Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:translesion synthesis
go back to main search page
Accession:GO:0019985 term browser browse the term
Definition:The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.
Synonyms:exact_synonym: bypass DNA synthesis


show annotations for term's descendants           Sort by:
 
translesion synthesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dtl denticleless E3 ubiquitin protein ligase homolog ISO (PMID:20129063) RGD PMID:20129063 NCBI chr13:110,219,276...110,257,345
Ensembl chr13:110,220,283...110,257,367
JBrowse link
G Faap20 FA core complex associated protein 20 ISO
ISS
(PMID:22266823)
GO_REF:0000024
RGD
UniProt
PMID:22266823 GO_REF:0000024 NCBI chr 5:172,648,171...172,655,576
Ensembl chr 5:172,648,950...172,655,576
JBrowse link
G Parp10 poly (ADP-ribose) polymerase family, member 10 ISO (PMID:24695737) RGD PMID:24695737 NCBI chr 7:117,291,592...117,300,878
Ensembl chr 7:117,291,877...117,300,662
JBrowse link
G Pclaf PCNA clamp associated factor ISO
IBA
ISS
(PMID:23000965)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:23000965, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 8:71,514,281...71,526,182
Ensembl chr 8:71,514,281...71,526,182
JBrowse link
G Pcna proliferating cell nuclear antigen ISO
IBA
ISS
(PMID:20129063)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:20129063, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Poli DNA polymerase iota ISO
IBA
MGI:MGI:3055735 (MGI:MGI:3695544|PMID:17114294)
PMID:21873635
RGD PMID:17114294, PMID:21873635 MGI:MGI:3695544, RGD:13792537 NCBI chr18:65,749,107...65,768,805
Ensembl chr18:65,748,908...65,768,781
JBrowse link
G Polk DNA polymerase kappa IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:27,305,718...27,364,906
Ensembl chr 2:27,305,728...27,364,906
JBrowse link
G Poln DNA polymerase nu ISO (PMID:19908865), (PMID:20102227) RGD PMID:19908865, PMID:20102227 NCBI chr14:81,837,764...82,037,999
Ensembl chr14:81,858,737...82,037,747
JBrowse link
G Primpol primase and DNA directed polymerase ISO
IBA
(PMID:24240614), (PMID:24267451)
PMID:21873635
RGD PMID:24240614, PMID:24267451, PMID:21873635 RGD:13792537 NCBI chr16:48,863,385...48,900,409
Ensembl chr16:48,863,418...48,897,795
JBrowse link
G Sprtn SprT-like N-terminal domain IEA
ISO
ISS
GO_REF:0000107
(PMID:22681887), (PMID:22902628), (PMID:23042605), (PMID:23042607)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:22681887, PMID:22902628, PMID:23042605, PMID:23042607 GO_REF:0000024, GO_REF:0000107 NCBI chr19:57,649,901...57,657,158
Ensembl chr19:57,650,163...57,654,864
JBrowse link
G Vcp valosin-containing protein ISO
ISS
(PMID:23042605)
GO_REF:0000024
RGD
UniProt
PMID:23042605 GO_REF:0000024 NCBI chr 5:58,426,548...58,445,953
Ensembl chr 5:58,426,549...58,445,953
JBrowse link
G Zbtb1 zinc finger and BTB domain containing 1 ISO (PMID:24657165) RGD PMID:24657165 NCBI chr 6:99,401,775...99,425,739
Ensembl chr 6:99,402,360...99,424,019
JBrowse link
error-free translesion synthesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pold1 DNA polymerase delta 1, catalytic subunit ISO
ISS
(PMID:24191025)
GO_REF:0000024
RGD
UniProt
PMID:24191025 GO_REF:0000024 NCBI chr 1:100,538,066...100,554,105
Ensembl chr 1:100,537,900...100,554,488
JBrowse link
G Poldip2 DNA polymerase delta interacting protein 2 ISO
IBA
(PMID:24191025)
PMID:21873635
RGD PMID:24191025, PMID:21873635 RGD:13792537 NCBI chr10:65,781,994...65,790,833
Ensembl chr10:65,780,494...65,790,272
JBrowse link
G Rev1 REV1, DNA directed polymerase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:44,714,137...44,786,330
Ensembl chr 9:44,714,386...44,786,041
JBrowse link
error-prone translesion synthesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pole2 DNA polymerase epsilon 2, accessory subunit IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:91,494,348...91,532,355
Ensembl chr 6:91,494,393...91,518,996
JBrowse link
G Polh DNA polymerase eta IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:17,163,354...17,198,006
Ensembl chr 9:17,163,354...17,197,132
JBrowse link
G Polk DNA polymerase kappa ISO
IBA
(PMID:28297716)
PMID:21873635
RGD PMID:28297716, PMID:21873635 RGD:13792537 NCBI chr 2:27,305,718...27,364,906
Ensembl chr 2:27,305,728...27,364,906
JBrowse link
G Primpol primase and DNA directed polymerase ISO (PMID:24682820), (PMID:25746449), (PMID:28534480) RGD PMID:24682820, PMID:25746449, PMID:28534480 NCBI chr16:48,863,385...48,900,409
Ensembl chr16:48,863,418...48,897,795
JBrowse link
G Rev1 REV1, DNA directed polymerase ISO
IBA
(MGI:MGI:2157239|PMID:11711549)
PMID:21873635
RGD PMID:11711549, PMID:21873635 MGI:MGI:2157239, RGD:13792537 NCBI chr 9:44,714,137...44,786,330
Ensembl chr 9:44,714,386...44,786,041
JBrowse link
G Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:44,803,664...44,961,362
Ensembl chr20:44,803,666...44,961,382
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    metabolic process 12271
      cellular metabolic process 11085
        cellular macromolecule metabolic process 8554
          DNA metabolic process 923
            DNA repair 487
              DNA synthesis involved in DNA repair 31
                translesion synthesis 18
                  error-free translesion synthesis 3
                  error-prone translesion synthesis + 6
Path 2
Term Annotations click to browse term
  biological_process 20028
    metabolic process 12271
      cellular metabolic process 11085
        cellular aromatic compound metabolic process 5715
          nucleobase-containing compound metabolic process 5489
            nucleic acid metabolic process 4985
              DNA metabolic process 923
                DNA repair 487
                  DNA synthesis involved in DNA repair 31
                    translesion synthesis 18
                      error-free translesion synthesis 3
                      error-prone translesion synthesis + 6
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.