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ONTOLOGY REPORT - ANNOTATIONS


Term:sphingolipid biosynthetic process
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Accession:GO:0030148 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
Synonyms:exact_synonym: sphingolipid anabolism;   sphingolipid biosynthesis;   sphingolipid formation;   sphingolipid synthesis
 xref: MetaCyc:PWY-5129


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sphingolipid biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acer1 alkaline ceramidase 1 JBrowse link 9 10,061,978 10,093,588 RGD:1624291
G Cerkl ceramide kinase-like JBrowse link 3 66,268,835 66,395,615 RGD:1624291
RGD:1600115
G Cers1 ceramide synthase 1 JBrowse link 16 20,845,580 20,860,789 RGD:1624291
G Cers2 ceramide synthase 2 JBrowse link 2 196,487,656 196,495,930 RGD:1624291
G Cers3 ceramide synthase 3 JBrowse link 1 127,706,618 127,781,041 RGD:1624291
G Cers4 ceramide synthase 4 JBrowse link 12 4,439,750 4,474,759 RGD:1624291
G Cers5 ceramide synthase 5 JBrowse link 7 141,386,391 141,424,375 RGD:1624291
G Cers6 ceramide synthase 6 JBrowse link 3 55,094,240 55,338,370 RGD:1624291
G Degs2 delta(4)-desaturase, sphingolipid 2 JBrowse link 6 132,591,968 132,608,600 RGD:1624291
G Elovl1 ELOVL fatty acid elongase 1 JBrowse link 5 137,255,868 137,260,486 RGD:1624291
RGD:13792537
G Elovl2 ELOVL fatty acid elongase 2 JBrowse link 17 21,382,461 21,422,413 RGD:13792537
G Elovl3 ELOVL fatty acid elongase 3 JBrowse link 1 265,883,353 265,887,181 RGD:13792537
G Elovl4 ELOVL fatty acid elongase 4 JBrowse link 8 91,310,690 91,338,625 RGD:13792537
G Elovl5 ELOVL fatty acid elongase 5 JBrowse link 8 85,220,941 85,287,449 RGD:13792537
G Elovl6 ELOVL fatty acid elongase 6 JBrowse link 2 234,187,490 234,296,124 RGD:13792537
G Elovl7 ELOVL fatty acid elongase 7 JBrowse link 2 40,373,211 40,386,643 RGD:13792537
G Hacd1 3-hydroxyacyl-CoA dehydratase 1 JBrowse link 17 81,173,238 81,196,012 RGD:1624291
RGD:13792537
G Hacd2 3-hydroxyacyl-CoA dehydratase 2 JBrowse link 11 68,893,684 68,985,635 RGD:1624291
RGD:13792537
G Hacd3 3-hydroxyacyl-CoA dehydratase 3 JBrowse link 8 70,471,572 70,509,874 RGD:13792537
G Hacd4 3-hydroxyacyl-CoA dehydratase 4 JBrowse link 5 106,728,401 106,758,068 RGD:13792537
G Kdsr 3-ketodihydrosphingosine reductase JBrowse link 13 26,779,386 26,812,271 RGD:1624291
RGD:13792537
G LOC102549542 elongation of very long chain fatty acids protein 6-like JBrowse link 2 234,375,172 234,486,639 RGD:13792537
G Samd8 sterile alpha motif domain containing 8 JBrowse link 15 2,685,504 2,731,062 RGD:13792537
G Sgms1 sphingomyelin synthase 1 JBrowse link 1 250,692,448 250,951,685 RGD:13792537
G Sgms2 sphingomyelin synthase 2 JBrowse link 2 236,458,276 236,530,667 RGD:13792537
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 JBrowse link 17 11,856,525 11,895,566 RGD:1624291
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 JBrowse link 6 111,334,408 111,417,960 RGD:1624291
RGD:1600115
G Sptssb serine palmitoyltransferase, small subunit B JBrowse link 2 166,654,036 166,682,325 RGD:1624291
ceramide biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agk acylglycerol kinase JBrowse link 4 68,483,345 68,561,518 RGD:1624291
RGD:1600115
G Alox12b arachidonate 12-lipoxygenase, 12R type JBrowse link 10 55,744,646 55,756,524 RGD:1600115
RGD:1624291
G Aloxe3 arachidonate lipoxygenase 3 JBrowse link 10 55,711,996 55,735,915 RGD:1624291
RGD:1600115
G Asah1 N-acylsphingosine amidohydrolase 1 JBrowse link 16 53,998,604 54,030,006 RGD:1600115
RGD:1624291
G Asah2 N-acylsphingosine amidohydrolase 2 JBrowse link 1 250,557,042 250,665,083 RGD:13838803
RGD:1624291
RGD:13838793
G Cers1 ceramide synthase 1 JBrowse link 16 20,845,580 20,860,789 RGD:1624291
G Cers2 ceramide synthase 2 JBrowse link 2 196,487,656 196,495,930 RGD:1624291
RGD:13792537
G Cers3 ceramide synthase 3 JBrowse link 1 127,706,618 127,781,041 RGD:1624291
RGD:13792537
G Cers4 ceramide synthase 4 JBrowse link 12 4,439,750 4,474,759 RGD:1624291
