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ONTOLOGY REPORT - ANNOTATIONS


Term:spinal cord dorsal/ventral patterning
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Accession:GO:0021513 term browser browse the term
Definition:The process that regulates the coordinated growth and differentiation that establishes the non-random dorsal-ventral spatial arrangement of the spinal cord.
Synonyms:exact_synonym: spinal cord dorsoventral patterning


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spinal cord dorsal/ventral patterning term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fuz fuzzy planar cell polarity protein ISO (MGI:5052192|PMID:21761479) MGI PMID:21761479 MGI:5052192 NCBI chrNW_004936664:3,596,764...3,601,676 JBrowse link
G Gli2 GLI family zinc finger 2 ISO (MGI:3051712|PMID:15215207)
(MGI:3612806|PMID:16364285)
(MGI:2154468|PMID:11748151)
MGI PMID:11748151, PMID:15215207, PMID:16364285 MGI:2154468, MGI:3051712, MGI:3612806 NCBI chrNW_004936469:49,616,552...49,788,760 JBrowse link
G Gli3 GLI family zinc finger 3 ISO (MGI:3612806|PMID:16364285)
(MGI:3051712|PMID:15215207)
MGI PMID:15215207, PMID:16364285 MGI:3051712, MGI:3612806 NCBI chrNW_004936478:17,129,922...17,403,630 JBrowse link
G Ift88 intraflagellar transport 88 ISO (MGI:5052192|PMID:21761479) MGI PMID:21761479 MGI:5052192 NCBI chrNW_004936720:1,041,216...1,168,725 JBrowse link
G Intu inturned planar cell polarity protein ISO (MGI:5052192|PMID:21761479) MGI PMID:21761479 MGI:5052192 NCBI chrNW_004936642:2,950,197...3,025,079 JBrowse link
G Rab23 RAB23, member RAS oncogene family ISO (MGI:3577662|PMID:15755804), (MGI:3612806|PMID:16364285)
(MGI:3612806|PMID:16364285)
(MGI:2679893|PMID:14603322)
MGI PMID:14603322, PMID:15755804, PMID:16364285 MGI:2679893, MGI:3577662, MGI:3612806 NCBI chrNW_004936476:4,095,829...4,127,714 JBrowse link
G Shh sonic hedgehog signaling molecule ISO PMID:9230312
(MGI:2154468|PMID:11748151)
MGI PMID:9230312, PMID:11748151 MGI:2154468, RGD:8553789 NCBI chrNW_004936527:10,033,095...10,042,713 JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling ISO (MGI:3616741|PMID:16459298) MGI PMID:16459298 MGI:3616741 NCBI chrNW_004936600:3,270,662...3,381,722 JBrowse link
BMP signaling pathway involved in spinal cord dorsal/ventral patterning term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrd chordin ISO (PMID:11472837) BHF-UCL PMID:11472837 NCBI chrNW_004936578:5,498,473...5,507,195 JBrowse link
negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ift122 intraflagellar transport 122 ISO (MGI:4888042|PMID:21209331) BHF-UCL PMID:21209331 MGI:4888042 NCBI chrNW_004936602:908,034...956,634 JBrowse link
G Rfx4 regulatory factor X4 ISO (MGI:5430880|PMID:19887680) MGI PMID:19887680 MGI:5430880 NCBI chrNW_004936492:8,201,951...8,345,788 JBrowse link
G Tulp3 TUB like protein 3 ISO (MGI:3841503|PMID:19286674) MGI PMID:19286674 MGI:3841503 NCBI chrNW_004936606:3,209,170...3,278,809 JBrowse link
smoothened signaling pathway involved in spinal cord motor neuron cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli2 GLI family zinc finger 2 ISO (MGI:3051712|PMID:15215207) MGI PMID:15215207 MGI:3051712 NCBI chrNW_004936469:49,616,552...49,788,760 JBrowse link
G Gli3 GLI family zinc finger 3 ISO (MGI:3051712|PMID:15215207) MGI PMID:15215207 MGI:3051712 NCBI chrNW_004936478:17,129,922...17,403,630 JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling ISO (MGI:4355593|PMID:19684112) MGI PMID:19684112 MGI:4355593 NCBI chrNW_004936600:3,270,662...3,381,722 JBrowse link
smoothened signaling pathway involved in ventral spinal cord interneuron specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli2 GLI family zinc finger 2 ISO (MGI:3051712|PMID:15215207) MGI PMID:15215207 MGI:3051712 NCBI chrNW_004936469:49,616,552...49,788,760 JBrowse link
