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ONTOLOGY REPORT - ANNOTATIONS


Term:optic nerve development
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Accession:GO:0021554 term browser browse the term
Definition:The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.
Synonyms:exact_synonym: cranial nerve 2 development;   cranial nerve II development
 related_synonym: CN II development


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optic nerve development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atoh7 atonal bHLH transcription factor 7 ISO (PMID:21441919) RGD PMID:21441919 NCBI chr20:27,082,961...27,083,410
Ensembl chr20:27,082,961...27,083,410
JBrowse link
G Ext1 exostosin glycosyltransferase 1 ISO (MGI:MGI:5311271|PMID:21743013) RGD PMID:21743013 MGI:MGI:5311271 NCBI chr 7:92,605,008...92,881,392
Ensembl chr 7:92,605,728...92,882,068
JBrowse link
G Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 IEP RGD PMID:15198689 RGD:2326047 NCBI chr13:90,722,945...90,753,338
Ensembl chr13:90,723,092...90,752,581
JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 IEP RGD PMID:12139919 RGD:727395 NCBI chr 5:75,557,038...75,678,067
Ensembl chr 5:75,557,042...75,676,584
JBrowse link
G Nav2 neuron navigator 2 ISO MGI:MGI:3054375 (MGI:MGI:3051916|PMID:15158073) RGD PMID:15158073 MGI:MGI:3051916 NCBI chr 1:104,575,765...104,941,554
Ensembl chr 1:104,576,589...104,941,552
JBrowse link
G Nkx2-2 NK2 homeobox 2 IEP RGD PMID:15048854 RGD:2306244 NCBI chr 3:141,408,460...141,419,083
Ensembl chr 3:141,408,798...141,411,170
JBrowse link
G Pax2 paired box 2 ISO
ISS
(MGI:MGI:84247|PMID:8951055)
GO_REF:0000024
RGD
UniProt
PMID:8951055 GO_REF:0000024, MGI:MGI:84247 NCBI chr 1:264,493,579...264,585,073
Ensembl chr 1:264,504,591...264,583,329
JBrowse link
G Rpl24 ribosomal protein L24 ISO MGI:MGI:1856685 (MGI:MGI:1097191|PMID:9331275) RGD PMID:9331275 MGI:MGI:1097191 NCBI chr11:47,116,885...47,122,093
Ensembl chr11:47,116,886...47,122,095
JBrowse link
G Slc25a46 solute carrier family 25, member 46 ISO MGI:MGI:6358090 (MGI:MGI:5921109|PMID:28934388) RGD PMID:28934388 MGI:MGI:5921109 NCBI chr18:24,369,104...24,397,412
Ensembl chr18:24,369,125...24,397,551
JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 ISO MGI:MGI:3852642 (MGI:MGI:4819740|PMID:20711468) RGD PMID:20711468 MGI:MGI:4819740 NCBI chr 1:219,126,687...219,139,466
Ensembl chr 1:219,127,602...219,139,464
JBrowse link
G Tmem126a transmembrane protein 126A ISO (PMID:19327736) RGD PMID:19327736 NCBI chr 1:156,283,105...156,291,057
Ensembl chr 1:156,283,128...156,291,052
JBrowse link
optic chiasma development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pax2 paired box 2 ISO
ISS
(MGI:MGI:84247|PMID:8951055)
GO_REF:0000024
RGD
UniProt
PMID:8951055 GO_REF:0000024, MGI:MGI:84247 NCBI chr 1:264,493,579...264,585,073
Ensembl chr 1:264,504,591...264,583,329
JBrowse link
optic nerve morphogenesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit ISO MGI:MGI:1926253|MGI:MGI:2158714 (MGI:MGI:2181503|PMID:11344259), (MGI:MGI:3721829|PMID:12097474) RGD PMID:11344259, PMID:12097474 MGI:MGI:2181503, MGI:MGI:3721829 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Ephb1 Eph receptor B1 ISO MGI:MGI:2677305 (MGI:MGI:2675767|PMID:12971893) RGD PMID:12971893 MGI:MGI:2675767 NCBI chr 8:110,376,954...110,813,193
Ensembl chr 8:110,376,954...110,813,000
JBrowse link
G Ephb2 Eph receptor B2 ISO MGI:MGI:2149765 (MGI:MGI:2675767|PMID:12971893) RGD PMID:12971893 MGI:MGI:2675767 NCBI chr 5:155,024,478...155,143,539
Ensembl chr 5:155,022,493...155,204,456
JBrowse link
G Gli3 GLI family zinc finger 3 ISO MGI:MGI:1856276 (MGI:MGI:3617688|PMID:16342201) RGD PMID:16342201 MGI:MGI:3617688 NCBI chr17:52,294,942...52,569,036
Ensembl chr17:52,294,942...52,569,036
JBrowse link
G Pax2 paired box 2 ISO
ISS
(MGI:MGI:84247|PMID:8951055)
GO_REF:0000024
RGD
UniProt
PMID:8951055 GO_REF:0000024, MGI:MGI:84247 NCBI chr 1:264,493,579...264,585,073
Ensembl chr 1:264,504,591...264,583,329
JBrowse link
optic nerve structural organization term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcna2 potassium voltage-gated channel subfamily A member 2 ISO MGI:MGI:3043422 (MGI:MGI:3042560|PMID:15102918) RGD PMID:15102918 MGI:MGI:3042560 NCBI chr 2:209,838,607...209,852,471
Ensembl chr 2:209,838,869...209,852,471
JBrowse link
G Pax2 paired box 2 ISO
ISS
(MGI:MGI:84247|PMID:8951055)
GO_REF:0000024
RGD
UniProt
PMID:8951055 GO_REF:0000024, MGI:MGI:84247 NCBI chr 1:264,493,579...264,585,073
Ensembl chr 1:264,504,591...264,583,329
JBrowse link
positive regulation of optic nerve formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pax2 paired box 2 ISO
ISS
(MGI:MGI:5009386|PMID:18083586)
GO_REF:0000024
RGD
UniProt
PMID:18083586 GO_REF:0000024, MGI:MGI:5009386 NCBI chr 1:264,493,579...264,585,073
Ensembl chr 1:264,504,591...264,583,329
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    developmental process 6812
      anatomical structure development 6256
        nerve development 91
          cranial nerve development 57
            optic nerve development 16
              optic chiasma development 1
              optic nerve maturation 0
              optic nerve morphogenesis + 6
Path 2
Term Annotations click to browse term
  biological_process 20014
    developmental process 6812
      anatomical structure development 6256
        multicellular organism development 5735
          system development 5272
            nervous system development 2716
              nerve development 91
                cranial nerve development 57
                  optic nerve development 16
                    optic chiasma development 1
                    optic nerve maturation 0
                    optic nerve morphogenesis + 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.