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ONTOLOGY REPORT - ANNOTATIONS


Term:plasma membrane phospholipid scrambling
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Accession:GO:0017121 term browser browse the term
Definition:The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE).
Comment:Note that this term describes the trans-bilayer motion of a population of phospholipid molecules, and should not be confused with 'phospholipid translocation ; GO:0045332'.
Synonyms:exact_synonym: PL scrambling
 related_synonym: phospholipid scrambling


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plasma membrane phospholipid scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 1700057G04Rik RIKEN cDNA 1700057G04 gene IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 9:92,309,326...92,357,876
Ensembl chr 9:92,309,377...92,357,876
JBrowse link
G Ano6 anoctamin 6 ISO
IMP
(MGI:5440105|PMID:23021219) MGI
UniProt
PMID:23021219 GO_REF:0000096, MGI:4834177, MGI:5440105 NCBI chr15:95,790,843...95,975,472
Ensembl chr15:95,790,843...95,974,751
JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 5:122,643,927...122,692,336
Ensembl chr 5:122,643,911...122,691,432
JBrowse link
G Plscr1 phospholipid scramblase 1 IBA
ISO
IDA
(MGI:6201960|PMID:21873635)
(MGI:5284813|PMID:12509439)
GO_Central
MGI
UniProt
PMID:12509439, PMID:21873635 GO_REF:0000096, MGI:4417868, MGI:4834177, MGI:5284813, MGI:6201960 NCBI chr 9:92,250,194...92,272,561
Ensembl chr 9:92,249,750...92,272,278
JBrowse link
G Plscr2 phospholipid scramblase 2 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 9:92,275,602...92,297,752
Ensembl chr 9:92,275,602...92,297,752
JBrowse link
G Plscr3 phospholipid scramblase 3 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr11:69,846,372...69,852,058
Ensembl chr11:69,846,376...69,852,058
JBrowse link
G Plscr4 phospholipid scramblase 4 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 9:92,457,372...92,493,513
Ensembl chr 9:92,457,373...92,492,456
JBrowse link
G Plscr5 phospholipid scramblase family, member 5 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 9:92,186,516...92,212,536
Ensembl chr 9:92,192,936...92,209,772
JBrowse link
G Slc4a1 solute carrier family 4 (anion exchanger), member 1 IMP (MGI:3619187|PMID:9716609) MGI PMID:9716609 MGI:3619187 NCBI chr11:102,348,820...102,365,281
Ensembl chr11:102,348,824...102,366,203
JBrowse link
calcium activated galactosylceramide scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano3 anoctamin 3 IDA (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr 2:110,655,201...110,950,391
Ensembl chr 2:110,655,201...110,950,923
JBrowse link
G Ano4 anoctamin 4 IDA (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr10:88,948,932...89,345,205
Ensembl chr10:88,948,994...89,344,762
JBrowse link
G Ano6 anoctamin 6 IDA (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr15:95,790,843...95,975,472
Ensembl chr15:95,790,843...95,974,751
JBrowse link
G Ano7 anoctamin 7 IDA (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr 1:93,373,796...93,404,304
Ensembl chr 1:93,373,930...93,404,303
JBrowse link
G Ano9 anoctamin 9 IDA (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr 7:141,101,212...141,117,806
Ensembl chr 7:141,101,212...141,117,806
JBrowse link
calcium activated phosphatidylcholine scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano3 anoctamin 3 IDA (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr 2:110,655,201...110,950,391
Ensembl chr 2:110,655,201...110,950,923
JBrowse link
G Ano4 anoctamin 4 IDA (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr10:88,948,932...89,345,205
Ensembl chr10:88,948,994...89,344,762
JBrowse link
G Ano6 anoctamin 6 IDA
IBA
(MGI:5496475|PMID:23532839)
(MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:21873635, PMID:23532839 MGI:5496475, MGI:6201960 NCBI chr15:95,790,843...95,975,472
Ensembl chr15:95,790,843...95,974,751
JBrowse link
G Ano7 anoctamin 7 IDA (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr 1:93,373,796...93,404,304
Ensembl chr 1:93,373,930...93,404,303
JBrowse link
G Ano9 anoctamin 9 IDA (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr 7:141,101,212...141,117,806
Ensembl chr 7:141,101,212...141,117,806
JBrowse link
calcium activated phosphatidylserine scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano4 anoctamin 4 IDA (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr10:88,948,932...89,345,205
Ensembl chr10:88,948,994...89,344,762
JBrowse link
G Ano6 anoctamin 6 IDA
IBA
(MGI:5496475|PMID:23532839)
(MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:21873635, PMID:23532839 MGI:5496475, MGI:6201960 NCBI chr15:95,790,843...95,975,472
Ensembl chr15:95,790,843...95,974,751
JBrowse link
G Ano7 anoctamin 7 IDA (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr 1:93,373,796...93,404,304
Ensembl chr 1:93,373,930...93,404,303
JBrowse link
G Ano9 anoctamin 9 IDA (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr 7:141,101,212...141,117,806