G Gli3 GLI family zinc finger 3 ISO (MGI:3051712|PMID:15215207) MGI PMID:15215207 MGI:3051712 NCBI chrNW_004936478:17,129,922...17,403,630 JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling ISO (MGI:4355593|PMID:19684112) MGI PMID:19684112 MGI:4355593 NCBI chrNW_004936600:3,270,662...3,381,722 JBrowse link
smoothened signaling pathway involved in ventral spinal cord patterning term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smo smoothened, frizzled class receptor ISO (MGI:3841503|PMID:19286674)
(MGI:4888042|PMID:21209331)
MGI
CACAO
PMID:19286674, PMID:21209331 MGI:3841503, MGI:4888042 NCBI chrNW_004936579:5,893,064...5,917,021 JBrowse link
ventral spinal cord interneuron fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl1 achaete-scute family bHLH transcription factor 1 ISO (MGI:3587461|PMID:16020526) UniProt PMID:16020526 MGI:3587461 NCBI chrNW_004936492:11,315,929...11,317,166 JBrowse link
G Dll4 delta like canonical Notch ligand 4 ISO (PMID:17728344) UniProtKB PMID:17728344 NCBI chrNW_004936471:4,320,235...4,330,251 JBrowse link
G Foxn4 forkhead box N4 ISO (MGI:3587461|PMID:16020526), (MGI:3765356|PMID:17728344) UniProt PMID:16020526, PMID:17728344 MGI:3587461, MGI:3765356 NCBI chrNW_004936769:1,061,907...1,081,350 JBrowse link
ventral spinal cord interneuron fate determination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nkx2-2 NK2 homeobox 2 ISO (MGI:1334824|PMID:10217145) MGI PMID:10217145 MGI:1334824 NCBI chrNW_004936620:3,961,106...3,962,910 JBrowse link
ventral spinal cord interneuron specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbx1 developing brain homeobox 1 ISO (MGI:2136554|PMID:11239429) MGI PMID:11239429 MGI:2136554 NCBI chrNW_004936654:1,139,500...1,143,477 JBrowse link
G Dmrt3 doublesex and mab-3 related transcription factor 3 ISO (MGI:5435948|PMID:22932389) MGI PMID:22932389 MGI:5435948 NCBI chrNW_004936503:3,922,417...3,936,493 JBrowse link
G Lhx3 LIM homeobox 3 ISO (MGI:4356383|PMID:19666821) MGI PMID:19666821 MGI:4356383 NCBI chrNW_004936669:1,561,433...1,573,074 JBrowse link
G Shh sonic hedgehog signaling molecule ISO PMID:9230312 MGI PMID:9230312 RGD:8553789 NCBI chrNW_004936527:10,033,095...10,042,713 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12002
    multicellular organismal process 6221
      pattern specification process 440
        regionalization 354
          spinal cord patterning 22
            spinal cord dorsal/ventral patterning 20
              BMP signaling pathway involved in spinal cord dorsal/ventral patterning 1
              negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning 3
              retinoic acid receptor signaling pathway involved in spinal cord dorsal/ventral patterning + 0
              smoothened signaling pathway involved in ventral spinal cord patterning + 7
              ventral spinal cord interneuron fate commitment + 11
Path 2
Term Annotations click to browse term
  biological_process 12002
    developmental process 5648
      anatomical structure development 5286
        multicellular organism development 4845
          system development 4567
            nervous system development 2365
              central nervous system development 1140
                spinal cord development 132
                  spinal cord patterning 22
                    spinal cord dorsal/ventral patterning 20
                      BMP signaling pathway involved in spinal cord dorsal/ventral patterning 1
                      negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning 3
                      retinoic acid receptor signaling pathway involved in spinal cord dorsal/ventral patterning + 0
                      smoothened signaling pathway involved in ventral spinal cord patterning + 7
                      ventral spinal cord interneuron fate commitment + 11
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.