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ONTOLOGY REPORT - ANNOTATIONS


Term:ubiquitin-dependent ERAD pathway
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Accession:GO:0030433 term browser browse the term
Definition:The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
Comment:See also the biological process terms 'ERAD pathway ; GO:0036503', 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'.
Synonyms:exact_synonym: ER-associated ubiquitin-dependent protein breakdown;   ER-associated ubiquitin-dependent protein catabolic process;   ER-associated ubiquitin-dependent protein catabolism;   ER-associated ubiquitin-dependent protein degradation;   ERAD;   endoplasmic reticulum-associated ubiquitin-dependent protein catabolic process;   endoplasmic reticulum-associated ubiqutin-dependent protein catabolism;   ubiquitin-dependent proteasomal protein catabolism of ER proteins


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ubiquitin-dependent ERAD pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07002848.1 RGD:13792537
G Amfr autocrine motility factor receptor JBrowse link 19 11,473,538 11,509,500 RGD:1624291
G Ankzf1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 JBrowse link 9 82,393,619 82,400,537 RGD:13792537
G Aup1 AUP1, lipid droplet regulating VLDL assembly factor JBrowse link 4 113,887,030 113,890,103 RGD:13792537
G Bag6 BAG cochaperone 6 JBrowse link 20 5,124,512 5,138,084 RGD:1600115
RGD:13792537
RGD:1624291
G Ccdc47 coiled-coil domain containing 47 JBrowse link 10 94,388,425 94,406,949 RGD:1624291
G Derl1 derlin 1 JBrowse link 7 97,737,176 97,759,852 RGD:1624291
RGD:13792537
G Derl2 derlin 2 JBrowse link 10 57,641,682 57,653,554 RGD:1624291
RGD:13792537
G Derl3 derlin 3 JBrowse link 20 13,692,102 13,707,645 RGD:1624291
RGD:13792537
G Dnajb12 DnaJ heat shock protein family (Hsp40) member B12 JBrowse link 20 29,445,510 29,463,739 RGD:13792537
G Dnajb14 DnaJ heat shock protein family (Hsp40) member B14 JBrowse link 2 243,108,443 243,151,933 RGD:13792537
G Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 JBrowse link 9 82,436,453 82,444,669 RGD:1624291
RGD:13792537
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 JBrowse link 6 64,165,913 64,170,122 RGD:1624291
RGD:1600115
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 JBrowse link 3 67,538,289 67,578,308 RGD:1624291
RGD:1600115
G Dnajc18 DnaJ heat shock protein family (Hsp40) member C18 JBrowse link 18 28,466,892 28,501,013 RGD:13792537
G Ecpas Ecm29 proteasome adaptor and scaffold JBrowse link 5 75,928,510 76,040,771 RGD:1624291
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 JBrowse link 4 140,886,644 140,918,654 RGD:1624291
G Erlec1 endoplasmic reticulum lectin 1 JBrowse link 14 115,314,890 115,352,871 RGD:1624291
RGD:13792537
G Erlin1 ER lipid raft associated 1 JBrowse link 1 263,810,439 263,845,762 RGD:1624291
G Erlin2 ER lipid raft associated 2 JBrowse link 16 69,179,005 69,195,452 RGD:1624291
G Faf2 Fas associated factor family member 2 JBrowse link 17 10,485,650 10,527,886 RGD:1600115
RGD:1624291
G Fbxo17 F-box protein 17 JBrowse link 1 86,903,762 86,919,238 RGD:13792537
G Fbxo2 F-box protein 2 JBrowse link 5 164,972,483 164,977,912 RGD:1624291
RGD:13792537
G Fbxo44 F-box protein 44 JBrowse link 5 164,962,921 164,972,273 RGD:13792537
G Fbxo6 F-box protein 6 JBrowse link 5 164,956,285 164,962,075 RGD:1624291
RGD:13792537
RGD:1600115
G Foxred2 FAD-dependent oxidoreductase domain containing 2 JBrowse link 7 119,172,189 119,186,670 RGD:1624291
RGD:13792537
G Hsp90b1 heat shock protein 90 beta family member 1 JBrowse link 7 27,226,570 27,240,533 RGD:1600115
RGD:13792537
RGD:1624291
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:13792537
G Jkamp JNK1/MAPK8-associated membrane protein JBrowse link 6 94,835,845 94,849,784 RGD:1624291
