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ONTOLOGY REPORT - ANNOTATIONS


Term:nonribosomal peptide biosynthetic process
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Accession:GO:0019184 term browser browse the term
Definition:The biosynthetic process in which peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione.
Synonyms:exact_synonym: non-ribosomal peptide biosynthesis;   non-ribosomal peptide biosynthetic process;   non-ribosomal peptide formation;   non-ribosomal peptide synthesis;   nonribosomal peptide anabolism;   nonribosomal peptide biosynthesis;   nonribosomal peptide formation;   nonribosomal peptide synthesis
 related_synonym: nonribosomal peptide synthetase


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amino acid activation for nonribosomal peptide biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aasdh aminoadipate-semialdehyde dehydrogenase ISO (MGI:MGI:5630050|PMID:24467666) RGD PMID:24467666 MGI:MGI:5630050 NCBI chr14:33,619,990...33,647,268
Ensembl chr14:33,624,390...33,647,180
JBrowse link
glutathione biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase, catalytic subunit IMP
ISO
IBA
ISS
IEA
(PMID:10395918), (PMID:12663448), (PMID:8104187), (PMID:9675072)
PMID:21873635
MGI:MGI:2387010 (MGI:MGI:1858542|PMID:10805773), (MGI:MGI:3607629|PMID:16081425)
GO_REF:0000024
GO_REF:0000041
RGD
UniProt
PMID:8104187, PMID:9675072, PMID:10395918, PMID:10805773, PMID:12663448, PMID:16081425, PMID:16183645, PMID:21873635 GO_REF:0000024, GO_REF:0000041, MGI:MGI:1858542, MGI:MGI:3607629, RGD:1582661, RGD:13792537 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit IMP
ISO
IBA
ISS
IEA
(PMID:10395918), (PMID:12081989), (PMID:9675072)
PMID:21873635
GO_REF:0000024
GO_REF:0000041
(MGI:MGI:3607629|PMID:16081425)
RGD
UniProt
PMID:9675072, PMID:10395918, PMID:12081989, PMID:16081425, PMID:16183645, PMID:21873635 GO_REF:0000024, GO_REF:0000041, MGI:MGI:3607629, RGD:1582661, RGD:13792537 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO
IEA
(MGI:MGI:5294309|PMID:12468440)
GO_REF:0000043
RGD
UniProt
PMID:12468440 GO_REF:0000043, MGI:MGI:5294309 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Ggt5 gamma-glutamyltransferase 5 IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:13,988,444...14,001,296 JBrowse link
G Ggt6 gamma-glutamyl transferase 6 IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:58,995,253...58,998,431
Ensembl chr10:58,995,556...58,998,033
JBrowse link
G Ggt7 gamma-glutamyltransferase 7 IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:151,005,960...151,029,941
Ensembl chr 3:151,006,531...151,032,302
JBrowse link
G Gss glutathione synthetase IDA
IEA
GO_REF:0000041 UniProt PMID:10964706 GO_REF:0000041, RGD:1599340 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
JBrowse link
G Hagh hydroxyacyl glutathione hydrolase IEA
ISO
GO_REF:0000107
(PMID:8550579)
Ensembl
RGD
PMID:8550579 GO_REF:0000107 NCBI chr10:14,215,913...14,230,506
Ensembl chr10:14,216,155...14,230,515
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 ISO (PMID:8703034) RGD PMID:8703034 NCBI chr 2:140,708,396...140,727,381
Ensembl chr 2:140,708,397...140,727,281
JBrowse link
positive regulation of glutathione biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO (MGI:MGI:5616326|PMID:14978030) RGD PMID:14978030 MGI:MGI:5616326 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 ISO (MGI:MGI:5616326|PMID:14978030) RGD PMID:14978030 MGI:MGI:5616326 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
regulation of glutathione biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc7a11 solute carrier family 7 member 11 ISO MGI:MGI:1857061 (MGI:MGI:3588610|PMID:16037214) RGD PMID:16037214 MGI:MGI:3588610 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
siderophore biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdh2 3-hydroxybutyrate dehydrogenase 2 ISO
IBA
ISS
(MGI:MGI:4820913|PMID:20550936)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:20550936, PMID:21873635 GO_REF:0000024, MGI:MGI:4820913, RGD:13792537 NCBI chr 2:240,461,505...240,482,149
Ensembl chr 2:240,461,505...240,482,145
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      biosynthetic process 6217
        organic substance biosynthetic process 6115
          organonitrogen compound biosynthetic process 2029
            peptide biosynthetic process 1116
              nonribosomal peptide biosynthetic process 14
                amino acid activation for nonribosomal peptide biosynthetic process + 1
                glutathione biosynthetic process + 12
                siderophore biosynthetic process + 1
                vancomycin biosynthetic process 0
Path 2
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      nitrogen compound metabolic process 10342
        cellular nitrogen compound metabolic process 6683
          cellular amide metabolic process 1527
            peptide metabolic process 1268
              peptide biosynthetic process 1116
                nonribosomal peptide biosynthetic process 14
                  amino acid activation for nonribosomal peptide biosynthetic process + 1
                  glutathione biosynthetic process + 12
                  siderophore biosynthetic process + 1
                  vancomycin biosynthetic process 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.