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ONTOLOGY REPORT - ANNOTATIONS


Term:B cell differentiation
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Accession:GO:0030183 term browser browse the term
Definition:The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: B lymphocyte differentiation
 related_synonym: B cell development
 alt_id: GO:0042115


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B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM17 ADAM metallopeptidase domain 17 ISS (PMID:10433800) BHF-UCL PMID:10433800 NCBI chr 2:9,488,486...9,555,830
Ensembl chr 2:9,488,486...9,556,732
JBrowse link
G ADGRG3 adhesion G protein-coupled receptor G3 ISS UniProtKB GO_REF:0000024 NCBI chr16:57,663,998...57,689,378
Ensembl chr16:57,668,277...57,689,378
JBrowse link
G AICDA activation induced cytidine deaminase NAS (PMID:11007475) UniProtKB PMID:11007475 NCBI chr12:8,602,170...8,612,970
Ensembl chr12:8,602,170...8,612,867
JBrowse link
G BCL11A BAF chromatin remodeling complex subunit BCL11A ISO (MGI:MGI:2662805|PMID:12717432) MGI PMID:12717432 MGI:MGI:2662805 NCBI chr 2:60,450,520...60,553,654
Ensembl chr 2:60,450,520...60,554,467
JBrowse link
G BCL2 BCL2 apoptosis regulator ISO (MGI:MGI:2156164|PMID:8170972), (MGI:MGI:85476|PMID:9028316) MGI PMID:8170972, PMID:9028316 MGI:MGI:2156164, MGI:MGI:85476 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL6 BCL6 transcription repressor IEA Ensembl GO_REF:0000107 NCBI chr 3:187,721,377...187,745,472
Ensembl chr 3:187,721,377...187,745,725
JBrowse link
G BLNK B cell linker NAS (PMID:10583958) UniProtKB PMID:10583958 NCBI chr10:96,189,171...96,271,569
Ensembl chr10:96,191,702...96,271,587
Ensembl chr10:96,191,702...96,271,587
JBrowse link
G CARD11 caspase recruitment domain family member 11 IEA Ensembl GO_REF:0000107 NCBI chr 7:2,906,142...3,043,867
Ensembl chr 7:2,906,141...3,043,945
JBrowse link
G CD40LG CD40 ligand IEA Ensembl GO_REF:0000107 NCBI chr  X:136,648,158...136,660,390
Ensembl chr  X:136,648,158...136,660,390
Ensembl chr  X:136,648,158...136,660,390
JBrowse link
G CD79A CD79a molecule ISS
IBA
(PMID:21873635) UniProtKB
GO_Central
PMID:21873635 GO_REF:0000024 NCBI chr19:41,877,279...41,881,372
Ensembl chr19:41,877,279...41,881,372
Ensembl chr19:41,877,279...41,881,372
JBrowse link
G CD79B CD79b molecule IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:63,928,740...63,932,331
Ensembl chr17:63,928,740...63,932,354
Ensembl chr17:63,928,740...63,932,354
JBrowse link
G CDH17 cadherin 17 ISO (MGI:MGI:3531365|PMID:15688343) UniProtKB PMID:15688343 MGI:MGI:3531365 NCBI chr 8:94,127,162...94,217,278
Ensembl chr 8:94,127,162...94,217,303
JBrowse link
G CEBPG CCAAT enhancer binding protein gamma ISS UniProtKB GO_REF:0000024 NCBI chr19:33,373,709...33,382,686
Ensembl chr19:33,373,685...33,382,686
JBrowse link
G CLCF1 cardiotrophin like cytokine factor 1 ISS BHF-UCL GO_REF:0000024 NCBI chr11:67,364,168...67,374,177
Ensembl chr11:67,364,168...67,374,177
JBrowse link
G CR2 complement C3d receptor 2 IDA (PMID:2995485) UniProtKB PMID:2995485 NCBI chr 1:207,454,328...207,489,892
Ensembl chr 1:207,454,230...207,489,895
JBrowse link
G DCAF1 DDB1 and CUL4 associated factor 1 ISS UniProtKB GO_REF:0000024 NCBI chr 3:51,394,261...51,505,620
Ensembl chr 3:51,395,867...51,500,002
JBrowse link
G DCLRE1C DNA cross-link repair 1C IEA Ensembl GO_REF:0000107 NCBI chr10:14,897,359...14,954,432
Ensembl chr10:14,897,359...14,954,432
JBrowse link
G DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 ISS UniProtKB GO_REF:0000024 NCBI chr 7:108,569,874...108,574,850
Ensembl chr 7:108,569,867...108,574,850
JBrowse link
G EP300 E1A binding protein p300 IEA Ensembl GO_REF:0000107 NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,592...41,180,077
JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit ISO (MGI:MGI:5484711|PMID:23531880) MGI PMID:23531880 MGI:MGI:5484711 NCBI chr 7:148,807,374...148,884,344
Ensembl chr 7:148,807,383...148,884,321
JBrowse link
G FLT3 fms related receptor tyrosine kinase 3 ISS
IBA
(PMID:21873635) UniProtKB
GO_Central
PMID:21873635 GO_REF:0000024 NCBI chr13:28,003,274...28,100,587
Ensembl chr13:28,003,274...28,100,592
JBrowse link
