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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of ossification
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Accession:GO:0030279 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
Synonyms:exact_synonym: down regulation of ossification;   downregulation of ossification;   negative regulation of bone biosynthesis;   negative regulation of bone formation
 narrow_synonym: inhibition of ossification


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negative regulation of ossification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 IMP RGD PMID:16177600 RGD:1598747 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Bcl2 BCL2, apoptosis regulator IEA
ISO
GO_REF:0000107
(MGI:85084|PMID:9008714)
Ensembl
RGD
PMID:9008714 GO_REF:0000107, MGI:85084 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Calca calcitonin-related polypeptide alpha ISO MGI:3527257 (MGI:2447255|PMID:12488435), (MGI:3653805|PMID:15537449) RGD PMID:12488435, PMID:15537449 MGI:2447255, MGI:3653805 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Calcr calcitonin receptor IEA
ISO
GO_REF:0000107
MGI:3038975 (MGI:3037515|PMID:14970190)
Ensembl
RGD
PMID:14970190 GO_REF:0000107, MGI:3037515 NCBI chr 4:28,627,439...28,702,559
Ensembl chr 4:28,627,442...28,702,559
JBrowse link
G Chsy1 chondroitin sulfate synthase 1 ISO (PMID:21129727) RGD PMID:21129727 NCBI chr 1:127,010,587...127,071,570
Ensembl chr 1:127,010,588...127,071,570
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 IMP
ISO
(MGI:3803396|PMID:18505822) RGD PMID:18505822, PMID:21773994 MGI:3803396, RGD:6907379 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 ISO MGI:1857079 (MGI:1270097|PMID:9662402) RGD PMID:9662402 MGI:1270097 NCBI chr 1:21,748,201...21,813,205
Ensembl chr 1:21,748,261...21,813,371
JBrowse link
G Gfra4 GDNF family receptor alpha 4 ISO MGI:3625130 (MGI:3623870|PMID:16497798) RGD PMID:16497798 MGI:3623870 NCBI chr 3:123,573,394...123,582,431
Ensembl chr 3:123,578,997...123,581,518
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO (MGI:5300390|PMID:22081627) RGD PMID:22081627 MGI:5300390 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Kremen1 kringle containing transmembrane protein 1 IEA
ISO
GO_REF:0000107
(MGI:3803396|PMID:18505822)
Ensembl
RGD
PMID:18505822 GO_REF:0000107, MGI:3803396 NCBI chr14:85,441,209...85,503,661
Ensembl chr14:85,438,707...85,484,275
JBrowse link
G Kremen2 kringle containing transmembrane protein 2 ISO (MGI:3803396|PMID:18505822) RGD PMID:18505822 MGI:3803396 NCBI chr10:13,076,042...13,081,210
Ensembl chr10:13,076,679...13,081,136
JBrowse link
G Lrp4 LDL receptor related protein 4 ISO (PMID:21471202) RGD PMID:21471202 NCBI chr 3:80,362,643...80,416,684
Ensembl chr 3:80,362,858...80,416,679
JBrowse link
G Mdk midkine ISS
ISO
GO_REF:0000024
(MGI:5780844|PMID:20200993)
UniProt
RGD
PMID:20200993 GO_REF:0000024, MGI:5780844 NCBI chr 3:80,841,003...80,843,895
Ensembl chr 3:80,841,005...80,842,916
JBrowse link
G Mef2c myocyte enhancer factor 2C ISO
IEA
ISS
(PMID:17696759)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:17696759 GO_REF:0000024, GO_REF:0000107 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787
JBrowse link
G Notch1 notch receptor 1 ISO (MGI:5437413|PMID:21493891) RGD PMID:21493891 MGI:5437413 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G P2ry2 purinergic receptor P2Y2 IDA RGD PMID:12210747 RGD:729594 NCBI chr 1:166,031,228...166,045,423
