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ONTOLOGY REPORT - ANNOTATIONS


Term:plasma membrane phospholipid scrambling
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Accession:GO:0017121 term browser browse the term
Definition:The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE).
Comment:Note that this term describes the trans-bilayer motion of a population of phospholipid molecules, and should not be confused with 'phospholipid translocation ; GO:0045332'.
Synonyms:exact_synonym: PL scrambling
 related_synonym: phospholipid scrambling


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plasma membrane phospholipid scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANO6 anoctamin 6 ISO (PMID:25651887), (PMID:30700552)
(MGI:5440105|PMID:23021219)
UniProt PMID:23021219, PMID:25651887, PMID:30700552 MGI:5440105 NCBI chr 5:76,112,428...76,337,073
Ensembl chr 5:76,113,243...76,337,073
JBrowse link
G P2RX7 purinergic receptor P2X 7 IEA Ensembl GO_REF:0000107 NCBI chr14:31,415,188...31,476,502
Ensembl chr14:31,415,192...31,476,472
JBrowse link
G PLSCR1 phospholipid scramblase 1 IEA
IBA
(PMID:21873635) InterPro
GO_Central
Ensembl
PMID:21873635 GO_REF:0000002, GO_REF:0000107 NCBI chr13:86,836,288...86,869,569
Ensembl chr13:86,649,586...86,869,297
JBrowse link
G PLSCR3 phospholipid scramblase 3 IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr12:52,719,060...52,724,570
Ensembl chr12:52,719,060...52,724,982
JBrowse link
G PLSCR4 phospholipid scramblase 4 IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr13:86,542,279...86,573,665
Ensembl chr13:86,542,283...86,573,629
JBrowse link
G PLSCR5 phospholipid scramblase family member 5 IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr13:86,920,326...86,954,257
Ensembl chr13:86,928,254...86,954,266
JBrowse link
G SLC4A1 solute carrier family 4 member 1 IEA Ensembl GO_REF:0000107 NCBI chr12:18,957,813...18,975,266
Ensembl chr12:18,957,805...18,974,216
JBrowse link
calcium activated galactosylceramide scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANO3 anoctamin 3 IEA Ensembl GO_REF:0000107 NCBI chr 2:33,618,740...34,048,973
Ensembl chr 2:33,617,991...33,987,210
JBrowse link
G ANO4 anoctamin 4 IEA Ensembl GO_REF:0000107 NCBI chr 5:83,052,070...83,489,523
Ensembl chr 5:83,052,958...83,489,395
JBrowse link
G ANO6 anoctamin 6 IEA Ensembl GO_REF:0000107 NCBI chr 5:76,112,428...76,337,073
Ensembl chr 5:76,113,243...76,337,073
JBrowse link
G ANO7 anoctamin 7 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr15:139,951,191...139,956,575 JBrowse link
G ANO9 anoctamin 9 IEA Ensembl GO_REF:0000107 NCBI chr 2:232,761...250,966
Ensembl chr 2:232,197...250,935
JBrowse link
calcium activated phosphatidylcholine scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANO3 anoctamin 3 IEA Ensembl GO_REF:0000107 NCBI chr 2:33,618,740...34,048,973
Ensembl chr 2:33,617,991...33,987,210
JBrowse link
G ANO4 anoctamin 4 IEA Ensembl GO_REF:0000107 NCBI chr 5:83,052,070...83,489,523
Ensembl chr 5:83,052,958...83,489,395
JBrowse link
G ANO6 anoctamin 6 IEA
IBA
(PMID:21873635) Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr 5:76,112,428...76,337,073
Ensembl chr 5:76,113,243...76,337,073
JBrowse link
G ANO7 anoctamin 7 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr15:139,951,191...139,956,575 JBrowse link
G ANO9 anoctamin 9 IEA Ensembl GO_REF:0000107 NCBI chr 2:232,761...250,966
Ensembl chr 2:232,197...250,935
JBrowse link
calcium activated phosphatidylserine scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANO4 anoctamin 4 IEA Ensembl GO_REF:0000107 NCBI chr 5:83,052,070...83,489,523
Ensembl chr 5:83,052,958...83,489,395
JBrowse link
G ANO6 anoctamin 6 IEA
IBA
(PMID:21873635) Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr 5:76,112,428...76,337,073
Ensembl chr 5:76,113,243...76,337,073
JBrowse link
G ANO7 anoctamin 7 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chr15:139,951,191...139,956,575 JBrowse link
