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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of DNA-dependent DNA replication initiation
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Accession:GO:0030174 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.
Synonyms:exact_synonym: DNA replication licencing;   DNA replication licensing
 broad_synonym: regulation of DNA replication initiation


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regulation of DNA-dependent DNA replication initiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 ISO
IBA
(PMID:11125146)
PMID:21873635
(MGI:MGI:2388867|PMID:12192004)
RGD PMID:11125146, PMID:12192004, PMID:21873635 MGI:MGI:2388867, RGD:13792537 NCBI chr19:55,381,565...55,386,511
Ensembl chr19:55,381,565...55,386,511
JBrowse link
G Kat7 lysine acetyltransferase 7 ISO
ISS
IEA
(PMID:26620551)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:26620551 GO_REF:0000024, GO_REF:0000107 NCBI chr10:83,095,067...83,128,342
Ensembl chr10:83,095,068...83,128,297
JBrowse link
G Ticrr TOPBP1-interacting checkpoint and replication regulator ISO
IBA
(PMID:20116089)
PMID:21873635
RGD PMID:20116089, PMID:21873635 RGD:13792537 NCBI chr 1:141,391,738...141,433,615
Ensembl chr 1:141,391,262...141,433,109
JBrowse link
G Wdr18 WD repeat domain 18 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:12,561,318...12,569,120
Ensembl chr 7:12,561,324...12,569,143
JBrowse link
G Wrnip1 WRN helicase interacting protein 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:15670210)
Ensembl
UniProt
RGD
PMID:15670210 GO_REF:0000024, GO_REF:0000107 NCBI chr17:32,933,395...32,953,641
Ensembl chr17:32,933,396...32,953,641
JBrowse link
positive regulation of DNA-dependent DNA replication initiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk2 cyclin dependent kinase 2 ISO
IEA
MGI:MGI:1920234 (MGI:MGI:4439421|PMID:20215406)
GO_REF:0000107
RGD
Ensembl
PMID:20215406 GO_REF:0000107, MGI:MGI:4439421 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Ciz1 CDKN1A interacting zinc finger protein 1 ISO MGI:MGI:104772 (MGI:MGI:3513706|PMID:15585571), (MGI:MGI:4439421|PMID:20215406) RGD PMID:15585571, PMID:20215406 MGI:MGI:3513706, MGI:MGI:4439421 NCBI chr 3:11,392,046...11,409,218
Ensembl chr 3:11,392,791...11,410,180
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20015
    metabolic process 12259
      regulation of metabolic process 7010
        regulation of macromolecule metabolic process 6495
          regulation of DNA metabolic process 392
            regulation of DNA-dependent DNA replication initiation 7
              negative regulation of DNA-dependent DNA replication initiation + 0
              positive regulation of DNA-dependent DNA replication initiation + 2
              regulation of DNA replication initiation involved in plasmid copy number maintenance + 0
              regulation of initiation of premeiotic DNA replication + 0
              regulation of mitotic DNA replication initiation + 0
Path 2
Term Annotations click to browse term
  biological_process 20015
    metabolic process 12259
      organic substance metabolic process 11639
        macromolecule metabolic process 10084
          macromolecule biosynthetic process 5162
            cellular macromolecule biosynthetic process 5075
              DNA replication 256
                DNA-dependent DNA replication 151
                  DNA replication initiation 28
                    regulation of DNA-dependent DNA replication initiation 7
                      negative regulation of DNA-dependent DNA replication initiation + 0
                      positive regulation of DNA-dependent DNA replication initiation + 2
                      regulation of DNA replication initiation involved in plasmid copy number maintenance + 0
                      regulation of initiation of premeiotic DNA replication + 0
                      regulation of mitotic DNA replication initiation + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.