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ONTOLOGY REPORT - ANNOTATIONS


Term:proteoglycan biosynthetic process
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Accession:GO:0030166 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.
Synonyms:exact_synonym: proteoglycan anabolism;   proteoglycan biosynthesis;   proteoglycan formation;   proteoglycan synthesis


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proteoglycan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acan aggrecan JBrowse link 1 140,762,758 140,824,441 RGD:1624291
RGD:1600115
G Bmpr2 bone morphogenetic protein receptor type 2 JBrowse link 9 66,568,074 66,683,019 RGD:1600115
G Cant1 calcium activated nucleotidase 1 JBrowse link 10 107,432,500 107,445,634 RGD:1624291
RGD:13792537
RGD:1600115
G Chst10 carbohydrate sulfotransferase 10 JBrowse link 9 45,528,928 45,559,365 RGD:13792537
G Chst11 carbohydrate sulfotransferase 11 JBrowse link 7 26,641,856 26,890,503 RGD:13792537
G Chst12 carbohydrate sulfotransferase 12 JBrowse link 12 16,199,975 16,218,404 RGD:13792537
G Chst13 carbohydrate sulfotransferase 13 JBrowse link 4 122,223,846 122,244,848 RGD:13792537
G Chst8 carbohydrate sulfotransferase 8 JBrowse link 1 90,542,095 90,685,257 RGD:1624291
RGD:13792537
G Chst9 carbohydrate sulfotransferase 9 JBrowse link 18 6,833,408 7,115,815 RGD:13792537
G Csgalnact2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 JBrowse link 4 150,148,626 150,185,062 RGD:1624291
G Ext1 exostosin glycosyltransferase 1 JBrowse link 7 92,605,008 92,881,392 RGD:1624291
G Fam20b FAM20B, glycosaminoglycan xylosylkinase JBrowse link 13 74,280,173 74,333,463 RGD:13792537
G Foxl1 forkhead box L1 JBrowse link 19 53,054,887 53,058,624 RGD:1624291
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:1624291
RGD:1600115
G Xylt1 xylosyltransferase 1 JBrowse link 1 186,939,698 187,264,758 RGD:2313142
RGD:1624291
RGD:1600115
G Xylt2 xylosyltransferase 2 JBrowse link 10 82,386,003 82,399,485 RGD:1624291
chondroitin sulfate biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chpf chondroitin polymerizing factor JBrowse link 9 82,669,199 82,673,898 RGD:1624291
G Chst11 carbohydrate sulfotransferase 11 JBrowse link 7 26,641,856 26,890,503 RGD:1624291
G Chst12 carbohydrate sulfotransferase 12 JBrowse link 12 16,199,975 16,218,404 RGD:1624291
G Chst13 carbohydrate sulfotransferase 13 JBrowse link 4 122,223,846 122,244,848 RGD:1624291
G Chst3 carbohydrate sulfotransferase 3 JBrowse link 20 29,731,828 29,768,656 RGD:1600115
RGD:13792537
RGD:1624291
G Chst7 carbohydrate sulfotransferase 7 JBrowse link X 2,623,018 2,657,155 RGD:1624291
RGD:13792537
G Chsy1 chondroitin sulfate synthase 1 JBrowse link 1 127,010,587 127,071,570 RGD:1624291
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 JBrowse link 16 22,704,318 23,075,071 RGD:1624291
G Slc35d1 solute carrier family 35 member D1 JBrowse link 5 122,700,396 122,746,815 RGD:1624291
G Ugdh UDP-glucose 6-dehydrogenase JBrowse link 14 44,479,614 44,502,845 RGD:1600115
RGD:1624291
G Xylt1 xylosyltransferase 1 JBrowse link 1 186,939,698 187,264,758 RGD:1600115
RGD:1624291
G Xylt2 xylosyltransferase 2 JBrowse link 10 82,386,003 82,399,485 RGD:1600115
chondroitin sulfate proteoglycan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B3gat1 beta-1,3-glucuronyltransferase 1 JBrowse link 8 27,777,024 27,804,368 RGD:13792537
G B3gat2 beta-1,3-glucuronyltransferase 2 JBrowse link 9 29,984,077 30,068,649 RGD:13792537
G B3gat3 beta-1,3-glucuronyltransferase 3 JBrowse link 1 225,120,061 225,126,579 RGD:1624291
RGD:13792537
G Csgalnact2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 JBrowse link 4 150,148,626 150,185,062 RGD:1624291
G Cytl1 cytokine like 1 JBrowse link 14 77,805,137 77,810,147 RGD:1624291
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:1624291
G Pxylp1 2-phosphoxylose phosphatase 1 JBrowse link 8 104,724,728 104,790,639 RGD:1624291
RGD:1600115
G Xylt1 xylosyltransferase 1 JBrowse link 1 186,939,698 187,264,758 RGD:1600115
RGD:13792537
RGD:1624291
G Xylt2 xylosyltransferase 2 JBrowse link 10 82,386,003 82,399,485 RGD:1600115
RGD:13792537
RGD:1624291
chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 JBrowse link 16 22,704,318 23,075,071 RGD:1624291
dermatan sulfate biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chst12 carbohydrate sulfotransferase 12 JBrowse link 12 16,199,975 16,218,404 RGD:1624291
G Chst14 carbohydrate sulfotransferase 14 JBrowse link 3 110,734,105 110,736,162 RGD:1624291
G Dse dermatan sulfate epimerase JBrowse link 20 27,703,738 27,784,982 RGD:1624291
dermatan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B3gat3 beta-1,3-glucuronyltransferase 3 JBrowse link 1 225,120,061 225,126,579 RGD:1624291
G Csgalnact2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 JBrowse link 4 150,148,626 150,185,062 RGD:1624291
heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B3gat3 beta-1,3-glucuronyltransferase 3 JBrowse link 1 225,120,061 225,126,579 RGD:1624291
