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ONTOLOGY REPORT - ANNOTATIONS


Term:ovulation cycle process
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Accession:GO:0022602 term browser browse the term
Definition:A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years.
Synonyms:related_synonym: estrous cycle process;   menstrual cycle process
 only_in_taxon: NCBITaxon:7742 ! Vertebrata


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ovulation cycle process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CMPK1 cytidine/uridine monophosphate kinase 1 ISO RGD PMID:16400681 RGD:5133250 NCBI chr15:13,324,235...13,357,387
Ensembl chr15:13,326,185...13,358,152
JBrowse link
G FSHR follicle stimulating hormone receptor ISO (MGI:1926755|PMID:11089565) MGI PMID:11089565 MGI:1926755 NCBI chr10:50,765,591...50,938,643
Ensembl chr10:50,770,995...50,938,474
JBrowse link
G GLRX glutaredoxin ISO RGD PMID:15956334 RGD:9686044 NCBI chr 3:13,795,609...13,804,732
Ensembl chr 3:13,795,817...13,803,895
JBrowse link
G LHCGR luteinizing hormone/choriogonadotropin receptor IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:50,540,706...50,594,336
Ensembl chr10:50,541,960...50,598,036
JBrowse link
G MAP2K6 mitogen-activated protein kinase kinase 6 ISO RGD PMID:11328854 RGD:7495835 NCBI chr 9:15,840,714...15,962,400
Ensembl chr 9:15,840,983...15,952,026
JBrowse link
G MSTN myostatin ISO RGD PMID:18845635 RGD:2303546 NCBI chr37:729,172...734,255
Ensembl chr37:729,172...734,362
JBrowse link
G PAM peptidylglycine alpha-amidating monooxygenase ISO RGD PMID:9618561 RGD:2302425 NCBI chr 3:8,141,508...8,312,081
Ensembl chr 3:8,142,061...8,290,477
JBrowse link
antral ovarian follicle growth term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNE1 cyclin E1 ISO RGD PMID:17084963 RGD:2289278 NCBI chr 1:121,688,622...121,697,533
Ensembl chr 1:121,688,796...121,697,649
JBrowse link
G CHAT choline O-acetyltransferase ISO RGD PMID:16846505 RGD:1600848 NCBI chr28:1,480,364...1,528,858
Ensembl chr28:1,482,202...1,528,776
JBrowse link
G ESR1 estrogen receptor 1 IEA Ensembl GO_REF:0000107 NCBI chr 1:42,081,952...42,368,544
Ensembl chr 1:42,081,969...42,368,544
JBrowse link
G FOXO3 forkhead box O3 IEA Ensembl GO_REF:0000107 NCBI chr12:65,552,455...65,673,467
Ensembl chr12:65,552,310...65,670,198
JBrowse link
G GAS2 growth arrest specific 2 IEA Ensembl GO_REF:0000107 NCBI chr21:44,277,996...44,406,210
Ensembl chr21:44,286,531...44,405,060
JBrowse link
G GPR149 G protein-coupled receptor 149 IEA Ensembl GO_REF:0000107 NCBI chr23:48,470,428...48,535,861
Ensembl chr23:48,471,701...48,535,195
JBrowse link
apoptotic process involved in luteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ROBO2 roundabout guidance receptor 2 IEA Ensembl GO_REF:0000107 NCBI chr31:9,415,390...11,047,710
Ensembl chr31:9,419,026...11,022,392
JBrowse link
G SLIT2 slit guidance ligand 2 IEA Ensembl GO_REF:0000107 NCBI chr 3:88,964,707...89,311,817
Ensembl chr 3:88,966,232...89,312,955
JBrowse link
G SLIT3 slit guidance ligand 3 IEA Ensembl GO_REF:0000107 NCBI chr 4:42,506,680...43,099,053
Ensembl chr 4:42,508,426...43,094,714
JBrowse link
follicle-stimulating hormone signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRM1 adhesion regulating molecule 1 ISO (MGI:4849324|PMID:21048919) BHF-UCL PMID:21048919 MGI:4849324 NCBI chr24:46,309,478...46,314,892
Ensembl chr24:46,275,175...46,491,347
JBrowse link
G ARRB1 arrestin beta 1 ISO RGD PMID:16899567 RGD:4140424 NCBI chr21:23,261,020...23,304,448
Ensembl chr21:23,235,711...23,297,786
JBrowse link
