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ONTOLOGY REPORT - ANNOTATIONS


Term:heparin metabolic process
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Accession:GO:0030202 term browser browse the term
Definition:The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
Synonyms:exact_synonym: heparin metabolism
 related_synonym: heparan sulfate metabolic process


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heparin metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ext1 exostosin glycosyltransferase 1 JBrowse link 7 92,605,008 92,881,392 RGD:1624291
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 JBrowse link 2 250,467,428 250,600,517 RGD:1624291
heparin biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Angpt1 angiopoietin 1 JBrowse link 7 81,338,327 81,592,459 RGD:1600115
RGD:1624291
G Ext1 exostosin glycosyltransferase 1 JBrowse link 7 92,605,008 92,881,392 RGD:1624291
G Ext2 exostosin glycosyltransferase 2 JBrowse link 3 82,602,784 82,734,557 RGD:1624291
G Glce glucuronic acid epimerase JBrowse link 8 67,006,588 67,073,723 RGD:1624291
G Ndst1 N-deacetylase and N-sulfotransferase 1 JBrowse link 18 55,951,497 56,014,107 RGD:1600115
G Slc10a7 solute carrier family 10, member 7 JBrowse link 19 32,857,984 33,081,359 RGD:1624291
G Xylt2 xylosyltransferase 2 JBrowse link 10 82,386,003 82,399,485 RGD:1624291
RGD:1600115
heparin catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Idua alpha-L-iduronidase JBrowse link 14 2,041,828 2,056,762 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    cellular process 18618
      cellular metabolic process 10918
        sulfur compound metabolic process 298
          heparin metabolic process 9
            heparin biosynthetic process 7
            heparin catabolic process 1
Path 2
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12097
      organic substance metabolic process 11495
        macromolecule metabolic process 9944
          aminoglycan metabolic process 111
            glycosaminoglycan metabolic process 92
              mucopolysaccharide metabolic process 69
                heparin metabolic process 9
                  heparin biosynthetic process 7
                  heparin catabolic process 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.