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ONTOLOGY REPORT - ANNOTATIONS


Term:ventral spinal cord interneuron specification
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Accession:GO:0021521 term browser browse the term
Definition:The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway.


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ventral spinal cord interneuron specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DBX1 developing brain homeobox 1 ISO (MGI:2136554|PMID:11239429) MGI PMID:11239429 MGI:2136554 NCBI chr11:20,180,704...20,185,164
Ensembl chr11:20,092,540...20,097,727
JBrowse link
G DMRT3 doublesex and mab-3 related transcription factor 3 ISO (MGI:5435948|PMID:22932389) MGI PMID:22932389 MGI:5435948 NCBI chr 9:786,402...801,114 JBrowse link
G LHX3 LIM homeobox 3 ISO (MGI:4356383|PMID:19666821) MGI PMID:19666821 MGI:4356383 NCBI chr 9:107,271,131...107,280,001
Ensembl chr 9:136,252,880...136,260,366
JBrowse link
G SHH sonic hedgehog signaling molecule ISO PMID:9230312 MGI PMID:9230312 RGD:8553789 NCBI chr 7:147,400,112...147,414,036
Ensembl chr 7:159,114,666...159,126,651
JBrowse link
G SOX1 SRY-box transcription factor 1 ISO (MGI:4834949|PMID:20844123) MGI PMID:20844123 MGI:4834949 NCBI chr13:93,023,958...93,269,467 JBrowse link
smoothened signaling pathway involved in ventral spinal cord interneuron specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLI2 GLI family zinc finger 2 ISO (MGI:3051712|PMID:15215207) MGI PMID:15215207 MGI:3051712 NCBI chr2B:7,665,403...7,922,840
Ensembl chr2B:121,303,831...121,497,442
JBrowse link
G GLI3 GLI family zinc finger 3 ISO (MGI:3051712|PMID:15215207) MGI PMID:15215207 MGI:3051712 NCBI chr 7:42,004,965...42,280,772
Ensembl chr 7:42,056,565...42,322,865
JBrowse link
G SUFU SUFU negative regulator of hedgehog signaling ISO (MGI:4355593|PMID:19684112) MGI PMID:19684112 MGI:4355593 NCBI chr10:99,107,516...99,231,761
Ensembl chr10:102,571,886...102,696,472
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12566
    cellular process 11671
      cellular developmental process 3766
        cell fate specification 83
          cell fate specification involved in pattern specification 8
            ventral spinal cord interneuron specification 8
              retinoic acid receptor signaling pathway involved in ventral spinal cord interneuron specification 0
              smoothened signaling pathway involved in ventral spinal cord interneuron specification 3
Path 2
Term Annotations click to browse term
  biological_process 12566
    developmental process 5839
      anatomical structure development 5452
        multicellular organism development 4984
          system development 4688
            nervous system development 2406
              neurogenesis 1723
                generation of neurons 1578
                  neuron differentiation 1429
                    central nervous system neuron differentiation 223
                      ventral spinal cord interneuron differentiation 14
                        ventral spinal cord interneuron fate commitment 12
                          ventral spinal cord interneuron specification 8
                            retinoic acid receptor signaling pathway involved in ventral spinal cord interneuron specification 0
                            smoothened signaling pathway involved in ventral spinal cord interneuron specification 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.