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ONTOLOGY REPORT - ANNOTATIONS


Term:ventral spinal cord interneuron specification
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Accession:GO:0021521 term browser browse the term
Definition:The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway.


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ventral spinal cord interneuron specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DBX1 developing brain homeobox 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:39,229,392...39,234,304
Ensembl chr 2:39,229,356...39,234,969
JBrowse link
G DMRT3 doublesex and mab-3 related transcription factor 3 IEA Ensembl GO_REF:0000107 NCBI chr 1:220,819,525...220,834,080
Ensembl chr 1:220,820,556...220,833,835
JBrowse link
G LHX3 LIM homeobox 3 IEA Ensembl GO_REF:0000107
G SHH sonic hedgehog signaling molecule ISO PMID:9230312 MGI PMID:9230312 RGD:8553789 NCBI chr18:2,546,202...2,555,484
Ensembl chr18:2,545,718...2,555,484
JBrowse link
G SOX1 SRY-box transcription factor 1 ISO (MGI:4834949|PMID:20844123) MGI PMID:20844123 MGI:4834949 NCBI chr11:77,985,771...77,989,383 JBrowse link
smoothened signaling pathway involved in ventral spinal cord interneuron specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLI2 GLI family zinc finger 2 IEA Ensembl GO_REF:0000107 NCBI chr15:30,312,528...30,580,272
Ensembl chr15:30,313,817...30,579,306
JBrowse link
G GLI3 GLI family zinc finger 3 IEA Ensembl GO_REF:0000107 NCBI chr18:52,403,463...52,697,906
Ensembl chr18:52,404,071...52,697,903
JBrowse link
G SUFU SUFU negative regulator of hedgehog signaling ISO (MGI:4355593|PMID:19684112) MGI PMID:19684112 MGI:4355593 NCBI chr14:113,500,001...113,628,064
Ensembl chr14:113,500,842...113,614,517
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16548
    cellular process 15780
      cellular developmental process 4143
        cell fate specification 99
          cell fate specification involved in pattern specification 8
            ventral spinal cord interneuron specification 8
              retinoic acid receptor signaling pathway involved in ventral spinal cord interneuron specification 0
              smoothened signaling pathway involved in ventral spinal cord interneuron specification 3
Path 2
Term Annotations click to browse term
  biological_process 16548
    developmental process 6302
      anatomical structure development 5842
        multicellular organism development 5340
          system development 4963
            nervous system development 2592
              neurogenesis 1866
                generation of neurons 1718
                  neuron differentiation 1560
                    central nervous system neuron differentiation 240
                      ventral spinal cord interneuron differentiation 14
                        ventral spinal cord interneuron fate commitment 12
                          ventral spinal cord interneuron specification 8
                            retinoic acid receptor signaling pathway involved in ventral spinal cord interneuron specification 0
                            smoothened signaling pathway involved in ventral spinal cord interneuron specification 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.