G FZD9 frizzled class receptor 9 IEA Ensembl GO_REF:0000107 NCBI chr 7:73,433,778...73,436,120
Ensembl chr 7:73,433,778...73,436,120
JBrowse link
G GIMAP1 GTPase, IMAP family member 1 ISO (MGI:MGI:4455099|PMID:20194894) MGI PMID:20194894 MGI:MGI:4455099 NCBI chr 7:150,716,613...150,724,284
Ensembl chr 7:150,716,606...150,724,284
JBrowse link
G GON4L gon-4 like IEA InterPro GO_REF:0000002 NCBI chr 1:155,749,659...155,859,431
Ensembl chr 1:155,749,662...155,859,400
JBrowse link
G GPS2 G protein pathway suppressor 2 ISS UniProtKB GO_REF:0000024 NCBI chr17:7,312,661...7,315,360
Ensembl chr17:7,311,324...7,315,564
JBrowse link
G HDAC4 histone deacetylase 4 TAS (PMID:12711221) UniProtKB PMID:12711221 NCBI chr 2:239,048,168...239,401,649
Ensembl chr 2:239,048,168...239,401,654
JBrowse link
G HDAC5 histone deacetylase 5 TAS (PMID:12711221) UniProtKB PMID:12711221 NCBI chr17:44,076,753...44,123,651
Ensembl chr17:44,076,746...44,123,702
JBrowse link
G HDAC9 histone deacetylase 9 TAS (PMID:12711221) UniProtKB PMID:12711221 NCBI chr 7:18,086,825...19,002,416
Ensembl chr 7:18,086,949...19,002,416
JBrowse link
G HHEX hematopoietically expressed homeobox ISS BHF-UCL GO_REF:0000024 NCBI chr10:92,689,955...92,695,647
Ensembl chr10:92,689,955...92,695,647
JBrowse link
G IFNA1 interferon alpha 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:21,440,439...21,441,316
Ensembl chr 9:21,440,439...21,441,316
JBrowse link
G IFNA10 interferon alpha 10 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:21,206,181...21,207,143
Ensembl chr 9:21,206,181...21,207,143
JBrowse link
G IFNA13 interferon alpha 13 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:21,367,372...21,368,057
Ensembl chr 9:21,367,424...21,368,962
JBrowse link
G IFNA14 interferon alpha 14 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:21,239,002...21,240,005
Ensembl chr 9:21,239,002...21,240,005
JBrowse link
G IFNA16 interferon alpha 16 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:21,216,373...21,217,311
Ensembl chr 9:21,216,373...21,217,311
JBrowse link
G IFNA17 interferon alpha 17 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:21,227,243...21,228,222
Ensembl chr 9:21,227,243...21,228,222
JBrowse link
G IFNA2 interferon alpha 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:21,384,255...21,385,398
Ensembl chr 9:21,384,255...21,385,398
JBrowse link
G IFNA21 interferon alpha 21 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:21,165,637...21,166,660
Ensembl chr 9:21,165,637...21,166,660
JBrowse link
G IFNA4 interferon alpha 4 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:21,186,618...21,187,682
Ensembl chr 9:21,186,694...21,187,671
JBrowse link
G IFNA5 interferon alpha 5 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:21,304,326...21,305,313
Ensembl chr 9:21,304,326...21,305,312
JBrowse link
G IFNA6 interferon alpha 6 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:21,350,318...21,350,887
Ensembl chr 9:21,349,835...21,351,378
JBrowse link
G IFNA7 interferon alpha 7 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:21,201,469...21,202,205
Ensembl chr 9:21,201,469...21,202,205
JBrowse link
G IFNA8 interferon alpha 8 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:21,409,117...21,410,185
Ensembl chr 9:21,409,117...21,410,185
JBrowse link
G IFNB1 interferon beta 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:21,077,104...21,077,942
Ensembl chr 9:21,077,104...21,077,942
JBrowse link
G IFNE interferon epsilon IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:21,480,839...21,482,313
Ensembl chr 9:21,480,839...21,482,313
JBrowse link
G IFNK interferon kappa IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:27,524,290...27,526,498
Ensembl chr 9:27,524,314...27,526,498
JBrowse link
G IFNW1 interferon omega 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:21,140,632...21,141,901
Ensembl chr 9:21,140,214...21,142,145
JBrowse link
G IGKC immunoglobulin kappa constant ISO (MGI:MGI:3622844|PMID:8080841) MGI PMID:8080841 MGI:MGI:3622844 NCBI chr 2:88,857,361...88,857,683
Ensembl chr 2:88,857,161...88,857,683
JBrowse link
G IKZF1 IKAROS family zinc finger 1 ISO (MGI:MGI:5449477|PMID:23071339)
(MGI:MGI:68746|PMID:7923373)