Ensembl chr 1:166,031,272...166,037,424
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta IMP RGD PMID:17537919 RGD:1642610 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region ISO (MGI:5437413|PMID:21493891) RGD PMID:21493891 MGI:5437413 NCBI chr14:59,657,738...59,865,427
Ensembl chr14:59,658,935...59,735,450
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 ISO (PMID:15677765), (PMID:19254787)
(MGI:3850611|PMID:19254787)
RGD PMID:15677765, PMID:19254787 MGI:3850611 NCBI chr16:73,372,007...73,410,777
Ensembl chr16:73,372,007...73,410,777
JBrowse link
G Smad6 SMAD family member 6 ISO (MGI:1352979|PMID:10655064) RGD PMID:10655064 MGI:1352979 NCBI chr 8:68,897,746...68,967,221
Ensembl chr 8:68,898,296...68,966,108
JBrowse link
G Smad7 SMAD family member 7 IEA
ISO
GO_REF:0000107
(MGI:6377914|PMID:29503843)
Ensembl
RGD
PMID:29503843 GO_REF:0000107, MGI:6377914 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 ISO MGI:3576775 (MGI:3575204|PMID:15820682) RGD PMID:15820682 MGI:3575204 NCBI chr12:11,433,815...11,526,465
Ensembl chr12:11,407,213...11,526,465
JBrowse link
G Sost sclerostin ISO MGI:5544793 (MGI:5509072|PMID:23918385) RGD PMID:23918385 MGI:5509072 NCBI chr10:89,897,087...89,900,131
Ensembl chr10:89,897,087...89,900,131
JBrowse link
G Sox9 SRY-box transcription factor 9 ISS
ISO
GO_REF:0000024
(MGI:4947506|PMID:20056916)
(PMID:29503843)
UniProt
RGD
PMID:20056916, PMID:29503843 GO_REF:0000024, MGI:4947506 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO (MGI:3575204|PMID:15820682) RGD PMID:15820682 MGI:3575204 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tph1 tryptophan hydroxylase 1 IMP RGD PMID:20139991 RGD:5686362 NCBI chr 1:102,669,868...102,699,442
Ensembl chr 1:102,669,868...102,699,442
JBrowse link
negative regulation of bone mineralization term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahsg alpha-2-HS-glycoprotein IMP
ISO
ISS
(MGI:3687916|PMID:12556469)
GO_REF:0000024
RGD
UniProt
PMID:12556469, PMID:8702833 GO_REF:0000024, MGI:3687916, RGD:1626074 NCBI chr11:81,711,269...81,717,594 JBrowse link
G Bcor BCL6 co-repressor ISO (PMID:19578371) RGD PMID:19578371 NCBI chr  X:11,570,155...11,692,022
Ensembl chr  X:11,648,989...11,691,099
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 ISO (PMID:21403648) RGD PMID:21403648 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 ISO (PMID:21403648) RGD PMID:21403648 NCBI chr 8:132,996,646...133,002,201
Ensembl chr 8:132,996,649...133,002,201
JBrowse link
G Ecm1 extracellular matrix protein 1 ISO
ISS
(PMID:11165938)
GO_REF:0000024
RGD
UniProt
PMID:11165938 GO_REF:0000024 NCBI chr 2:197,855,468...197,860,973
Ensembl chr 2:197,855,460...197,860,699
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 ISS
ISO
GO_REF:0000024
(MGI:5607146|PMID:25479107), (MGI:6220772|PMID:30111653), (MGI:6294341|PMID:22510396)
UniProt
RGD
PMID:22510396, PMID:25479107, PMID:30111653 GO_REF:0000024, MGI:5607146, MGI:6220772, MGI:6294341 NCBI chr 1:21,748,201...21,813,205
Ensembl chr 1:21,748,261...21,813,371
JBrowse link
G Fgf23 fibroblast growth factor 23 ISO (PMID:18282132) RGD PMID:18282132 NCBI chr 4:159,622,404...159,630,082
Ensembl chr 4:159,622,404...159,630,082
JBrowse link
G Gata1 GATA binding protein 1 ISO MGI:2177586 (MGI:3653541|PMID:15005853) RGD PMID:15005853 MGI:3653541 NCBI chr  X:15,273,937...15,281,759