G ARRB2 arrestin beta 2 ISO RGD PMID:16899567 RGD:4140424 NCBI chr 5:31,831,208...31,838,875
Ensembl chr 5:31,829,864...31,839,454
JBrowse link
G CENPI centromere protein I ISO RGD PMID:7758824 RGD:728588 NCBI chr  X:75,035,147...75,112,991
Ensembl chr  X:75,035,141...75,211,971
JBrowse link
G FSHB follicle stimulating hormone subunit beta IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr21:50,279,320...50,282,843
Ensembl chr21:50,280,208...50,282,680
JBrowse link
G FSHR follicle stimulating hormone receptor IEA
IBA
(PMID:21873635) GOC
GO_Central
Ensembl
PMID:21873635 GO_REF:0000107, GO_REF:0000108 NCBI chr10:50,765,591...50,938,643
Ensembl chr10:50,770,995...50,938,474
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:16899567 RGD:4140424 NCBI chr18:50,148,566...50,167,422
Ensembl chr18:50,148,598...50,167,428
JBrowse link
G MYH9 myosin heavy chain 9 ISO RGD PMID:20068007 RGD:6902910 NCBI chr10:28,063,626...28,122,953
Ensembl chr10:28,063,624...28,122,953
JBrowse link
generation of ovulation cycle rhythm term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit IEA Ensembl GO_REF:0000107 NCBI chr 3:36,852,082...37,164,930
Ensembl chr 3:36,852,543...36,978,399
JBrowse link
G KISS1 KiSS-1 metastasis suppressor ISO RGD PMID:15976058 RGD:2292152 NCBI chr38:768,333...774,328
Ensembl chr38:768,585...773,382
JBrowse link
G NPY5R neuropeptide Y receptor Y5 ISO RGD PMID:12047724 RGD:1625504 NCBI chr15:59,600,212...59,608,576
Ensembl chr15:59,606,902...59,608,273
JBrowse link
initiation of primordial ovarian follicle growth term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXO3 forkhead box O3 IEA Ensembl GO_REF:0000107 NCBI chr12:65,552,455...65,673,467
Ensembl chr12:65,552,310...65,670,198
JBrowse link
G GAS2 growth arrest specific 2 IEA Ensembl GO_REF:0000107 NCBI chr21:44,277,996...44,406,210
Ensembl chr21:44,286,531...44,405,060
JBrowse link
luteinization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAPN5 calpain 5 ISO RGD PMID:19415717 RGD:2313170 NCBI chr21:21,626,090...21,678,545
Ensembl chr21:21,627,791...21,678,880
JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 ISO RGD PMID:23183184 RGD:7257725 NCBI chr30:16,954,020...17,056,728
Ensembl chr30:16,957,215...16,988,353
JBrowse link
G FZD4 frizzled class receptor 4 ISO (MGI:3692134|PMID:16093361) MGI PMID:16093361 MGI:3692134 NCBI chr21:12,699,886...12,709,132
Ensembl chr21:12,699,774...12,724,923
JBrowse link
G LOC477699 alpha-2-macroglobulin ISO RGD PMID:2479532 RGD:10046034 NCBI chr27:36,654,328...36,695,775 JBrowse link
G MMP1 matrix metallopeptidase 1 ISO RGD PMID:8835383 RGD:7207087 NCBI chr 5:28,978,385...28,986,644
Ensembl chr 5:28,978,473...28,986,648
JBrowse link
G MMP2 matrix metallopeptidase 2 ISO RGD PMID:10537164 RGD:7207086 NCBI chr 2:60,471,092...60,492,991
Ensembl chr 2:60,471,257...60,494,113
JBrowse link
G NR6A1 nuclear receptor subfamily 6 group A member 1 IEA Ensembl GO_REF:0000107 NCBI chr 9:58,385,981...58,485,003
Ensembl chr 9:58,266,726...58,446,000
Ensembl chr 9:58,266,726...58,446,000
JBrowse link
G PDGFRA platelet derived growth factor receptor alpha IEA Ensembl GO_REF:0000107 NCBI chr13:46,729,722...46,775,828
Ensembl chr13:46,730,703...46,773,278
JBrowse link
G PGR progesterone receptor ISO RGD PMID:8344215 RGD:1601291 NCBI chr21:447,197...552,511
Ensembl chr21:447,319...552,511
JBrowse link
G PLEKHA1 pleckstrin homology domain containing A1 IEA Ensembl GO_REF:0000107 NCBI chr28:32,025,791...32,081,824
Ensembl chr28:32,026,350...32,081,835
JBrowse link
G PTPRN protein tyrosine phosphatase receptor type N ISO (MGI:3769282|PMID:16269463) UniProt PMID:16269463 MGI:3769282 NCBI chr37:25,835,590...25,854,050
