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ONTOLOGY REPORT - ANNOTATIONS


Term:plasma membrane phospholipid scrambling
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Accession:GO:0017121 term browser browse the term
Definition:The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE).
Comment:Note that this term describes the trans-bilayer motion of a population of phospholipid molecules, and should not be confused with 'phospholipid translocation ; GO:0045332'.
Synonyms:exact_synonym: PL scrambling
 related_synonym: phospholipid scrambling


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plasma membrane phospholipid scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANO6 anoctamin 6 ISO (PMID:25651887), (PMID:30700552)
(MGI:5440105|PMID:23021219)
UniProt PMID:23021219, PMID:25651887, PMID:30700552 MGI:5440105 NCBI chr12:43,295,928...43,512,073
Ensembl chr12:44,164,375...44,303,259
JBrowse link
G P2RX7 purinergic receptor P2X 7 ISO (PMID:25651887) UniProtKB PMID:25651887 NCBI chr12:118,731,761...118,786,039
Ensembl chr12:122,102,888...122,154,068
JBrowse link
G PLSCR1 phospholipid scramblase 1 ISO (PMID:10770950), (PMID:18629440), (PMID:9218461)
(MGI:5284813|PMID:12509439)
PMID:17712045
UniProtKB
UniProt
PMID:9218461, PMID:10770950, PMID:12509439, PMID:17712045, PMID:18629440 MGI:5284813, RGD:8553758 NCBI chr 3:143,528,967...143,558,468
Ensembl chr 3:151,112,483...151,132,964
JBrowse link
G SLC4A1 solute carrier family 4 member 1 (Diego blood group) ISO (MGI:3619187|PMID:9716609) MGI PMID:9716609 MGI:3619187 NCBI chr17:13,131,851...13,150,872
Ensembl chr17:13,302,796...13,317,312
JBrowse link
calcium activated galactosylceramide scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANO3 anoctamin 3 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr11:26,287,123...26,618,710
Ensembl chr11:26,047,200...26,519,646
JBrowse link
G ANO4 anoctamin 4 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr12:98,295,875...98,709,918
Ensembl chr12:101,885,088...102,111,806
JBrowse link
G ANO6 anoctamin 6 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr12:43,295,928...43,512,073
Ensembl chr12:44,164,375...44,303,259
JBrowse link
G ANO7 anoctamin 7 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr2B:128,458,076...128,496,307
Ensembl chr2B:247,254,473...247,290,136
JBrowse link
G ANO9 anoctamin 9 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr11:415,570...441,389
Ensembl chr11:453,054...477,950
JBrowse link
calcium activated phosphatidylcholine scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANO3 anoctamin 3 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr11:26,287,123...26,618,710
Ensembl chr11:26,047,200...26,519,646
JBrowse link
G ANO4 anoctamin 4 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr12:98,295,875...98,709,918
Ensembl chr12:101,885,088...102,111,806
JBrowse link
G ANO6 anoctamin 6 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr12:43,295,928...43,512,073
Ensembl chr12:44,164,375...44,303,259
JBrowse link
G ANO7 anoctamin 7 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr2B:128,458,076...128,496,307
Ensembl chr2B:247,254,473...247,290,136
JBrowse link
G ANO9 anoctamin 9 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr11:415,570...441,389
Ensembl chr11:453,054...477,950
JBrowse link
calcium activated phosphatidylserine scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANO4 anoctamin 4 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr12:98,295,875...98,709,918
Ensembl chr12:101,885,088...102,111,806
JBrowse link
G ANO6 anoctamin 6 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr12:43,295,928...43,512,073
Ensembl chr12:44,164,375...44,303,259
JBrowse link
G ANO7 anoctamin 7 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr2B:128,458,076...128,496,307
Ensembl chr2B:247,254,473...247,290,136
JBrowse link
G ANO9 anoctamin 9 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr11:415,570...441,389
Ensembl chr11:453,054...477,950
JBrowse link
calcium activated phospholipid scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANO6 anoctamin 6 ISO (MGI:5496475|PMID:23532839)
(MGI:5486117|PMID:22936354)
MGI PMID:22936354, PMID:23532839 MGI:5486117, MGI:5496475 NCBI chr12:43,295,928...43,512,073
Ensembl chr12:44,164,375...44,303,259
JBrowse link
phosphatidylserine exposure on apoptotic cell surface term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANO6 anoctamin 6 NOT ISO (MGI:5496475|PMID:23532839)
(MGI:5486117|PMID:22936354)
MGI PMID:22936354, PMID:23532839 MGI:5486117, MGI:5496475 NCBI chr12:43,295,928...43,512,073
Ensembl chr12:44,164,375...44,303,259
JBrowse link
G PLSCR1 phospholipid scramblase 1 ISO (PMID:32110987)
(MGI:6450314|PMID:32110987)
(MGI:5284813|PMID:12509439)
UniProt
MGI
PMID:12509439, PMID:32110987 MGI:5284813, MGI:6450314 NCBI chr 3:143,528,967...143,558,468
Ensembl chr 3:151,112,483...151,132,964
JBrowse link
G TRPC5 transient receptor potential cation channel subfamily C member 5 ISO (MGI:6450314|PMID:32110987) UniProt PMID:32110987 MGI:6450314 NCBI chr  X:100,886,122...101,191,425
Ensembl chr  X:111,346,804...111,648,201
JBrowse link
G XKR8 XK related 8 ISO (PMID:23845944)
(MGI:6120635|PMID:29440417)
(MGI:5502792|PMID:23845944)
UniProtKB
MGI
UniProt
PMID:23845944, PMID:29440417 MGI:5502792, MGI:6120635 NCBI chr 1:27,219,682...27,228,381
Ensembl chr 1:28,259,993...28,266,978
JBrowse link
phosphatidylserine exposure on blood platelet term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANO6 anoctamin 6 ISO (PMID:21107324) UniProtKB PMID:21107324 NCBI chr12:43,295,928...43,512,073
Ensembl chr12:44,164,375...44,303,259
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12566
    cellular process 11671
      cellular component organization or biogenesis 5015
        cellular component organization 4935
          membrane organization 567
            plasma membrane organization 95
              plasma membrane phospholipid scrambling 10
                calcium activated phospholipid scrambling + 5
                phosphatidylserine exposure on apoptotic cell surface + 4
                phosphatidylserine exposure on blood platelet 1
                phosphatidylserine exposure on osteoblast involved in bone mineralization 0
Path 2
Term Annotations click to browse term
  biological_process 12566
    localization 4923
      establishment of localization 3510
        transport 3358
          ion transport 2392
            anion transport 1816
              organic substance transport 1736
                organophosphate ester transport 86
                  phospholipid transport 56
                    phospholipid translocation 24
                      plasma membrane phospholipid scrambling 10
                        calcium activated phospholipid scrambling + 5
                        phosphatidylserine exposure on apoptotic cell surface + 4
                        phosphatidylserine exposure on blood platelet 1
                        phosphatidylserine exposure on osteoblast involved in bone mineralization 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.