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ONTOLOGY REPORT - ANNOTATIONS


Term:glycosaminoglycan metabolic process
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Accession:GO:0030203 term browser browse the term
Definition:The chemical reactions and pathways involving glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. Formerly known as mucopolysaccharides, they include hyaluronic acid and chondroitin, which provide lubrication in joints and form part of the matrix of cartilage. The three-dimensional structure of these molecules enables them to trap water, which forms a gel and gives glycosaminoglycans their elastic properties.
Synonyms:exact_synonym: glycosaminoglycan metabolism


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glycosaminoglycan metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cln6 CLN6, transmembrane ER protein JBrowse link 8 67,733,215 67,748,170 RGD:1624291
G Foxc1 forkhead box C1 JBrowse link 17 33,947,501 33,951,484 RGD:1624291
G Hexa hexosaminidase subunit alpha JBrowse link 8 64,325,435 64,350,775 RGD:1624291
G Hexb hexosaminidase subunit beta JBrowse link 2 27,983,925 28,003,260 RGD:1624291
RGD:1600115
G Ndst1 N-deacetylase and N-sulfotransferase 1 JBrowse link 18 55,951,497 56,014,107 RGD:1624291
chondroitin sulfate biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chpf chondroitin polymerizing factor JBrowse link 9 82,669,199 82,673,898 RGD:1624291
G Chst11 carbohydrate sulfotransferase 11 JBrowse link 7 26,641,856 26,890,503 RGD:1624291
G Chst12 carbohydrate sulfotransferase 12 JBrowse link 12 16,199,975 16,218,404 RGD:1624291
G Chst13 carbohydrate sulfotransferase 13 JBrowse link 4 122,223,846 122,244,848 RGD:1624291
G Chst3 carbohydrate sulfotransferase 3 JBrowse link 20 29,731,828 29,768,656 RGD:1600115
RGD:13792537
RGD:1624291
G Chst7 carbohydrate sulfotransferase 7 JBrowse link X 2,623,018 2,657,155 RGD:1624291
RGD:13792537
G Chsy1 chondroitin sulfate synthase 1 JBrowse link 1 127,010,587 127,071,570 RGD:1624291
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 JBrowse link 16 22,704,318 23,075,071 RGD:1624291
G Slc35d1 solute carrier family 35 member D1 JBrowse link 5 122,700,396 122,746,815 RGD:1624291
G Ugdh UDP-glucose 6-dehydrogenase JBrowse link 14 44,479,614 44,502,845 RGD:1600115
RGD:1624291
G Xylt1 xylosyltransferase 1 JBrowse link 1 186,939,698 187,264,758 RGD:1600115
RGD:1624291
G Xylt2 xylosyltransferase 2 JBrowse link 10 82,386,003 82,399,485 RGD:1600115
chondroitin sulfate catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hyal4 hyaluronidase 4 JBrowse link 4 52,147,641 52,166,276 RGD:1624291
chondroitin sulfate metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chst11 carbohydrate sulfotransferase 11 JBrowse link 7 26,641,856 26,890,503 RGD:1624291
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 JBrowse link 16 22,704,318 23,075,071 RGD:1624291
G Dse dermatan sulfate epimerase JBrowse link 20 27,703,738 27,784,982 RGD:13792537
G Dsel dermatan sulfate epimerase-like JBrowse link 13 1,942,384 1,948,563 RGD:1624291
RGD:13792537
G Impad1 inositol monophosphatase domain containing 1 JBrowse link 17 90,191,119 90,218,013 RGD:1624291
dermatan sulfate biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chst12 carbohydrate sulfotransferase 12 JBrowse link 12 16,199,975 16,218,404 RGD:1624291
G Chst14 carbohydrate sulfotransferase 14 JBrowse link 3 110,734,105 110,736,162 RGD:1624291
RGD:1600115
G Dse dermatan sulfate epimerase JBrowse link 20 27,703,738 27,784,982 RGD:1624291
dermatan sulfate catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Idua alpha-L-iduronidase JBrowse link 14 2,041,828 2,056,762 RGD:1624291
dermatan sulfate metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dse dermatan sulfate epimerase JBrowse link 20 27,703,738 27,784,982 RGD:13792537
G Dsel dermatan sulfate epimerase-like JBrowse link 13 1,942,384 1,948,563 RGD:1624291
RGD:13792537
glycosaminoglycan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B3galt6 Beta-1,3-galactosyltransferase 6 JBrowse link 5 173,423,475 173,425,611 RGD:1624291
RGD:13792537
G B3gat3 beta-1,3-glucuronyltransferase 3 JBrowse link 1 225,120,061 225,126,579 RGD:1624291
G B4galt7 beta-1,4-galactosyltransferase 7 JBrowse link 17 9,549,605 9,558,672 RGD:1624291