MGI PMID:7923373, PMID:23071339 MGI:MGI:5449477, MGI:MGI:68746 NCBI chr 7:50,303,453...50,405,101
Ensembl chr 7:50,304,068...50,405,101
JBrowse link
G IL10 interleukin 10 NAS (PMID:8228801) UniProtKB PMID:8228801 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL11 interleukin 11 NAS (PMID:2145578) UniProtKB PMID:2145578 NCBI chr19:55,364,382...55,370,463
Ensembl chr19:55,364,382...55,370,463
JBrowse link
G IL4 interleukin 4 TAS (PMID:11418631) UniProtKB PMID:11418631 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G ITGA4 integrin subunit alpha 4 IC (PMID:1715889) BHF-UCL PMID:1715889 NCBI chr 2:181,457,205...181,538,940
Ensembl chr 2:181,457,202...181,538,940
JBrowse link
G ITGB1 integrin subunit beta 1 IC (PMID:1715889) BHF-UCL PMID:1715889 NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,900,318...33,005,792
JBrowse link
G JAK3 Janus kinase 3 ISS
IBA
(PMID:21873635) BHF-UCL
GO_Central
PMID:21873635 GO_REF:0000024 NCBI chr19:17,824,782...17,848,071
Ensembl chr19:17,824,780...17,848,071
JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,918...54,740,715
JBrowse link
G KLF6 Kruppel like factor 6 NAS (PMID:9000136) UniProtKB PMID:9000136 NCBI chr10:3,775,996...3,785,209
Ensembl chr10:3,775,996...3,785,281
JBrowse link
G LYL1 LYL1 basic helix-loop-helix family member ISS UniProtKB GO_REF:0000024 NCBI chr19:13,099,033...13,102,858
Ensembl chr19:13,099,033...13,103,161
JBrowse link
G MS4A1 membrane spanning 4-domains A1 IDA (PMID:3925015) UniProt PMID:3925015 NCBI chr11:60,455,847...60,470,752
Ensembl chr11:60,455,752...60,470,760
Ensembl chr11:60,455,752...60,470,760
JBrowse link
G MSH2 mutS homolog 2 ISS BHF-UCL GO_REF:0000024 NCBI chr 2:47,403,067...47,634,501
Ensembl chr 2:47,403,067...47,663,146
Ensembl chr 2:47,403,067...47,663,146
JBrowse link
G MYB MYB proto-oncogene, transcription factor ISO (MGI:MGI:3763573|PMID:17927961) MGI PMID:17927961 MGI:MGI:3763573 NCBI chr 6:135,181,308...135,219,172
Ensembl chr 6:135,181,308...135,219,173
JBrowse link
G NFAM1 NFAT activating protein with ITAM motif 1 ISS (PMID:15143214) HGNC PMID:15143214 NCBI chr22:42,380,407...42,437,986
Ensembl chr22:42,380,407...42,432,403
Ensembl chr22:42,380,407...42,432,403
JBrowse link
G NHEJ1 non-homologous end joining factor 1 IMP (PMID:16439204) UniProtKB PMID:16439204 NCBI chr 2:219,069,357...219,160,815
Ensembl chr 2:219,069,357...219,160,865
Ensembl chr 2:219,069,357...219,160,865
JBrowse link
G NKX2-3 NK2 homeobox 3 ISO (MGI:MGI:2654966|PMID:12682228) MGI PMID:12682228 MGI:MGI:2654966 NCBI chr10:99,532,942...99,536,524
Ensembl chr10:99,532,942...99,536,524
JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 IEA Ensembl GO_REF:0000107 NCBI chr 1:156,815,750...156,881,850
Ensembl chr 1:156,815,640...156,881,850
JBrowse link
G ONECUT1 one cut homeobox 1 IEA Ensembl GO_REF:0000107 NCBI chr15:52,755,053...52,790,336
Ensembl chr15:52,755,053...52,791,078
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 IEA Ensembl GO_REF:0000107 NCBI chr 5:68,215,737...68,301,821
Ensembl chr 5:68,215,756...68,301,821
JBrowse link
G PLCG2 phospholipase C gamma 2 ISS UniProtKB GO_REF:0000024 NCBI chr16:81,779,291...81,962,685
Ensembl chr16:81,739,097...81,962,685
JBrowse link
G POLM DNA polymerase mu IEA Ensembl GO_REF:0000107 NCBI chr 7:44,072,062...44,082,530
Ensembl chr 7:44,072,062...44,082,530
JBrowse link
G POU1F1 POU class 1 homeobox 1 IEA Ensembl GO_REF:0000107 NCBI chr 3:87,259,404...87,276,584
Ensembl chr 3:87,259,404...87,276,584
JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 ISS UniProtKB GO_REF:0000024 NCBI chr18:12,785,478...12,884,351
Ensembl chr18:12,785,478...12,929,643
JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C ISS ARUK-UCL GO_REF:0000024 NCBI chr 1:198,639,025...198,757,476
Ensembl chr 1:198,638,457...198,757,476
JBrowse link
G PTPRJ protein tyrosine phosphatase receptor type J ISS ARUK-UCL GO_REF:0000024 NCBI chr11:47,980,504...48,170,839
Ensembl chr11:47,980,558...48,170,841
JBrowse link
G RABL3 RAB, member of RAS oncogene family like 3 ISS UniProt GO_REF:0000024 NCBI chr 3:120,684,938...120,742,680
Ensembl chr 3:120,686,681...120,742,993
Ensembl chr 3:120,686,681...120,742,993
JBrowse link
G RAG1 recombination activating 1 ISS UniProtKB GO_REF:0000024 NCBI chr11:36,510,353...36,579,762
