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ONTOLOGY REPORT - ANNOTATIONS


Term:natural killer cell activation
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Accession:GO:0030101 term browser browse the term
Definition:The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor.
Synonyms:exact_synonym: NK cell activation


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natural killer cell activation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bag6 BAG cochaperone 6 JBrowse link 20 5,124,512 5,138,084 RGD:1624291
G Ifna1 interferon, alpha 1 JBrowse link 5 106,951,822 106,952,908 RGD:1624291
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:1624291
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:1624291
RGD:1600115
G Il18r1 interleukin 18 receptor 1 JBrowse link 9 47,184,404 47,217,403 RGD:1624291
G Il2rb interleukin 2 receptor subunit beta JBrowse link 7 119,701,338 119,716,238 RGD:2303496
G Itgb2 integrin subunit beta 2 JBrowse link 20 11,777,773 11,815,647 RGD:1600235
G Klra5 killer cell lectin-like receptor, subfamily A, member 5 JBrowse link 4 165,169,417 165,317,573 RGD:61085
G Klre1 killer cell lectin-like receptor, family E, member 1 JBrowse link 4 163,346,684 163,355,050 RGD:1600115
G Klrk1 killer cell lectin like receptor K1 JBrowse link 4 163,392,652 163,403,735 RGD:1624291
G Ncr3 natural cytotoxicity triggering receptor 3 JBrowse link 20 5,170,169 5,175,773 RGD:1600115
RGD:13792537
RGD:1624291
G Prdx1 peroxiredoxin 1 JBrowse link 5 135,536,413 135,551,986 RGD:1624291
G Rasgrp1 RAS guanyl releasing protein 1 JBrowse link 3 108,984,029 109,044,420 RGD:1624291
G Ulbp1 UL16 binding protein 1 JBrowse link 1 1,181,301 1,200,526 RGD:1624291
natural killer cell activation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07049134.3 RGD:13792537
G Cd244 CD244 molecule JBrowse link 13 89,959,091 89,995,993 RGD:1624291
G Ifna11 interferon alpha family, gene 11 JBrowse link 5 107,504,741 107,505,783 RGD:13792537
G Ifna16l1 interferon, alpha 16-like 1 JBrowse link 5 107,446,898 107,447,636 RGD:13792537
G Ifna4 interferon, alpha 4 JBrowse link 5 106,922,563 106,923,132 RGD:1624291
RGD:13792537
G Ifna5 interferon, alpha 5 JBrowse link 5 107,039,347 107,039,925 RGD:13792537
G Ifnb1 interferon beta 1 JBrowse link 5 106,865,192 106,865,746 RGD:13792537
G Ifne interferon, epsilon JBrowse link 5 107,232,651 107,235,943 RGD:13792537
G Ifnk interferon kappa JBrowse link 5 50,631,217 50,634,142 RGD:13792537
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:1600048
G LOC100911527 interferon alpha-12-like JBrowse link 5 87,328,395 87,328,946 RGD:13792537
G LOC100912314 interferon alpha-1-like JBrowse link 5 107,369,378 107,370,443 RGD:13792537
G LOC100912356 interferon alpha-1-like JBrowse link 5 107,387,566 107,388,182 RGD:13792537
G RGD1560539 similar to interferon alpha 8/6 precursor; IFNa8/6 (B6) JBrowse link 5 87,353,750 87,354,699 RGD:13792537
natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Coro1a coronin 1A JBrowse link 1 198,123,883 198,128,890 RGD:1624291
G Rab27a RAB27A, member RAS oncogene family JBrowse link 8 79,722,334 79,776,228 RGD:1624291
G Stx11 syntaxin 11 JBrowse link 1 7,039,160 7,064,870 RGD:1624291
G Unc13d unc-13 homolog D JBrowse link 10 104,613,907 104,628,664 RGD:1624291
RGD:1600115
G Vamp2 vesicle-associated membrane protein 2 JBrowse link 10 55,675,171 55,679,405 RGD:1624291
G Vamp7 vesicle-associated membrane protein 7 JBrowse link 12 18,996,566 19,033,714 RGD:1624291
natural killer cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Axl Axl receptor tyrosine kinase JBrowse link 1 82,550,892 82,580,761 RGD:1624291
RGD:13792537
G Hectd1 HECT domain E3 ubiquitin protein ligase 1 JBrowse link 6 72,509,658 72,596,285 RGD:1624291
G Id2 inhibitor of DNA binding 2 JBrowse link 6 44,360,077 44,361,908 RGD:1624291
G Ikzf1 IKAROS family zinc finger 1 JBrowse link 14 91,782,281 91,867,828 RGD:1624291
G Il11ra1 interleukin 11 receptor subunit alpha 1 JBrowse link 5 58,149,150 58,159,072 RGD:1624291
G Kat7 lysine acetyltransferase 7 JBrowse link 10 83,095,067 83,128,342 RGD:1600115
RGD:1624291
G Mertk MER proto-oncogene, tyrosine kinase JBrowse link 3 121,235,230 121,340,932 RGD:1624291
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:1624291
