Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:calcium-ion regulated exocytosis
go back to main search page
Accession:GO:0017156 term browser browse the term
Definition:The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.
Comment:Note that the calcium regulated exocytosis pathway can be leaky: some level of exocytosis via this pathway occurs spontaneously. This phenomenon underlies spontaneous neurotransmitter release from presynapses. This phenomenon is distinct from the unregulated, calcium independent exocytosis pathway.
Synonyms:exact_synonym: calcium ion-dependent exocytosis


show annotations for term's descendants       view all columns           Sort by:
 
calcium-ion regulated exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arhgap17 Rho GTPase activating protein 17 JBrowse link 1 193,239,036 193,328,425 RGD:633422
RGD:13792537
G Cacna1a calcium voltage-gated channel subunit alpha1 A JBrowse link 19 25,453,236 25,749,550 RGD:1624291
G Cacna1c calcium voltage-gated channel subunit alpha1 C JBrowse link 4 150,635,808 151,270,790 RGD:1624291
G Chp1 calcineurin-like EF-hand protein 1 JBrowse link 3 111,354,506 111,389,998 RGD:724726
G Ppp3cb protein phosphatase 3 catalytic subunit beta JBrowse link 15 4,209,702 4,236,895 RGD:1600115
RGD:1624291
G Rab3a RAB3A, member RAS oncogene family JBrowse link 16 20,435,098 20,439,206 RGD:1624291
G Rapgef4 Rap guanine nucleotide exchange factor 4 JBrowse link 3 58,632,338 58,925,127 RGD:1624291
RGD:1600115
G Rims2 regulating synaptic membrane exocytosis 2 JBrowse link 7 78,091,998 78,594,164 RGD:1624291
RGD:1600115
G Rims3 regulating synaptic membrane exocytosis 3 JBrowse link 5 139,790,395 139,819,014 RGD:633421
G Sdf4 stromal cell derived factor 4 JBrowse link 5 173,425,922 173,444,478 RGD:2312426
RGD:13792537
G Stx1a syntaxin 1A JBrowse link 12 24,682,050 24,710,002 RGD:1624291
G Syn2 synapsin II JBrowse link 4 147,037,179 147,195,096 RGD:1600115
RGD:1624291
G Syt1 synaptotagmin 1 JBrowse link 7 50,084,063 50,638,996 RGD:729959
RGD:13792537
G Syt10 synaptotagmin 10 JBrowse link 7 130,769,039 130,827,030 RGD:13792537
G Syt11 synaptotagmin 11 JBrowse link 2 188,112,301 188,138,180 RGD:13792537
G Syt12 synaptotagmin 12 JBrowse link 1 219,690,013 219,719,359 RGD:13792537
G Syt13 synaptotagmin 13 JBrowse link 3 81,814,287 81,852,454 RGD:13792537
G Syt15 synaptotagmin 15 JBrowse link 16 10,554,136 10,564,934 RGD:13792537
G Syt17 synaptotagmin 17 JBrowse link 1 188,034,614 188,101,590 RGD:13792537
G Syt2 synaptotagmin 2 JBrowse link 13 51,569,248 51,577,824 RGD:13792537
G Syt3 synaptotagmin 3 JBrowse link 1 100,379,236 100,407,862 RGD:61762
RGD:13792537
RGD:1600115
G Syt4 synaptotagmin 4 JBrowse link 18 24,172,580 24,181,989 RGD:730180
RGD:13792537
G Syt5 synaptotagmin 5 JBrowse link 1 72,859,806 72,867,934 RGD:730140
RGD:13792537
G Syt6 synaptotagmin 6 JBrowse link 2 206,064,181 206,119,034 RGD:13792537
G Syt7 synaptotagmin 7 JBrowse link 1 226,435,816 226,498,008 RGD:634203
RGD:13792537
G Syt7_v1 synaptotagmin 7, variant 1 RGD:619692
G Syt7_v2 synaptotagmin 7, variant 2 RGD:619692
G Syt7_v3 synaptotagmin 7, variant 3 RGD:619692
G Syt8 synaptotagmin 8 JBrowse link 1 215,605,408 215,607,602 RGD:13792537
G Syt9 synaptotagmin 9 JBrowse link 1 171,592,703 171,769,780 RGD:13792537