Ensembl chr37:25,836,118...25,869,931
JBrowse link
G SGPL1 sphingosine-1-phosphate lyase 1 IEA Ensembl GO_REF:0000107 NCBI chr 4:21,666,264...21,717,476
Ensembl chr 4:21,660,939...21,715,155
JBrowse link
G STAT5A signal transducer and activator of transcription 5A ISO (MGI:2181561|PMID:9630227) MGI PMID:9630227 MGI:2181561 NCBI chr 9:20,616,041...20,638,523
Ensembl chr 9:20,617,151...20,638,103
JBrowse link
G STAT5B signal transducer and activator of transcription 5B IEA Ensembl GO_REF:0000107 NCBI chr 9:20,647,712...20,718,453
Ensembl chr 9:20,691,483...20,716,485
JBrowse link
luteolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP12 caspase 12 ISO RGD PMID:25332219 RGD:13782179 NCBI chr 5:27,162,840...27,176,964
Ensembl chr 5:27,161,700...27,177,683
JBrowse link
G CASP2 caspase 2 ISO RGD PMID:16940287 RGD:4107077 NCBI chr16:6,378,447...6,396,251
Ensembl chr16:6,379,913...6,396,646
JBrowse link
G CASP3 caspase 3 ISO RGD PMID:25332219 RGD:13782179 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505
JBrowse link
G DDIT3 DNA damage inducible transcript 3 ISO RGD PMID:25332219 RGD:13782179 NCBI chr10:1,606,693...1,612,410
Ensembl chr10:1,606,693...1,611,303
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO RGD PMID:25332219 RGD:13782179 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257
JBrowse link
G MMP1 matrix metallopeptidase 1 ISO RGD PMID:8835383 RGD:7207087 NCBI chr 5:28,978,385...28,986,644
Ensembl chr 5:28,978,473...28,986,648
JBrowse link
G MMP13 matrix metallopeptidase 13 ISO RGD PMID:10537164 RGD:7207086 NCBI chr 5:28,793,568...28,864,832
Ensembl chr 5:28,850,522...28,864,121
JBrowse link
G MMP19 matrix metallopeptidase 19 ISO RGD PMID:15286033 RGD:1642024 NCBI chr10:219,193...224,873
Ensembl chr10:219,618...224,778
JBrowse link
G PLA2G4A phospholipase A2 group IVA ISO RGD PMID:11444430 RGD:1642472 NCBI chr 7:19,804,412...19,955,215
Ensembl chr 7:19,832,664...19,966,936
JBrowse link
negative regulation of progesterone secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TP53 tumor protein p53 ISO (PMID:18703674) AgBase PMID:18703674 NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109
JBrowse link
ovarian cumulus expansion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMPR1B bone morphogenetic protein receptor type 1B IEA Ensembl GO_REF:0000107 NCBI chr32:17,761,555...17,978,056
Ensembl chr32:17,870,904...18,016,444
JBrowse link
G EREG epiregulin ISO PMID:15459120 UniProt PMID:15459120 RGD:2316284 NCBI chr13:62,857,325...62,877,831
Ensembl chr13:62,856,709...62,877,760
JBrowse link
G GDF9 growth differentiation factor 9 ISO (PMID:24313324) AgBase PMID:24313324 NCBI chr11:21,143,982...21,148,945
Ensembl chr11:21,143,975...21,149,825
JBrowse link
G KIF20A kinesin family member 20A ISO (PMID:25036038) AgBase PMID:25036038 NCBI chr11:25,826,140...25,834,220
Ensembl chr11:25,825,747...25,833,985
JBrowse link
G PTX3 pentraxin 3 IEA Ensembl GO_REF:0000107 NCBI chr23:50,952,835...50,958,607
Ensembl chr23:50,952,885...50,958,167
JBrowse link
ovarian follicle rupture term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO (MGI:1934990|PMID:11384650) MGI PMID:11384650 MGI:1934990 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880
JBrowse link
G EDN2 endothelin 2 ISO RGD PMID:16410304 RGD:1581792 NCBI chr15:1,647,966...1,654,272
Ensembl chr15:1,648,077...1,654,272
JBrowse link
G NRIP1 nuclear receptor interacting protein 1 IEA Ensembl GO_REF:0000107 NCBI chr31:11,852,330...11,951,735
Ensembl chr31:11,855,338...11,932,056
JBrowse link