Ensembl chr 7:141,101,212...141,117,806
JBrowse link
calcium activated phospholipid scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano3 anoctamin 3 IEA UniProt GO_REF:0000002, MGI:2152098 NCBI chr 2:110,655,201...110,950,391
Ensembl chr 2:110,655,201...110,950,923
JBrowse link
G Ano4 anoctamin 4 IEA UniProt GO_REF:0000002, MGI:2152098 NCBI chr10:88,948,932...89,345,205
Ensembl chr10:88,948,994...89,344,762
JBrowse link
G Ano6 anoctamin 6 IMP (MGI:5496475|PMID:23532839)
(MGI:5486117|PMID:22936354)
MGI PMID:22936354, PMID:23532839 MGI:5486117, MGI:5496475 NCBI chr15:95,790,843...95,975,472
Ensembl chr15:95,790,843...95,974,751
JBrowse link
G Ano7 anoctamin 7 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 1:93,373,796...93,404,304
Ensembl chr 1:93,373,930...93,404,303
JBrowse link
G Ano9 anoctamin 9 IEA UniProt GO_REF:0000002, MGI:2152098 NCBI chr 7:141,101,212...141,117,806
Ensembl chr 7:141,101,212...141,117,806
JBrowse link
phosphatidylserine exposure on apoptotic cell surface term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano6 anoctamin 6 NOT IMP (MGI:5486117|PMID:22936354)
(MGI:5496475|PMID:23532839)
MGI PMID:22936354, PMID:23532839 MGI:5486117, MGI:5496475 NCBI chr15:95,790,843...95,975,472
Ensembl chr15:95,790,843...95,974,751
JBrowse link
G Plscr1 phospholipid scramblase 1 IMP
IDA
ISO
IBA
(MGI:6450314|PMID:32110987)
(MGI:5284813|PMID:12509439)
(MGI:6201960|PMID:21873635)
UniProt
MGI
GO_Central
PMID:12509439, PMID:21873635, PMID:32110987 GO_REF:0000096, MGI:4834177, MGI:5284813, MGI:6201960, MGI:6450314 NCBI chr 9:92,250,194...92,272,561
Ensembl chr 9:92,249,750...92,272,278
JBrowse link
G Plscr2 phospholipid scramblase 2 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 9:92,275,602...92,297,752
Ensembl chr 9:92,275,602...92,297,752
JBrowse link
G Trpc5 transient receptor potential cation channel, subfamily C, member 5 IMP (MGI:6450314|PMID:32110987) UniProt PMID:32110987 MGI:6450314 NCBI chr  X:144,377,327...144,688,180
Ensembl chr  X:144,381,671...144,688,180
JBrowse link
G Xkr4 X-linked Kx blood group related 4 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 1:3,199,733...3,671,948
Ensembl chr 1:3,205,901...3,671,498
JBrowse link
G Xkr5 X-linked Kx blood group related 5 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 8:18,924,152...18,951,105
Ensembl chr 8:18,932,729...18,950,975
JBrowse link
G Xkr6 X-linked Kx blood group related 6 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr14:63,606,530...63,845,706
Ensembl chr14:63,606,503...63,820,809
JBrowse link
G Xkr7 X-linked Kx blood group related 7 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 2:153,031,852...153,060,294
Ensembl chr 2:153,031,852...153,055,775
JBrowse link
G Xkr8 X-linked Kx blood group related 8 IMP
IBA
ISO
(MGI:6120635|PMID:29440417)
(MGI:5502792|PMID:23845944)
(MGI:6201960|PMID:21873635)
MGI
UniProt
GO_Central
PMID:21873635, PMID:23845944, PMID:29440417 GO_REF:0000096, MGI:4834177, MGI:5502792, MGI:6120635, MGI:6201960 NCBI chr 4:132,724,901...132,732,614
Ensembl chr 4:132,724,897...132,732,546
JBrowse link
G Xkr9 X-linked Kx blood group related 9 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 1:13,668,738...13,702,230
Ensembl chr 1:13,668,771...13,701,723
JBrowse link
phosphatidylserine exposure on blood platelet term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano6 anoctamin 6 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr15:95,790,843...95,975,472
Ensembl chr15:95,790,843...95,974,751
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23386
    cellular process 17420
      cellular component organization or biogenesis 6413
        cellular component organization 6225
          membrane organization 822
            plasma membrane organization 117
              plasma membrane phospholipid scrambling 20
                calcium activated phospholipid scrambling + 5
                phosphatidylserine exposure on apoptotic cell surface + 10
                phosphatidylserine exposure on blood platelet 1
                phosphatidylserine exposure on osteoblast involved in bone mineralization 0
Path 2
Term Annotations click to browse term
  biological_process 23386
    localization 6231
      establishment of localization 4672
        transport 4521
          ion transport 3399
            anion transport 2645
              organic substance transport 2530
                organophosphate ester transport 117
                  phospholipid transport 85
                    phospholipid translocation 48
                      plasma membrane phospholipid scrambling 20
                        calcium activated phospholipid scrambling + 5
                        phosphatidylserine exposure on apoptotic cell surface + 10
                        phosphatidylserine exposure on blood platelet 1
                        phosphatidylserine exposure on osteoblast involved in bone mineralization 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.