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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of ossification
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Accession:GO:0030279 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
Synonyms:exact_synonym: down regulation of ossification;   downregulation of ossification;   negative regulation of bone biosynthesis;   negative regulation of bone formation
 narrow_synonym: inhibition of ossification


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negative regulation of ossification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:1598747
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:1624291
RGD:1600115
G Calca calcitonin-related polypeptide alpha JBrowse link 1 184,184,018 184,188,922 RGD:1624291
RGD:1600115
G Calcr calcitonin receptor JBrowse link 4 28,627,439 28,702,559 RGD:1624291
RGD:1600115
G Chsy1 chondroitin sulfate synthase 1 JBrowse link 1 127,010,587 127,071,570 RGD:1624291
RGD:1600115
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,952,896 248,956,579 RGD:6907379
RGD:1624291
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 JBrowse link 1 21,748,201 21,813,205 RGD:1624291
G Gfra4 GDNF family receptor alpha 4 JBrowse link 3 123,573,394 123,582,431 RGD:1624291
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:1624291
G Kremen1 kringle containing transmembrane protein 1 JBrowse link 14 85,441,209 85,503,661 RGD:1600115
RGD:1624291
G Kremen2 kringle containing transmembrane protein 2 JBrowse link 10 13,076,042 13,081,210 RGD:1624291
RGD:1600115
G Lrp4 LDL receptor related protein 4 JBrowse link 3 80,362,643 80,416,684 RGD:1624291
RGD:1600115
G Mdk midkine JBrowse link 3 80,841,003 80,843,895 RGD:1600115
RGD:1624291
G Mef2c myocyte enhancer factor 2C JBrowse link 2 11,658,534 11,822,788 RGD:1624291
RGD:1600115
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:1624291
G P2ry2 purinergic receptor P2Y2 JBrowse link 1 166,031,228 166,045,423 RGD:729594
G Ptk2b protein tyrosine kinase 2 beta JBrowse link 15 42,827,306 42,947,796 RGD:1642610
G Rbpj recombination signal binding protein for immunoglobulin kappa J region JBrowse link 14 59,657,738 59,865,427 RGD:1624291
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:1624291
G Smad6 SMAD family member 6 JBrowse link 8 68,897,746 68,967,221 RGD:1624291
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 JBrowse link 12 11,433,815 11,526,465 RGD:1624291
RGD:1600115
G Sost sclerostin JBrowse link 10 89,897,087 89,900,131 RGD:1624291
RGD:1600115
G Sox9 SRY-box transcription factor 9 JBrowse link 10 101,288,528 101,294,030 RGD:1624291
RGD:1600115
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1624291
RGD:1600115
G Tph1 tryptophan hydroxylase 1 JBrowse link 1 102,669,868 102,699,442 RGD:5686362
negative regulation of bone mineralization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahsg alpha-2-HS-glycoprotein JBrowse link 11 81,711,269 81,717,594 RGD:1626074
RGD:1600115
RGD:1624291
G Bcor BCL6 co-repressor JBrowse link X 11,570,155 11,692,022 RGD:1624291
RGD:1600115
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:1624291
G Ccr1 C-C motif chemokine receptor 1 JBrowse link 8 132,996,646 133,002,201 RGD:1624291
G Ecm1 extracellular matrix protein 1 JBrowse link 2 197,855,468 197,860,973 RGD:1624291
RGD:1600115
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 JBrowse link 1 21,748,201 21,813,205 RGD:1600115
RGD:1624291
G Fgf23 fibroblast growth factor 23 JBrowse link 4 159,622,404 159,630,082 RGD:1624291
RGD:1600115
G Gata1 GATA binding protein 1 JBrowse link X 15,273,937 15,281,759 RGD:1624291
