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ONTOLOGY REPORT - ANNOTATIONS


Term:smoothened signaling pathway involved in ventral spinal cord interneuron specification
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Accession:GO:0021775 term browser browse the term
Definition:The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate.
Synonyms:exact_synonym: hedgehog signaling pathway involved in ventral spinal cord interneuron specification;   hh signaling pathway involved in ventral spinal cord interneuron specification;   smoothened signalling pathway involved in ventral spinal cord interneuron specification


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smoothened signaling pathway involved in ventral spinal cord interneuron specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLI2 GLI family zinc finger 2 IEA Ensembl GO_REF:0000107 NCBI chr19:29,128,401...29,383,324
Ensembl chr19:29,130,227...29,383,658
JBrowse link
G GLI3 GLI family zinc finger 3 IEA Ensembl GO_REF:0000107 NCBI chr18:7,800,817...8,071,531
Ensembl chr18:7,801,394...8,068,132
JBrowse link
G SUFU SUFU negative regulator of hedgehog signaling ISO (MGI:4355593|PMID:19684112) MGI PMID:19684112 MGI:4355593 NCBI chr28:14,992,989...15,115,499
Ensembl chr28:14,992,618...15,112,389
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16190
    developmental process 6310
      cellular developmental process 4137
        cell fate specification 99
          cell fate specification involved in pattern specification 8
            ventral spinal cord interneuron specification 8
              smoothened signaling pathway involved in ventral spinal cord interneuron specification 3
Path 2
Term Annotations click to browse term
  biological_process 16190
    developmental process 6310
      anatomical structure development 5858
        multicellular organism development 5351
          system development 4984
            nervous system development 2586
              neurogenesis 1855
                generation of neurons 1707
                  neuron differentiation 1555
                    central nervous system neuron differentiation 235
                      ventral spinal cord interneuron differentiation 14
                        ventral spinal cord interneuron fate commitment 12
                          ventral spinal cord interneuron specification 8
                            smoothened signaling pathway involved in ventral spinal cord interneuron specification 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.