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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA damage response, signal transduction by p53 class mediator
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Accession:GO:0030330 term browser browse the term
Definition:A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
Synonyms:broad_synonym: p53-mediated DNA damage response
 related_synonym: DNA damage response, activation of p53;   TP53 signaling pathway;   p53 signaling pathway
 alt_id: GO:0006976


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DNA damage response, signal transduction by p53 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acer2 alkaline ceramidase 2 JBrowse link 5 105,230,540 105,279,732 RGD:1624291
G Atrx ATRX, chromatin remodeler JBrowse link X 76,820,110 76,979,155 RGD:1600115
RGD:1624291
G Batf basic leucine zipper ATF-like transcription factor JBrowse link 6 109,562,415 109,584,541 RGD:1624291
RGD:1600115
G Bcl3 BCL3, transcription coactivator JBrowse link 1 80,730,758 80,745,273 RGD:1624291
G E2f7 E2F transcription factor 7 JBrowse link 7 53,275,659 53,318,261 RGD:1624291
RGD:1600115
G Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:1624291
G Mdm4 MDM4 regulator of p53 JBrowse link 13 49,786,776 49,828,780 RGD:1624291
G Mif macrophage migration inhibitory factor JBrowse link 20 13,715,219 13,732,980 RGD:1624291
G Myo6 myosin VI JBrowse link 8 87,583,649 87,731,271 RGD:1624291
G Ndrg1 N-myc downstream regulated 1 JBrowse link 7 107,734,326 107,775,701 RGD:1624291
G Paxip1 PAX interacting protein 1 JBrowse link 4 3,956,931 4,008,326 RGD:1624291
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D JBrowse link 10 72,909,550 72,945,884 RGD:1624291
G Sesn2 sestrin 2 JBrowse link 5 150,684,891 150,703,846 RGD:1624291
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
G Triap1 TP53 regulated inhibitor of apoptosis 1 JBrowse link 12 46,987,404 46,989,906 RGD:1624291
G Usp10 ubiquitin specific peptidase 10 JBrowse link 19 52,566,274 52,608,820 RGD:1624291
RGD:13792537
RGD:1600115
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp2 caspase 2 JBrowse link 4 71,652,358 71,670,228 RGD:1624291
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:1624291
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain JBrowse link 7 36,395,665 36,408,588 RGD:1624291
RGD:13792537
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:1624291
G Muc1 mucin 1, cell surface associated JBrowse link 2 188,543,137 188,547,874 RGD:1624291
G Pidd1 p53-induced death domain protein 1 JBrowse link 1 214,418,751 214,423,959 RGD:1624291
G Pml PML nuclear body scaffold JBrowse link 8 63,002,515 63,034,310 RGD:1624291
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma JBrowse link 6 134,804,128 134,941,912 RGD:1624291
G Rbm38 RNA binding motif protein 38 JBrowse link 3 171,037,891 171,050,500 RGD:1624291
G Rpl26 ribosomal protein L26 JBrowse link 10 55,492,417 55,495,547 RGD:1624291
G Sox4 SRY-box transcription factor 4 JBrowse link 17 37,615,022 37,619,728 RGD:1624291
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Brca2 BRCA2, DNA repair associated JBrowse link 12 503,660 544,754 RGD:1624291
RGD:1600115
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:1624291
G Chek2 checkpoint kinase 2 JBrowse link 12 51,845,574 51,878,098 RGD:1624291
G Foxm1 forkhead box M1 JBrowse link 4 161,685,236 161,697,633 RGD:1600115
RGD:13792537
RGD:1624291
G Hipk2 homeodomain interacting protein kinase 2 JBrowse link 4 66,438,390 66,625,183 RGD:1624291
G Ing4 inhibitor of growth family, member 4 JBrowse link 4 157,554,729 157,563,353 RGD:1624291
G Kat5 lysine acetyltransferase 5 JBrowse link 1 220,967,795 220,974,596 RGD:1600115
RGD:1624291
G Muc1 mucin 1, cell surface associated JBrowse link 2 188,543,137 188,547,874 RGD:1624291
G Rbm38 RNA binding motif protein 38 JBrowse link 3 171,037,891 171,050,500 RGD:1624291
G Rps27l ribosomal protein S27-like JBrowse link 8 72,741,155 72,746,090 RGD:1624291
G Rps6ka6 ribosomal protein S6 kinase A6 JBrowse link X 82,641,679 82,743,771 RGD:1624291
G Sp100 SP100 nuclear antigen JBrowse link 9 92,675,103 92,718,489 RGD:1624291
G Tfap4 transcription factor AP-4 JBrowse link 10 11,204,616 11,222,975 RGD:1624291
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
negative regulation of DNA damage response, signal transduction by p53 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd44 CD44 molecule (Indian blood group) JBrowse link 3 92,695,083 92,783,820 RGD:1624291
RGD:1600115
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:1624291
RGD:13792537
RGD:1600115
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A JBrowse link 11 34,858,339 34,958,733 RGD:1624291
G Dyrk3 dual specificity tyrosine phosphorylation regulated kinase 3 JBrowse link 13 47,906,230 47,916,877 RGD:1600115