Ensembl chr11:36,510,709...36,593,156
JBrowse link
G RAG2 recombination activating 2 ISS UniProtKB GO_REF:0000024 NCBI chr11:36,591,943...36,598,236
Ensembl chr11:36,575,574...36,598,279
JBrowse link
G RBPJ recombination signal binding protein for immunoglobulin kappa J region IEA Ensembl GO_REF:0000107 NCBI chr 4:26,163,458...26,435,131
Ensembl chr 4:26,163,455...26,435,131
JBrowse link
G SP3 Sp3 transcription factor IEA Ensembl GO_REF:0000107 NCBI chr 2:173,900,775...173,965,702
Ensembl chr 2:173,880,850...173,965,702
JBrowse link
G TCF3 transcription factor 3 NAS (PMID:12435739) UniProtKB PMID:12435739 NCBI chr19:1,609,292...1,652,615
Ensembl chr19:1,609,290...1,652,615
JBrowse link
G TCIRG1 T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 IEA Ensembl GO_REF:0000107 NCBI chr11:68,039,000...68,053,846
Ensembl chr11:68,039,025...68,050,895
JBrowse link
G TPD52 tumor protein D52 IEP (PMID:15576473) UniProtKB PMID:15576473 NCBI chr 8:80,034,745...80,171,564
Ensembl chr 8:80,034,745...80,231,232
JBrowse link
G TSHR thyroid stimulating hormone receptor IEA Ensembl GO_REF:0000107 NCBI chr14:80,954,989...81,146,306
Ensembl chr14:80,954,989...81,146,302
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 IC (PMID:1715889) BHF-UCL PMID:1715889 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045
JBrowse link
G YY1 YY1 transcription factor ISO (MGI:MGI:5484711|PMID:23531880) MGI PMID:23531880 MGI:MGI:5484711 NCBI chr14:100,239,144...100,282,788
Ensembl chr14:100,238,298...100,282,788
JBrowse link
G ZBTB1 zinc finger and BTB domain containing 1 IEA Ensembl GO_REF:0000107 NCBI chr14:64,504,726...64,533,693
Ensembl chr14:64,503,712...64,533,690
JBrowse link
G ZBTB7A zinc finger and BTB domain containing 7A ISS UniProt GO_REF:0000024 NCBI chr19:4,043,303...4,066,899
Ensembl chr19:4,043,303...4,066,899
JBrowse link
B cell affinity maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BTK Bruton tyrosine kinase IEA Ensembl GO_REF:0000107 NCBI chr  X:101,349,450...101,390,796
Ensembl chr  X:101,349,447...101,390,796
JBrowse link
G HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 ISO (MGI:MGI:4943414|PMID:1378867) BHF-UCL PMID:1378867 MGI:MGI:4943414 NCBI chr 6:32,659,467...32,666,657
Ensembl chr 6:32,659,467...32,668,383
JBrowse link
G IGHM immunoglobulin heavy constant mu ISO (MGI:MGI:1277450|PMID:9707605) MGI PMID:9707605 MGI:MGI:1277450 NCBI chr14:105,851,966...105,856,217
Ensembl chr14:105,851,705...105,856,218
JBrowse link
B cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator IEA Ensembl GO_REF:0000107 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit IEA Ensembl GO_REF:0000107 NCBI chr 8:47,773,111...47,960,136
Ensembl chr 8:47,773,111...47,960,178
Ensembl chr 8:47,773,111...47,960,178
JBrowse link
G RAG2 recombination activating 2 IEA Ensembl GO_REF:0000107 NCBI chr11:36,591,943...36,598,236
Ensembl chr11:36,575,574...36,598,279
JBrowse link
G TCF3 transcription factor 3 NAS
IDA
(PMID:12435739)
(PMID:15030778)
UniProtKB PMID:12435739, PMID:15030778 NCBI chr19:1,609,292...1,652,615
Ensembl chr19:1,609,290...1,652,615
JBrowse link
G TP53 tumor protein p53 IEA Ensembl GO_REF:0000107 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
B cell negative selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAK1 BCL2 antagonist/killer 1 IEA Ensembl GO_REF:0000107 NCBI chr 6:33,572,552...33,580,296
Ensembl chr 6:33,572,547...33,580,293
JBrowse link
G BAX BCL2 associated X, apoptosis regulator IEA Ensembl GO_REF:0000107 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
B-1 B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD19 CD19 molecule IEA Ensembl GO_REF:0000107 NCBI chr16:28,931,735...28,939,347
Ensembl chr16:28,931,965...28,939,342
Ensembl chr16:28,931,965...28,939,342
JBrowse link
G MALT1 MALT1 paracaspase IEA Ensembl GO_REF:0000107 NCBI chr18:58,671,420...58,754,477
Ensembl chr18:58,671,465...58,754,477
JBrowse link
B-1 B cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLAMF8 SLAM family member 8 ISS (PMID:11313408) UniProt PMID:11313408 NCBI chr 1:159,826,689...159,837,497
Ensembl chr 1:159,826,811...159,837,492
JBrowse link