RGD:1600115
G Ext1 exostosin glycosyltransferase 1 JBrowse link 7 92,605,008 92,881,392 RGD:1624291
G Ext2 exostosin glycosyltransferase 2 JBrowse link 3 82,602,784 82,734,557 RGD:1624291
G Hexa hexosaminidase subunit alpha JBrowse link 8 64,325,435 64,350,775 RGD:1624291
G Pdgfrb platelet derived growth factor receptor beta JBrowse link 18 56,364,586 56,406,381 RGD:1581762
G Pxylp1 2-phosphoxylose phosphatase 1 JBrowse link 8 104,724,728 104,790,639 RGD:1624291
RGD:1600115
G Ugdh UDP-glucose 6-dehydrogenase JBrowse link 14 44,479,614 44,502,845 RGD:13792537
G Xylt1 xylosyltransferase 1 JBrowse link 1 186,939,698 187,264,758 RGD:1600115
G Xylt2 xylosyltransferase 2 JBrowse link 10 82,386,003 82,399,485 RGD:1624291
glycosaminoglycan catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07030903.1 RGD:1600115
G Hyal2 hyaluronidase 2 JBrowse link 8 116,324,062 116,328,978 RGD:1624291
RGD:1600115
G Hyal4 hyaluronidase 4 JBrowse link 4 52,147,641 52,166,276 RGD:1331360
G Ids iduronate 2-sulfatase JBrowse link 8 69,447,971 69,466,708 RGD:1624291
G Idua alpha-L-iduronidase JBrowse link 14 2,041,828 2,056,762 RGD:1599427
RGD:1624291
G Lyve1 lymphatic vessel endothelial hyaluronan receptor 1 JBrowse link 1 175,663,266 175,676,699 RGD:1624291
G Sgsh N-sulfoglucosamine sulfohydrolase JBrowse link 10 108,469,312 108,479,094 RGD:1624291
heparin biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Angpt1 angiopoietin 1 JBrowse link 7 81,338,327 81,592,459 RGD:1600115
RGD:1624291
G Glce glucuronic acid epimerase JBrowse link 8 67,006,588 67,073,723 RGD:1624291
G Ndst1 N-deacetylase and N-sulfotransferase 1 JBrowse link 18 55,951,497 56,014,107 RGD:1600115
G Slc10a7 solute carrier family 10, member 7 JBrowse link 19 32,857,984 33,081,359 RGD:1624291
G Xylt2 xylosyltransferase 2 JBrowse link 10 82,386,003 82,399,485 RGD:1624291
RGD:1600115
heparin catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Idua alpha-L-iduronidase JBrowse link 14 2,041,828 2,056,762 RGD:1624291
heparin metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 JBrowse link 2 250,467,428 250,600,517 RGD:1624291
hyaluronan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccnd3 cyclin D3 JBrowse link 9 15,404,816 15,410,905 RGD:2316018
G Has1 hyaluronan synthase 1 JBrowse link 1 59,720,612 59,732,409 RGD:1624291
RGD:13792537
G Has2 hyaluronan synthase 2 JBrowse link 7 96,438,046 96,464,049 RGD:1600115
RGD:13792537
RGD:1624291
RGD:8553259
G Has3 hyaluronan synthase 3 JBrowse link 19 39,063,298 39,077,745 RGD:1624291
RGD:13792537
G Hyal1 hyaluronidase 1 JBrowse link 8 116,332,834 116,337,522 RGD:1600115
RGD:1624291
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:1600115
RGD:1624291
hyaluronan catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd44 CD44 molecule (Indian blood group) JBrowse link 3 92,695,083 92,783,820 RGD:1600115
RGD:1624291
G Cemip cell migration inducing hyaluronidase JBrowse link 1 146,069,774 146,226,320 RGD:1624291
RGD:1600115
G Cemip2 cell migration inducing hyaluronidase 2 JBrowse link 1 239,397,322 239,474,931 RGD:1624291
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:1624291
G Hyal1 hyaluronidase 1 JBrowse link 8 116,332,834 116,337,522 RGD:1600115
RGD:1624291
G Hyal2 hyaluronidase 2 JBrowse link 8 116,324,062 116,328,978 RGD:8553259
RGD:1624291
RGD:1600115
G Hyal3 hyaluronidase 3 JBrowse link 8 116,336,512 116,342,147 RGD:1600115
RGD:1624291
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1624291
RGD:1600115
hyaluronan metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07028488.1 RGD:1600115
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:7243103
G Has2 hyaluronan synthase 2 JBrowse link 7 96,438,046 96,464,049 RGD:1624291
G Hgf hepatocyte growth factor JBrowse link 4 15,435,460 15,505,377 RGD:7243103
G Hyal1 hyaluronidase 1 JBrowse link 8 116,332,834 116,337,522 RGD:1624291
RGD:1600115
G Il15 interleukin 15 JBrowse link 19 23,542,606 23,624,366 RGD:5013835
G Itih1 inter-alpha trypsin inhibitor, heavy chain 1 JBrowse link 16 7,012,376 7,026,542 RGD:1600115
G Itih2 inter-alpha-trypsin inhibitor heavy chain 2 JBrowse link 17 72,160,734 72,197,248 RGD:1600115
G Itih3 inter-alpha trypsin inhibitor, heavy chain 3 JBrowse link 16 6,983,779 7,007,288 RGD:1600115