Ensembl chr  X:15,378,789...15,382,066
JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist ISO (PMID:15539560) RGD PMID:15539560 NCBI chr 3:105,203,309...105,214,989
Ensembl chr 3:105,203,309...105,214,989
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IEA
ISO
GO_REF:0000107
MGI:1857719 (MGI:3777866|PMID:17181398)
Ensembl
RGD
PMID:17181398 GO_REF:0000107, MGI:3777866 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 ISO MGI:2180017 (MGI:2178869|PMID:11790802) RGD PMID:11790802 MGI:2178869 NCBI chr 1:221,099,155...221,116,096
Ensembl chr 1:221,099,998...221,116,096
JBrowse link
G Mepe matrix extracellular phosphoglycoprotein ISO MGI:2448895 (MGI:2448336|PMID:12421822), (MGI:3851320|PMID:15843468), (MGI:5431257|PMID:22766095) RGD PMID:12421822, PMID:15843468, PMID:22766095 MGI:2448336, MGI:3851320, MGI:5431257 NCBI chr14:6,782,011...6,793,561
Ensembl chr14:6,782,012...6,793,558
JBrowse link
G Nfe2 nuclear factor, erythroid 2 ISO MGI:1857224 (MGI:3653541|PMID:15005853) RGD PMID:15005853 MGI:3653541 NCBI chr 7:144,872,739...144,880,092
Ensembl chr 7:144,872,747...144,880,092
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta ISS
ISO
GO_REF:0000024
(MGI:3713957|PMID:17537919)
UniProt
RGD
PMID:17537919 GO_REF:0000024, MGI:3713957 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Sox9 SRY-box transcription factor 9 ISO MGI:2158693 (MGI:2135696|PMID:11371614) RGD PMID:11371614 MGI:2135696 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
G Srgn serglycin ISO
IBA
ISS
(PMID:16870619)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:16870619, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr20:32,120,317...32,158,071
Ensembl chr20:32,120,320...32,139,789
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 IMP RGD PMID:23081848 RGD:10003033 NCBI chr 1:101,293,300...101,323,484
Ensembl chr 1:101,293,409...101,323,960
JBrowse link
negative regulation of bone mineralization involved in bone maturation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grem1 gremlin 1, DAN family BMP antagonist ISO (PMID:15539560) RGD PMID:15539560 NCBI chr 3:105,203,309...105,214,989
Ensembl chr 3:105,203,309...105,214,989
JBrowse link
G Pth parathyroid hormone IMP PMID:11604398 CAFA PMID:11604398 RGD:12793028 NCBI chr 1:178,215,829...178,218,761
Ensembl chr 1:178,215,829...178,218,761
JBrowse link
G Rflna refilin A IBA
ISO
PMID:21873635
MGI:1923816 (MGI:5570967|PMID:24436304)
RGD PMID:24436304, PMID:21873635 MGI:5570967, RGD:13792537 NCBI chr12:37,038,732...37,047,628
Ensembl chr12:37,038,733...37,047,628
JBrowse link
G Rflnb refilin B IBA
ISO
PMID:21873635
MGI:1920371 (MGI:5570967|PMID:24436304)
RGD PMID:24436304, PMID:21873635 MGI:5570967, RGD:13792537 NCBI chr10:64,196,103...64,202,380
Ensembl chr10:64,196,127...64,202,380
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    multicellular organismal process 9047
      ossification 432
        negative regulation of ossification 42
          negative regulation of bone mineralization + 20
Path 2
Term Annotations click to browse term
  biological_process 20020
    biological regulation 13769
      regulation of biological process 13071
        regulation of multicellular organismal process 2916
          regulation of ossification 133
            negative regulation of ossification 42
              negative regulation of bone mineralization + 20
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.