B-1a B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CMTM7 CKLF like MARVEL transmembrane domain containing 7 IEA Ensembl GO_REF:0000107 NCBI chr 3:32,391,825...32,455,528
Ensembl chr 3:32,391,698...32,483,067
JBrowse link
G NFATC1 nuclear factor of activated T cells 1 ISO (MGI:MGI:2680742|PMID:14595020) MGI PMID:14595020 MGI:MGI:2680742 NCBI chr18:79,395,930...79,529,323
Ensembl chr18:79,395,856...79,529,325
JBrowse link
G PLCL2 phospholipase C like 2 IEA Ensembl GO_REF:0000107 NCBI chr 3:16,802,691...17,090,606
Ensembl chr 3:16,802,651...17,090,604
JBrowse link
follicular B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FCGR2B Fc fragment of IgG receptor IIb TAS (PMID:26683154) ARUK-UCL PMID:26683154 NCBI chr 1:161,647,243...161,678,654
Ensembl chr 1:161,663,147...161,678,654
JBrowse link
G PLCG2 phospholipase C gamma 2 IEA Ensembl GO_REF:0000107 NCBI chr16:81,779,291...81,962,685
Ensembl chr16:81,739,097...81,962,685
JBrowse link
germinal center B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase IEA Ensembl GO_REF:0000107 NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,619,522...44,652,233
JBrowse link
G CDH17 cadherin 17 IEA Ensembl GO_REF:0000107 NCBI chr 8:94,127,162...94,217,278
Ensembl chr 8:94,127,162...94,217,303
JBrowse link
G IL21 interleukin 21 ISS UniProt GO_REF:0000024 NCBI chr 4:122,610,108...122,621,066
Ensembl chr 4:122,610,108...122,621,066
JBrowse link
G IL6 interleukin 6 ISS UniProt GO_REF:0000024 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G ITFG2 integrin alpha FG-GAP repeat containing 2 IEA Ensembl GO_REF:0000107 NCBI chr12:2,812,644...2,859,907
Ensembl chr12:2,812,622...2,859,791
JBrowse link
G POU2AF1 POU class 2 homeobox associating factor 1 ISS UniProt GO_REF:0000024 NCBI chr11:111,352,251...111,379,671
Ensembl chr11:111,352,255...111,455,630
JBrowse link
immature B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FNIP1 folliculin interacting protein 1 ISS UniProtKB GO_REF:0000024 NCBI chr 5:131,641,714...131,797,017
Ensembl chr 5:131,641,714...131,797,063
JBrowse link
G IRF2BP2 interferon regulatory factor 2 binding protein 2 IDA (PMID:27016798) UniProtKB PMID:27016798 NCBI chr 1:234,604,269...234,610,178
Ensembl chr 1:234,604,269...234,609,525
JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase ISS UniProtKB GO_REF:0000024 NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,918...54,740,715
JBrowse link
G SYVN1 synoviolin 1 ISS UniProt GO_REF:0000024 NCBI chr11:65,127,279...65,135,178
Ensembl chr11:65,121,780...65,134,532
Ensembl chr11:65,121,780...65,134,532
JBrowse link
marginal zone B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL3 BCL3 transcription coactivator ISO (MGI:MGI:85481|PMID:9009202) MGI PMID:9009202 MGI:MGI:85481 NCBI chr19:44,742,620...44,760,044
Ensembl chr19:44,747,705...44,760,044
JBrowse link
G CDH17 cadherin 17 IEA Ensembl GO_REF:0000107 NCBI chr 8:94,127,162...94,217,278
Ensembl chr 8:94,127,162...94,217,303
JBrowse link
G DLL1 delta like canonical Notch ligand 1 ISS UniProtKB GO_REF:0000024 NCBI chr 6:170,282,200...170,291,078
Ensembl chr 6:170,282,206...170,306,565
JBrowse link
G DOCK10 dedicator of cytokinesis 10 ISS UniProtKB GO_REF:0000024 NCBI chr 2:224,765,090...225,042,689
Ensembl chr 2:224,765,090...225,042,445
JBrowse link
G DOCK11 dedicator of cytokinesis 11 ISS UniProtKB GO_REF:0000024 NCBI chr  X:118,495,664...118,686,153
Ensembl chr  X:118,495,898...118,686,163
JBrowse link
G LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase ISS UniProtKB GO_REF:0000024 NCBI chr 7:2,512,529...2,529,177
Ensembl chr 7:2,512,529...2,529,177
JBrowse link
G MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase ISS UniProtKB GO_REF:0000024 NCBI chr22:37,469,063...37,486,384
Ensembl chr22:37,469,063...37,486,393
JBrowse link
G NOTCH2 notch receptor 2 ISS UniProtKB GO_REF:0000024 NCBI chr 1:119,911,553...120,069,662
Ensembl chr 1:119,911,553...120,100,779
JBrowse link
G PTK2B protein tyrosine kinase 2 beta ISS UniProtKB GO_REF:0000024 NCBI chr 8:27,311,478...27,459,391
Ensembl chr 8:27,311,482...27,459,391
JBrowse link
mature B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POU2F2 POU class 2 homeobox 2 IEA Ensembl GO_REF:0000107 NCBI chr19:42,086,113...42,197,931