RGD:13792537
G LOC103694875 derlin-3 RGD:13792537
G Man1b1 mannosidase, alpha, class 1B, member 1 JBrowse link 3 2,547,259 2,569,051 RGD:1624291
RGD:13792537
G Marchf6 membrane associated ring-CH-type finger 6 JBrowse link 2 84,533,546 84,608,743 RGD:13792537
G Nccrp1 NCCRP1, F-box associated domain containing JBrowse link 1
1
85,558,420
85,213,578
85,559,652
85,218,030
RGD:13792537
G Os9 OS9, endoplasmic reticulum lectin JBrowse link 7 70,378,625 70,407,135 RGD:1600115
RGD:13792537
RGD:1624291
G Psmc6 proteasome 26S subunit, ATPase 6 JBrowse link 15 19,667,453 19,688,916 RGD:13792537
G RGD1562515 similar to RIKEN cDNA 4931417E11 JBrowse link 4 101,392,229 101,393,329 RGD:13792537
G Rnf103 ring finger protein 103 JBrowse link 4 99,398,479 99,415,193 RGD:1600115
RGD:13792537
RGD:1624291
G Rnf121 ring finger protein 121 JBrowse link 1 167,095,916 167,165,257 RGD:13792537
G Rnf185 ring finger protein 185 JBrowse link 14 83,648,400 83,685,273 RGD:1624291
G Rnf5 ring finger protein 5 JBrowse link 20 4,366,244 4,368,690 RGD:1624291
G Sec61b SEC61 translocon subunit beta JBrowse link 5 63,192,322 63,200,532 RGD:1624291
G Sel1l SEL1L adaptor subunit of ERAD E3 ubiquitin ligase JBrowse link 6 115,572,683 115,616,904 RGD:13792537
G Sel1l2 SEL1L2 adaptor subunit of ERAD E3 ligase JBrowse link 3 134,281,809 134,406,560 RGD:13792537
G Selenos selenoprotein S JBrowse link 1 126,979,579 126,989,344 RGD:1600115
RGD:13792537
RGD:1624291
G Sgta small glutamine rich tetratricopeptide repeat containing alpha JBrowse link 7 11,521,949 11,538,691 RGD:1624291
RGD:13792537
RGD:1600115
G Sgtb small glutamine rich tetratricopeptide repeat containing beta JBrowse link 2 34,185,938 34,222,428 RGD:13792537
G Stt3b STT3 oligosaccharyltransferase complex catalytic subunit B JBrowse link 8 123,303,910 123,370,729 RGD:1624291
G Stub1 STIP1 homology and U-box containing protein 1 JBrowse link 10 15,197,754 15,200,035 RGD:1624291
G Syvn1 synoviolin 1 JBrowse link 1 221,409,281 221,416,229 RGD:1624291
RGD:13792537
G Tmem129 transmembrane protein 129, E3 ubiquitin ligase JBrowse link 14 82,350,734 82,356,084 RGD:1624291
G Tmem67 transmembrane protein 67 JBrowse link 5 25,666,138 25,721,056 RGD:1600115
RGD:1624291
G Tmub1 transmembrane and ubiquitin-like domain containing 1 JBrowse link 4 7,257,752 7,260,318 RGD:1624291
RGD:13792537
G Tmub2 transmembrane and ubiquitin-like domain containing 2 JBrowse link 10 90,230,428 90,234,874 RGD:13792537
G Trim13 tripartite motif-containing 13 JBrowse link 15 41,897,191 41,936,545 RGD:1624291
RGD:13792537
G Trim25 tripartite motif-containing 25 JBrowse link 10 76,343,847 76,362,159 RGD:1624291
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 JBrowse link 20 11,700,089 11,721,823 RGD:1624291
RGD:13792537
G Ube2j1 ubiquitin-conjugating enzyme E2, J1 JBrowse link 5 48,274,387 48,292,699 RGD:1624291
G Ube2j2 ubiquitin-conjugating enzyme E2, J2 JBrowse link 5 173,372,659 173,387,084 RGD:1624291
RGD:13792537
G Ube4a ubiquitination factor E4A JBrowse link 8 49,229,713 49,271,894 RGD:13792537
G Ube4b ubiquitination factor E4B JBrowse link 5 166,156,033 166,259,069 RGD:13792537
G Ubqln1 ubiquilin 1 JBrowse link 17 6,840,441 6,878,842 RGD:1600115
RGD:13792537
RGD:1624291
G Ubqln2 ubiquilin 2 JBrowse link X 18,723,313 18,726,732 RGD:1624291
RGD:13792537
G Ubxn4 UBX domain protein 4 JBrowse link 13 44,956,963 44,989,653 RGD:1624291
RGD:1600115
G Ubxn8 UBX domain protein 8 JBrowse link 16 62,251,243 62,272,838 RGD:1624291
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 JBrowse link 11 86,304,836 86,328,478 RGD:13792537
G Usp19 ubiquitin specific peptidase 19 JBrowse link 8 117,280,690 117,291,729 RGD:1600115
RGD:13792537
RGD:1624291
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:1600115
RGD:13792537
RGD:1624291