RGD:13792537
G Cers5 ceramide synthase 5 JBrowse link 7 141,386,391 141,424,375 RGD:1624291
RGD:13792537
G Cers6 ceramide synthase 6 JBrowse link 3 55,094,240 55,338,370 RGD:1624291
RGD:13792537
G Degs1 delta(4)-desaturase, sphingolipid 1 JBrowse link 13 100,665,265 100,672,731 RGD:1624291
RGD:13792537
G Degs2 delta(4)-desaturase, sphingolipid 2 JBrowse link 6 132,591,968 132,608,600 RGD:1624291
RGD:13792537
G Elovl1 ELOVL fatty acid elongase 1 JBrowse link 5 137,255,868 137,260,486 RGD:1600115
RGD:1624291
G Fa2h fatty acid 2-hydroxylase JBrowse link 19 43,545,380 43,596,788 RGD:1600115
RGD:1624291
G Gba glucosylceramidase beta JBrowse link 2 188,511,781 188,522,602 RGD:1624291
RGD:1600115
G LOC498300 similar to degenerative spermatocyte homolog JBrowse link 13 99,369,102 99,374,051 RGD:13792537
G P2rx1 purinergic receptor P2X 1 JBrowse link 10 59,566,268 59,581,328 RGD:1624291
RGD:1600115
G P2rx7 purinergic receptor P2X 7 JBrowse link 12 39,353,613 39,396,042 RGD:1624291
G RGD1564463 similar to Mdes protein JBrowse link 13 99,374,006 99,395,804 RGD:13792537
G Samd8 sterile alpha motif domain containing 8 JBrowse link 15 2,685,504 2,731,062 RGD:1624291
RGD:13792537
G Sgms1 sphingomyelin synthase 1 JBrowse link 1 250,692,448 250,951,685 RGD:1624291
RGD:13792537
G Sgms2 sphingomyelin synthase 2 JBrowse link 2 236,458,276 236,530,667 RGD:1624291
RGD:13792537
RGD:1600115
G Smpd1 sphingomyelin phosphodiesterase 1 JBrowse link 1 170,383,682 170,387,525 RGD:1601344
RGD:13792537
RGD:1624291
G Smpd2 sphingomyelin phosphodiesterase 2 JBrowse link 20 46,212,070 46,215,183 RGD:1581395
G Smpd4 sphingomyelin phosphodiesterase 4 JBrowse link 11 87,522,971 87,546,687 RGD:1624291
RGD:13792537
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 JBrowse link 17 11,856,525 11,895,566 RGD:1624291
RGD:1600115
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 JBrowse link 6 111,334,408 111,417,960 RGD:1624291
G Sptssa serine palmitoyltransferase, small subunit A JBrowse link 6 75,540,132 75,551,545 RGD:1624291
RGD:1600115
G Sptssb serine palmitoyltransferase, small subunit B JBrowse link 2 166,654,036 166,682,325 RGD:1624291
RGD:13792537
G Tlcd3b TLC domain containing 3B JBrowse link 1 198,252,208 198,265,840 RGD:1624291
RGD:1600115
ceramide phosphoethanolamine biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Samd8 sterile alpha motif domain containing 8 JBrowse link 15 2,685,504 2,731,062 RGD:1624291
RGD:1600115
G Sgms2 sphingomyelin synthase 2 JBrowse link 2 236,458,276 236,530,667 RGD:1624291
RGD:1600115
galactosylceramide biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B3galt1 Beta-1,3-galactosyltransferase 1 JBrowse link 3 53,699,409 54,269,612 RGD:1624291
RGD:1600115
G B3galt2 Beta-1,3-galactosyltransferase 2 JBrowse link 13 60,435,946 60,444,957 RGD:1624291
RGD:1600115
G B4galt3 beta-1,4-galactosyltransferase 3 JBrowse link 13 89,643,847 89,649,880 RGD:1624291
RGD:1600115
G Fa2h fatty acid 2-hydroxylase JBrowse link 19 43,545,380 43,596,788 RGD:1600115
RGD:13825191
RGD:1624291
G Gal3st1 galactose-3-O-sulfotransferase 1 JBrowse link 14 84,231,473 84,247,371 RGD:1624291
RGD:1600115
G Ugt8 UDP glycosyltransferase 8 JBrowse link 2 229,644,373 229,718,678 RGD:1600115
ganglioside biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B3galt4 Beta-1,3-galactosyltransferase 4 JBrowse link 20 5,446,104 5,447,679 RGD:1600115
RGD:1624291
G B4galnt1 beta-1,4-N-acetyl-galactosaminyl transferase 1 JBrowse link 7 70,439,273 70,459,556 RGD:1624291
RGD:1600115
G St6galnac3 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 JBrowse link 2 259,379,653 259,918,813 RGD:13792537
G St6galnac4 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 JBrowse link 3 11,607,103 11,619,595 RGD:13792537
G St6galnac5 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 JBrowse link 2 258,025,177 259,150,709 RGD:13792537
G St6galnac6 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 JBrowse link 3 11,620,050 11,641,460 RGD:1624291
RGD:13792537
