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ONTOLOGY REPORT - ANNOTATIONS


Term:cerebellar Purkinje cell layer morphogenesis
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Accession:GO:0021692 term browser browse the term
Definition:The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.


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cerebellar Purkinje cell layer morphogenesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 ISO MGI:1857876 (MGI:3709537|PMID:17409239) RGD PMID:17409239 MGI:3709537 NCBI chr 4:145,704,779...145,948,997
Ensembl chr 4:145,703,046...146,016,325
JBrowse link
G Coq8b coenzyme Q8B ISO
ISS
(PMID:27499294)
GO_REF:0000024
RGD
UniProt
PMID:27499294 GO_REF:0000024 NCBI chr 1:84,043,487...84,067,066
Ensembl chr 1:84,044,551...84,067,066
JBrowse link
G Sptbn2 spectrin, beta, non-erythrocytic 2 IEA
ISO
GO_REF:0000107
MGI:4127354 (MGI:4438955|PMID:20231455)
Ensembl
RGD
PMID:20231455 GO_REF:0000107, MGI:4438955 NCBI chr 1:219,964,429...220,006,811
Ensembl chr 1:219,964,429...220,005,068
JBrowse link
cerebellar Purkinje cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtpbp1 ATP/GTP binding protein 1 IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr17:5,510,009...5,614,416
Ensembl chr17:5,511,385...5,614,435
JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 ISO MGI:1857876 (MGI:1275896|PMID:9668038) RGD PMID:9668038 MGI:1275896 NCBI chr 4:145,704,779...145,948,997
Ensembl chr 4:145,703,046...146,016,325
JBrowse link
G Atp7a ATPase copper transporting alpha ISO MGI:1856466 (MGI:71790|PMID:2473662) RGD PMID:2473662 MGI:71790 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Atxn2 ataxin 2 ISO MGI:3505741 (MGI:3510013|PMID:10973246) RGD PMID:10973246 MGI:3510013 NCBI chr12:40,264,601...40,335,637
Ensembl chr12:40,266,662...40,332,612
JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A IEA
ISO
GO_REF:0000107
MGI:1856209|MGI:1856210 (MGI:1347769|PMID:10630211), (MGI:62667|PMID:1306163), (MGI:68980|PMID:7834360)
Ensembl
RGD
PMID:1306163, PMID:7834360, PMID:10630211 GO_REF:0000107, MGI:1347769, MGI:62667, MGI:68980 NCBI chr19:25,453,236...25,749,550
Ensembl chr19:25,526,751...25,749,550
JBrowse link
G Cend1 cell cycle exit and neuronal differentiation 1 IBA
ISO
PMID:21873635
MGI:4831137 (MGI:4830814|PMID:20153830)
RGD PMID:20153830, PMID:21873635 MGI:4830814, RGD:13792537 NCBI chr 1:214,407,072...214,410,069
Ensembl chr 1:214,408,100...214,408,549
JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 ISS
ISO
GO_REF:0000024
(MGI:5295128|PMID:21957071)
UniProt
RGD
PMID:21957071 GO_REF:0000024, MGI:5295128 NCBI chr 7:141,158,769...141,185,781
Ensembl chr 7:141,157,963...141,185,710
JBrowse link
G Herc1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 ISO MGI:3613033 (MGI:4461108|PMID:20041218) RGD PMID:20041218 MGI:4461108 NCBI chr 8:72,029,550...72,198,363
Ensembl chr 8:72,029,489...72,198,358
JBrowse link
G Ldb1 LIM domain binding 1 ISO MGI:3719683 (MGI:3718715|PMID:17664423) RGD PMID:17664423 MGI:3718715 NCBI chr 1:265,772,729...265,798,442
Ensembl chr 1:265,785,409...265,798,167
JBrowse link
G Lhx1 LIM homeobox 1 ISS
ISO
GO_REF:0000024
MGI:107792 (MGI:3718715|PMID:17664423)
UniProt
RGD
PMID:17664423 GO_REF:0000024, MGI:3718715 NCBI chr10:71,843,991...71,849,293
Ensembl chr10:71,843,991...71,849,293
JBrowse link
G Lhx5 LIM homeobox 5 ISO MGI:99783 (MGI:3718715|PMID:17664423) RGD PMID:17664423 MGI:3718715 NCBI chr12:41,663,000...41,671,437
Ensembl chr12:41,663,000...41,671,437
JBrowse link
G LOC100911402 cell cycle exit and neuronal differentiation protein 1-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:213,970,163...213,973,224
Ensembl chr 1:213,970,174...213,973,163
JBrowse link