G Vamp2 vesicle-associated membrane protein 2 JBrowse link 10 55,675,171 55,679,405 RGD:1624291
G Vamp3 vesicle-associated membrane protein 3 JBrowse link 5 168,126,157 168,136,628 RGD:1624291
G Vamp7 vesicle-associated membrane protein 7 JBrowse link 12 18,996,566 19,033,714 RGD:8553828
acrosomal vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eqtn equatorin JBrowse link 5 113,852,191 113,881,142 RGD:1624291
RGD:13792537
G Rab3a RAB3A, member RAS oncogene family JBrowse link 16 20,435,098 20,439,206 RGD:1624291
G Rims1 regulating synaptic membrane exocytosis 1 JBrowse link 9 28,440,408 28,973,246 RGD:1600115
RGD:1624291
G Syt6 synaptotagmin 6 JBrowse link 2 206,064,181 206,119,034 RGD:1624291
G Unc13b unc-13 homolog B JBrowse link 5 58,505,449 58,714,396 RGD:1600115
RGD:1624291
G Zp4 zona pellucida glycoprotein 4 JBrowse link 17 65,497,359 65,503,912 RGD:1600115
RGD:1624291
calcium ion regulated lysosome exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Syt11 synaptotagmin 11 JBrowse link 2 188,112,301 188,138,180 RGD:1624291
G Syt7 synaptotagmin 7 JBrowse link 1 226,435,816 226,498,008 RGD:2311145
RGD:1624291
RGD:11041027
calcium ion-regulated exocytosis of neurotransmitter term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cacna1a calcium voltage-gated channel subunit alpha1 A JBrowse link 19 25,453,236 25,749,550 RGD:1624291
RGD:1600115
G Doc2b double C2 domain beta JBrowse link 10 63,921,255 63,952,944 RGD:8554647
RGD:1624291
RGD:1600115
G Rims1 regulating synaptic membrane exocytosis 1 JBrowse link 9 28,440,408 28,973,246 RGD:1624291
RGD:13792537
G Rims2 regulating synaptic membrane exocytosis 2 JBrowse link 7 78,091,998 78,594,164 RGD:1624291
RGD:13792537
RGD:1600115
G Rims3 regulating synaptic membrane exocytosis 3 JBrowse link 5 139,790,395 139,819,014 RGD:13792537
G Rims4 regulating synaptic membrane exocytosis 4 JBrowse link 3 160,237,659 160,301,792 RGD:13792537
G Snap25 synaptosome associated protein 25 JBrowse link 3 129,697,408 129,788,417 RGD:1581082
G Stx1b syntaxin 1B JBrowse link 1 199,251,842 199,270,465 RGD:1624291
G Syt1 synaptotagmin 1 JBrowse link 7 50,084,063 50,638,996 RGD:1624291
RGD:13792537
G Syt10 synaptotagmin 10 JBrowse link 7 130,769,039 130,827,030 RGD:13792537
G Syt12 synaptotagmin 12 JBrowse link 1 219,690,013 219,719,359 RGD:13792537
G Syt2 synaptotagmin 2 JBrowse link 13 51,569,248 51,577,824 RGD:13792537
G Syt3 synaptotagmin 3 JBrowse link 1 100,379,236 100,407,862 RGD:13792537
G Syt5 synaptotagmin 5 JBrowse link 1 72,859,806 72,867,934 RGD:13792537
G Syt6 synaptotagmin 6 JBrowse link 2 206,064,181 206,119,034 RGD:13792537
G Syt7 synaptotagmin 7 JBrowse link 1 226,435,816 226,498,008 RGD:1624291
RGD:1600115
G Syt8 synaptotagmin 8 JBrowse link 1 215,605,408 215,607,602 RGD:13792537
G Syt9 synaptotagmin 9 JBrowse link 1 171,592,703 171,769,780 RGD:13792537
dense core granule docking term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Unc13a unc-13 homolog A JBrowse link 16 20,056,398 20,103,951 RGD:1624291
G Unc13b unc-13 homolog B JBrowse link 5 58,505,449 58,714,396 RGD:1624291
dense core granule exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cadps2 calcium dependent secretion activator 2 JBrowse link 4 50,326,447 50,861,161 RGD:1600115
