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ONTOLOGY REPORT - ANNOTATIONS


Term:muscle filament sliding
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Accession:GO:0030049 term browser browse the term
Definition:The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.


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muscle filament sliding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Myh6 myosin heavy chain 6 JBrowse link 15 33,605,653 33,629,730 RGD:1624291
RGD:1600115
G Myh7 myosin heavy chain 7 JBrowse link 15 33,605,769 33,657,761 RGD:1600115
RGD:1624291
G Myh8 myosin heavy chain 8 JBrowse link 10 53,818,818 53,848,490 RGD:1624291
RGD:1600115
G Myl6l myosin, light polypeptide 6, alkali, smooth muscle and non-muscle-like RGD:8554813
G Tnnt2 troponin T2, cardiac type JBrowse link 13 52,662,974 52,680,992 RGD:1600115
RGD:1624291
G Tpm1 tropomyosin 1 JBrowse link 8 72,814,737 72,841,496 RGD:1556479
negative regulation of muscle filament sliding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dbn1 drebrin 1 JBrowse link 17 9,679,511 9,693,878 RGD:10398727
regulation of muscle filament sliding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mylk2 myosin light chain kinase 2 JBrowse link 3 148,386,185 148,397,851 RGD:1624291
RGD:1600115
regulation of muscle filament sliding speed term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tnnc1 troponin C1, slow skeletal and cardiac type JBrowse link 16 7,292,207 7,295,238 RGD:1624291
G Tnnt2 troponin T2, cardiac type JBrowse link 13 52,662,974 52,680,992 RGD:8554013

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    multicellular organismal process 8951
      system process 3426
        muscle system process 457
          muscle contraction 331
            muscle filament sliding 9
              negative regulation of muscle filament sliding 1
              positive regulation of muscle filament sliding 0
              regulation of muscle filament sliding + 4
Path 2
Term Annotations click to browse term
  biological_process 19858
    cellular process 18618
      movement of cell or subcellular component 2162
        actin filament-based movement 127
          actin-mediated cell contraction 96
            actin-myosin filament sliding 10
              muscle filament sliding 9
                negative regulation of muscle filament sliding 1
                positive regulation of muscle filament sliding 0
                regulation of muscle filament sliding + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.