G Grem1 gremlin 1, DAN family BMP antagonist JBrowse link 3 105,203,309 105,214,989 RGD:1624291
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:1624291
RGD:1600115
G Ltbp3 latent transforming growth factor beta binding protein 3 JBrowse link 1 221,099,155 221,116,096 RGD:1624291
RGD:1600115
G Mepe matrix extracellular phosphoglycoprotein JBrowse link 14 6,782,011 6,793,561 RGD:1624291
G Nfe2 nuclear factor, erythroid 2 JBrowse link 7 144,872,739 144,880,092 RGD:1624291
G Ptk2b protein tyrosine kinase 2 beta JBrowse link 15 42,827,306 42,947,796 RGD:1624291
RGD:1600115
G Sox9 SRY-box transcription factor 9 JBrowse link 10 101,288,528 101,294,030 RGD:1624291
RGD:1600115
G Srgn serglycin JBrowse link 20 32,120,317 32,158,071 RGD:1624291
RGD:13792537
RGD:1600115
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 JBrowse link 1 101,293,300 101,323,484 RGD:10003033
negative regulation of bone mineralization involved in bone maturation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Grem1 gremlin 1, DAN family BMP antagonist JBrowse link 3 105,203,309 105,214,989 RGD:1624291
RGD:1600115
G Pth parathyroid hormone JBrowse link 1 178,215,829 178,218,761 RGD:12793028
G Rflna refilin A JBrowse link 12 37,038,732 37,047,628 RGD:1624291
RGD:13792537
G Rflnb refilin B JBrowse link 10 64,196,103 64,202,380 RGD:1624291
RGD:13792537
negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tnn tenascin N JBrowse link 13 77,829,384 77,896,831 RGD:1624291
RGD:1600115
negative regulation of osteoblast differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:625678
G Areg amphiregulin JBrowse link 14 18,521,921 18,531,179 RGD:1578718
G Axin2 axin 2 JBrowse link 10 97,212,483 97,238,824 RGD:1624291
RGD:1600115
G Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:1624291
RGD:1600115
G Chrd chordin JBrowse link 11 83,858,503 83,867,543 RGD:1624291
RGD:1600115
G Cited1 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 JBrowse link X 72,128,996 72,133,692 RGD:1624291
RGD:1600115
G Fgf23 fibroblast growth factor 23 JBrowse link 4 159,622,404 159,630,082 RGD:1624291
RGD:1600115
G Fgfr1 Fibroblast growth factor receptor 1 JBrowse link 16 71,265,390 71,319,046 RGD:2325179
G Fndc3b fibronectin type III domain containing 3B JBrowse link 2 113,109,949 113,415,171 RGD:1624291
G Gdf10 growth differentiation factor 10 JBrowse link 16 10,250,508 10,262,383 RGD:1600115
RGD:1624291
G Grem1 gremlin 1, DAN family BMP antagonist JBrowse link 3 105,203,309 105,214,989 RGD:1624291
RGD:1600115
G Hand2 heart and neural crest derivatives expressed 2 JBrowse link 16 36,371,489 36,373,551 RGD:1624291
RGD:1600115
G Hdac4 histone deacetylase 4 JBrowse link 9 99,052,945 99,299,715 RGD:1624291
RGD:1600115
G Hdac5 histone deacetylase 5 JBrowse link 10 90,140,183 90,169,853 RGD:1624291
G Hdac7 histone deacetylase 7 JBrowse link 7 139,280,396 139,319,108 RGD:1600115
RGD:1624291
G Hdac8 histone deacetylase 8 JBrowse link X 72,163,777 72,370,058 RGD:13208813
G Hoxa2 homeobox A2 JBrowse link 4 82,130,441 82,134,846 RGD:1624291
G Id1 inhibitor of DNA binding 1, HLH protein JBrowse link 3 148,214,623 148,216,715 RGD:1624291
RGD:1600115
G Id2 inhibitor of DNA binding 2 JBrowse link 6 44,360,077 44,361,908 RGD:1624291
G Id3 inhibitor of DNA binding 3, HLH protein JBrowse link 5 154,489,603 154,491,172 RGD:1624291
RGD:1600115
G Igfbp5 insulin-like growth factor binding protein 5 JBrowse link 9 80,154,230 80,166,813 RGD:1624291
RGD:1600115
G Limd1 LIM domains containing 1 JBrowse link 8 132,553,218 132,598,826 RGD:1624291
RGD:1600115
G Lrp5 LDL receptor related protein 5 JBrowse link 1 218,816,833 218,920,147 RGD:1624291
