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ONTOLOGY REPORT - ANNOTATIONS


Term:hyaluronan biosynthetic process
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Accession:GO:0030213 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
Synonyms:exact_synonym: hyaluronan anabolism;   hyaluronan biosynthesis;   hyaluronan formation;   hyaluronan synthesis


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hyaluronan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccnd3 cyclin D3 JBrowse link 9 15,404,816 15,410,905 RGD:2316018
G Has1 hyaluronan synthase 1 JBrowse link 1 59,720,612 59,732,409 RGD:1624291
RGD:13792537
G Has2 hyaluronan synthase 2 JBrowse link 7 96,438,046 96,464,049 RGD:1600115
RGD:13792537
RGD:1624291
RGD:8553259
G Has3 hyaluronan synthase 3 JBrowse link 19 39,063,298 39,077,745 RGD:1624291
RGD:13792537
G Hyal1 hyaluronidase 1 JBrowse link 8 116,332,834 116,337,522 RGD:1600115
RGD:1624291
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:1600115
RGD:1624291
negative regulation of hyaluronan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 JBrowse link 1 100,896,582 100,926,443 RGD:1624291
G Cltc clathrin heavy chain JBrowse link 10 74,014,560 74,070,578 RGD:1600115
RGD:1624291
G Smpd3 sphingomyelin phosphodiesterase 3 JBrowse link 19 38,237,963 38,321,572 RGD:1624291
RGD:1600115
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1624291
RGD:1600115
positive regulation of hyaluronan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:1624291
G Has2 hyaluronan synthase 2 JBrowse link 7 96,438,046 96,464,049 RGD:9588629
RGD:9588632
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:1600115
RGD:1624291
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:1600115
RGD:1624291
G Ptger4 prostaglandin E receptor 4 JBrowse link 2 54,951,625 54,966,470 RGD:9588632
regulation of hyaluronan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Smpd3 sphingomyelin phosphodiesterase 3 JBrowse link 19 38,237,963 38,321,572 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    cellular process 18618
      cellular metabolic process 10918
        cellular biosynthetic process 5930
          organic acid biosynthetic process 314
            carboxylic acid biosynthetic process 312
              hyaluronan biosynthetic process 14
                negative regulation of hyaluronan biosynthetic process 4
                positive regulation of hyaluronan biosynthetic process 5
                regulation of hyaluronan biosynthetic process + 9
Path 2
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12097
      organic substance metabolic process 11495
        organonitrogen compound metabolic process 7095
          aminoglycan metabolic process 111
            glycosaminoglycan metabolic process 92
              mucopolysaccharide metabolic process 69
                hyaluronan metabolic process 32
                  hyaluronan biosynthetic process 14
                    negative regulation of hyaluronan biosynthetic process 4
                    positive regulation of hyaluronan biosynthetic process 5
                    regulation of hyaluronan biosynthetic process + 9
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.