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ONTOLOGY REPORT - ANNOTATIONS


Term:ventral spinal cord interneuron specification
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Accession:GO:0021521 term browser browse the term
Definition:The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway.


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ventral spinal cord interneuron specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbx1 developing brain homeobox 1 ISO (MGI:2136554|PMID:11239429) MGI PMID:11239429 MGI:2136554 NCBI chrNW_004936654:1,139,500...1,143,477 JBrowse link
G Dmrt3 doublesex and mab-3 related transcription factor 3 ISO (MGI:5435948|PMID:22932389) MGI PMID:22932389 MGI:5435948 NCBI chrNW_004936503:3,922,417...3,936,493 JBrowse link
G Lhx3 LIM homeobox 3 ISO (MGI:4356383|PMID:19666821) MGI PMID:19666821 MGI:4356383 NCBI chrNW_004936669:1,561,433...1,573,074 JBrowse link
G Shh sonic hedgehog signaling molecule ISO PMID:9230312 MGI PMID:9230312 RGD:8553789 NCBI chrNW_004936527:10,033,095...10,042,713 JBrowse link
smoothened signaling pathway involved in ventral spinal cord interneuron specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli2 GLI family zinc finger 2 ISO (MGI:3051712|PMID:15215207) MGI PMID:15215207 MGI:3051712 NCBI chrNW_004936469:49,616,552...49,788,760 JBrowse link
G Gli3 GLI family zinc finger 3 ISO (MGI:3051712|PMID:15215207) MGI PMID:15215207 MGI:3051712 NCBI chrNW_004936478:17,129,922...17,403,630 JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling ISO (MGI:4355593|PMID:19684112) MGI PMID:19684112 MGI:4355593 NCBI chrNW_004936600:3,270,662...3,381,722 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12002
    cellular process 11179
      cellular developmental process 3662
        cell fate specification 82
          cell fate specification involved in pattern specification 7
            ventral spinal cord interneuron specification 7
              retinoic acid receptor signaling pathway involved in ventral spinal cord interneuron specification 0
              smoothened signaling pathway involved in ventral spinal cord interneuron specification 3
Path 2
Term Annotations click to browse term
  biological_process 12002
    developmental process 5648
      anatomical structure development 5286
        multicellular organism development 4845
          system development 4567
            nervous system development 2365
              neurogenesis 1700
                generation of neurons 1563
                  neuron differentiation 1412
                    central nervous system neuron differentiation 218
                      ventral spinal cord interneuron differentiation 13
                        ventral spinal cord interneuron fate commitment 11
                          ventral spinal cord interneuron specification 7
                            retinoic acid receptor signaling pathway involved in ventral spinal cord interneuron specification 0
                            smoothened signaling pathway involved in ventral spinal cord interneuron specification 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.