dense core granule priming term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Unc13a unc-13 homolog A JBrowse link 16 20,056,398 20,103,951 RGD:12050107
RGD:13792537
G Unc13b unc-13 homolog B JBrowse link 5 58,505,449 58,714,396 RGD:12050107
RGD:13792537
G Unc13c unc-13 homolog C JBrowse link 8 80,202,736 80,656,363 RGD:13792537
G Unc13d unc-13 homolog D JBrowse link 10 104,613,907 104,628,664 RGD:12050107
fast, calcium ion-dependent exocytosis of neurotransmitter term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Syt1 synaptotagmin 1 JBrowse link 7 50,084,063 50,638,996 RGD:1600115
RGD:1624291
negative regulation of calcium ion-dependent exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adra2a adrenoceptor alpha 2A JBrowse link 1 274,766,283 274,769,083 RGD:2316628
G Cbarp CACN subunit beta associated regulatory protein JBrowse link 7 12,433,422 12,441,048 RGD:1624291
RGD:13792537
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:13508598
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:1624291
G Pou5f1 POU class 5 homeobox 1 JBrowse link 20 3,747,231 3,751,994 RGD:1624291
G Ppp3ca protein phosphatase 3 catalytic subunit alpha JBrowse link 2 241,909,332 242,186,861 RGD:2316628
G Rap1b RAP1B, member of RAS oncogene family JBrowse link 7 60,850,406 60,878,226 RGD:1624291
G Rest RE1-silencing transcription factor JBrowse link 14 33,131,985 33,152,019 RGD:8554180
G Stxbp3 syntaxin binding protein 3 JBrowse link 2 211,595,763 211,638,756 RGD:1624291
G Syt4 synaptotagmin 4 JBrowse link 18 24,172,580 24,181,989 RGD:7205660
G Trim9 tripartite motif-containing 9 JBrowse link 6 92,660,026 92,760,036 RGD:631246
negative regulation of dense core granule exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Syt4 synaptotagmin 4 JBrowse link 18 24,172,580 24,181,989 RGD:11541109
neuronal dense core vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Unc13a unc-13 homolog A JBrowse link 16 20,056,398 20,103,951 RGD:1600115
G Unc13b unc-13 homolog B JBrowse link 5 58,505,449 58,714,396 RGD:1600115
positive regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hyal3 hyaluronidase 3 JBrowse link 8 116,336,512 116,342,147 RGD:1600115
RGD:1624291
G Zp3 zona pellucida glycoprotein 3 JBrowse link 12 23,735,225 23,752,734 RGD:1600115
RGD:1624291
positive regulation of calcium ion-dependent exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arf1 ADP-ribosylation factor 1 JBrowse link 10 45,562,700 45,579,214 RGD:9684853
G Cacna1g calcium voltage-gated channel subunit alpha1 G JBrowse link 10 82,129,071 82,197,828 RGD:2316206
RGD:13792537
G Cacna1h calcium voltage-gated channel subunit alpha1 H JBrowse link 10 14,730,932 14,789,201 RGD:13792537
G Cacna1i calcium voltage-gated channel subunit alpha1 I JBrowse link 7 121,521,787 121,619,300 RGD:13792537
G Cadps calcium dependent secretion activator JBrowse link 15 15,275,489 15,690,575 RGD:1299539
G Cdk5 cyclin-dependent kinase 5 JBrowse link 4 7,282,945 7,287,427 RGD:1624291
G Cdk5r2 cyclin-dependent kinase 5 regulatory subunit 2 JBrowse link 9 82,120,059 82,121,527 RGD:1624291
G Cltrn collectrin, amino acid transport regulator JBrowse link X 32,118,082 32,153,687 RGD:1624291
G Doc2b double C2 domain beta JBrowse link 10 63,921,255 63,952,944 RGD:8554556
