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ONTOLOGY REPORT - ANNOTATIONS


Term:smoothened signaling pathway involved in ventral spinal cord interneuron specification
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Accession:GO:0021775 term browser browse the term
Definition:The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate.
Synonyms:exact_synonym: hedgehog signaling pathway involved in ventral spinal cord interneuron specification;   hh signaling pathway involved in ventral spinal cord interneuron specification;   smoothened signalling pathway involved in ventral spinal cord interneuron specification


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smoothened signaling pathway involved in ventral spinal cord interneuron specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli2 GLI family zinc finger 2 ISO (MGI:3051712|PMID:15215207) MGI PMID:15215207 MGI:3051712 NCBI chrNW_004936469:49,616,552...49,788,760 JBrowse link
G Gli3 GLI family zinc finger 3 ISO (MGI:3051712|PMID:15215207) MGI PMID:15215207 MGI:3051712 NCBI chrNW_004936478:17,129,922...17,403,630 JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling ISO (MGI:4355593|PMID:19684112) MGI PMID:19684112 MGI:4355593 NCBI chrNW_004936600:3,270,662...3,381,722 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12002
    developmental process 5648
      cellular developmental process 3662
        cell fate specification 82
          cell fate specification involved in pattern specification 7
            ventral spinal cord interneuron specification 7
              smoothened signaling pathway involved in ventral spinal cord interneuron specification 3
Path 2
Term Annotations click to browse term
  biological_process 12002
    developmental process 5648
      anatomical structure development 5286
        multicellular organism development 4845
          system development 4567
            nervous system development 2365
              neurogenesis 1700
                generation of neurons 1563
                  neuron differentiation 1412
                    central nervous system neuron differentiation 218
                      ventral spinal cord interneuron differentiation 13
                        ventral spinal cord interneuron fate commitment 11
                          ventral spinal cord interneuron specification 7
                            smoothened signaling pathway involved in ventral spinal cord interneuron specification 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.