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ONTOLOGY REPORT - ANNOTATIONS


Term:calcium-ion regulated exocytosis
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Accession:GO:0017156 term browser browse the term
Definition:The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.
Comment:Note that the calcium regulated exocytosis pathway can be leaky: some level of exocytosis via this pathway occurs spontaneously. This phenomenon underlies spontaneous neurotransmitter release from presynapses. This phenomenon is distinct from the unregulated, calcium independent exocytosis pathway.
Synonyms:exact_synonym: calcium ion-dependent exocytosis


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calcium-ion regulated exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LOC100625711 synaptotagmin-15 JBrowse link 14 88,123,832 88,132,098 RGD:14298760
G PPP3CB protein phosphatase 3 catalytic subunit beta JBrowse link 14 76,239,497 76,305,345 RGD:14298760
G RAPGEF4 Rap guanine nucleotide exchange factor 4 JBrowse link 15 78,773,270 79,094,490 RGD:14298760
G SDF4 stromal cell derived factor 4 JBrowse link 6 63,529,853 63,539,979 RGD:14298760
G STX1A syntaxin 1A JBrowse link 3 10,974,127 10,991,846 RGD:14298760
G SYT1 synaptotagmin 1 JBrowse link 5 101,871,313 102,394,310 RGD:14298760
G SYT10 synaptotagmin 10 JBrowse link 5 40,869,418 40,940,851 RGD:14298760
G SYT11 synaptotagmin 11 JBrowse link 4 94,139,345 94,163,091 RGD:14298760
G SYT12 synaptotagmin 12 JBrowse link 2 5,410,605 5,434,492 RGD:14298760
G SYT13 synaptotagmin 13 JBrowse link 2 17,120,127 17,166,997 RGD:14298760
G SYT17 synaptotagmin 17 JBrowse link 3 26,447,303 26,548,362 RGD:14298760
G SYT2 synaptotagmin 2 JBrowse link 10 24,638,645 24,727,198 RGD:14298760
G SYT3 synaptotagmin 3 JBrowse link 6 55,417,949 55,449,322 RGD:14298760
G SYT4 synaptotagmin 4 JBrowse link 6 127,382,248 127,392,258 RGD:14298760
G SYT5 synaptotagmin 5 JBrowse link 6 59,381,649 59,389,014 RGD:14298760
G SYT6 synaptotagmin 6 JBrowse link 4 106,420,614 106,485,468 RGD:14298760
G SYT7 synaptotagmin 7 JBrowse link 2 9,947,962 10,012,713 RGD:14298760
G SYT8 synaptotagmin 8 JBrowse link 2 1,245,988 1,250,422 RGD:14298760
G SYT9 synaptotagmin 9 JBrowse link 9 2,191,757 2,395,157 RGD:14298760
acrosomal vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RAB3A RAB3A, member RAS oncogene family JBrowse link 2 59,603,090 59,609,773 RGD:14298760
G SYT6 synaptotagmin 6 JBrowse link 4 106,420,614 106,485,468 RGD:14298760
G ZP4 zona pellucida glycoprotein 4 JBrowse link 14 53,577,138 53,584,544 RGD:14298760
calcium ion regulated lysosome exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SYT11 synaptotagmin 11 JBrowse link 4 94,139,345 94,163,091 RGD:14298760
G SYT7 synaptotagmin 7 JBrowse link 2 9,947,962 10,012,713 RGD:14298760
calcium ion-regulated exocytosis of neurotransmitter term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DOC2B double C2 domain beta JBrowse link 12 47,529,383 47,558,236 RGD:14298760
G RIMS1 regulating synaptic membrane exocytosis 1 JBrowse link 1 51,785,140 52,246,456 RGD:14298760
G RIMS2 regulating synaptic membrane exocytosis 2 JBrowse link 4 32,999,615 33,613,413 RGD:14298760
G RIMS3 regulating synaptic membrane exocytosis 3 JBrowse link 6 170,506,392 170,546,939 RGD:14298760
G RIMS4 regulating synaptic membrane exocytosis 4 JBrowse link 17 47,167,302 47,235,237 RGD:14298760
G STX1B syntaxin 1B JBrowse link 3 17,439,563 17,459,517 RGD:14298760
G SYT1 synaptotagmin 1 JBrowse link 5 101,871,313 102,394,310 RGD:14298760
G SYT10 synaptotagmin 10 JBrowse link 5 40,869,418 40,940,851 RGD:14298760
G SYT12 synaptotagmin 12 JBrowse link 2 5,410,605 5,434,492 RGD:14298760