G Rabl3 RAB, member of RAS oncogene family-like 3 JBrowse link 11 66,049,635 66,078,669 RGD:1624291
G Slamf1 signaling lymphocytic activation molecule family member 1 JBrowse link 13 90,184,545 90,219,170 RGD:1624291
G Slamf6 SLAM family member 6 JBrowse link 13 90,300,160 90,321,781 RGD:1624291
G Sp3 Sp3 transcription factor JBrowse link 3 59,644,579 59,689,011 RGD:1624291
G Stat5a signal transducer and activator of transcription 5A JBrowse link 10 88,764,732 88,789,060 RGD:1624291
G Stat5b signal transducer and activator of transcription 5B JBrowse link 10 88,686,207 88,712,313 RGD:1624291
RGD:1600115
G Tcf3 transcription factor 3 JBrowse link 7 12,146,642 12,168,400 RGD:1624291
G Tox thymocyte selection-associated high mobility group box JBrowse link 5 19,892,698 20,189,721 RGD:1624291
G Tusc2 tumor suppressor 2, mitochondrial calcium regulator JBrowse link 8 116,318,963 116,322,181 RGD:1624291
G Tyro3 TYRO3 protein tyrosine kinase JBrowse link 3 111,597,102 111,616,142 RGD:1624291
RGD:1600115
G Zfp683 zinc finger protein 683 JBrowse link 5 152,280,982 152,288,208 RGD:1624291
natural killer cell proliferation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Elf4 E74 like ETS transcription factor 4 JBrowse link X 135,239,626 135,284,330 RGD:1624291
G Slamf1 signaling lymphocytic activation molecule family member 1 JBrowse link 13 90,184,545 90,219,170 RGD:1624291
G Slamf6 SLAM family member 6 JBrowse link 13 90,300,160 90,321,781 RGD:1624291
negative regulation of natural killer cell activation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clnk cytokine-dependent hematopoietic cell linker JBrowse link 14 76,657,165 76,834,050 RGD:1624291
G Fgr FGR proto-oncogene, Src family tyrosine kinase JBrowse link 5 151,172,189 151,199,746 RGD:1624291
G Havcr2 hepatitis A virus cellular receptor 2 JBrowse link 10 31,561,838 31,590,624 RGD:1624291
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:1624291
G Mill1 MHC I like leukocyte 1 JBrowse link 1 79,631,266 79,657,943 RGD:1624291
G Pibf1 progesterone immunomodulatory binding factor 1 JBrowse link 15 83,494,110 83,663,202 RGD:1624291
G Rhbdd3 rhomboid domain containing 3 JBrowse link 14 85,350,852 85,357,029 RGD:1624291
negative regulation of natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:1624291
G RT1-CE5 RT1 class I, locus CE5 JBrowse link 20 4,892,702 4,896,993 RGD:1624291
negative regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pglyrp1 peptidoglycan recognition protein 1 JBrowse link 1 79,790,879 79,796,064 RGD:1624291
RGD:1600115
G Pglyrp2 peptidoglycan recognition protein 2 JBrowse link 7 14,426,481 14,435,987 RGD:1624291
G Pglyrp3 peptidoglycan recognition protein 3 JBrowse link 2 191,903,626 192,264,872 RGD:1624291
G Pglyrp4 peptidoglycan recognition protein 4 JBrowse link 2 190,125,655 190,204,230 RGD:1624291
positive regulation of natural killer cell activation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bloc1s3 biogenesis of lysosomal organelles complex-1, subunit 3 JBrowse link 1 80,414,766 80,417,385 RGD:1624291
G Bloc1s6 biogenesis of lysosomal organelles complex 1 subunit 6 JBrowse link 3 114,869,478 114,880,218 RGD:1624291
G Hps1 HPS1, biogenesis of lysosomal organelles complex 3 subunit 1 JBrowse link 1 261,989,178 262,015,282 RGD:1624291
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:1624291
RGD:1600115
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:1624291
G Lyst lysosomal trafficking regulator JBrowse link 17 90,323,055 90,522,091 RGD:1624291
G Rasgrp1 RAS guanyl releasing protein 1 JBrowse link 3 108,984,029 109,044,420 RGD:1624291
G Ticam1 toll-like receptor adaptor molecule 1 JBrowse link 9 10,780,185 10,790,280 RGD:1624291
G Tyrobp transmembrane immune signaling adaptor Tyrobp JBrowse link 1 88,875,370 88,879,305 RGD:1624291
RGD:13792537
G Ulbp1 UL16 binding protein 1 JBrowse link 1 1,181,301 1,200,526 RGD:1624291
positive regulation of natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 JBrowse link 19 41,805,252 41,860,076 RGD:1624291
G Cd160 CD160 molecule JBrowse link 2 198,933,681 198,965,380 RGD:1624291
G Lamp1 lysosomal-associated membrane protein 1 JBrowse link 16 81,689,576 81,714,341 RGD:1624291
G RT1-CE5 RT1 class I, locus CE5 JBrowse link 20 4,892,702 4,896,993 RGD:1624291
