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ONTOLOGY REPORT - ANNOTATIONS


Term:insulin processing
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Accession:GO:0030070 term browser browse the term
Definition:The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form proinsulin; proinsulin is then cleaved to release the C peptide, leaving the A and B chains of mature insulin linked by disulfide bridges.


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insulin processing term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cpe carboxypeptidase E JBrowse link 16 26,906,716 27,014,811 RGD:1626225
RGD:1600115
RGD:1624291
G Ero1b endoplasmic reticulum oxidoreductase 1 beta JBrowse link 17 90,709,394 90,783,110 RGD:1624291
G Pcsk2 proprotein convertase subtilisin/kexin type 2 JBrowse link 3 137,618,891 137,923,385 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19439
    metabolic process 11641
      hormone metabolic process 239
        peptide hormone processing 15
          insulin processing 3
Path 2
Term Annotations click to browse term
  biological_process 19439
    metabolic process 11641
      organic substance metabolic process 11030
        macromolecule metabolic process 9494
          protein metabolic process 6017
            proteolysis 1837
              protein processing 227
                signaling receptor ligand precursor processing 0
                  peptide hormone processing 15
                    insulin processing 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.