G SYT2 synaptotagmin 2 JBrowse link 10 24,638,645 24,727,198 RGD:14298760
G SYT3 synaptotagmin 3 JBrowse link 6 55,417,949 55,449,322 RGD:14298760
G SYT5 synaptotagmin 5 JBrowse link 6 59,381,649 59,389,014 RGD:14298760
G SYT6 synaptotagmin 6 JBrowse link 4 106,420,614 106,485,468 RGD:14298760
G SYT7 synaptotagmin 7 JBrowse link 2 9,947,962 10,012,713 RGD:14298760
G SYT8 synaptotagmin 8 JBrowse link 2 1,245,988 1,250,422 RGD:14298760
G SYT9 synaptotagmin 9 JBrowse link 9 2,191,757 2,395,157 RGD:14298760
dense core granule exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CADPS calcium dependent secretion activator JBrowse link 13 43,979,694 44,482,985 RGD:14298760
G CADPS2 calcium dependent secretion activator 2 JBrowse link 18 24,372,547 24,867,287 RGD:14298760
dense core granule priming term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G UNC13B unc-13 homolog B JBrowse link 1 235,918,751 236,158,098 RGD:14298760
fast, calcium ion-dependent exocytosis of neurotransmitter term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SYT1 synaptotagmin 1 JBrowse link 5 101,871,313 102,394,310 RGD:14298760
negative regulation of calcium ion-dependent exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CBARP CACN subunit beta associated regulatory protein JBrowse link 2 77,220,790 77,230,418 RGD:14298760
G LOC100621006 RE1-silencing transcription factor-like JBrowse link 8 56,048,280 56,215,011 RGD:14298760
G NOTCH1 notch receptor 1 RGD:14298760
G POU5F1 POU class 5 homeobox 1 JBrowse link 7 23,564,654 23,570,691 RGD:14298760
G RAP1B RAP1B, member of RAS oncogene family JBrowse link 5 32,910,181 32,961,972 RGD:14298760
G REST RE1 silencing transcription factor JBrowse link 8 56,035,182 56,061,140 RGD:14298760
positive regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HYAL3 hyaluronidase 3 JBrowse link 13 32,790,843 32,796,995 RGD:14298760
G ZP3 zona pellucida glycoprotein 3 JBrowse link 3 9,934,760 9,944,924 RGD:14298760
positive regulation of calcium ion-dependent exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CACNA1B calcium voltage-gated channel subunit alpha1 B RGD:14298760
G CACNA1F calcium voltage-gated channel subunit alpha1 F JBrowse link X 43,250,449 43,284,458 RGD:14298760
G CACNA1G calcium voltage-gated channel subunit alpha1 G JBrowse link 12 26,838,633 26,912,344 RGD:14298760
G CACNA1I calcium voltage-gated channel subunit alpha1 I JBrowse link 5 8,593,014 8,702,734 RGD:14298760
G CDK5 cyclin dependent kinase 5 JBrowse link 18 6,166,914 6,171,157 RGD:14298760
G CDK5R2 cyclin dependent kinase 5 regulatory subunit 2 JBrowse link 15 120,985,069 120,990,864 RGD:14298760
G DOC2B double C2 domain beta JBrowse link 12 47,529,383 47,558,236 RGD:14298760
G KCNB1 potassium voltage-gated channel subfamily B member 1 JBrowse link 17 51,032,163 51,152,566 RGD:14298760
G STXBP1 syntaxin binding protein 1 JBrowse link 1 268,116,124 268,205,805 RGD:14298760
G SYT10 synaptotagmin 10 JBrowse link 5 40,869,418 40,940,851 RGD:14298760
positive regulation of calcium ion-dependent exocytosis of neurotransmitter term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SYT1 synaptotagmin 1 JBrowse link 5 101,871,313 102,394,310 RGD:14298760
positive regulation of dense core granule exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SYT4 synaptotagmin 4 JBrowse link 6 127,382,248 127,392,258 RGD:14298760
presynaptic dense core vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G STXBP1 syntaxin binding protein 1 JBrowse link 1 268,116,124 268,205,805 RGD:14298760
G UNC13B unc-13 homolog B JBrowse link 1 235,918,751 236,158,098 RGD:14298760
regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G STXBP1 syntaxin binding protein 1 JBrowse link 1 268,116,124 268,205,805 RGD:14298760
regulation of calcium ion-dependent exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DOC2A double C2 domain alpha JBrowse link 3 18,211,264 18,216,096 RGD:14298760
G LOC100625711 synaptotagmin-15 JBrowse link 14 88,123,832 88,132,098 RGD:14298760
G RPH3AL rabphilin 3A like (without C2 domains) JBrowse link 12 47,322,505 47,497,904 RGD:14298760
G SYT1 synaptotagmin 1 JBrowse link 5 101,871,313 102,394,310 RGD:14298760
G SYT10 synaptotagmin 10 JBrowse link 5 40,869,418 40,940,851 RGD:14298760
G SYT11 synaptotagmin 11 JBrowse link 4 94,139,345 94,163,091 RGD:14298760
G SYT12 synaptotagmin 12 JBrowse link 2 5,410,605 5,434,492 RGD:14298760
G SYT13 synaptotagmin 13 JBrowse link 2 17,120,127 17,166,997 RGD:14298760
G SYT17 synaptotagmin 17 JBrowse link 3 26,447,303 26,548,362 RGD:14298760
G SYT2 synaptotagmin 2 JBrowse link 10 24,638,645 24,727,198 RGD:14298760
G SYT3 synaptotagmin 3 JBrowse link 6 55,417,949 55,449,322 RGD:14298760
G SYT4 synaptotagmin 4 JBrowse link 6 127,382,248 127,392,258 RGD:14298760
G SYT5 synaptotagmin 5 JBrowse link 6 59,381,649 59,389,014 RGD:14298760
G SYT6 synaptotagmin 6 JBrowse link 4 106,420,614 106,485,468 RGD:14298760
G SYT7 synaptotagmin 7 JBrowse link 2 9,947,962 10,012,713 RGD:14298760
G SYT8 synaptotagmin 8 JBrowse link 2 1,245,988 1,250,422 RGD:14298760
G SYT9 synaptotagmin 9 JBrowse link 9 2,191,757 2,395,157 RGD:14298760
regulation of calcium ion-dependent exocytosis of neurotransmitter term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 JBrowse link 14 31,674,659 31,744,981 RGD:14298760
G RAB3GAP1 RAB3 GTPase activating protein catalytic subunit 1 JBrowse link 15 16,756,368 16,893,148 RGD:14298760
regulation of presynaptic dense core granule exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SYT4 synaptotagmin 4 JBrowse link 6 127,382,248 127,392,258 RGD:14298760

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14401
    cellular process 12771
      export from cell 684
        secretion by cell 650
          exocytosis 243
            regulated exocytosis 159
              calcium-ion regulated exocytosis 50
                acrosomal vesicle exocytosis + 6
                calcium ion regulated lysosome exocytosis 2
                calcium ion-regulated exocytosis of neurotransmitter + 21
                cortical granule exocytosis + 0
                dense core granule exocytosis + 5
                negative regulation of calcium ion-dependent exocytosis + 6
                positive regulation of calcium ion-dependent exocytosis + 14
                regulation of calcium ion-dependent exocytosis + 36
                zymogen granule exocytosis 0
Path 2
Term Annotations click to browse term
  biological_process 14401
    localization 4586
      establishment of localization 3474
        transport 3371
          secretion 735
            secretion by cell 650
              exocytosis 243
                regulated exocytosis 159
                  calcium-ion regulated exocytosis 50
                    acrosomal vesicle exocytosis + 6
                    calcium ion regulated lysosome exocytosis 2
                    calcium ion-regulated exocytosis of neurotransmitter + 21
                    cortical granule exocytosis + 0
                    dense core granule exocytosis + 5
                    negative regulation of calcium ion-dependent exocytosis + 6
                    positive regulation of calcium ion-dependent exocytosis + 14
                    regulation of calcium ion-dependent exocytosis + 36
                    zymogen granule exocytosis 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.