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ONTOLOGY REPORT - ANNOTATIONS


Term:smoothened signaling pathway involved in ventral spinal cord patterning
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Accession:GO:0021910 term browser browse the term
Definition:The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord.
Synonyms:exact_synonym: hedgehog signaling pathway involved in ventral spinal cord patterning;   hh signaling pathway involved in ventral spinal cord patterning;   smoothened signalling pathway in ventral spinal cord patterning


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smoothened signaling pathway involved in ventral spinal cord patterning term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smo smoothened, frizzled class receptor IEA
ISO
GO_REF:0000107
MGI:MGI:2176255 (MGI:MGI:3841503|PMID:19286674), (MGI:MGI:4888042|PMID:21209331)
Ensembl
RGD
PMID:19286674, PMID:21209331 GO_REF:0000107, MGI:MGI:3841503, MGI:MGI:4888042 NCBI chr 4:57,019,941...57,041,779
Ensembl chr 4:57,019,941...57,042,770
JBrowse link
negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ift122 intraflagellar transport 122 ISO (MGI:MGI:4888042|PMID:21209331) RGD PMID:21209331 MGI:MGI:4888042 NCBI chr 4:147,756,574...147,826,983
Ensembl chr 4:147,756,553...147,826,997
JBrowse link
G Rfx4 regulatory factor X4 ISO
IBA
MGI:MGI:3799278 (MGI:MGI:5430880|PMID:19887680)
PMID:21873635
RGD PMID:19887680, PMID:21873635 MGI:MGI:5430880, RGD:13792537 NCBI chr 7:25,831,358...25,909,976
Ensembl chr 7:25,808,419...25,907,849
JBrowse link
G Tulp3 TUB like protein 3 ISO MGI:MGI:2388066 (MGI:MGI:3841503|PMID:19286674) RGD PMID:19286674 MGI:MGI:3841503 NCBI chr 4:161,636,084...161,677,807
Ensembl chr 4:161,637,892...161,658,519
JBrowse link
smoothened signaling pathway involved in spinal cord motor neuron cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli2 GLI family zinc finger 2 ISO MGI:MGI:95729 (MGI:MGI:3051712|PMID:15215207) RGD PMID:15215207 MGI:MGI:3051712 NCBI chr13:34,829,021...35,049,172
Ensembl chr13:34,829,139...35,048,444
JBrowse link
G Gli3 GLI family zinc finger 3 ISO MGI:MGI:95728 (MGI:MGI:3051712|PMID:15215207) RGD PMID:15215207 MGI:MGI:3051712 NCBI chr17:52,294,942...52,569,036
Ensembl chr17:52,294,942...52,569,036
JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling ISO MGI:MGI:4840420 (MGI:MGI:4355593|PMID:19684112) RGD PMID:19684112 MGI:MGI:4355593 NCBI chr 1:266,143,766...266,241,742
Ensembl chr 1:266,143,818...266,239,016
JBrowse link
smoothened signaling pathway involved in ventral spinal cord interneuron specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli2 GLI family zinc finger 2 ISO MGI:MGI:95729 (MGI:MGI:3051712|PMID:15215207) RGD PMID:15215207 MGI:MGI:3051712 NCBI chr13:34,829,021...35,049,172
Ensembl chr13:34,829,139...35,048,444
JBrowse link
G Gli3 GLI family zinc finger 3 ISO MGI:MGI:95728 (MGI:MGI:3051712|PMID:15215207) RGD PMID:15215207 MGI:MGI:3051712 NCBI chr17:52,294,942...52,569,036
Ensembl chr17:52,294,942...52,569,036
JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling ISO MGI:MGI:4840420 (MGI:MGI:4355593|PMID:19684112) RGD PMID:19684112 MGI:MGI:4355593 NCBI chr 1:266,143,766...266,241,742
Ensembl chr 1:266,143,818...266,239,016
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    signaling 7583
      signal transduction 7011
        cell surface receptor signaling pathway 2761
          smoothened signaling pathway 160
            smoothened signaling pathway involved in ventral spinal cord patterning 7
              negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning 3
              smoothened signaling pathway involved in spinal cord motor neuron cell fate specification 3
              smoothened signaling pathway involved in ventral spinal cord interneuron specification 3
Path 2
Term Annotations click to browse term
  biological_process 20027
    developmental process 6827
      anatomical structure development 6269
        multicellular organism development 5744
          system development 5280
            nervous system development 2722
              central nervous system development 1262
                spinal cord development 144
                  spinal cord patterning 27
                    spinal cord dorsal/ventral patterning 25
                      smoothened signaling pathway involved in ventral spinal cord patterning 7
                        negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning 3
                        smoothened signaling pathway involved in spinal cord motor neuron cell fate specification 3
                        smoothened signaling pathway involved in ventral spinal cord interneuron specification 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.