Ensembl chr19:42,086,110...42,196,585
JBrowse link
mature B cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C17orf99 chromosome 17 open reading frame 99 ISS UniProtKB GO_REF:0000024 NCBI chr17:78,146,035...78,166,297
Ensembl chr17:78,146,353...78,166,177
JBrowse link
G FCGR2B Fc fragment of IgG receptor IIb TAS (PMID:26683154) ARUK-UCL PMID:26683154 NCBI chr 1:161,647,243...161,678,654
Ensembl chr 1:161,663,147...161,678,654
JBrowse link
G GPR183 G protein-coupled receptor 183 ISS UniProtKB GO_REF:0000024 NCBI chr13:99,294,273...99,307,399
Ensembl chr13:99,294,539...99,307,399
JBrowse link
memory B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 ISO (MGI:MGI:2387354|PMID:10755614) UniProt PMID:10755614 MGI:MGI:2387354 NCBI chr 8:133,454,848...133,572,534
Ensembl chr 8:133,454,848...133,571,940
JBrowse link
negative regulation of B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLT3 fms related receptor tyrosine kinase 3 ISO (MGI:MGI:3623701|PMID:16618805) MGI PMID:16618805 MGI:MGI:3623701 NCBI chr13:28,003,274...28,100,587
Ensembl chr13:28,003,274...28,100,592
JBrowse link
G HMGB3 high mobility group box 3 IEA Ensembl GO_REF:0000107 NCBI chr  X:150,980,507...150,990,773
Ensembl chr  X:150,980,509...150,990,771
JBrowse link
G ID2 inhibitor of DNA binding 2 IEA Ensembl GO_REF:0000107 NCBI chr 2:8,682,056...8,684,461
Ensembl chr 2:8,678,845...8,684,461
JBrowse link
G INHA inhibin subunit alpha TAS (PMID:12456957) UniProtKB PMID:12456957 NCBI chr 2:219,572,310...219,575,711
Ensembl chr 2:219,569,162...219,575,711
JBrowse link
G INHBA inhibin subunit beta A TAS (PMID:12456957) UniProtKB PMID:12456957 NCBI chr 7:41,685,101...41,710,532
Ensembl chr 7:41,667,168...41,705,834
JBrowse link
G SFRP1 secreted frizzled related protein 1 IMP (PMID:18941195) UniProtKB PMID:18941195 NCBI chr 8:41,261,962...41,309,473
Ensembl chr 8:41,261,962...41,309,473
JBrowse link
negative regulation of plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CR1 complement C3b/C4b receptor 1 (Knops blood group) IDA (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chr 1:207,496,157...207,641,765
Ensembl chr 1:207,496,147...207,641,765
JBrowse link
plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ITM2A integral membrane protein 2A IEA Ensembl GO_REF:0000107 NCBI chr  X:79,360,384...79,367,334
Ensembl chr  X:79,360,384...79,367,667
JBrowse link
G LGALS1 galectin 1 IEA Ensembl GO_REF:0000107 NCBI chr22:37,675,636...37,679,802
Ensembl chr22:37,675,636...37,679,802
JBrowse link
G LGALS8 galectin 8 ISO (MGI:MGI:5301217|PMID:21753146) MGI PMID:21753146 MGI:MGI:5301217 NCBI chr 1:236,518,214...236,552,981
Ensembl chr 1:236,518,000...236,552,981
JBrowse link
G NKX2-3 NK2 homeobox 3 IEA Ensembl GO_REF:0000107 NCBI chr10:99,532,942...99,536,524
Ensembl chr10:99,532,942...99,536,524
JBrowse link
positive regulation of B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP11C ATPase phospholipid transporting 11C IEA Ensembl GO_REF:0000107 NCBI chr  X:139,726,346...139,933,083
Ensembl chr  X:139,726,346...139,945,276
JBrowse link
G BAD BCL2 associated agonist of cell death IEA Ensembl GO_REF:0000107 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704
JBrowse link
G BTK Bruton tyrosine kinase TAS (PMID:19290921) UniProtKB PMID:19290921 NCBI chr  X:101,349,450...101,390,796
Ensembl chr  X:101,349,447...101,390,796
JBrowse link
G CD27 CD27 molecule NAS (PMID:10809378) UniProtKB PMID:10809378 NCBI chr12:6,444,867...6,451,718
Ensembl chr12:6,444,867...6,451,718
JBrowse link
G IL2RG interleukin 2 receptor subunit gamma ISO (MGI:MGI:1095961|PMID:9252128) MGI PMID:9252128 MGI:MGI:1095961 NCBI chr  X:71,107,404...71,111,577
Ensembl chr  X:71,107,404...71,112,108
JBrowse link
G IL7 interleukin 7 IEA Ensembl GO_REF:0000107 NCBI chr 8:78,675,870...78,806,830
Ensembl chr 8:78,675,743...78,805,523
JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D IEA Ensembl GO_REF:0000107 NCBI chr 2:233,060,342...233,207,903
Ensembl chr 2:233,059,967...233,207,903
JBrowse link
G MMP14 matrix metallopeptidase 14 ISS UniProtKB GO_REF:0000024 NCBI chr14:22,836,585...22,847,758
Ensembl chr14:22,836,560...22,849,027
JBrowse link
G NCKAP1L NCK associated protein 1 like ISS UniProtKB GO_REF:0000024 NCBI chr12:54,497,752...54,548,243