RGD:1624291
G Kdm1a lysine demethylase 1A JBrowse link 5 154,909,003 154,965,171 RGD:1624291
G Marchf7 membrane associated ring-CH-type finger 7 JBrowse link 3 46,284,961 46,325,230 RGD:1624291
RGD:1600115
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:1624291
G Mif macrophage migration inhibitory factor JBrowse link 20 13,715,219 13,732,980 RGD:1624291
G Psmd10 proteasome 26S subunit, non-ATPase 10 JBrowse link X 112,323,188 112,328,642 RGD:1624291
RGD:1600115
G Pttg1ip PTTG1 interacting protein JBrowse link 20 11,746,369 11,764,097 RGD:1624291
G Senp2 SUMO specific peptidase 2 JBrowse link 11 82,627,973 82,664,702 RGD:1624291
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:1624291
RGD:1600115
G Snai1 snail family transcriptional repressor 1 JBrowse link 3 164,274,710 164,279,199 RGD:1624291
G Snai2 snail family transcriptional repressor 2 JBrowse link 11 90,404,421 90,406,730 RGD:1624291
G Twist1 twist family bHLH transcription factor 1 JBrowse link 6 53,401,241 53,403,235 RGD:1624291
negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pcbp4 poly(rC) binding protein 4 JBrowse link 8 115,154,848 115,165,706 RGD:1624291
positive regulation of DNA damage response, signal transduction by p53 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ankrd1 ankyrin repeat domain 1 JBrowse link 1 254,726,985 254,745,673 RGD:1624291
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:1624291
G Atr ATR serine/threonine kinase JBrowse link 8 103,673,578 103,770,886 RGD:1624291
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:1624291
G Ddx5 DEAD-box helicase 5 JBrowse link 10 94,979,759 94,988,461 RGD:1624291
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 JBrowse link 17 26,785,017 26,795,723 RGD:1624291
G Hic1 HIC ZBTB transcriptional repressor 1 JBrowse link 10 62,007,150 62,010,774 RGD:1624291
G Pla2r1 phospholipase A2 receptor 1 JBrowse link 3 46,488,963 46,621,873 RGD:1624291
RGD:1600115
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 62,159,128 62,179,635 RGD:1624291
G Spred1 sprouty-related, EVH1 domain containing 1 JBrowse link 3 108,795,337 108,861,650 RGD:1624291
RGD:13792537
G Spred2 sprouty-related, EVH1 domain containing 2 JBrowse link 14 104,268,362 104,290,206 RGD:1624291
RGD:13792537
RGD:1600115
G Spred3 sprouty-related, EVH1 domain containing 3 JBrowse link 1 88,101,213 88,112,719 RGD:13792537
positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rpl26 ribosomal protein L26 JBrowse link 10 55,492,417 55,495,547 RGD:1624291
G Zfp385a zinc finger protein 385A JBrowse link 7 144,939,616 144,966,364 RGD:1624291
regulation of DNA damage response, signal transduction by p53 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kmt5a lysine methyltransferase 5A JBrowse link 12 37,558,150 37,581,183 RGD:1624291
G Npm1 nucleophosmin 1 JBrowse link 10 18,080,949 18,091,062 RGD:1624291
G Smyd2 SET and MYND domain containing 2 JBrowse link 13 108,642,156 108,686,293 RGD:1624291
RGD:1600115
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
G Zmpste24 zinc metallopeptidase STE24 JBrowse link 5 139,982,404 140,015,541 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    cellular process 18618
      signal transduction 6968
        intracellular signal transduction 2597
          signal transduction by p53 class mediator 140
            DNA damage response, signal transduction by p53 class mediator 68
              DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 12
              DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator + 17
              negative regulation of DNA damage response, signal transduction by p53 class mediator + 16
              positive regulation of DNA damage response, signal transduction by p53 class mediator + 14
              regulation of DNA damage response, signal transduction by p53 class mediator + 35
Path 2
Term Annotations click to browse term
  biological_process 19858
    biological regulation 13636
      regulation of biological process 12959
        regulation of cellular process 12442
          signal transduction 6968
            intracellular signal transduction 2597
              signal transduction in response to DNA damage 95
                DNA damage response, signal transduction by p53 class mediator 68
                  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 12
                  DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator + 17
                  negative regulation of DNA damage response, signal transduction by p53 class mediator + 16
                  positive regulation of DNA damage response, signal transduction by p53 class mediator + 14
                  regulation of DNA damage response, signal transduction by p53 class mediator + 35
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.