G St8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 JBrowse link 1 135,336,374 135,406,699 RGD:1624291
G St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 JBrowse link 18 59,748,766 59,755,257 RGD:1624291
RGD:1600115
G St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 JBrowse link 9 103,117,705 103,207,154 RGD:1624291
RGD:1600115
G St8sia6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 JBrowse link 17 80,960,785 81,002,830 RGD:1624291
ganglioside biosynthetic process via lactosylceramide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B4galt5 beta-1,4-galactosyltransferase 5 JBrowse link 3 164,039,731 164,055,561 RGD:1600115
RGD:1624291
G B4galt6 beta-1,4-galactosyltransferase 6 JBrowse link 18 15,462,913 15,525,584 RGD:1600115
RGD:1624291
globoside biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A4galt alpha 1,4-galactosyltransferase (P blood group) JBrowse link 7 124,085,832 124,110,440 RGD:1624291
RGD:1600115
glucosylceramide biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fa2h fatty acid 2-hydroxylase JBrowse link 19 43,545,380 43,596,788 RGD:1600115
RGD:1624291
G Ugcg UDP-glucose ceramide glucosyltransferase JBrowse link 5 76,376,722 76,419,564 RGD:13792537
RGD:1624291
RGD:1600115
glycosphingolipid biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A3galt2 alpha 1,3-galactosyltransferase 2 JBrowse link 5 146,933,592 146,945,882 RGD:1299594
RGD:1624291
RGD:632674
G B4galt6 beta-1,4-galactosyltransferase 6 JBrowse link 18 15,462,913 15,525,584 RGD:70807
G St6galnac5 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 JBrowse link 2 258,025,177 259,150,709 RGD:1624291
G Ugt8 UDP glycosyltransferase 8 JBrowse link 2 229,644,373 229,718,678 RGD:70050
lactosylceramide biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B4galt6 beta-1,4-galactosyltransferase 6 JBrowse link 18 15,462,913 15,525,584 RGD:1600115
RGD:1624291
negative regulation of ceramide biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 JBrowse link 9 53,110,628 53,120,454 RGD:1624291
RGD:13792537
G Ormdl2 ORMDL sphingolipid biosynthesis regulator 2 JBrowse link 7 3,242,991 3,246,085 RGD:1624291
RGD:13792537
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 JBrowse link 10 86,545,910 86,554,478 RGD:1624291
RGD:13792537
RGD:1600115
G Sphk1 sphingosine kinase 1 JBrowse link 10 105,498,728 105,504,401 RGD:1600115
RGD:1624291
negative regulation of sphingolipid biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca2 ATP binding cassette subfamily A member 2 JBrowse link 3 2,648,787 2,668,770 RGD:1624291
RGD:14697729
RGD:1600115
G Atg7 autophagy related 7 JBrowse link 4 146,570,113 146,777,093 RGD:1624291
phytosphingosine biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acer3 alkaline ceramidase 3 JBrowse link 1 163,160,987 163,263,621 RGD:1624291
RGD:13792537
positive regulation of ceramide biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccn1 cellular communication network factor 1 JBrowse link 2 251,529,354 251,532,312 RGD:1624291
RGD:1600115
G Pla2g6 phospholipase A2 group VI JBrowse link 7 120,519,479 120,559,716 RGD:6482750
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:1624291
RGD:1600115
G Sirt3 sirtuin 3 JBrowse link 1 213,613,502 213,636,061 RGD:1624291
G Smpd3 sphingomyelin phosphodiesterase 3 JBrowse link 19 38,237,963 38,321,572 RGD:10041064
G Sphk2 sphingosine kinase 2 JBrowse link 1 101,692,972 101,700,604 RGD:1600115
RGD:1624291
regulation of ceramide biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Samd8 sterile alpha motif domain containing 8 JBrowse link 15 2,685,504 2,731,062 RGD:1624291
RGD:1600115
sphinganine biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 JBrowse link 17 11,856,525 11,895,566 RGD:1624291
RGD:1600115
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 JBrowse link 6 111,334,408 111,417,960 RGD:1624291
sphinganine-1-phosphate biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sphk2 sphingosine kinase 2 JBrowse link 1 101,692,972 101,700,604 RGD:1600115
RGD:1624291