Ensembl chr12:54,497,752...54,548,243
JBrowse link
G PCID2 PCI domain containing 2 IEA Ensembl GO_REF:0000107 NCBI chr13:113,165,002...113,209,467
Ensembl chr13:113,177,536...113,208,715
JBrowse link
G PPP2R3C protein phosphatase 2 regulatory subunit B''gamma IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:35,085,472...35,122,662
Ensembl chr14:35,085,467...35,122,517
JBrowse link
G PRDM1 PR/SET domain 1 NOT ISO (MGI:MGI:3826899|PMID:18845144) MGI PMID:18845144 MGI:MGI:3826899 NCBI chr 6:106,046,729...106,109,938
Ensembl chr 6:105,993,463...106,109,939
JBrowse link
G STAT5A signal transducer and activator of transcription 5A ISO (MGI:MGI:1889695|PMID:10979977) MGI PMID:10979977 MGI:MGI:1889695 NCBI chr17:42,287,547...42,311,943
Ensembl chr17:42,287,547...42,311,943
JBrowse link
G STAT5B signal transducer and activator of transcription 5B IEA Ensembl GO_REF:0000107 NCBI chr17:42,199,177...42,288,437
Ensembl chr17:42,199,177...42,276,707
Ensembl chr17:42,199,177...42,276,707
JBrowse link
G SYK spleen associated tyrosine kinase IMP
IBA
(PMID:18369315)
(PMID:21873635)
CACAO
GO_Central
PMID:18369315, PMID:21873635 NCBI chr 9:90,801,600...90,898,549
Ensembl chr 9:90,801,787...90,898,549
JBrowse link
G XBP1 X-box binding protein 1 IDA (PMID:11460154) UniProtKB PMID:11460154 NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597
JBrowse link
positive regulation of plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL10 interleukin 10 IGI (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL2 interleukin 2 IGI (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G XBP1 X-box binding protein 1 IDA (PMID:11460154) UniProtKB PMID:11460154 NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597
JBrowse link
pre-B cell allelic exclusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase ISS UniProtKB GO_REF:0000024 NCBI chr11:108,222,484...108,369,102
Ensembl chr11:108,222,832...108,369,102
Ensembl chr11:108,222,832...108,369,102
JBrowse link
G RAG1 recombination activating 1 ISS
IBA
(PMID:21873635) UniProtKB
GO_Central
PMID:21873635 GO_REF:0000024 NCBI chr11:36,510,353...36,579,762
Ensembl chr11:36,510,709...36,593,156
JBrowse link
G RAG2 recombination activating 2 ISS UniProtKB GO_REF:0000024 NCBI chr11:36,591,943...36,598,236
Ensembl chr11:36,575,574...36,598,279
JBrowse link
pre-B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP11C ATPase phospholipid transporting 11C IEA Ensembl GO_REF:0000107 NCBI chr  X:139,726,346...139,933,083
Ensembl chr  X:139,726,346...139,945,276
JBrowse link
G CD24 CD24 molecule ISO (MGI:MGI:2179980|PMID:9028339), (MGI:MGI:74794|PMID:7795661) MGI PMID:7795661, PMID:9028339 MGI:MGI:2179980, MGI:MGI:74794 NCBI chr 6:106,969,831...106,976,855
Ensembl chr 6:106,969,831...106,975,627
JBrowse link
G FOXP1 forkhead box P1 ISO (MGI:MGI:3662963|PMID:16819554) MGI PMID:16819554 MGI:MGI:3662963 NCBI chr 3:70,954,708...71,583,983
Ensembl chr 3:70,952,817...71,583,993
Ensembl chr 3:70,952,817...71,583,993
JBrowse link
G LRRC8A leucine rich repeat containing 8 VRAC subunit A ISS UniProtKB GO_REF:0000024 NCBI chr 9:128,882,133...128,918,042
Ensembl chr 9:128,882,133...128,918,039
Ensembl chr 9:128,882,133...128,918,039
JBrowse link
G MIR17 microRNA 17 ISO (MGI:MGI:3789916|PMID:18329372) MGI PMID:18329372 MGI:MGI:3789916 NCBI chr13:91,350,605...91,350,688
Ensembl chr13:91,350,605...91,350,688
JBrowse link
G MIR18A microRNA 18a ISO (MGI:MGI:3789916|PMID:18329372) MGI PMID:18329372 MGI:MGI:3789916 NCBI chr13:91,350,751...91,350,821
Ensembl chr13:91,350,751...91,350,821
JBrowse link
G MIR19A microRNA 19a ISO (MGI:MGI:3789916|PMID:18329372) MGI PMID:18329372 MGI:MGI:3789916 NCBI chr13:91,350,891...91,350,972
Ensembl chr13:91,350,891...91,350,972
JBrowse link
G MIR19B1 microRNA 19b-1 ISO (MGI:MGI:3789916|PMID:18329372) MGI PMID:18329372 MGI:MGI:3789916 NCBI chr13:91,351,192...91,351,278
Ensembl chr13:91,351,192...91,351,278
JBrowse link
G MIR20A microRNA 20a ISO (MGI:MGI:3789916|PMID:18329372) MGI PMID:18329372 MGI:MGI:3789916 NCBI chr13:91,351,065...91,351,135
Ensembl chr13:91,351,065...91,351,135
JBrowse link
G MIR92A1 microRNA 92a-1 ISO (MGI:MGI:3789916|PMID:18329372) MGI PMID:18329372 MGI:MGI:3789916 NCBI chr13:91,351,314...91,351,391
