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ONTOLOGY REPORT - ANNOTATIONS


Term:smoothened signaling pathway involved in ventral spinal cord interneuron specification
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Accession:GO:0021775 term browser browse the term
Definition:The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate.
Synonyms:exact_synonym: hedgehog signaling pathway involved in ventral spinal cord interneuron specification;   hh signaling pathway involved in ventral spinal cord interneuron specification;   smoothened signalling pathway involved in ventral spinal cord interneuron specification


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smoothened signaling pathway involved in ventral spinal cord interneuron specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli2 GLI family zinc finger 2 ISO MGI:95729 (MGI:3051712|PMID:15215207) RGD PMID:15215207 MGI:3051712 NCBI chr13:34,829,021...35,049,172
Ensembl chr13:34,829,139...35,048,444
JBrowse link
G Gli3 GLI family zinc finger 3 ISO MGI:95728 (MGI:3051712|PMID:15215207) RGD PMID:15215207 MGI:3051712 NCBI chr17:52,294,942...52,569,036
Ensembl chr17:52,294,942...52,569,036
JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling ISO MGI:4840420 (MGI:4355593|PMID:19684112) RGD PMID:19684112 MGI:4355593 NCBI chr 1:266,143,766...266,241,742
Ensembl chr 1:266,143,818...266,239,016
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    developmental process 6826
      cellular developmental process 4457
        cell fate specification 100
          cell fate specification involved in pattern specification 8
            ventral spinal cord interneuron specification 8
              smoothened signaling pathway involved in ventral spinal cord interneuron specification 3
Path 2
Term Annotations click to browse term
  biological_process 20020
    developmental process 6826
      anatomical structure development 6268
        multicellular organism development 5743
          system development 5279
            nervous system development 2719
              neurogenesis 1936
                generation of neurons 1780
                  neuron differentiation 1614
                    central nervous system neuron differentiation 240
                      ventral spinal cord interneuron differentiation 14
                        ventral spinal cord interneuron fate commitment 12
                          ventral spinal cord interneuron specification 8
                            smoothened signaling pathway involved in ventral spinal cord interneuron specification 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.