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ONTOLOGY REPORT - ANNOTATIONS


Term:hexose biosynthetic process
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Accession:GO:0019319 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule.
Synonyms:exact_synonym: hexose anabolism;   hexose biosynthesis;   hexose formation;   hexose synthesis


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hexose biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chst15 carbohydrate sulfotransferase 15 ISO (PMID:11572857) UniProtKB PMID:11572857 NCBI chrNW_004936486:12,429,391...12,456,549 JBrowse link
fructose biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sord sorbitol dehydrogenase ISO (PMID:3365415), (PMID:6870831), (PMID:8487505) UniProtKB PMID:3365415, PMID:6870831, PMID:8487505 NCBI chrNW_004936471:7,760,097...7,805,475 JBrowse link
gluconeogenesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf3 activating transcription factor 3 ISO (MGI:MGI:2180255|PMID:11916968) MGI PMID:11916968 MGI:MGI:2180255 NCBI chrNW_004936557:909,302...922,619 JBrowse link
G Atf4 activating transcription factor 4 ISO (MGI:MGI:2180255|PMID:11916968) MGI PMID:11916968 MGI:MGI:2180255 NCBI chrNW_004936492:2,114,478...2,115,969 JBrowse link
G Crtc2 CREB regulated transcription coactivator 2 ISO (MGI:MGI:3606826|PMID:16148943) UniProtKB PMID:16148943 MGI:MGI:3606826 NCBI chrNW_004936580:3,693,429...3,704,104 JBrowse link
G Cry1 cryptochrome circadian regulator 1 ISO (MGI:MGI:5567906|PMID:20852621) UniProtKB PMID:20852621 MGI:MGI:5567906 NCBI chrNW_004936492:7,929,138...7,994,797 JBrowse link
G Eno2 enolase 2 ISO RGD PMID:15720133 RGD:2302795 NCBI chrNW_004936709:904,647...913,445 JBrowse link
G Fbp1 fructose-bisphosphatase 1 ISO (PMID:19259699), (PMID:20096900) RGD
UniProtKB
PMID:4353083, PMID:11440903, PMID:19259699, PMID:20096900 RGD:2302851, RGD:2302970 NCBI chrNW_004936626:3,555,835...3,581,651 JBrowse link
G Fbp2 fructose-bisphosphatase 2 ISO RGD PMID:4353083, PMID:11440903 RGD:2302851, RGD:2302970 NCBI chrNW_004936626:3,521,953...3,548,206 JBrowse link
G G6pc glucose-6-phosphatase catalytic subunit ISO (PMID:8211187) UniProtKB
RGD
PMID:4303362, PMID:4353083, PMID:8211187, PMID:11440903 RGD:2302850, RGD:2302851, RGD:2302970 NCBI chrNW_004936490:17,605,865...17,614,754 JBrowse link
G G6pc3 glucose-6-phosphatase catalytic subunit 3 ISO RGD PMID:4303362, PMID:4353083, PMID:11440903 RGD:2302850, RGD:2302851, RGD:2302970 NCBI chrNW_004936541:556,413...561,336 JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase ISO RGD PMID:15720133, PMID:28258188 RGD:13792662, RGD:2302795 NCBI chrNW_004936709:1,243,149...1,247,782 JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 ISO (MGI:MGI:2386349|PMID:12093800) MGI PMID:12093800 MGI:MGI:2386349 NCBI chrNW_004936512:7,762,325...7,770,007 JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 ISO (MGI:MGI:2386349|PMID:12093800) MGI PMID:12093800 MGI:MGI:2386349 NCBI chrNW_004936469:21,705,421...21,833,143 JBrowse link
G Pc pyruvate carboxylase ISO RGD PMID:4353083, PMID:6049928 RGD:2302851, RGD:2302971 NCBI chrNW_004936599:2,677,770...2,793,033 JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 ISO (PMID:26971250)
(MGI:MGI:6119963|PMID:29230018)
(MGI:MGI:2180255|PMID:11916968)
PMID:4186849
UniProtKB
UniProt
RGD
MGI
BHF-UCL