RGD:1600115
G Kcnb1 potassium voltage-gated channel subfamily B member 1 JBrowse link 3 163,850,785 163,935,610 RGD:10047384
RGD:10047179
RGD:10047360
G Scamp5 secretory carrier membrane protein 5 JBrowse link 8 62,221,820 62,266,269 RGD:1600115
RGD:1624291
G Stx1a syntaxin 1A JBrowse link 12 24,682,050 24,710,002 RGD:10047384
RGD:10047179
RGD:10047360
G Stxbp1 syntaxin binding protein 1 JBrowse link 3 11,823,779 11,885,479 RGD:1624291
G Syt1 synaptotagmin 1 JBrowse link 7 50,084,063 50,638,996 RGD:7205660
G Syt10 synaptotagmin 10 JBrowse link 7 130,769,039 130,827,030 RGD:1624291
RGD:1600115
G Syt7 synaptotagmin 7 JBrowse link 1 226,435,816 226,498,008 RGD:7205660
G Syt9 synaptotagmin 9 JBrowse link 1 171,592,703 171,769,780 RGD:7205660
positive regulation of calcium ion-dependent exocytosis of neurotransmitter term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Syt1 synaptotagmin 1 JBrowse link 7 50,084,063 50,638,996 RGD:1600115
RGD:1624291
positive regulation of dense core granule exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Syt4 synaptotagmin 4 JBrowse link 18 24,172,580 24,181,989 RGD:1624291
presynaptic dense core vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cadps calcium dependent secretion activator JBrowse link 15 15,275,489 15,690,575 RGD:1600115
RGD:1624291
G Stxbp1 syntaxin binding protein 1 JBrowse link 3 11,823,779 11,885,479 RGD:1624291
G Syt6 synaptotagmin 6 JBrowse link 2 206,064,181 206,119,034 RGD:13702162
G Unc13a unc-13 homolog A JBrowse link 16 20,056,398 20,103,951 RGD:1600115
RGD:13792537
RGD:1624291
G Unc13b unc-13 homolog B JBrowse link 5 58,505,449 58,714,396 RGD:1624291
RGD:13792537
G Unc13c unc-13 homolog C JBrowse link 8 80,202,736 80,656,363 RGD:13792537
regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Stxbp1 syntaxin binding protein 1 JBrowse link 3 11,823,779 11,885,479 RGD:1624291
regulation of calcium ion-dependent exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cacna1a calcium voltage-gated channel subunit alpha1 A JBrowse link 19 25,453,236 25,749,550 RGD:1624291
RGD:1600115
G Doc2a double C2 domain alpha JBrowse link 1 198,282,828 198,288,611 RGD:1624291
G Rph3al rabphilin 3A-like (without C2 domains) JBrowse link 10 63,989,556 64,140,584 RGD:1624291
G Sptbn2 spectrin, beta, non-erythrocytic 2 JBrowse link 1 219,964,429 220,006,811 RGD:70020
G Sycn syncollin JBrowse link 1 85,219,827 85,220,239 RGD:634177
G Syt1 synaptotagmin 1 JBrowse link 7 50,084,063 50,638,996 RGD:2311146
RGD:13792537
RGD:11079189
RGD:1624291
RGD:7205657
G Syt10 synaptotagmin 10 JBrowse link 7 130,769,039 130,827,030 RGD:1624291
RGD:13792537
G Syt11 synaptotagmin 11 JBrowse link 2 188,112,301 188,138,180 RGD:13792537
G Syt12 synaptotagmin 12 JBrowse link 1 219,690,013 219,719,359 RGD:13792537
G Syt13 synaptotagmin 13 JBrowse link 3 81,814,287 81,852,454 RGD:13792537
G Syt15 synaptotagmin 15 JBrowse link 16 10,554,136 10,564,934 RGD:13792537
G Syt17 synaptotagmin 17 JBrowse link 1 188,034,614 188,101,590 RGD:13792537
G Syt2 synaptotagmin 2 JBrowse link 13 51,569,248 51,577,824 RGD:13792537
G Syt3 synaptotagmin 3 JBrowse link 1 100,379,236 100,407,862 RGD:11079189
RGD:13792537
G Syt4 synaptotagmin 4 JBrowse link 18 24,172,580 24,181,989 RGD:1624291
