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ONTOLOGY REPORT - ANNOTATIONS


Term:L-ascorbic acid biosynthetic process
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Accession:GO:0019853 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.
Synonyms:exact_synonym: L-ascorbic acid anabolism;   L-ascorbic acid biosynthesis;   L-ascorbic acid formation;   L-ascorbic acid synthesis;   ascorbate biosynthesis;   ascorbate biosynthetic process;   vitamin C biosynthesis;   vitamin C biosynthetic process
 xref: MetaCyc:PWY-882


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L-ascorbic acid biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 ISO (MGI:MGI:3588122|PMID:15769935)
PMID:22820017
(MGI:MGI:4834110|PMID:20410296)
MGI
UniProt
PMID:15769935, PMID:20410296, PMID:22820017 MGI:MGI:3588122, MGI:MGI:4834110, RGD:13825440 NCBI chrNW_004936474:26,680,736...26,696,996 JBrowse link
G Gsto1 glutathione S-transferase omega 1 ISO RGD PMID:9786866 RGD:70644 NCBI chrNW_004936600:1,932,152...1,943,342 JBrowse link
G Rgn regucalcin ISO (MGI:MGI:5486063|PMID:23349732) UniProtKB PMID:23349732 MGI:MGI:5486063 NCBI chrNW_004936502:12,872,938...12,891,270 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11968
    metabolic process 7653
      small molecule metabolic process 1240
        monosaccharide metabolic process 205
          monosaccharide biosynthetic process 74
            L-ascorbic acid biosynthetic process 3
              L-ascorbic acid biosynthetic process via GDP-alpha-D-mannose 0
              L-ascorbic acid biosynthetic process via UDP-alpha-D-glucuronate 0
              negative regulation of L-ascorbic acid biosynthetic process 0
              regulation of L-ascorbic acid biosynthetic process + 0
Path 2
Term Annotations click to browse term
  biological_process 11968
    metabolic process 7653
      cellular metabolic process 7051
        organic acid metabolic process 697
          oxoacid metabolic process 682
            carboxylic acid metabolic process 651
              carboxylic acid biosynthetic process 227
                L-ascorbic acid biosynthetic process 3
                  L-ascorbic acid biosynthetic process via GDP-alpha-D-mannose 0
                  L-ascorbic acid biosynthetic process via UDP-alpha-D-glucuronate 0
                  negative regulation of L-ascorbic acid biosynthetic process 0
                  regulation of L-ascorbic acid biosynthetic process + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.