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ONTOLOGY REPORT - ANNOTATIONS


Term:spinal cord motor neuron differentiation
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Accession:GO:0021522 term browser browse the term
Definition:The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.
Comment:This term was added by GO_REF:0000021.


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spinal cord motor neuron differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abt1 activator of basal transcription 1 JBrowse link 17 43,946,118 43,948,224 RGD:1624291
RGD:1600115
G Cacna1a calcium voltage-gated channel subunit alpha1 A JBrowse link 19 25,453,236 25,749,550 RGD:1624291
RGD:1600115
G Cln8 CLN8, transmembrane ER and ERGIC protein JBrowse link 16 79,828,321 79,838,212 RGD:1624291
G Dicer1 dicer 1 ribonuclease III JBrowse link 6 128,388,084 128,453,234 RGD:1624291
G Dync2h1 dynein cytoplasmic 2 heavy chain 1 JBrowse link 8 5,217,054 5,436,969 RGD:1624291
RGD:1600115
G Gbx1 gastrulation brain homeobox 1 JBrowse link 4 7,173,961 7,200,752 RGD:1624291
RGD:1600115
G Gdpd5 glycerophosphodiester phosphodiesterase domain containing 5 JBrowse link 1 164,337,176 164,418,056 RGD:1624291
RGD:1600115
G Gigyf2 GRB10 interacting GYF protein 2 JBrowse link 9 94,425,191 94,550,431 RGD:1624291
G Gli2 GLI family zinc finger 2 JBrowse link 13 34,829,021 35,049,172 RGD:1624291
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:1624291
G Ift172 intraflagellar transport 172 JBrowse link 6 26,390,686 26,485,459 RGD:1624291
G Ighmbp2 immunoglobulin mu DNA binding protein 2 JBrowse link 1 218,509,274 218,531,922 RGD:1624291
G Isl1 ISL LIM homeobox 1 JBrowse link 2 48,488,911 48,501,217 RGD:1624291
G Lbx1 ladybird homeobox 1 JBrowse link 1 264,973,315 264,975,132 RGD:1624291
RGD:1600115
G Lmo4 LIM domain only 4 JBrowse link 2 250,218,635 250,235,435 RGD:1624291
RGD:1600115
G Mdga2 MAM domain containing glycosylphosphatidylinositol anchor 2 JBrowse link 6 88,442,620 89,292,454 RGD:8554528
G Mir17 microRNA 17 JBrowse link 15 100,179,879 100,179,962 RGD:1624291
G Mir18a microRNA 18a JBrowse link 15 100,180,015 100,180,110 RGD:1624291
G Mir19a microRNA 19a JBrowse link 15 100,180,162 100,180,243 RGD:1624291
G Mir19b1 microRNA 19b-1 JBrowse link 15 100,180,464 100,180,550 RGD:1624291
G Mir20a microRNA 20a JBrowse link 15 100,180,334 100,180,418 RGD:1624291
G Mir92a1 microRNA 92a-1 JBrowse link 15 100,180,586 100,180,663 RGD:1624291
G Nfe2l1 nuclear factor, erythroid 2-like 1 JBrowse link 10 84,686,762 84,699,313 RGD:1600115
RGD:1624291
G Nkx2-2 NK2 homeobox 2 JBrowse link 3 141,408,460 141,419,083 RGD:1624291
RGD:1600115
G Olig2 oligodendrocyte transcription factor 2 JBrowse link 11 31,389,514 31,392,890 RGD:1624291
RGD:1600115
G Olig3 oligodendrocyte transcription factor 3 JBrowse link 1 14,797,766 14,799,835 RGD:1624291
G Ptch1 patched 1 JBrowse link 17 1,032,242 1,085,885 RGD:1624291
RGD:1600115
G Scyl1 SCY1 like pseudokinase 1 JBrowse link 1 221,115,992 221,129,668 RGD:1624291
RGD:1600115
G Scyl3 SCY1 like pseudokinase 3 JBrowse link 13 82,230,938 82,255,640 RGD:1624291
RGD:1600115
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:1624291
RGD:1600115
G Sox4 SRY-box transcription factor 4 JBrowse link 17 37,615,022 37,619,728 RGD:1624291
medial motor column neuron differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lhx3 LIM homeobox 3 JBrowse link 3 3,653,861 3,662,509 RGD:1624291
RGD:1600115
G Lhx4 LIM homeobox 4 JBrowse link 13 73,348,874 73,400,416 RGD:1624291
RGD:1600115
regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pax6 paired box 6 JBrowse link 3 95,700,241 95,728,682 RGD:1624291
RGD:1600115
regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nkx6-1 NK6 homeobox 1 JBrowse link 14 9,555,264 9,562,197 RGD:1624291
RGD:1600115
G Nkx6-2 NK6 homeobox 2 JBrowse link 1 211,922,389 211,923,929 RGD:1624291
RGD:1600115
G Pax6 paired box 6 JBrowse link 3 95,700,241 95,728,682 RGD:1624291
RGD:1600115
smoothened signaling pathway involved in spinal cord motor neuron cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gli2 GLI family zinc finger 2 JBrowse link 13 34,829,021 35,049,172 RGD:1624291
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:1624291
RGD:1600115
G Sufu SUFU negative regulator of hedgehog signaling JBrowse link 1 266,143,766 266,241,742 RGD:1624291
RGD:1600115
somatic motor neuron differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cln8 CLN8, transmembrane ER and ERGIC protein JBrowse link 16 79,828,321 79,838,212 RGD:1624291
RGD:1600115
G Phox2a paired-like homeobox 2a JBrowse link 1 166,893,734 166,898,252 RGD:1624291
RGD:1600115
G Tctn1 tectonic family member 1 JBrowse link 12 39,790,948 39,828,215 RGD:1624291
RGD:1600115
spinal cord motor neuron cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hoxc10 homeo box C10 JBrowse link 7 144,577,578 144,582,802 RGD:1624291
RGD:1600115
G Hoxd10 homeo box D10 JBrowse link 3 61,614,133 61,617,342 RGD:1624291
RGD:1600115
G Isl1 ISL LIM homeobox 1 JBrowse link 2 48,488,911 48,501,217 RGD:1624291
RGD:1600115
G Isl2 ISL LIM homeobox 2 JBrowse link 8 60,117,565 60,122,716 RGD:1624291
RGD:1600115
G Lhx3 LIM homeobox 3 JBrowse link 3 3,653,861 3,662,509 RGD:1624291
RGD:1600115
G Mnx1 motor neuron and pancreas homeobox 1 JBrowse link 4 2,376,350 2,381,308 RGD:1624291
RGD:13792537
G Olig3 oligodendrocyte transcription factor 3 JBrowse link 1 14,797,766 14,799,835 RGD:1624291
RGD:1600115
visceral motor neuron differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Isl1 ISL LIM homeobox 1 JBrowse link 2 48,488,911 48,501,217 RGD:1624291
RGD:1600115
G Isl2 ISL LIM homeobox 2 JBrowse link 8 60,117,565 60,122,716 RGD:1624291
RGD:1600115
G Tbx20 T-box transcription factor 20 JBrowse link 8 25,849,394 25,904,570 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19312
    developmental process 6637
      anatomical structure development 6101
        ventral spinal cord development 60
          spinal cord motor neuron differentiation 44
            lateral motor column neuron differentiation 0
            somatic motor neuron differentiation + 6
            spinal cord motor neuron cell fate specification + 13
            visceral motor neuron differentiation 3
Path 2
Term Annotations click to browse term
  biological_process 19312
    developmental process 6637
      anatomical structure development 6101
        multicellular organism development 5570
          system development 5099
            nervous system development 2597
              neurogenesis 1882
                generation of neurons 1747
                  neuron differentiation 1574
                    central nervous system neuron differentiation 238
                      spinal cord motor neuron differentiation 44
                        lateral motor column neuron differentiation 0
                        somatic motor neuron differentiation + 6
                        spinal cord motor neuron cell fate specification + 13
                        visceral motor neuron differentiation 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.