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ONTOLOGY REPORT - ANNOTATIONS


Term:hyaluronan metabolic process
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Accession:GO:0030212 term browser browse the term
Definition:The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
Synonyms:exact_synonym: hyaluronan metabolism


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hyaluronan metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07028488.1 RGD:1600115
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:7243103
G Has2 hyaluronan synthase 2 JBrowse link 7 96,438,046 96,464,049 RGD:1624291
G Hgf hepatocyte growth factor JBrowse link 4 15,435,460 15,505,377 RGD:7243103
G Hyal1 hyaluronidase 1 JBrowse link 8 116,332,834 116,337,522 RGD:1624291
RGD:1600115
G Il15 interleukin 15 JBrowse link 19 23,542,606 23,624,366 RGD:5013835
G Itih1 inter-alpha trypsin inhibitor, heavy chain 1 JBrowse link 16 7,012,376 7,026,542 RGD:1600115
G Itih2 inter-alpha-trypsin inhibitor heavy chain 2 JBrowse link 17 72,160,734 72,197,248 RGD:1600115
G Itih3 inter-alpha trypsin inhibitor, heavy chain 3 JBrowse link 16 6,983,779 7,007,288 RGD:1600115
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 JBrowse link 16 6,970,367 6,985,538 RGD:1600115
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:7243103
G Mki67 marker of proliferation Ki-67 JBrowse link 1 207,993,895 208,020,454 RGD:7243103
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase JBrowse link 20 8,165,423 8,169,557 RGD:7243103
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:7243103
hyaluronan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccnd3 cyclin D3 JBrowse link 9 15,404,816 15,410,905 RGD:2316018
G Has1 hyaluronan synthase 1 JBrowse link 1 59,720,612 59,732,409 RGD:1624291
RGD:13792537
G Has2 hyaluronan synthase 2 JBrowse link 7 96,438,046 96,464,049 RGD:1600115
RGD:13792537
RGD:1624291
RGD:8553259
G Has3 hyaluronan synthase 3 JBrowse link 19 39,063,298 39,077,745 RGD:1624291
RGD:13792537
G Hyal1 hyaluronidase 1 JBrowse link 8 116,332,834 116,337,522 RGD:1600115
RGD:1624291
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:1600115
RGD:1624291
hyaluronan catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd44 CD44 molecule (Indian blood group) JBrowse link 3 92,695,083 92,783,820 RGD:1600115
RGD:1624291
G Cemip cell migration inducing hyaluronidase JBrowse link 1 146,069,774 146,226,320 RGD:1624291
RGD:1600115
G Cemip2 cell migration inducing hyaluronidase 2 JBrowse link 1 239,397,322 239,474,931 RGD:1624291
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:1624291
G Hyal1 hyaluronidase 1 JBrowse link 8 116,332,834 116,337,522 RGD:1600115
RGD:1624291
G Hyal2 hyaluronidase 2 JBrowse link 8 116,324,062 116,328,978 RGD:8553259
RGD:1624291
RGD:1600115
G Hyal3 hyaluronidase 3 JBrowse link 8 116,336,512 116,342,147 RGD:1600115
RGD:1624291
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1624291
RGD:1600115
negative regulation of hyaluronan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 JBrowse link 1 100,896,582 100,926,443 RGD:1624291
G Cltc clathrin heavy chain JBrowse link 10 74,014,560 74,070,578 RGD:1600115
RGD:1624291
G Smpd3 sphingomyelin phosphodiesterase 3 JBrowse link 19 38,237,963 38,321,572 RGD:1624291
RGD:1600115
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1624291
RGD:1600115
positive regulation of hyaluronan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:1624291
G Has2 hyaluronan synthase 2 JBrowse link 7 96,438,046 96,464,049 RGD:9588629
RGD:9588632
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:1600115
RGD:1624291
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:1600115
RGD:1624291
G Ptger4 prostaglandin E receptor 4 JBrowse link 2 54,951,625 54,966,470 RGD:9588632
regulation of hyaluronan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Smpd3 sphingomyelin phosphodiesterase 3 JBrowse link 19 38,237,963 38,321,572 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19334
    metabolic process 11555
      cellular metabolic process 10567
        organic acid metabolic process 1030
          oxoacid metabolic process 1004
            carboxylic acid metabolic process 959
              hyaluronan metabolic process 32
                hyaluronan biosynthetic process + 14
                hyaluronan catabolic process 8
Path 2
Term Annotations click to browse term
  biological_process 19334
    metabolic process 11555
      nitrogen compound metabolic process 9892
        organonitrogen compound metabolic process 6852
          aminoglycan metabolic process 108
            glycosaminoglycan metabolic process 92
              mucopolysaccharide metabolic process 67
                hyaluronan metabolic process 32
                  hyaluronan biosynthetic process + 14
                  hyaluronan catabolic process 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.