ovulation from ovarian follicle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif 1 IEA Ensembl GO_REF:0000107 NCBI chr31:22,169,821...22,178,879
Ensembl chr31:22,170,381...22,178,945
JBrowse link
G AFM afamin IEA Ensembl GO_REF:0000107 NCBI chr13:62,212,230...62,235,136
Ensembl chr13:62,053,814...62,294,709
JBrowse link
G AFP alpha fetoprotein IEA Ensembl GO_REF:0000107 NCBI chr13:62,182,876...62,203,414
Ensembl chr13:62,053,814...62,294,709
JBrowse link
G ALB albumin IEA Ensembl GO_REF:0000107 NCBI chr13:62,133,747...62,169,349
Ensembl chr13:62,053,814...62,294,709
JBrowse link
G FOXO3 forkhead box O3 IEA Ensembl GO_REF:0000107 NCBI chr12:65,552,455...65,673,467
Ensembl chr12:65,552,310...65,670,198
JBrowse link
G LEP leptin ISO RGD PMID:17071778 RGD:1582677 NCBI chr14:8,115,396...8,130,946
Ensembl chr14:8,116,122...8,131,395
JBrowse link
G LEPR leptin receptor ISO RGD PMID:12959975 RGD:1582680 NCBI chr 5:44,684,118...44,775,626
Ensembl chr 5:44,688,109...44,775,636
JBrowse link
G LOC482194 alpha-fetoprotein-like IEA Ensembl GO_REF:0000107 NCBI chr13:62,244,712...62,294,282
Ensembl chr13:62,053,814...62,294,709
JBrowse link
G LOC610164 carbonyl reductase [NADPH] 1 ISO RGD PMID:10642578 RGD:1299856 NCBI chr31:31,316,573...31,321,413 JBrowse link
G MMP19 matrix metallopeptidase 19 ISO RGD PMID:15286033 RGD:1642024 NCBI chr10:219,193...224,873
Ensembl chr10:219,618...224,778
JBrowse link
G MMP2 matrix metallopeptidase 2 ISO RGD PMID:14668206 RGD:1582606 NCBI chr 2:60,471,092...60,492,991
Ensembl chr 2:60,471,257...60,494,113
JBrowse link
G NOS2 nitric oxide synthase 2 NOT ISO (MGI:2157249|PMID:11779605) MGI PMID:11779605 MGI:2157249 NCBI chr 9:42,171,821...42,210,217
Ensembl chr 9:42,171,821...42,208,588
JBrowse link
G NOS3 nitric oxide synthase 3 IEA Ensembl GO_REF:0000107 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277
JBrowse link
G PGR progesterone receptor IEA Ensembl GO_REF:0000107 NCBI chr21:447,197...552,511
Ensembl chr21:447,319...552,511
JBrowse link
G PLA2G4A phospholipase A2 group IVA ISO RGD PMID:10189070 RGD:1642477 NCBI chr 7:19,804,412...19,955,215
Ensembl chr 7:19,832,664...19,966,936
JBrowse link
G SIRT1 sirtuin 1 ISO (MGI:2447945|PMID:12482959) MGI PMID:12482959 MGI:2447945 NCBI chr 4:19,188,616...19,220,031
Ensembl chr 4:19,188,675...19,218,279
JBrowse link
positive regulation of antral ovarian follicle growth term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGER4 prostaglandin E receptor 4 ISO RGD PMID:15944932 RGD:10003098 NCBI chr 4:68,663,362...68,676,241
Ensembl chr 4:68,663,364...68,676,358
JBrowse link
G ZP3 zona pellucida glycoprotein 3 ISS
IEA
UniProtKB
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr 6:7,586,212...7,594,610
Ensembl chr 6:7,585,970...7,594,610
JBrowse link
positive regulation of progesterone secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MFN2 mitofusin 2 ISO RGD PMID:25120590 RGD:13204819 NCBI chr 2:84,284,719...84,310,715
Ensembl chr 2:84,284,719...84,308,225
JBrowse link
G RETN resistin ISO RGD PMID:21239528 RGD:7207233 NCBI chr20:52,434,148...52,435,627
Ensembl chr20:52,434,271...52,435,624
JBrowse link
G RUNX1 RUNX family transcription factor 1 ISO RGD PMID:16675540 RGD:6482842 NCBI chr31:30,170,859...30,420,344
Ensembl chr31:30,170,605...30,420,839
JBrowse link
preantral ovarian follicle growth term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMH anti-Mullerian hormone ISO RGD PMID:11133686 RGD:2315649 NCBI chr20:56,785,960...56,788,815 JBrowse link
G GPR149 G protein-coupled receptor 149 IEA Ensembl GO_REF:0000107 NCBI chr23:48,470,428...48,535,861
