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ONTOLOGY REPORT - ANNOTATIONS


Term:heparin biosynthetic process
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Accession:GO:0030210 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
Synonyms:exact_synonym: heparin anabolism;   heparin biosynthesis;   heparin formation;   heparin synthesis
 related_synonym: heparan sulfate biosynthetic process


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heparin biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt1 angiopoietin 1 IEA
ISO
GO_REF:0000107
(PMID:19297368)
Ensembl
RGD
PMID:19297368 GO_REF:0000107 NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206
JBrowse link
G Ext1 exostosin glycosyltransferase 1 ISO MGI:MGI:108050 (MGI:MGI:3050709|PMID:15161920), (MGI:MGI:3051956|PMID:15177029), (MGI:MGI:4360160|PMID:18480751), (MGI:MGI:6406739|PMID:21310272), (MGI:MGI:6406770|PMID:21148566) RGD PMID:15161920, PMID:15177029, PMID:18480751, PMID:21148566, PMID:21310272 MGI:MGI:3050709, MGI:MGI:3051956, MGI:MGI:4360160, MGI:MGI:6406739, MGI:MGI:6406770 NCBI chr 7:92,605,008...92,881,392
Ensembl chr 7:92,605,728...92,882,068
JBrowse link
G Ext2 exostosin glycosyltransferase 2 ISO MGI:MGI:894663 (MGI:MGI:6406739|PMID:21310272) RGD PMID:21310272 MGI:MGI:6406739 NCBI chr 3:82,602,784...82,734,557
Ensembl chr 3:82,602,785...82,734,533
JBrowse link
G Glce glucuronic acid epimerase ISO
IEA
(MGI:MGI:2135754|PMID:11279150)
GO_REF:0000041
RGD
UniProt
PMID:11279150 GO_REF:0000041, MGI:MGI:2135754 NCBI chr 8:67,006,588...67,073,723
Ensembl chr 8:67,006,592...67,040,005
JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr18:55,951,497...56,014,107
Ensembl chr18:55,955,389...55,992,885
JBrowse link
G Ndst2 N-deacetylase and N-sulfotransferase 2 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr15:3,995,797...4,006,491
Ensembl chr15:3,996,048...4,006,491
JBrowse link
G Ndst3 N-deacetylase and N-sulfotransferase 3 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:227,736,491...227,903,657
Ensembl chr 2:227,738,650...227,890,077
JBrowse link
G Ndst4 N-deacetylase and N-sulfotransferase 4 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:229,170,781...229,496,732
Ensembl chr 2:229,196,616...229,496,516
JBrowse link
G NEWGENE_1304700 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr15:3,750,058...3,760,616
Ensembl chr15:3,754,262...3,760,663
JBrowse link
G Slc10a7 solute carrier family 10, member 7 ISO (PMID:30082715)
(MGI:MGI:6198941|PMID:30082715)
RGD PMID:30082715 MGI:MGI:6198941 NCBI chr19:32,857,984...33,081,359
Ensembl chr19:32,855,343...33,080,998
JBrowse link
G Xylt2 xylosyltransferase 2 ISO
IEA
MGI:MGI:3714171 (MGI:MGI:3713963|PMID:17517600)
GO_REF:0000107
RGD
Ensembl
PMID:17517600 GO_REF:0000107, MGI:MGI:3713963 NCBI chr10:82,386,003...82,399,485
Ensembl chr10:82,386,005...82,399,485
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    metabolic process 12271
      cellular metabolic process 11085
        sulfur compound metabolic process 310
          heparin metabolic process 13
            heparin biosynthetic process 11
Path 2
Term Annotations click to browse term
  biological_process 20028
    metabolic process 12271
      organic substance metabolic process 11651
        macromolecule metabolic process 10086
          aminoglycan metabolic process 119
            glycosaminoglycan metabolic process 100
              mucopolysaccharide metabolic process 77
                heparin metabolic process 13
                  heparin biosynthetic process 11
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.