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ONTOLOGY REPORT - ANNOTATIONS


Term:smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
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Accession:GO:0021776 term browser browse the term
Definition:The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway.
Synonyms:exact_synonym: hedgehog signaling pathway involved in spinal cord motor neuron cell fate specification;   hh signaling pathway involved in spinal cord motor neuron cell fate specification;   smoothened signalling pathway involved in spinal cord motor neuron cell fate specification


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smoothened signaling pathway involved in spinal cord motor neuron cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli2 GLI family zinc finger 2 ISO MGI:95729 (MGI:3051712|PMID:15215207) RGD PMID:15215207 MGI:3051712 NCBI chr13:34,829,021...35,049,172
Ensembl chr13:34,829,139...35,048,444
JBrowse link
G Gli3 GLI family zinc finger 3 ISO MGI:95728 (MGI:3051712|PMID:15215207) RGD PMID:15215207 MGI:3051712 NCBI chr17:52,294,942...52,569,036
Ensembl chr17:52,294,942...52,569,036
JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling ISO MGI:4840420 (MGI:4355593|PMID:19684112) RGD PMID:19684112 MGI:4355593 NCBI chr 1:266,143,766...266,241,742
Ensembl chr 1:266,143,818...266,239,016
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    signaling 7579
      signal transduction 7010
        cell surface receptor signaling pathway 2761
          smoothened signaling pathway 160
            smoothened signaling pathway involved in ventral spinal cord patterning 7
              smoothened signaling pathway involved in spinal cord motor neuron cell fate specification 3
Path 2
Term Annotations click to browse term
  biological_process 20020
    developmental process 6826
      anatomical structure development 6268
        multicellular organism development 5743
          system development 5279
            nervous system development 2719
              neurogenesis 1936
                generation of neurons 1780
                  neuron differentiation 1614
                    neuron fate commitment 74
                      neuron fate specification 32
                        spinal cord motor neuron cell fate specification 10
                          smoothened signaling pathway involved in spinal cord motor neuron cell fate specification 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.