBrowse link
G Trpc5 transient receptor potential cation channel, subfamily C, member 5 ISO (MGI:MGI:6450314|PMID:32110987) RGD PMID:32110987 MGI:MGI:6450314 NCBI chr  X:115,624,670...115,908,248
Ensembl chr  X:115,627,653...115,908,693
JBrowse link
G Xkr4 XK related 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:15,746,012...16,141,059
Ensembl chr 5:15,747,614...16,140,896
JBrowse link
G Xkr5 XK related 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:75,744,786...75,762,694
Ensembl chr16:75,744,786...75,762,693
JBrowse link
G Xkr6 XK related 6 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:46,784,963...47,173,352
Ensembl chr15:46,784,963...47,173,335
JBrowse link
G Xkr7 XK related 7 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:148,508,622...148,537,904
Ensembl chr 3:148,510,779...148,533,404
JBrowse link
G Xkr8 XK related 8 ISO
IBA
(PMID:23845944)
MGI:MGI:5528895 (MGI:MGI:5502792|PMID:23845944), (MGI:MGI:6120635|PMID:29440417)
PMID:21873635
RGD PMID:23845944, PMID:29440417, PMID:21873635 MGI:MGI:5502792, MGI:MGI:6120635, RGD:13792537 NCBI chr 5:150,918,600...150,925,727
Ensembl chr 5:150,918,603...150,925,727
JBrowse link
G Xkr9 XK related 9 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:4,946,332...4,975,436
Ensembl chr 5:4,946,006...4,975,436
JBrowse link
phosphatidylserine exposure on blood platelet term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano6 anoctamin 6 ISO (PMID:21107324) RGD PMID:21107324 NCBI chr 7:137,142,063...137,335,208
Ensembl chr 7:137,142,170...137,335,208
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    cellular process 18798
      cellular component organization or biogenesis 6789
        cellular component organization 6534
          membrane organization 865
            plasma membrane organization 126
              plasma membrane phospholipid scrambling 25
                calcium activated phospholipid scrambling + 5
                phosphatidylserine exposure on apoptotic cell surface + 9
                phosphatidylserine exposure on blood platelet 1
                phosphatidylserine exposure on osteoblast involved in bone mineralization 0
Path 2
Term Annotations click to browse term
  biological_process 20027
    localization 6496
      establishment of localization 4911
        transport 4759
          ion transport 1787
            anion transport 679
              organic anion transport 535
                phospholipid transport 98
                  phospholipid translocation 54
                    plasma membrane phospholipid scrambling 25
                      calcium activated phospholipid scrambling + 5
                      phosphatidylserine exposure on apoptotic cell surface + 9
                      phosphatidylserine exposure on blood platelet 1
                      phosphatidylserine exposure on osteoblast involved in bone mineralization 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.