ONTOLOGY REPORT - ANNOTATIONS


Term:platelet activation
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Accession:GO:0030168 term browser browse the term
Definition:A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
Synonyms:exact_synonym: blood coagulation, platelet activation


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platelet activation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actn1 actinin, alpha 1 JBrowse link 6 103,376,557 103,470,497 RGD:1624291
G Adra2a adrenoceptor alpha 2A JBrowse link 1 274,766,283 274,769,083 RGD:1600115
G Adra2b adrenoceptor alpha 2B JBrowse link 3 119,805,941 119,809,987 RGD:1600115
G Adra2c adrenoceptor alpha 2C JBrowse link 14 80,730,307 80,732,010 RGD:1600115
G Axl Axl receptor tyrosine kinase JBrowse link 1 82,550,892 82,580,761 RGD:1624291
RGD:13792537
G Bloc1s3 biogenesis of lysosomal organelles complex-1, subunit 3 JBrowse link 1 80,414,766 80,417,385 RGD:1624291
RGD:1600115
G C1galt1c1 C1GALT1-specific chaperone 1 JBrowse link X 124,921,686 124,926,171 RGD:1624291
RGD:1600115
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:1624291
RGD:1600115
G Cx3cl1 C-X3-C motif chemokine ligand 1 JBrowse link 19 10,644,267 10,654,861 RGD:4891996
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 JBrowse link 1 259,692,020 259,818,922 RGD:1624291
G Entpd2 ectonucleoside triphosphate diphosphohydrolase 2 JBrowse link 3 2,617,795 2,623,818 RGD:1624291
RGD:1600115
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:1624291
RGD:1600115
G F2r coagulation factor II (thrombin) receptor JBrowse link 2 26,118,760 26,135,340 RGD:1624291
RGD:1600115
G F8 coagulation factor VIII JBrowse link 18 367,862 399,242 RGD:1600115
G Fga fibrinogen alpha chain JBrowse link 2 181,997,562 182,013,726 RGD:1600115
G Fzd6 frizzled class receptor 6 JBrowse link 7 77,898,329 77,931,034 RGD:1624291
RGD:1600115
G Gna13 G protein subunit alpha 13 JBrowse link 10 97,647,196 97,680,030 RGD:1624291
RGD:1600115
G Hrg histidine-rich glycoprotein JBrowse link 11 81,621,274 81,639,938 RGD:1600115
RGD:1624291
G Itgb3 integrin subunit beta 3 JBrowse link 10 92,667,869 92,783,413 RGD:1624291
G LOC100910021 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like JBrowse link 8 106,862,181 106,871,375 RGD:13792537
G LOC681544 similar to histidine-rich glycoprotein RGD:1600115
G Mertk MER proto-oncogene, tyrosine kinase JBrowse link 3 121,235,230 121,340,932 RGD:1624291
RGD:1600115
G P2rx1 purinergic receptor P2X 1 JBrowse link 10 59,566,268 59,581,328 RGD:1624291
RGD:1600115
G P2ry1 purinergic receptor P2Y1 JBrowse link 2 151,314,818 151,320,312 RGD:1600115
G P2ry12 purinergic receptor P2Y12 JBrowse link 2 149,440,807 149,482,592 RGD:1624291
G Pdia6 protein disulfide isomerase family A, member 6 JBrowse link 6 42,568,269 42,585,654 RGD:1600115
G Pf4 platelet factor 4 JBrowse link 14 18,848,549 18,849,258 RGD:1624291
RGD:1600115
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:13792537
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:1624291
RGD:1600115
RGD:13792537
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:13792537
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma JBrowse link 6 51,465,696 51,501,234 RGD:13792537
G Ppbp pro-platelet basic protein JBrowse link 14 18,852,433 18,853,237 RGD:70252
G Rap2b RAP2B, member of RAS oncogene family JBrowse link 2 151,685,251 151,685,802 RGD:1624291
G Srf serum response factor JBrowse link 9 16,737,637 16,747,226 RGD:1624291
RGD:1600115
G Treml1 triggering receptor expressed on myeloid cells-like 1 JBrowse link 9 14,597,172 14,603,622 RGD:1624291
G Tyro3 TYRO3 protein tyrosine kinase JBrowse link 3 111,597,102 111,616,142 RGD:1624291
RGD:1600115
G Ubash3b ubiquitin associated and SH3 domain containing, B JBrowse link 8 45,224,053 45,375,450 RGD:1624291
G Vwf von Willebrand factor JBrowse link 4 158,085,059 158,219,525 RGD:1599012
RGD:1624291