positive regulation of natural killer cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Axl Axl receptor tyrosine kinase JBrowse link 1 82,550,892 82,580,761 RGD:1624291
G Flt3lg Fms related receptor tyrosine kinase 3 ligand JBrowse link 1 101,126,006 101,131,413 RGD:1624291
G Gas6 growth arrest specific 6 JBrowse link 16 81,213,364 81,243,824 RGD:1624291
RGD:1600115
G Il15 interleukin 15 JBrowse link 19 23,542,606 23,624,366 RGD:1624291
G Il15ra interleukin 15 receptor subunit alpha JBrowse link 17 70,451,861 70,481,838 RGD:1624291
G Il21 interleukin 21 JBrowse link 2 123,965,021 123,972,356 RGD:1624291
G Rasgrp1 RAS guanyl releasing protein 1 JBrowse link 3 108,984,029 109,044,420 RGD:1624291
G Stat5a signal transducer and activator of transcription 5A JBrowse link 10 88,764,732 88,789,060 RGD:1624291
G Stat5b signal transducer and activator of transcription 5B JBrowse link 10 88,686,207 88,712,313 RGD:1624291
RGD:1600115
G Tox thymocyte selection-associated high mobility group box JBrowse link 5 19,892,698 20,189,721 RGD:1624291
G Zbtb1 zinc finger and BTB domain containing 1 JBrowse link 6 99,401,775 99,425,739 RGD:1624291
positive regulation of natural killer cell proliferation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd244 CD244 molecule JBrowse link 13 89,959,091 89,995,993 RGD:1624291
G Flt3lg Fms related receptor tyrosine kinase 3 ligand JBrowse link 1 101,126,006 101,131,413 RGD:11049499
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:1624291
G Il15 interleukin 15 JBrowse link 19 23,542,606 23,624,366 RGD:1624291
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:1624291
RGD:1600115
G Il23a interleukin 23 subunit alpha JBrowse link 7 2,710,609 2,712,723 RGD:1624291
G RT1-S3 RT1 class Ib, locus S3 JBrowse link 20 3,176,124 3,180,825 RGD:1624291
G Stat5b signal transducer and activator of transcription 5B JBrowse link 10 88,686,207 88,712,313 RGD:1624291
RGD:1600115
regulation of natural killer cell activation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dcaf15 DDB1 and CUL4 associated factor 15 JBrowse link 19 25,212,469 25,219,803 RGD:1624291
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:1624291
RGD:1600115
G Sh2d1b2 SH2 domain containing 1B2 JBrowse link 13 88,557,361 88,584,078 RGD:1624291
G Slamf7 SLAM family member 7 JBrowse link 13 90,056,726 90,075,159 RGD:1624291
regulation of natural killer cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:1624291
G Prdm1 PR/SET domain 1 JBrowse link 20 49,464,921 49,556,623 RGD:1624291
G Zfp683 zinc finger protein 683 JBrowse link 5 152,280,982 152,288,208 RGD:1624291
regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Zfp683 zinc finger protein 683 JBrowse link 5 152,280,982 152,288,208 RGD:1624291
regulation of natural killer cell proliferation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:1624291
RGD:1600115
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 JBrowse link 2 206,342,066 206,390,348 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19576
    immune system process 2692
      leukocyte activation 1008
        lymphocyte activation 828
          natural killer cell activation 89
            establishment of natural killer cell polarity 0
            natural killer cell activation involved in immune response + 30
            natural killer cell differentiation + 32
            natural killer cell proliferation + 13
            negative regulation of natural killer cell activation + 12
            positive regulation of natural killer cell activation + 28
            regulation of natural killer cell activation + 46
Path 2
Term Annotations click to browse term
  biological_process 19576
    cellular process 18361
      cell activation 1131
        leukocyte activation 1008
          lymphocyte activation 828
            natural killer cell activation 89
              establishment of natural killer cell polarity 0
              natural killer cell activation involved in immune response + 30
              natural killer cell differentiation + 32
              natural killer cell proliferation + 13
              negative regulation of natural killer cell activation + 12
              positive regulation of natural killer cell activation + 28
              regulation of natural killer cell activation + 46
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.