PMID:4186849, PMID:4303362, PMID:4353083, PMID:6049928, PMID:11440903, PMID:11916968, PMID:26971250, PMID:29230018 MGI:MGI:2180255, MGI:MGI:6119963, RGD:2302850, RGD:2302851, RGD:2302970, RGD:2302971, RGD:8553288 NCBI chrNW_004936530:361,872...367,005 JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2, mitochondrial ISO RGD PMID:4353083, PMID:6049928, PMID:11440903 RGD:2302851, RGD:2302970, RGD:2302971 NCBI chrNW_004936722:428,473...450,452 JBrowse link
G Per2 period circadian regulator 2 ISO (MGI:MGI:5319572|PMID:22504074) UniProtKB PMID:22504074 MGI:MGI:5319572 NCBI chrNW_004936525:221,601...263,284 JBrowse link
G Pgam2 phosphoglycerate mutase 2 ISO RGD PMID:15720133 RGD:2302795 NCBI chrNW_004936478:19,021,928...19,026,110 JBrowse link
G Pgk1 phosphoglycerate kinase 1 ISO RGD PMID:3091090, PMID:15720133 RGD:2302795, RGD:2302860 NCBI chrNW_004936547:286,267...310,062 JBrowse link
G Ppargc1a PPARG coactivator 1 alpha ISO RGD PMID:21212096 RGD:9585757 NCBI chrNW_004936477:4,881,230...5,488,208 JBrowse link
G Rbp4 retinol binding protein 4 ISO (PMID:18466349)
(MGI:MGI:3584329|PMID:16034410)
BHF-UCL PMID:16034410, PMID:18466349 MGI:MGI:3584329 NCBI chrNW_004936601:1,401,215...1,410,195 JBrowse link
G Slc39a14 solute carrier family 39 member 14 ISO (MGI:MGI:4950776|PMID:21445361) UniProt PMID:21445361 MGI:MGI:4950776 NCBI chrNW_004939045:1...7,491 JBrowse link
negative regulation of gluconeogenesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing ISO (MGI:MGI:3055866|PMID:11479628) MGI PMID:11479628 MGI:MGI:3055866 NCBI chrNW_004936578:3,168,599...3,179,369 JBrowse link
G C1qtnf12 C1q and TNF related 12 ISO (MGI:MGI:5317500|PMID:22275362) MGI PMID:22275362 MGI:MGI:5317500 NCBI chrNW_004936737:1,877,428...1,881,345 JBrowse link
G C1qtnf3 C1q and TNF related 3 ISO (PMID:20952387)
(MGI:MGI:4868567|PMID:20952387)
MGI PMID:20952387 MGI:MGI:4868567 NCBI chrNW_004936518:7,039,590...7,060,463 JBrowse link
G Clk2 CDC like kinase 2 ISO (MGI:MGI:4429735|PMID:20074525) UniProtKB PMID:20074525 MGI:MGI:4429735 NCBI chrNW_004936580:4,746,276...4,758,236 JBrowse link
G Cry1 cryptochrome circadian regulator 1 ISO (MGI:MGI:5914352|PMID:28790135), (MGI:MGI:6208175|PMID:29937374) UniProt PMID:28790135, PMID:29937374 MGI:MGI:5914352, MGI:MGI:6208175 NCBI chrNW_004936492:7,929,138...7,994,797 JBrowse link
G Ep300 E1A binding protein p300 ISO (PMID:30193097) UniProt PMID:30193097 NCBI chrNW_004936492:696,982...778,132 JBrowse link
G Gck glucokinase ISO (PMID:8878425) UniProtKB PMID:8878425 NCBI chrNW_004936478:19,104,477...19,118,915 JBrowse link
G Ins insulin ISO (PMID:8069456) AgBase PMID:8069456 NCBI chrNW_004936816:1,002,137...1,003,357 JBrowse link
G Lepr leptin receptor ISO (MGI:MGI:5529403|PMID:24051374) MGI PMID:24051374 MGI:MGI:5529403 NCBI chrNW_004936591:5,771,371...5,846,177 JBrowse link
G Mst1 macrophage stimulating 1 ISO (PMID:19720831) UniProtKB PMID:19720831 NCBI chrNW_004936529:1,298,853...1,306,088 JBrowse link
G Pgp phosphoglycolate phosphatase ISO PMID:26755581
(PMID:26755581)
UniProt
UniProtKB
PMID:26755581 RGD:10679995 NCBI chrNW_004936694:1,834,016...1,836,359 JBrowse link
G Sik1 salt inducible kinase 1 ISO (MGI:MGI:3606826|PMID:16148943) UniProtKB PMID:16148943 MGI:MGI:3606826 NCBI chrNW_004936500:774,749...784,326 JBrowse link
G Soga1 suppressor of glucose, autophagy associated 1 ISO (MGI:MGI:4837302|PMID:20813965) UniProtKB PMID:20813965 MGI:MGI:4837302 NCBI chrNW_004936561:4,249,878...4,315,108 JBrowse link
positive regulation of gluconeogenesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arpp19 cAMP regulated phosphoprotein 19 ISO (PMID:9653196) UniProtKB PMID:9653196 NCBI chrNW_004936471:14,334,667...14,353,131 JBrowse link