Ensembl chr13:91,351,314...91,351,391
JBrowse link
regulation of B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANKLE1 ankyrin repeat and LEM domain containing 1 NOT ISO (MGI:MGI:5800654|PMID:27010503) UniProtKB PMID:27010503 MGI:MGI:5800654 NCBI chr19:17,281,901...17,287,646
Ensembl chr19:17,281,645...17,287,646
JBrowse link
G CARD11 caspase recruitment domain family member 11 IEA Ensembl GO_REF:0000107 NCBI chr 7:2,906,142...3,043,867
Ensembl chr 7:2,906,141...3,043,945
JBrowse link
G CD24 CD24 molecule ISO (MGI:MGI:2179980|PMID:9028339), (MGI:MGI:74794|PMID:7795661) MGI PMID:7795661, PMID:9028339 MGI:MGI:2179980, MGI:MGI:74794 NCBI chr 6:106,969,831...106,976,855
Ensembl chr 6:106,969,831...106,975,627
JBrowse link
G CYLD CYLD lysine 63 deubiquitinase IEA Ensembl GO_REF:0000107 NCBI chr16:50,742,086...50,801,935
Ensembl chr16:50,742,050...50,801,935
JBrowse link
G FCRL3 Fc receptor like 3 IDA (PMID:23857366) UniProtKB PMID:23857366 NCBI chr 1:157,676,481...157,700,985
Ensembl chr 1:157,674,321...157,700,769
JBrowse link
G IKZF3 IKAROS family zinc finger 3 ISS UniProtKB GO_REF:0000024 NCBI chr17:39,757,715...39,864,312
Ensembl chr17:39,757,718...39,864,312
JBrowse link
G MIR150 microRNA 150 ISO (MGI:MGI:3763573|PMID:17927961) MGI PMID:17927961 MGI:MGI:3763573 NCBI chr19:49,500,785...49,500,868
Ensembl chr19:49,500,785...49,500,868
JBrowse link
G NFAM1 NFAT activating protein with ITAM motif 1 IEA InterPro GO_REF:0000002 NCBI chr22:42,380,407...42,437,986
Ensembl chr22:42,380,407...42,432,403
Ensembl chr22:42,380,407...42,432,403
JBrowse link
G PTPN6 protein tyrosine phosphatase non-receptor type 6 IEA Ensembl GO_REF:0000107 NCBI chr12:6,946,577...6,961,316
Ensembl chr12:6,946,468...6,961,316
JBrowse link
G SLAMF8 SLAM family member 8 ISS (PMID:11313408) UniProt PMID:11313408 NCBI chr 1:159,826,689...159,837,497
Ensembl chr 1:159,826,811...159,837,492
JBrowse link
G TLR9 toll like receptor 9 IDA (PMID:23857366) UniProtKB PMID:23857366 NCBI chr 3:52,221,080...52,225,645
Ensembl chr 3:52,221,080...52,226,163
JBrowse link
G ZFP36L1 ZFP36 ring finger protein like 1 ISS UniProtKB GO_REF:0000024 NCBI chr14:68,787,655...68,796,243
Ensembl chr14:68,787,660...68,796,253
JBrowse link
G ZFP36L2 ZFP36 ring finger protein like 2 ISS UniProtKB GO_REF:0000024 NCBI chr 2:43,222,402...43,226,606
Ensembl chr 2:43,222,402...43,226,606
JBrowse link
transitional one stage B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase IEA Ensembl GO_REF:0000107 NCBI chr 9:130,713,881...130,887,675
Ensembl chr 9:130,713,016...130,887,675
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18670
    immune system process 3584
      leukocyte activation 1476
        lymphocyte activation 888
          lymphocyte differentiation 433
            B cell differentiation 164
              B cell lineage commitment + 6
              B cell selection + 5
              immature B cell differentiation + 18
              mature B cell differentiation + 34
              negative regulation of B cell differentiation + 7
              positive regulation of B cell differentiation + 18
              regulation of B cell differentiation + 38
Path 2
Term Annotations click to browse term
  biological_process 18670
    developmental process 7464
      anatomical structure development 6871
        multicellular organism development 6344
          system development 5748
            immune system development 1221
              hematopoietic or lymphoid organ development 1152
                hemopoiesis 1104
                  leukocyte differentiation 635
                    lymphocyte differentiation 433
                      B cell differentiation 164
                        B cell lineage commitment + 6
                        B cell selection + 5
                        immature B cell differentiation + 18
                        mature B cell differentiation + 34
                        negative regulation of B cell differentiation + 7
                        positive regulation of B cell differentiation + 18
                        regulation of B cell differentiation + 38
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.