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 JBrowse link 16 6,970,367 6,985,538 RGD:1600115
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:7243103
G Mki67 marker of proliferation Ki-67 JBrowse link 1 207,993,895 208,020,454 RGD:7243103
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase JBrowse link 20 8,165,423 8,169,557 RGD:7243103
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:7243103
keratan sulfate biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chst4 carbohydrate sulfotransferase 4 JBrowse link 19 41,630,060 41,642,373 RGD:13792537
G Chst5 carbohydrate sulfotransferase 5 JBrowse link 19 44,115,065 44,136,092 RGD:1624291
RGD:13792537
keratan sulfate catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gns glucosamine (N-acetyl)-6-sulfatase JBrowse link 7 63,467,027 63,501,054 RGD:1600571
keratan sulfate metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chst1 carbohydrate sulfotransferase 1 JBrowse link 3 81,441,785 81,512,829 RGD:1624291
RGD:13792537
negative regulation of hyaluronan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 JBrowse link 1 100,896,582 100,926,443 RGD:1624291
G Cltc clathrin heavy chain JBrowse link 10 74,014,560 74,070,578 RGD:1600115
RGD:1624291
G Smpd3 sphingomyelin phosphodiesterase 3 JBrowse link 19 38,237,963 38,321,572 RGD:1624291
RGD:1600115
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1624291
RGD:1600115
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bgn biglycan JBrowse link X 157,319,042 157,331,204 RGD:1624291
G Dcn decorin JBrowse link 7 38,742,250 38,782,282 RGD:1624291
G Egflam EGF-like, fibronectin type III and laminin G domains JBrowse link 2 56,503,002 56,681,334 RGD:1624291
RGD:1600115
G Mamdc2 MAM domain containing 2 JBrowse link 1 241,071,110 241,223,798 RGD:1624291
G Ndnf neuron-derived neurotrophic factor JBrowse link 4 96,528,830 96,565,780 RGD:1624291
G Prss34 protease, serine, 34 JBrowse link 10 14,656,812 14,658,569 RGD:1600115
G Spock2 SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2 JBrowse link 20 29,654,926 29,679,927 RGD:1624291
G Spock3 SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3 JBrowse link 16 28,372,067 28,716,762 RGD:1624291
peptidoglycan catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07067422.1 RGD:1600115
G LOC100910070 lysozyme g-like protein 1-like JBrowse link 9 44,605,306 44,611,810 RGD:1600115
G LOC103693222 lysozyme g-like protein 2 JBrowse link 9 44,574,626 44,590,028 RGD:1600115
G Lyg1 lysozyme G1 JBrowse link 9 44,527,596 44,539,320 RGD:1600115
G Lyg2 lysozyme G2 JBrowse link 9 44,497,508 44,509,921 RGD:1600115
G Pglyrp1 peptidoglycan recognition protein 1 JBrowse link 1 79,790,879 79,796,064 RGD:1600115
G Pglyrp2 peptidoglycan recognition protein 2 JBrowse link 7 14,426,481 14,435,987 RGD:1600115
G Pglyrp3 peptidoglycan recognition protein 3 JBrowse link 2 191,903,626 192,264,872 RGD:1600115
G Pglyrp3b peptidoglycan recognition protein 3b JBrowse link 2 191,900,147 191,916,863 RGD:1600115
G Pglyrp4 peptidoglycan recognition protein 4 JBrowse link 2 190,125,655 190,204,230 RGD:1600115
positive regulation of hyaluronan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:1624291
G Has2 hyaluronan synthase 2 JBrowse link 7 96,438,046 96,464,049 RGD:9588629
RGD:9588632
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:1600115
RGD:1624291
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:1600115
RGD:1624291
G Ptger4 prostaglandin E receptor 4 JBrowse link 2 54,951,625 54,966,470 RGD:9588632
regulation of hyaluronan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Smpd3 sphingomyelin phosphodiesterase 3 JBrowse link 19 38,237,963 38,321,572 RGD:1624291

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  biological_process 19335
    metabolic process 11555
      organic substance metabolic process 10949
        macromolecule metabolic process 9418
          aminoglycan metabolic process 108
            glycosaminoglycan metabolic process 92
              galactosaminoglycan metabolic process + 0
              glycosaminoglycan biosynthetic process + 42
              glycosaminoglycan catabolic process + 25
              mucopolysaccharide metabolic process + 67
              peptidoglycan metabolic process + 10
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.