G Ddb1 damage specific DNA binding protein 1 ISO (MGI:MGI:5914352|PMID:28790135) UniProt PMID:28790135 MGI:MGI:5914352 NCBI chrNW_004936581:1,710,382...1,742,598 JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 ISO RGD PMID:17526931 RGD:10400884 NCBI chrNW_004936498:4,514,212...4,544,523 JBrowse link
G Foxo1 forkhead box O1 ISO (MGI:MGI:4454855|PMID:12783775) MGI PMID:12783775 MGI:MGI:4454855 NCBI chrNW_004936565:5,210,014...5,299,213 JBrowse link
G Gcg glucagon ISO (MGI:MGI:5529403|PMID:24051374) MGI PMID:24051374 MGI:MGI:5529403 NCBI chrNW_004936469:16,906,658...16,916,045 JBrowse link
G Gpt glutamic--pyruvic transaminase ISO RGD PMID:25865565 RGD:11342811 NCBI chrNW_004936470:7,765,810...7,770,837 JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 ISO RGD PMID:25865565 RGD:11342811 NCBI chrNW_004936475:262,558...299,766 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO RGD PMID:24177414 RGD:10445837 NCBI chrNW_004936495:5,770,988...5,816,157 JBrowse link
G Hnf4a hepatocyte nuclear factor 4 alpha ISO RGD PMID:16893891, PMID:24177414 RGD:10445837, RGD:1624992 NCBI chrNW_004936530:2,401,053...2,425,989 JBrowse link
G Kat2a lysine acetyltransferase 2A ISO (MGI:MGI:5529403|PMID:24051374) MGI PMID:24051374 MGI:MGI:5529403 NCBI chrNW_004936490:16,952,698...16,960,424 JBrowse link
G Kat2b lysine acetyltransferase 2B ISO (MGI:MGI:5529403|PMID:24051374) MGI PMID:24051374 MGI:MGI:5529403 NCBI chrNW_004936473:12,341,545...12,415,637 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha ISO (MGI:MGI:3046612|PMID:15232616) MGI PMID:15232616 MGI:MGI:3046612 NCBI chrNW_004936629:3,672,445...3,725,645 JBrowse link
G Ppp4r3a protein phosphatase 4 regulatory subunit 3A ISO (MGI:MGI:4837269|PMID:20876121) MGI PMID:20876121 MGI:MGI:4837269 NCBI chrNW_004936488:18,423,353...18,467,363 JBrowse link
G Ppp4r3b protein phosphatase 4 regulatory subunit 3B ISO (MGI:MGI:4837269|PMID:20876121) MGI PMID:20876121 MGI:MGI:4837269 NCBI chrNW_004936491:1,917,559...1,981,954 JBrowse link
G Ptpn2 protein tyrosine phosphatase non-receptor type 2 ISO (MGI:MGI:4941441|PMID:20484139) UniProtKB PMID:20484139 MGI:MGI:4941441 NCBI chrNW_004936626:2,390,004...2,472,039 JBrowse link
G Sirt1 sirtuin 1 ISO (PMID:30193097) UniProt
RGD
PMID:21212096, PMID:30193097 RGD:9585757 NCBI chrNW_004936521:10,296,097...10,316,673 JBrowse link
G Stk11 serine/threonine kinase 11 ISO RGD PMID:17083919 RGD:2291956 NCBI chrNW_004936588:579,816...601,033 JBrowse link
G Supt20h SPT20 homolog, SAGA complex component ISO (MGI:MGI:5529403|PMID:24051374) MGI PMID:24051374 MGI:MGI:5529403 NCBI chrNW_004936472:31,119,671...31,129,939 JBrowse link
G Tcf7l2 transcription factor 7 like 2 ISO (MGI:MGI:5468191|PMID:23260145) MGI PMID:23260145 MGI:MGI:5468191 NCBI chrNW_004936486:3,473,877...3,660,565 JBrowse link
G Wdr5 WD repeat domain 5 ISO (MGI:MGI:5529403|PMID:24051374) MGI PMID:24051374 MGI:MGI:5529403 NCBI chrNW_004936669:2,943,759...2,959,788 JBrowse link
regulation of gluconeogenesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadm acyl-CoA dehydrogenase medium chain ISO (MGI:MGI:4412440|PMID:18459129) BHF-UCL PMID:18459129 MGI:MGI:4412440 NCBI chrNW_004936571:2,761,254...2,797,045 JBrowse link
G Dgkq diacylglycerol kinase theta ISO (PMID:23767959) ParkinsonsUK-UCL PMID:23767959 NCBI chrNW_004936477:22,225,624...22,238,825 JBrowse link
G Fbp1 fructose-bisphosphatase 1 ISO (PMID:7558035) UniProtKB PMID:7558035 NCBI chrNW_004936626:3,555,835...3,581,651 JBrowse link