G Psap prosaposin IEA
ISO
GO_REF:0000107
MGI:3521746 (MGI:3512714|PMID:15345707)
Ensembl
RGD
PMID:15345707 GO_REF:0000107, MGI:3512714 NCBI chr20:29,831,302...29,856,876
Ensembl chr20:29,831,314...29,856,875
JBrowse link
G Rora RAR-related orphan receptor A ISO MGI:1857035 (MGI:86446|PMID:8996814) RGD PMID:8996814 MGI:86446 NCBI chr 8:75,515,886...75,616,477
Ensembl chr 8:75,516,904...75,607,212
JBrowse link
G Skor2 SKI family transcriptional corepressor 2 ISO MGI:5300464 (MGI:5300220|PMID:21937600), (MGI:5565016|PMID:24491816) RGD PMID:21937600, PMID:24491816 MGI:5300220, MGI:5565016 NCBI chr18:73,145,596...73,199,395
Ensembl chr18:73,157,973...73,193,377
JBrowse link
G Slc25a46 solute carrier family 25, member 46 ISO MGI:6358090 (MGI:5921109|PMID:28934388) RGD PMID:28934388 MGI:5921109 NCBI chr18:24,369,104...24,397,412
Ensembl chr18:24,369,125...24,397,551
JBrowse link
G Top2a DNA topoisomerase II alpha IEP RGD PMID:11170002 RGD:8693630 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Ttc21b tetratricopeptide repeat domain 21B ISO MGI:2137515|MGI:2152544|MGI:2179048|MGI:5587034 (MGI:6152587|PMID:29615573) RGD PMID:29615573 MGI:6152587 NCBI chr 3:52,286,794...52,361,060
Ensembl chr 3:52,286,794...52,361,060
JBrowse link
G Ttll1 tubulin tyrosine ligase like 1 ISO MGI:1918244 (MGI:6269036|PMID:30420556) RGD PMID:30420556 MGI:6269036 NCBI chr 7:124,338,396...124,367,719
Ensembl chr 7:124,338,395...124,367,630
JBrowse link
cerebellar Purkinje cell layer formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gba glucosylceramidase beta ISO (MGI:3762988|PMID:17954912) RGD PMID:17954912 MGI:3762988 NCBI chr 2:188,511,781...188,522,602
Ensembl chr 2:188,516,582...188,522,601
JBrowse link
G Whrn whirlin IEA
ISO
GO_REF:0000107
(MGI:5516521|PMID:24011083)
Ensembl
RGD
PMID:24011083 GO_REF:0000107, MGI:5516521 NCBI chr 5:79,235,541...79,317,206
Ensembl chr 5:79,234,950...79,317,206
JBrowse link
cerebellar Purkinje cell layer structural organization term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll1 delta like canonical Notch ligand 1 IEA
ISO
ISS
GO_REF:0000107
(MGI:5504540|PMID:23688253)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:23688253 GO_REF:0000024, GO_REF:0000107, MGI:5504540 NCBI chr 1:57,318,621...57,326,732
Ensembl chr 1:57,318,708...57,327,379
JBrowse link
G Kif14 kinesin family member 14 ISO (MGI:5485315|PMID:23308235) RGD PMID:23308235 MGI:5485315 NCBI chr13:53,350,073...53,421,992
Ensembl chr13:53,351,717...53,420,111
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    developmental process 6826
      anatomical structure morphogenesis 2879
        cerebellar Purkinje cell layer morphogenesis 25
          cerebellar Purkinje cell layer formation + 21
          cerebellar Purkinje cell layer structural organization 2
Path 2
Term Annotations click to browse term
  biological_process 20020
    developmental process 6826
      anatomical structure development 6268
        multicellular organism development 5743
          system development 5279
            nervous system development 2719
              central nervous system development 1260
                brain development 965
                  hindbrain development 218
                    metencephalon development 167
                      cerebellum development 155
                        cerebellum morphogenesis 58
                          cerebellar cortex morphogenesis 47
                            cerebellar Purkinje cell layer morphogenesis 25
                              cerebellar Purkinje cell layer formation + 21
                              cerebellar Purkinje cell layer structural organization 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.