Ensembl chr23:48,471,701...48,535,195
JBrowse link
G ZNF830 zinc finger protein 830 IEA Ensembl GO_REF:0000107 NCBI chr 9:38,382,508...38,384,060
Ensembl chr 9:38,382,900...38,384,015
JBrowse link
primary ovarian follicle growth term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FSHR follicle stimulating hormone receptor IEA Ensembl GO_REF:0000107 NCBI chr10:50,765,591...50,938,643
Ensembl chr10:50,770,995...50,938,474
JBrowse link
G SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2 ISO (MGI:3836097|PMID:18753606) MGI PMID:18753606 MGI:3836097 NCBI chr25:4,345,785...4,419,352
Ensembl chr25:4,345,771...4,778,047
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:22905678 RGD:13210788 NCBI chr24:25,982,499...26,019,748
Ensembl chr24:25,999,048...26,018,077
JBrowse link
progesterone secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FZD4 frizzled class receptor 4 IEA Ensembl GO_REF:0000107 NCBI chr21:12,699,886...12,709,132
Ensembl chr21:12,699,774...12,724,923
JBrowse link
G INHBA inhibin subunit beta A ISS UniProtKB GO_REF:0000024 NCBI chr18:8,272,978...8,288,432
Ensembl chr18:8,272,872...8,283,794
JBrowse link
regulation of progesterone secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GDF9 growth differentiation factor 9 IEA Ensembl GO_REF:0000107 NCBI chr11:21,143,982...21,148,945
Ensembl chr11:21,143,975...21,149,825
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16190
    reproductive process 1594
      ovulation cycle process 78
        antral ovarian follicle growth + 13
        apoptotic process involved in luteolysis 3
        cumulus cell differentiation + 0
        follicle-stimulating hormone signaling pathway 8
        follicular fluid formation in ovarian follicle antrum + 0
        generation of ovulation cycle rhythm 3
        initiation of primordial ovarian follicle growth 2
        luteinization + 20
        luteolysis + 12
        negative regulation of progesterone biosynthesis involved in luteolysis 0
        ovarian cumulus expansion 5
        ovarian follicle endowment 0
        ovarian follicle rupture 3
        ovulation from ovarian follicle + 19
        preantral ovarian follicle growth 3
        primary ovarian follicle growth + 3
        progesterone secretion + 7
        uterine wall breakdown 0
        uterine wall growth 0
Path 2
Term Annotations click to browse term
  biological_process 16190
    reproduction 1596
      reproductive process 1594
        multicellular organismal reproductive process 901
          ovulation cycle 122
            ovulation cycle process 78
              antral ovarian follicle growth + 13
              apoptotic process involved in luteolysis 3
              cumulus cell differentiation + 0
              follicle-stimulating hormone signaling pathway 8
              follicular fluid formation in ovarian follicle antrum + 0
              generation of ovulation cycle rhythm 3
              initiation of primordial ovarian follicle growth 2
              luteinization + 20
              luteolysis + 12
              negative regulation of progesterone biosynthesis involved in luteolysis 0
              ovarian cumulus expansion 5
              ovarian follicle endowment 0
              ovarian follicle rupture 3
              ovulation from ovarian follicle + 19
              preantral ovarian follicle growth 3
              primary ovarian follicle growth + 3
              progesterone secretion + 7
              uterine wall breakdown 0
              uterine wall growth 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.