G ANO9 anoctamin 9 IEA Ensembl GO_REF:0000107 NCBI chr 2:232,761...250,966
Ensembl chr 2:232,197...250,935
JBrowse link
calcium activated phospholipid scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANO3 anoctamin 3 IEA InterPro GO_REF:0000002 NCBI chr 2:33,618,740...34,048,973
Ensembl chr 2:33,617,991...33,987,210
JBrowse link
G ANO4 anoctamin 4 IEA InterPro GO_REF:0000002 NCBI chr 5:83,052,070...83,489,523
Ensembl chr 5:83,052,958...83,489,395
JBrowse link
G ANO6 anoctamin 6 IEA InterPro GO_REF:0000002 NCBI chr 5:76,112,428...76,337,073
Ensembl chr 5:76,113,243...76,337,073
JBrowse link
G ANO9 anoctamin 9 IEA InterPro GO_REF:0000002 NCBI chr 2:232,761...250,966
Ensembl chr 2:232,197...250,935
JBrowse link
phosphatidylserine exposure on apoptotic cell surface term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANO6 anoctamin 6 NOT ISO (MGI:5486117|PMID:22936354)
(MGI:5496475|PMID:23532839)
MGI PMID:22936354, PMID:23532839 MGI:5486117, MGI:5496475 NCBI chr 5:76,112,428...76,337,073
Ensembl chr 5:76,113,243...76,337,073
JBrowse link
G PLSCR1 phospholipid scramblase 1 ISO (PMID:32110987)
(MGI:5284813|PMID:12509439)
(MGI:6450314|PMID:32110987)
UniProt
MGI
PMID:12509439, PMID:32110987 MGI:5284813, MGI:6450314 NCBI chr13:86,836,288...86,869,569
Ensembl chr13:86,649,586...86,869,297
JBrowse link
G TRPC5 transient receptor potential cation channel subfamily C member 5 ISO (MGI:6450314|PMID:32110987) UniProt PMID:32110987 MGI:6450314 NCBI chr  X:91,716,334...91,988,364
Ensembl chr  X:91,721,617...91,988,120
JBrowse link
G XKR4 XK related 4 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:76,056,895...76,382,976
Ensembl chr 4:76,062,403...76,382,818
JBrowse link
G XKR5 XK related 5 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:37,880,406...37,898,737
Ensembl chr15:37,880,101...37,898,718
JBrowse link
G XKR7 XK related 7 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:35,632,287...35,662,600
Ensembl chr17:35,632,158...35,658,305
JBrowse link
G XKR8 XK related 8 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:85,084,641...85,093,167
Ensembl chr 6:85,083,859...85,093,166
JBrowse link
G XKR9 XK related 9 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:64,678,734...64,727,495
Ensembl chr 4:64,679,170...64,707,710
JBrowse link
phosphatidylserine exposure on blood platelet term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANO6 anoctamin 6 IEA Ensembl GO_REF:0000107 NCBI chr 5:76,112,428...76,337,073
Ensembl chr 5:76,113,243...76,337,073
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16548
    cellular process 15780
      cellular component organization or biogenesis 5992
        cellular component organization 5824
          membrane organization 702
            plasma membrane organization 115
              plasma membrane phospholipid scrambling 17
                calcium activated phospholipid scrambling + 5
                phosphatidylserine exposure on apoptotic cell surface + 8
                phosphatidylserine exposure on blood platelet 1
                phosphatidylserine exposure on osteoblast involved in bone mineralization 0
Path 2
Term Annotations click to browse term
  biological_process 16548
    localization 5910
      establishment of localization 4408
        transport 4261
          ion transport 3194
            anion transport 2449
              organic substance transport 2324
                organophosphate ester transport 144
                  phospholipid transport 91
                    phospholipid translocation 44
                      plasma membrane phospholipid scrambling 17
                        calcium activated phospholipid scrambling + 5
                        phosphatidylserine exposure on apoptotic cell surface + 8
                        phosphatidylserine exposure on blood platelet 1
                        phosphatidylserine exposure on osteoblast involved in bone mineralization 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.