RGD:1600115
RGD:1599016
G Wnt3a Wnt family member 3A JBrowse link 10 45,598,898 45,643,151 RGD:1624291
negative regulation of platelet activation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:1624291
RGD:1600115
G C1qtnf1 C1q and TNF related 1 JBrowse link 10 107,455,845 107,477,160 RGD:1624291
G Gp5 glycoprotein V (platelet) JBrowse link 11 73,015,380 73,017,570 RGD:1624291
G Pdgfa platelet derived growth factor subunit A JBrowse link 12 17,734,141 17,756,186 RGD:1624291
RGD:1600115
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:1624291
RGD:1600115
G Pdgfra platelet derived growth factor receptor alpha JBrowse link 14 35,527,926 35,581,130 RGD:1624291
RGD:1600115
G Serpine2 serpin family E member 2 JBrowse link 9 85,560,852 85,629,410 RGD:1624291
negative regulation of platelet aggregation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abat 4-aminobutyrate aminotransferase JBrowse link 10 7,093,406 7,200,439 RGD:10047059
G Adamts18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 JBrowse link 19 46,005,055 46,167,912 RGD:1624291
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:8548522
G Alox12 arachidonate 12-lipoxygenase, 12S type JBrowse link 10 56,851,734 56,864,049 RGD:1624291
RGD:1600115
G C1qtnf1 C1q and TNF related 1 JBrowse link 10 107,455,845 107,477,160 RGD:1600115
RGD:1624291
G Cd9 CD9 molecule JBrowse link 4 157,977,163 158,010,091 RGD:1624291
RGD:1600115
G Ceacam1 carcinoembryonic antigen related cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:1624291
RGD:1600115
G Fgg fibrinogen gamma chain JBrowse link 2 181,987,080 181,994,523 RGD:11352706
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:1600115
RGD:1624291
G Prkg1 protein kinase cGMP-dependent 1 JBrowse link 1 248,982,039 250,300,952 RGD:1624291
G Ptger3 prostaglandin E receptor 3 JBrowse link 2 263,895,093 263,979,682 RGD:10043327
G Serpine2 serpin family E member 2 JBrowse link 9 85,560,852 85,629,410 RGD:1624291
RGD:1600115
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:1600115
RGD:1624291
G Ubash3b ubiquitin associated and SH3 domain containing, B JBrowse link 8 45,224,053 45,375,450 RGD:1624291
RGD:1600115
platelet aggregation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actn1 actinin, alpha 1 JBrowse link 6 103,376,557 103,470,497 RGD:1624291
G Bloc1s4 biogenesis of lysosomal organelles complex 1 subunit 4 JBrowse link 14 79,013,808 79,015,108 RGD:1624291
RGD:1600115
G Comp cartilage oligomeric matrix protein JBrowse link 16 20,798,437 20,807,070 RGD:1624291
RGD:1600115
G Fermt3 fermitin family member 3 JBrowse link 1 222,254,183 222,272,775 RGD:1624291
RGD:1600115
G Fga fibrinogen alpha chain JBrowse link 2 181,997,562 182,013,726 RGD:1624291
RGD:1600115
G Fgb fibrinogen beta chain JBrowse link 2 182,028,044 182,035,026 RGD:1624291
RGD:1600115
G Fgg fibrinogen gamma chain JBrowse link 2 181,987,080 181,994,523 RGD:1624291
RGD:1600115
G Gata1 GATA binding protein 1 JBrowse link X 15,273,937 15,281,759 RGD:1624291
G Gnas GNAS complex locus JBrowse link 3 172,374,957 172,434,988 RGD:1624291
G Gp1ba glycoprotein Ib platelet subunit alpha JBrowse link 10 57,260,680 57,263,546 RGD:10450868
RGD:13792537
G Itga2b integrin subunit alpha 2b JBrowse link 10 90,397,960 90,416,550 RGD:2316357
G Itgb3 integrin subunit beta 3 JBrowse link 10 92,667,869 92,783,413 RGD:2316357
RGD:1624291
G Mpl MPL proto-oncogene, thrombopoietin receptor JBrowse link 5 137,268,412 137,282,032 RGD:10448997
G P2ry12 purinergic receptor P2Y12 JBrowse link 2 149,440,807 149,482,592 RGD:6480528
RGD:1624291
G Pdgfra platelet derived growth factor receptor alpha JBrowse link 14 35,527,926 35,581,130 RGD:1624291
RGD:1600115
G Pdia6 protein disulfide isomerase family A, member 6 JBrowse link 6 42,568,269 42,585,654 RGD:1600115
G Pear1 platelet endothelial aggregation receptor 1 JBrowse link 2 187,114,219 187,134,209 RGD:1600115
RGD:1624291