G Ext1 exostosin glycosyltransferase 1 JBrowse link 7 92,605,008 92,881,392 RGD:1624291
G Ext2 exostosin glycosyltransferase 2 JBrowse link 3 82,602,784 82,734,557 RGD:1624291
G Extl3 exostosin-like glycosyltransferase 3 JBrowse link 15 48,420,419 48,465,171 RGD:1624291
G Glce glucuronic acid epimerase JBrowse link 8 67,006,588 67,073,723 RGD:1624291
RGD:13792537
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 JBrowse link 9 42,620,006 42,659,184 RGD:1624291
G Lipc lipase C, hepatic type JBrowse link 8 77,272,582 77,398,485 RGD:1580511
G Ndst1 N-deacetylase and N-sulfotransferase 1 JBrowse link 18 55,951,497 56,014,107 RGD:12907548
G Ndst2 N-deacetylase and N-sulfotransferase 2 JBrowse link 15 3,995,797 4,006,491 RGD:1624291
G Ndst3 N-deacetylase and N-sulfotransferase 3 JBrowse link 2 227,736,491 227,903,657 RGD:1624291
G Ugdh UDP-glucose 6-dehydrogenase JBrowse link 14 44,479,614 44,502,845 RGD:1600115
RGD:1624291
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link 13 90,379,203 90,405,627 RGD:1624291
G Xylt1 xylosyltransferase 1 JBrowse link 1 186,939,698 187,264,758 RGD:1600115
RGD:13792537
RGD:1624291
G Xylt2 xylosyltransferase 2 JBrowse link 10 82,386,003 82,399,485 RGD:1600115
RGD:13792537
RGD:1624291
heparan sulfate proteoglycan biosynthetic process, enzymatic modification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 JBrowse link 2 250,467,428 250,600,517 RGD:13792537
G Hs3st5 heparan sulfate-glucosamine 3-sulfotransferase 5 JBrowse link 20 40,236,437 40,545,502 RGD:1624291
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 JBrowse link 9 42,620,006 42,659,184 RGD:1624291
RGD:13792537
G Hs6st2 heparan sulfate 6-O-sulfotransferase 2 JBrowse link X 138,675,326 138,972,774 RGD:1624291
RGD:13792537
G Hs6st3 heparan sulfate 6-O-sulfotransferase 3 JBrowse link 15 104,448,479 105,254,540 RGD:1624291
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ext1 exostosin glycosyltransferase 1 JBrowse link 7 92,605,008 92,881,392 RGD:1624291
G Ext2 exostosin glycosyltransferase 2 JBrowse link 3 82,602,784 82,734,557 RGD:1624291
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 JBrowse link 2 250,467,428 250,600,517 RGD:1624291
RGD:13792537
G Ndst1 N-deacetylase and N-sulfotransferase 1 JBrowse link 18 55,951,497 56,014,107 RGD:13792537
G Ndst2 N-deacetylase and N-sulfotransferase 2 JBrowse link 15 3,995,797 4,006,491 RGD:13792537
G Ndst3 N-deacetylase and N-sulfotransferase 3 JBrowse link 2 227,736,491 227,903,657 RGD:1624291
RGD:13792537
G Ndst4 N-deacetylase and N-sulfotransferase 4 JBrowse link 2 229,170,781 229,496,732 RGD:13792537
G NEWGENE_1304700 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 JBrowse link 15 3,750,058 3,760,616 RGD:13792537
negative regulation of proteoglycan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc2a10 solute carrier family 2 member 10 JBrowse link 3 162,182,156 162,194,610 RGD:1624291
positive regulation of heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1624291
RGD:1600115
G Pxylp1 2-phosphoxylose phosphatase 1 JBrowse link 8 104,724,728 104,790,639 RGD:1624291
RGD:1600115
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1 276,686,911 276,730,517 RGD:1624291
positive regulation of proteoglycan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mustn1 musculoskeletal, embryonic nuclear protein 1 JBrowse link 16 6,962,737 6,964,987 RGD:1624291
G Slc2a10 solute carrier family 2 member 10 JBrowse link 3 162,182,156 162,194,610 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19576
    metabolic process 11899
      primary metabolic process 10563
        protein metabolic process 6070
          glycoprotein metabolic process 357
            proteoglycan metabolic process 74
              proteoglycan biosynthetic process 49
                chondroitin sulfate proteoglycan biosynthetic process + 19
                dermatan sulfate proteoglycan biosynthetic process + 5
                heparan sulfate proteoglycan biosynthetic process + 23
                negative regulation of proteoglycan biosynthetic process 1
                positive regulation of proteoglycan biosynthetic process + 5
Path 2
Term Annotations click to browse term
  biological_process 19576
    metabolic process 11899
      organic substance metabolic process 11297
        organic substance biosynthetic process 5872
          macromolecule biosynthetic process 4939
            cellular macromolecule biosynthetic process 4805
              glycoprotein biosynthetic process 292
                proteoglycan biosynthetic process 49
                  chondroitin sulfate proteoglycan biosynthetic process + 19
                  dermatan sulfate proteoglycan biosynthetic process + 5
                  heparan sulfate proteoglycan biosynthetic process + 23
                  negative regulation of proteoglycan biosynthetic process 1
                  positive regulation of proteoglycan biosynthetic process + 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.