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ONTOLOGY REPORT - ANNOTATIONS


Term:chondroitin sulfate metabolic process
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Accession:GO:0030204 term browser browse the term
Definition:The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate.
Synonyms:exact_synonym: chondroitin sulfate metabolism;   chondroitin sulphate metabolic process;   chondroitin sulphate metabolism


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chondroitin sulfate metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bpnt2 3'(2'), 5'-bisphosphate nucleotidase 2 JBrowse link 17 90,191,119 90,218,013 RGD:1624291
G Chst11 carbohydrate sulfotransferase 11 JBrowse link 7 26,641,856 26,890,503 RGD:1624291
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 JBrowse link 16 22,704,318 23,075,071 RGD:1624291
G Dse dermatan sulfate epimerase JBrowse link 20 27,703,738 27,784,982 RGD:13792537
G Dsel dermatan sulfate epimerase-like JBrowse link 13 1,942,384 1,948,563 RGD:1624291
RGD:13792537
chondroitin sulfate biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chpf chondroitin polymerizing factor JBrowse link 9 82,669,199 82,673,898 RGD:1624291
G Chst11 carbohydrate sulfotransferase 11 JBrowse link 7 26,641,856 26,890,503 RGD:1624291
G Chst12 carbohydrate sulfotransferase 12 JBrowse link 12 16,199,975 16,218,404 RGD:1624291
G Chst13 carbohydrate sulfotransferase 13 JBrowse link 4 122,223,846 122,244,848 RGD:1624291
G Chst3 carbohydrate sulfotransferase 3 JBrowse link 20 29,731,828 29,768,656 RGD:1600115
RGD:13792537
RGD:1624291
G Chst7 carbohydrate sulfotransferase 7 JBrowse link X 2,623,018 2,657,155 RGD:1624291
RGD:13792537
G Chsy1 chondroitin sulfate synthase 1 JBrowse link 1 127,010,587 127,071,570 RGD:1624291
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 JBrowse link 16 22,704,318 23,075,071 RGD:1624291
G Slc35d1 solute carrier family 35 member D1 JBrowse link 5 122,700,396 122,746,815 RGD:1624291
G Ugdh UDP-glucose 6-dehydrogenase JBrowse link 14 44,479,614 44,502,845 RGD:1600115
RGD:1624291
G Xylt1 xylosyltransferase 1 JBrowse link 1 186,939,698 187,264,758 RGD:1600115
RGD:1624291
G Xylt2 xylosyltransferase 2 JBrowse link 10 82,386,003 82,399,485 RGD:1600115
chondroitin sulfate catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hyal4 hyaluronidase 4 JBrowse link 4 52,147,641 52,166,276 RGD:1624291
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07060833.1 RGD:13792537
G Bgn biglycan JBrowse link X 157,319,042 157,331,204 RGD:1624291
G Dcn decorin JBrowse link 7 38,742,250 38,782,282 RGD:1624291
G Egflam EGF-like, fibronectin type III and laminin G domains JBrowse link 2 56,503,002 56,681,334 RGD:1624291
RGD:1600115
G Mamdc2 MAM domain containing 2 JBrowse link 1 241,071,110 241,223,798 RGD:1624291
G Ndnf neuron-derived neurotrophic factor JBrowse link 4 96,528,830 96,565,780 RGD:1624291
G Prss34 protease, serine, 34 JBrowse link 10 14,656,812 14,658,569 RGD:1600115
G Spock2 SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2 JBrowse link 20 29,654,926 29,679,927 RGD:1624291
G Spock3 SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3 JBrowse link 16 28,372,067 28,716,762 RGD:1624291

Term paths to the root
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Term Annotations click to browse term
  biological_process 19858
    metabolic process 12097
      cellular metabolic process 10918
        sulfur compound metabolic process 298
          chondroitin sulfate metabolic process 25
            chondroitin sulfate biosynthetic process 12
            chondroitin sulfate catabolic process 1
            peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan 9
            protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine 0
Path 2
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12097
      organic substance metabolic process 11495
        macromolecule metabolic process 9944
          cellular macromolecule metabolic process 8393
            glycoprotein metabolic process 360
              proteoglycan metabolic process 75
                chondroitin sulfate proteoglycan metabolic process 32
                  chondroitin sulfate metabolic process 25
                    chondroitin sulfate biosynthetic process 12
                    chondroitin sulfate catabolic process 1
                    peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan 9
                    protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.