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma JBrowse link 7 11,267,207 11,294,291 RGD:1624291
G Plek pleckstrin JBrowse link 14 100,151,518 100,184,192 RGD:1624291
RGD:1600115
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:1624291
RGD:1600115
G Rap2b RAP2B, member of RAS oncogene family JBrowse link 2 151,685,251 151,685,802 RGD:1624291
RGD:1600115
G Slc7a11 solute carrier family 7 member 11 JBrowse link 2 139,453,774 139,528,479 RGD:1624291
RGD:1600115
G Stxbp1 syntaxin binding protein 1 JBrowse link 3 11,823,779 11,885,479 RGD:1624291
RGD:1600115
G Stxbp3 syntaxin binding protein 3 JBrowse link 2 211,595,763 211,638,756 RGD:1624291
RGD:1600115
G Tspan32 tetraspanin 32 JBrowse link 1 216,189,535 216,206,202 RGD:1624291
RGD:1600115
G Tyro3 TYRO3 protein tyrosine kinase JBrowse link 3 111,597,102 111,616,142 RGD:1600115
RGD:13792537
RGD:1624291
G Ubash3a ubiquitin associated and SH3 domain containing, A JBrowse link 20 9,941,102 9,986,012 RGD:1624291
G Ubash3b ubiquitin associated and SH3 domain containing, B JBrowse link 8 45,224,053 45,375,450 RGD:1624291
RGD:13792537
G Wnt3a Wnt family member 3A JBrowse link 10 45,598,898 45,643,151 RGD:1624291
RGD:1600115
positive regulation of platelet activation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pdpn podoplanin JBrowse link 5 161,947,137 161,981,441 RGD:2292241
G Plek pleckstrin JBrowse link 14 100,151,518 100,184,192 RGD:1624291
RGD:1600115
G Ptprj protein tyrosine phosphatase, receptor type, J JBrowse link 3 79,233,519 79,390,956 RGD:1624291
G Selp selectin P JBrowse link 13 82,428,914 82,464,629 RGD:1624291
RGD:1600115
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1624291
RGD:1600115
positive regulation of platelet aggregation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dmtn dematin actin binding protein JBrowse link 15 52,292,762 52,320,385 RGD:1624291
RGD:1600115
G Pdpn podoplanin JBrowse link 5 161,947,137 161,981,441 RGD:1600115
RGD:1624291
regulation of platelet activation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fcer1g Fc fragment of IgE receptor Ig JBrowse link 13 89,601,894 89,606,326 RGD:1624291
RGD:13792537
G Hrg histidine-rich glycoprotein JBrowse link 11 81,621,274 81,639,938 RGD:1600115
RGD:13792537
RGD:1624291
G LOC681544 similar to histidine-rich glycoprotein RGD:1600115
RGD:13792537
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:1624291
RGD:1600115
G Tec tec protein tyrosine kinase JBrowse link 14 37,918,884 38,027,953 RGD:1624291
RGD:13792537
regulation of platelet aggregation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link 5 16,526,058 16,642,648 RGD:1624291
RGD:13792537
RGD:1600115
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:1600115
RGD:1624291
G Prkcq protein kinase C, theta JBrowse link 17 70,971,915 71,105,286 RGD:1600115
RGD:1624291
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:1600115
RGD:13792537
RGD:1624291
G Vps33b VPS33B, late endosome and lysosome associated JBrowse link 1 142,060,955 142,083,955 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17895
    cellular process 16036
      cell activation 987
        platelet activation 87
          negative regulation of platelet activation + 19
          platelet aggregation + 48
          positive regulation of platelet activation + 6
          regulation of platelet activation + 34
Path 2
Term Annotations click to browse term
  biological_process 17895
    biological regulation 12603
      regulation of biological quality 4124
        regulation of body fluid levels 385
          hemostasis 167
            blood coagulation 165
              platelet activation 87
                negative regulation of platelet activation + 19
                platelet aggregation + 48
                positive regulation of platelet activation + 6
                regulation of platelet activation + 34
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.