G Men1 menin 1 JBrowse link 1 221,704,394 221,710,343 RGD:1624291
RGD:1600115
G Mir133a1 microRNA 133a-1 JBrowse link 18 2,052,478 2,052,564 RGD:1624291
G Mir137 microRNA 137 JBrowse link 2 221,658,106 221,658,207 RGD:1624291
G Mir204 microRNA 204 JBrowse link 1 240,403,000 240,403,109 RGD:1624291
G Mir205 microRNA 205 JBrowse link 13 112,233,283 112,233,390 RGD:1624291
G Mir217 microRNA 217 JBrowse link 14 113,119,529 113,119,633 RGD:1624291
G Mir23a microRNA 23a JBrowse link 19 25,318,582 25,318,656 RGD:1624291
G Mir30c1 microRNA 30c-1 JBrowse link 5 139,699,877 139,699,965 RGD:1624291
G Mir30c2 microRNA 30c-2 JBrowse link 9 29,562,376 29,562,459 RGD:1624291
G Nbr1 NBR1, autophagy cargo receptor JBrowse link 10 89,455,202 89,483,791 RGD:1624291
RGD:1600115
G Nfatc1 nuclear factor of activated T-cells 1 JBrowse link 18 77,203,517 77,322,690 RGD:1624291
G Noct nocturnin JBrowse link 2 140,286,661 140,306,869 RGD:1624291
RGD:1600115
G Nog noggin JBrowse link 10 76,811,759 76,813,386 RGD:1624291
RGD:1600115
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:1624291
RGD:1600115
G Ostn osteocrin JBrowse link 11 76,851,923 76,888,140 RGD:1624291
RGD:1600115
G Ptch1 patched 1 JBrowse link 17 1,032,242 1,085,885 RGD:1624291
RGD:1600115
G Ranbp3l RAN binding protein 3-like JBrowse link 2 58,221,773 58,458,072 RGD:1624291
G Riox1 ribosomal oxygenase 1 JBrowse link 6 107,428,508 107,431,126 RGD:1624291
RGD:1600115
G Rorb RAR-related orphan receptor B JBrowse link 1 234,252,757 234,442,597 RGD:1600115
RGD:1624291
G Sema4d semaphorin 4D JBrowse link 17 13,516,276 13,538,513 RGD:1624291
RGD:1600115
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:1624291
RGD:1600115
G Ski SKI proto-oncogene JBrowse link 5 172,556,196 172,623,878 RGD:1624291
RGD:1600115
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:1624291
RGD:1600115
G Smad6 SMAD family member 6 JBrowse link 8 68,897,746 68,967,221 RGD:1600115
RGD:1624291
G Sox2 SRY-box transcription factor 2 JBrowse link 2 121,165,137 121,167,545 RGD:1624291
G Tmem64 transmembrane protein 64 JBrowse link 5 28,850,864 28,898,203 RGD:1624291
RGD:1600115
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1624291
G Tnn tenascin N JBrowse link 13 77,829,384 77,896,831 RGD:1624291
G Tob1 transducer of ErbB-2.1 JBrowse link 10 81,913,689 81,915,727 RGD:1624291
RGD:1600115
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 JBrowse link 1 101,293,300 101,323,484 RGD:10003033
G Twist1 twist family bHLH transcription factor 1 JBrowse link 6 53,401,241 53,403,235 RGD:1624291
RGD:1600115
G Twist2 twist family bHLH transcription factor 2 JBrowse link 9 98,924,134 98,968,510 RGD:1624291
RGD:1600115
G Twsg1 twisted gastrulation BMP signaling modulator 1 JBrowse link 9 113,699,151 113,732,601 RGD:1624291
RGD:1600115
G Ucma upper zone of growth plate and cartilage matrix associated JBrowse link 17 77,252,099 77,262,301 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19245
    multicellular organismal process 8749
      ossification 411
        negative regulation of ossification 92
          negative regulation of bone mineralization + 20
          negative regulation of osteoblast differentiation + 57
Path 2
Term Annotations click to browse term
  biological_process 19245
    biological regulation 13198
      regulation of biological process 12516
        regulation of multicellular organismal process 3338
          regulation of ossification 229
            negative regulation of ossification 92
              negative regulation of bone mineralization + 20
              negative regulation of osteoblast differentiation + 57
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.