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ONTOLOGY REPORT - ANNOTATIONS


Term:ventral spinal cord interneuron specification
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Accession:GO:0021521 term browser browse the term
Definition:The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway.


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ventral spinal cord interneuron specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbx1 developing brain homeobox 1 ISO MGI:MGI:2182329 (MGI:MGI:2136554|PMID:11239429) RGD PMID:11239429 MGI:MGI:2136554 NCBI chr 1:104,969,218...104,973,648
Ensembl chr 1:104,969,218...104,973,648
JBrowse link
G Dmrt3 doublesex and mab-3 related transcription factor 3 ISO MGI:MGI:4420993 (MGI:MGI:5435948|PMID:22932389) RGD PMID:22932389 MGI:MGI:5435948 NCBI chr 1:243,589,607...243,602,926
Ensembl chr 1:243,589,607...243,602,926
JBrowse link
G Lhx3 LIM homeobox 3 ISO (MGI:MGI:4356383|PMID:19666821) RGD PMID:19666821 MGI:MGI:4356383 NCBI chr 3:3,653,861...3,662,509
Ensembl chr 3:3,654,755...3,661,810
JBrowse link
G Shh sonic hedgehog signaling molecule IDA PMID:9230312 MGI PMID:9230312 RGD:8553789 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
G Sox1 SRY-box transcription factor 1 ISO MGI:MGI:3653406 (MGI:MGI:4834949|PMID:20844123) RGD PMID:20844123 MGI:MGI:4834949
regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Evx1 even-skipped homeobox 1 ISO MGI:MGI:2182858 (MGI:MGI:2136555|PMID:11239430) RGD PMID:11239430 MGI:MGI:2136555 NCBI chr 4:82,370,829...82,374,313
Ensembl chr 4:82,370,997...82,375,374
JBrowse link
G Nkx6-1 NK6 homeobox 1 ISO MGI:MGI:2386119 (MGI:MGI:2150481|PMID:11567614) RGD PMID:11567614 MGI:MGI:2150481 NCBI chr14:9,555,264...9,562,197
Ensembl chr14:9,555,264...9,562,189
JBrowse link
G Nkx6-2 NK6 homeobox 2 ISO MGI:MGI:2651850 (MGI:MGI:2150481|PMID:11567614) RGD PMID:11567614 MGI:MGI:2150481 NCBI chr 1:211,922,389...211,923,929
Ensembl chr 1:211,922,389...211,923,929
JBrowse link
G Pax6 paired box 6 ISO
IEA
MGI:MGI:1856155 (MGI:MGI:894150|PMID:9230312)
GO_REF:0000107
RGD
Ensembl
PMID:9230312 GO_REF:0000107, MGI:MGI:894150 NCBI chr 3:95,700,241...95,728,682
Ensembl chr 3:95,707,386...95,728,624
JBrowse link
smoothened signaling pathway involved in ventral spinal cord interneuron specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli2 GLI family zinc finger 2 ISO MGI:MGI:95729 (MGI:MGI:3051712|PMID:15215207) RGD PMID:15215207 MGI:MGI:3051712 NCBI chr13:34,829,021...35,049,172
Ensembl chr13:34,829,139...35,048,444
JBrowse link
G Gli3 GLI family zinc finger 3 ISO MGI:MGI:95728 (MGI:MGI:3051712|PMID:15215207) RGD PMID:15215207 MGI:MGI:3051712 NCBI chr17:52,294,942...52,569,036
Ensembl chr17:52,294,942...52,569,036
JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling ISO MGI:MGI:4840420 (MGI:MGI:4355593|PMID:19684112) RGD PMID:19684112 MGI:MGI:4355593 NCBI chr 1:266,143,766...266,241,742
Ensembl chr 1:266,143,818...266,239,016
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    cellular process 18798
      cellular developmental process 4459
        cell fate specification 104
          cell fate specification involved in pattern specification 12
            ventral spinal cord interneuron specification 12
              regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification 4
              retinoic acid receptor signaling pathway involved in ventral spinal cord interneuron specification 0
              smoothened signaling pathway involved in ventral spinal cord interneuron specification 3
Path 2
Term Annotations click to browse term
  biological_process 20027
    developmental process 6827
      anatomical structure development 6269
        multicellular organism development 5744
          system development 5280
            nervous system development 2722
              neurogenesis 1938
                generation of neurons 1781
                  neuron differentiation 1617
                    central nervous system neuron differentiation 243
                      ventral spinal cord interneuron differentiation 18
                        ventral spinal cord interneuron fate commitment 16
                          ventral spinal cord interneuron specification 12
                            regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification 4
                            retinoic acid receptor signaling pathway involved in ventral spinal cord interneuron specification 0
                            smoothened signaling pathway involved in ventral spinal cord interneuron specification 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.