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ONTOLOGY REPORT - ANNOTATIONS


Term:heparan sulfate proteoglycan metabolic process
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Accession:GO:0030201 term browser browse the term
Definition:The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups.
Synonyms:exact_synonym: heparan sulfate proteoglycan metabolism;   heparan sulphate proteoglycan metabolic process;   heparan sulphate proteoglycan metabolism
 related_synonym: heparin proteoglycan metabolic process


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heparan sulfate proteoglycan metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sulf1 sulfatase 1 JBrowse link 5 5,999,520 6,186,901 RGD:1624291
RGD:13792537
RGD:1600115
G Sulf2 sulfatase 2 JBrowse link 3 162,791,349 162,872,984 RGD:1624291
RGD:13792537
heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B3gat3 beta-1,3-glucuronyltransferase 3 JBrowse link 1 225,120,061 225,126,579 RGD:1624291
G Ext1 exostosin glycosyltransferase 1 JBrowse link 7 92,605,008 92,881,392 RGD:1624291
G Ext2 exostosin glycosyltransferase 2 JBrowse link 3 82,602,784 82,734,557 RGD:1624291
G Extl3 exostosin-like glycosyltransferase 3 JBrowse link 15 48,420,419 48,465,171 RGD:1624291
G Glce glucuronic acid epimerase JBrowse link 8 67,006,588 67,073,723 RGD:1624291
RGD:13792537
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 JBrowse link 9 42,620,006 42,659,184 RGD:1624291
G Lipc lipase C, hepatic type JBrowse link 8 77,272,582 77,398,485 RGD:1580511
G Ndst1 N-deacetylase and N-sulfotransferase 1 JBrowse link 18 55,951,497 56,014,107 RGD:12907548
G Ndst2 N-deacetylase and N-sulfotransferase 2 JBrowse link 15 3,995,797 4,006,491 RGD:1624291
G Ndst3 N-deacetylase and N-sulfotransferase 3 JBrowse link 2 227,736,491 227,903,657 RGD:1624291
G Ugdh UDP-glucose 6-dehydrogenase JBrowse link 14 44,479,614 44,502,845 RGD:1600115
RGD:1624291
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link 13 90,379,203 90,405,627 RGD:1624291
G Xylt1 xylosyltransferase 1 JBrowse link 1 186,939,698 187,264,758 RGD:1600115
RGD:13792537
RGD:1624291
G Xylt2 xylosyltransferase 2 JBrowse link 10 82,386,003 82,399,485 RGD:1600115
RGD:13792537
RGD:1624291
heparan sulfate proteoglycan biosynthetic process, enzymatic modification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 JBrowse link 2 250,467,428 250,600,517 RGD:13792537
G Hs3st5 heparan sulfate-glucosamine 3-sulfotransferase 5 JBrowse link 20 40,236,437 40,545,502 RGD:1624291
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 JBrowse link 9 42,620,006 42,659,184 RGD:1624291
RGD:13792537
G Hs6st2 heparan sulfate 6-O-sulfotransferase 2 JBrowse link X 138,675,326 138,972,774 RGD:1624291
RGD:13792537
G Hs6st3 heparan sulfate 6-O-sulfotransferase 3 JBrowse link 15 104,448,479 105,254,540 RGD:1624291
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ext1 exostosin glycosyltransferase 1 JBrowse link 7 92,605,008 92,881,392 RGD:1624291
G Ext2 exostosin glycosyltransferase 2 JBrowse link 3 82,602,784 82,734,557 RGD:1624291
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 JBrowse link 2 250,467,428 250,600,517 RGD:1624291
RGD:13792537
G Ndst1 N-deacetylase and N-sulfotransferase 1 JBrowse link 18 55,951,497 56,014,107 RGD:13792537
G Ndst2 N-deacetylase and N-sulfotransferase 2 JBrowse link 15 3,995,797 4,006,491 RGD:13792537
G Ndst3 N-deacetylase and N-sulfotransferase 3 JBrowse link 2 227,736,491 227,903,657 RGD:1624291
RGD:13792537
G Ndst4 N-deacetylase and N-sulfotransferase 4 JBrowse link 2 229,170,781 229,496,732 RGD:13792537
G NEWGENE_1304700 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 JBrowse link 15 3,750,058 3,760,616 RGD:13792537
heparan sulfate proteoglycan catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07030903.1 RGD:1600115
G Gpc1 glypican 1 JBrowse link 9 99,998,275 100,026,818 RGD:1600115
RGD:1624291
G Hpse heparanase JBrowse link 14 10,534,358 10,576,686 RGD:1600115
RGD:1624291
G Sgsh N-sulfoglucosamine sulfohydrolase JBrowse link 10 108,469,312 108,479,094 RGD:1624291
positive regulation of heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1624291
RGD:1600115
G Pxylp1 2-phosphoxylose phosphatase 1 JBrowse link 8 104,724,728 104,790,639 RGD:1624291
RGD:1600115
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1 276,686,911 276,730,517 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19578
    cellular process 18362
      cellular metabolic process 10737
        cellular macromolecule metabolic process 8223
          glycoprotein metabolic process 357
            proteoglycan metabolic process 74
              heparan sulfate proteoglycan metabolic process 29
                heparan sulfate proteoglycan biosynthetic process + 23
                heparan sulfate proteoglycan biosynthetic process, enzymatic modification 5
                heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                heparan sulfate proteoglycan catabolic process 4
Path 2
Term Annotations click to browse term
  biological_process 19578
    metabolic process 11901
      organic substance metabolic process 11299
        macromolecule metabolic process 9767
          protein metabolic process 6070
            glycoprotein metabolic process 357
              proteoglycan metabolic process 74
                heparan sulfate proteoglycan metabolic process 29
                  heparan sulfate proteoglycan biosynthetic process + 23
                  heparan sulfate proteoglycan biosynthetic process, enzymatic modification 5
                  heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                  heparan sulfate proteoglycan catabolic process 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.