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ONTOLOGY REPORT - ANNOTATIONS


Term:plasma membrane phospholipid scrambling
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Accession:GO:0017121 term browser browse the term
Definition:The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE).
Comment:Note that this term describes the trans-bilayer motion of a population of phospholipid molecules, and should not be confused with 'phospholipid translocation ; GO:0045332'.
Synonyms:exact_synonym: PL scrambling
 related_synonym: phospholipid scrambling


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plasma membrane phospholipid scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano6 anoctamin 6 ISO (PMID:25651887), (PMID:30700552)
(MGI:5440105|PMID:23021219)
UniProt PMID:23021219 PMID:25651887 PMID:30700552 MGI:5440105 NCBI chrNW_004936512:3,649,103...3,736,274 JBrowse link
G P2rx7 purinergic receptor P2X 7 ISO (PMID:25651887) UniProtKB PMID:25651887 NCBI chrNW_004936558:3,106,819...3,149,689 JBrowse link
G Plscr1 phospholipid scramblase 1 ISO (PMID:10770950), (PMID:18629440), (PMID:9218461)
(MGI:5284813|PMID:12509439)
PMID:17712045
UniProtKB
UniProt
PMID:9218461 PMID:10770950 PMID:12509439 PMID:17712045 PMID:18629440 MGI:5284813 RGD:8553758 NCBI chrNW_004936519:8,759,702...8,790,823 JBrowse link
G Slc4a1 solute carrier family 4 member 1 (Diego blood group) ISO (MGI:3619187|PMID:9716609) MGI PMID:9716609 MGI:3619187 NCBI chrNW_004936541:718,577...727,420 JBrowse link
calcium activated galactosylceramide scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano3 anoctamin 3 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chrNW_004936540:6,437,362...6,712,433 JBrowse link
G Ano4 anoctamin 4 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chrNW_004936492:12,810,004...13,000,647 JBrowse link
G Ano6 anoctamin 6 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chrNW_004936512:3,649,103...3,736,274 JBrowse link
G Ano9 anoctamin 9 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chrNW_004936888:289,309...306,184 JBrowse link
calcium activated phosphatidylcholine scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano3 anoctamin 3 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chrNW_004936540:6,437,362...6,712,433 JBrowse link
G Ano4 anoctamin 4 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chrNW_004936492:12,810,004...13,000,647 JBrowse link
G Ano6 anoctamin 6 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chrNW_004936512:3,649,103...3,736,274 JBrowse link
G Ano9 anoctamin 9 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chrNW_004936888:289,309...306,184 JBrowse link
calcium activated phosphatidylserine scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano4 anoctamin 4 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chrNW_004936492:12,810,004...13,000,647 JBrowse link
G Ano6 anoctamin 6 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chrNW_004936512:3,649,103...3,736,274 JBrowse link
G Ano9 anoctamin 9 ISO (MGI:5496475|PMID:23532839) MGI PMID:23532839 MGI:5496475 NCBI chrNW_004936888:289,309...306,184 JBrowse link
calcium activated phospholipid scrambling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano6 anoctamin 6 ISO (MGI:5486117|PMID:22936354)
(MGI:5496475|PMID:23532839)
MGI PMID:22936354 PMID:23532839 MGI:5486117 MGI:5496475 NCBI chrNW_004936512:3,649,103...3,736,274 JBrowse link
phosphatidylserine exposure on apoptotic cell surface term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano6 anoctamin 6 NOT ISO (MGI:5486117|PMID:22936354)
(MGI:5496475|PMID:23532839)
MGI PMID:22936354 PMID:23532839 MGI:5486117 MGI:5496475 NCBI chrNW_004936512:3,649,103...3,736,274 JBrowse link
G Plscr1 phospholipid scramblase 1 ISO (PMID:32110987)
(MGI:5284813|PMID:12509439)
(MGI:6450314|PMID:32110987)
UniProt
MGI
PMID:12509439 PMID:32110987 MGI:5284813 MGI:6450314 NCBI chrNW_004936519:8,759,702...8,790,823 JBrowse link
G Trpc5 transient receptor potential cation channel subfamily C member 5 ISO (MGI:6450314|PMID:32110987) UniProt PMID:32110987 MGI:6450314 NCBI chrNW_004936499:3,391,386...3,541,406 JBrowse link
G Xkr8 XK related 8 ISO (PMID:23845944)
(MGI:6120635|PMID:29440417)
(MGI:5502792|PMID:23845944)
UniProtKB
MGI
UniProt
PMID:23845944 PMID:29440417 MGI:5502792 MGI:6120635 NCBI chrNW_004936474:12,180,741...12,187,904 JBrowse link
phosphatidylserine exposure on blood platelet term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano6 anoctamin 6 ISO (PMID:21107324) UniProtKB PMID:21107324 NCBI chrNW_004936512:3,649,103...3,736,274 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12003
    cellular process 11179
      cellular component organization or biogenesis 4923
        cellular component organization 4845
          membrane organization 559
            plasma membrane organization 92
              plasma membrane phospholipid scrambling 9
                calcium activated phospholipid scrambling + 4
                phosphatidylserine exposure on apoptotic cell surface + 4
                phosphatidylserine exposure on blood platelet 1
                phosphatidylserine exposure on osteoblast involved in bone mineralization 0
Path 2
Term Annotations click to browse term
  biological_process 12003
    localization 4766
      establishment of localization 3410
        transport 3258
          ion transport 2326
            anion transport 1771
              organic substance transport 1695
                organophosphate ester transport 82
                  phospholipid transport 54
                    phospholipid translocation 22
                      plasma membrane phospholipid scrambling 9
                        calcium activated phospholipid scrambling + 4
                        phosphatidylserine exposure on apoptotic cell surface + 4
                        phosphatidylserine exposure on blood platelet 1
                        phosphatidylserine exposure on osteoblast involved in bone mineralization 0
paths to the root