G Wfs1 wolframin ER transmembrane glycoprotein JBrowse link 14 78,640,707 78,665,224 RGD:1624291
G Yod1 YOD1 deubiquitinase JBrowse link 13 47,441,296 47,443,013 RGD:1624291
RGD:13792537
RGD:1600115
mannose trimming involved in glycoprotein ERAD pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 JBrowse link 4 140,886,644 140,918,654 RGD:1624291
G Edem2 ER degradation enhancing alpha-mannosidase like protein 2 JBrowse link 3 151,232,741 151,258,559 RGD:1624291
G Edem3 ER degradation enhancing alpha-mannosidase like protein 3 JBrowse link 13 69,135,095 69,197,708 RGD:1624291
G Man1b1 mannosidase, alpha, class 1B, member 1 JBrowse link 3 2,547,259 2,569,051 RGD:1624291
negative regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sgta small glutamine rich tetratricopeptide repeat containing alpha JBrowse link 7 11,521,949 11,538,691 RGD:1624291
RGD:1600115
G Svip small VCP interacting protein JBrowse link 1 107,368,117 107,373,807 RGD:10047192
RGD:1624291
G Usp14 ubiquitin specific peptidase 14 JBrowse link 18 1,178,785 1,216,573 RGD:1624291
positive regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcap31 B-cell receptor-associated protein 31 JBrowse link X 157,094,365 157,126,397 RGD:1624291
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:1600115
RGD:1624291
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 JBrowse link 19 11,046,905 11,057,440 RGD:10047316
RGD:1624291
G Sgta small glutamine rich tetratricopeptide repeat containing alpha JBrowse link 7 11,521,949 11,538,691 RGD:1624291
G Ubqln1 ubiquilin 1 JBrowse link 17 6,840,441 6,878,842 RGD:1600115
RGD:1624291
G Ubqln2 ubiquilin 2 JBrowse link X 18,723,313 18,726,732 RGD:1624291
regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 JBrowse link 19 11,046,905 11,057,440 RGD:1624291
RGD:13792537
ubiquitin-dependent glycoprotein ERAD pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 JBrowse link 4 140,886,644 140,918,654 RGD:1624291
G Edem2 ER degradation enhancing alpha-mannosidase like protein 2 JBrowse link 3 151,232,741 151,258,559 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19578
    response to stimulus 10490
      response to chemical 6403
        response to organic substance 3825
          response to organonitrogen compound 1445
            ERAD pathway 96
              ubiquitin-dependent ERAD pathway 76
                negative regulation of ER-associated ubiquitin-dependent protein catabolic process 3
                positive regulation of ER-associated ubiquitin-dependent protein catabolic process 6
                regulation of ER-associated ubiquitin-dependent protein catabolic process + 8
                ubiquitin-dependent glycoprotein ERAD pathway + 4
Path 2
Term Annotations click to browse term
  biological_process 19578
    metabolic process 11901
      organic substance metabolic process 11299
        macromolecule metabolic process 9767
          macromolecule catabolic process 1309
            protein catabolic process 970
              cellular protein catabolic process 804
                proteolysis involved in cellular protein catabolic process 751
                  modification-dependent protein catabolic process 639
                    ubiquitin-dependent protein catabolic process 628
                      proteasome-mediated ubiquitin-dependent protein catabolic process 412
                        ubiquitin-dependent ERAD pathway 76
                          negative regulation of ER-associated ubiquitin-dependent protein catabolic process 3
                          positive regulation of ER-associated ubiquitin-dependent protein catabolic process 6
                          regulation of ER-associated ubiquitin-dependent protein catabolic process + 8
                          ubiquitin-dependent glycoprotein ERAD pathway + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.