sphingoid biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sptlc3 serine palmitoyltransferase, long chain base subunit 3 JBrowse link 3 132,560,437 132,689,313 RGD:1624291
RGD:1600115
sphingomyelin biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pemt phosphatidylethanolamine N-methyltransferase JBrowse link 10 46,339,821 46,404,640 RGD:1624291
G Sgms1 sphingomyelin synthase 1 JBrowse link 1 250,692,448 250,951,685 RGD:1600115
RGD:13792537
RGD:1624291
G Sgms2 sphingomyelin synthase 2 JBrowse link 2 236,458,276 236,530,667 RGD:1624291
RGD:13792537
RGD:1600115
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 JBrowse link 17 11,856,525 11,895,566 RGD:1600115
RGD:1624291
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 JBrowse link 6 111,334,408 111,417,960 RGD:1624291
sphingosine biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca2 ATP binding cassette subfamily A member 2 JBrowse link 3 2,648,787 2,668,770 RGD:1624291
RGD:1600115
G Acer1 alkaline ceramidase 1 JBrowse link 9 10,061,978 10,093,588 RGD:1600115
RGD:1624291
G Acer2 alkaline ceramidase 2 JBrowse link 5 105,230,540 105,279,732 RGD:1600115
RGD:1624291
G Acer3 alkaline ceramidase 3 JBrowse link 1 163,160,987 163,263,621 RGD:1600115
RGD:1624291
G Asah1 N-acylsphingosine amidohydrolase 1 JBrowse link 16 53,998,604 54,030,006 RGD:1600115
RGD:1624291
G Asah2 N-acylsphingosine amidohydrolase 2 JBrowse link 1 250,557,042 250,665,083 RGD:13838800
RGD:13792537
RGD:1624291
RGD:13838794
RGD:13838793
G Gba glucosylceramidase beta JBrowse link 2 188,511,781 188,522,602 RGD:1624291
RGD:1600115
G Sphk1 sphingosine kinase 1 JBrowse link 10 105,498,728 105,504,401 RGD:1624291
G Sphk2 sphingosine kinase 2 JBrowse link 1 101,692,972 101,700,604 RGD:1624291
RGD:1600115
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 JBrowse link 17 11,856,525 11,895,566 RGD:1624291
RGD:1600115
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 JBrowse link 6 111,334,408 111,417,960 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18166
    metabolic process 10845
      cellular metabolic process 9907
        cellular biosynthetic process 5293
          membrane lipid biosynthetic process 122
            sphingolipid biosynthetic process 81
              ceramide biosynthetic process + 59
              ceramide phosphoethanolamine biosynthetic process 2
              glycosphingolipid biosynthetic process + 21
              negative regulation of sphingolipid biosynthetic process + 6
              positive regulation of sphingolipid biosynthetic process + 6
              regulation of sphingolipid biosynthetic process + 13
              sphinganine-1-phosphate biosynthetic process 1
              sphingoid biosynthetic process + 12
              sphingolipid biosynthesis involved in endoplasmic reticulum membrane organization 0
              sphingomyelin biosynthetic process 5
Path 2
Term Annotations click to browse term
  biological_process 18166
    metabolic process 10845
      primary metabolic process 9754
        lipid metabolic process 1278
          cellular lipid metabolic process 969
            membrane lipid metabolic process 176
              membrane lipid biosynthetic process 122
                sphingolipid biosynthetic process 81
                  ceramide biosynthetic process + 59
                  ceramide phosphoethanolamine biosynthetic process 2
                  glycosphingolipid biosynthetic process + 21
                  negative regulation of sphingolipid biosynthetic process + 6
                  positive regulation of sphingolipid biosynthetic process + 6
                  regulation of sphingolipid biosynthetic process + 13
                  sphinganine-1-phosphate biosynthetic process 1
                  sphingoid biosynthetic process + 12
                  sphingolipid biosynthesis involved in endoplasmic reticulum membrane organization 0
                  sphingomyelin biosynthetic process 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.