G Foxo1 forkhead box O1 ISO (MGI:MGI:3801555|PMID:18497885) MGI PMID:18497885 MGI:MGI:3801555 NCBI chrNW_004936565:5,210,014...5,299,213 JBrowse link
G Insr insulin receptor ISO RGD PMID:29896241 RGD:14700925 NCBI chrNW_004936588:4,345,306...4,453,380 JBrowse link
G Lep leptin ISO (MGI:MGI:3769319|PMID:16513828) MGI PMID:16513828 MGI:MGI:3769319 NCBI chrNW_004936479:15,394,966...15,411,334 JBrowse link
G LOC101964621 glycine N-methyltransferase ISO (MGI:MGI:3842675|PMID:17937387) MGI PMID:17937387 MGI:MGI:3842675 NCBI chrNW_004936476:16,961,734...16,965,487 JBrowse link
G LOC101974817 E3 SUMO-protein ligase RanBP2 ISO (MGI:MGI:3693040|PMID:17069463) MGI PMID:17069463 MGI:MGI:3693040 NCBI chrNW_004936829:261,017...333,910 JBrowse link
G Nln neurolysin ISO (MGI:MGI:5588077|PMID:24719317) MGI PMID:24719317 MGI:MGI:5588077 NCBI chrNW_004936480:3,383,514...3,480,991 JBrowse link
G Nr3c1 nuclear receptor subfamily 3 group C member 1 ISO (MGI:MGI:74913|PMID:7628695) MGI PMID:7628695 MGI:MGI:74913 NCBI chrNW_004936504:10,960,069...11,056,834 JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase ISO (MGI:MGI:5495336|PMID:23395176) UniProtKB PMID:23395176 MGI:MGI:5495336 NCBI chrNW_004936762:99,335...137,833 JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 ISO (MGI:MGI:5428826|PMID:22360721) UniProtKB PMID:22360721 MGI:MGI:5428826 NCBI chrNW_004936490:11,534,412...11,549,128 JBrowse link
G Sesn2 sestrin 2 ISO (MGI:MGI:5444071|PMID:22958918) MGI PMID:22958918 MGI:MGI:5444071 NCBI chrNW_004936474:12,416,652...12,436,799 JBrowse link
G Sirt7 sirtuin 7 ISO (PMID:28655758) UniProt PMID:28655758 NCBI chrNW_004936594:5,418,331...5,425,050 JBrowse link
G Slc35b4 solute carrier family 35 member B4 ISO (MGI:MGI:5142157|PMID:21507882) MGI PMID:21507882 MGI:MGI:5142157 NCBI chrNW_004936579:1,454,951...1,474,035 JBrowse link
G Tcf7l2 transcription factor 7 like 2 ISO (MGI:MGI:5448876|PMID:23028378) MGI PMID:23028378 MGI:MGI:5448876 NCBI chrNW_004936486:3,473,877...3,660,565 JBrowse link
G Usp7 ubiquitin specific peptidase 7 ISO (PMID:28655758) UniProt PMID:28655758 NCBI chrNW_004936530:7,693,681...7,724,215 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11968
    metabolic process 7653
      small molecule metabolic process 1240
        monosaccharide metabolic process 205
          monosaccharide biosynthetic process 74
            hexose biosynthetic process 69
              allose biosynthetic process + 0
              fructose biosynthetic process 1
              fucose biosynthetic process + 0
              galactose biosynthetic process + 0
              gluconeogenesis + 67
              mannose biosynthetic process 0
              rhamnose biosynthetic process 0
              sorbose biosynthetic process + 0
Path 2
Term Annotations click to browse term
  biological_process 11968
    metabolic process 7653
      primary metabolic process 6774
        carbohydrate metabolic process 382
          monosaccharide metabolic process 205
            hexose metabolic process 192
              hexose biosynthetic process 69
                allose biosynthetic process + 0
                fructose biosynthetic process 1
                fucose biosynthetic process + 0
                galactose biosynthetic process + 0
                gluconeogenesis + 67
                mannose biosynthetic process 0
                rhamnose biosynthetic process 0
                sorbose biosynthetic process + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.