RGD:13792537
G Syt5 synaptotagmin 5 JBrowse link 1 72,859,806 72,867,934 RGD:1624291
RGD:13792537
G Syt6 synaptotagmin 6 JBrowse link 2 206,064,181 206,119,034 RGD:13792537
G Syt7 synaptotagmin 7 JBrowse link 1 226,435,816 226,498,008 RGD:2311145
RGD:13792537
RGD:1624291
RGD:7241272
G Syt8 synaptotagmin 8 JBrowse link 1 215,605,408 215,607,602 RGD:13792537
G Syt9 synaptotagmin 9 JBrowse link 1 171,592,703 171,769,780 RGD:2311146
RGD:13792537
RGD:1624291
RGD:7241274
RGD:7205657
regulation of calcium ion-dependent exocytosis of neurotransmitter term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 JBrowse link 12 39,553,903 39,603,326 RGD:1624291
G Rab3gap1 RAB3 GTPase activating protein catalytic subunit 1 JBrowse link 13 44,578,208 44,649,876 RGD:1624291
RGD:1600115
regulation of dense core granule exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Baiap3 BAI1-associated protein 3 JBrowse link 10 14,601,133 14,613,881 RGD:1624291
regulation of presynaptic dense core granule exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G P2rx7 purinergic receptor P2X 7 JBrowse link 12 39,353,613 39,396,042 RGD:13702177
G Syt4 synaptotagmin 4 JBrowse link 18 24,172,580 24,181,989 RGD:1624291
zymogen granule exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sdf4 stromal cell derived factor 4 JBrowse link 5 173,425,922 173,444,478 RGD:2312426
G Vamp8 vesicle-associated membrane protein 8 JBrowse link 4 100,250,301 100,252,756 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19335
    cellular process 17239
      export from cell 1206
        secretion by cell 1158
          exocytosis 405
            regulated exocytosis 285
              calcium-ion regulated exocytosis 77
                acrosomal vesicle exocytosis + 9
                calcium ion regulated lysosome exocytosis 2
                calcium ion-regulated exocytosis of neurotransmitter + 27
                cortical granule exocytosis + 0
                dense core granule exocytosis + 11
                negative regulation of calcium ion-dependent exocytosis + 11
                positive regulation of calcium ion-dependent exocytosis + 20
                regulation of calcium ion-dependent exocytosis + 49
                zymogen granule exocytosis 2
Path 2
Term Annotations click to browse term
  biological_process 19335
    localization 6324
      establishment of localization 4866
        transport 4727
          secretion 1348
            secretion by cell 1158
              exocytosis 405
                regulated exocytosis 285
                  calcium-ion regulated exocytosis 77
                    acrosomal vesicle exocytosis + 9
                    calcium ion regulated lysosome exocytosis 2
                    calcium ion-regulated exocytosis of neurotransmitter + 27
                    cortical granule exocytosis + 0
                    dense core granule exocytosis + 11
                    negative regulation of calcium ion-dependent exocytosis + 11
                    positive regulation of calcium ion-dependent exocytosis + 20
                    regulation of calcium ion-dependent exocytosis + 49
                    zymogen granule exocytosis 2
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.