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ONTOLOGY REPORT - ANNOTATIONS


Term:ubiquitin-dependent ERAD pathway
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Accession:GO:0030433 term browser browse the term
Definition:The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
Comment:See also the biological process terms 'ERAD pathway ; GO:0036503', 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'.
Synonyms:exact_synonym: ER-associated ubiquitin-dependent protein breakdown;   ER-associated ubiquitin-dependent protein catabolic process;   ER-associated ubiquitin-dependent protein catabolism;   ER-associated ubiquitin-dependent protein degradation;   ERAD;   endoplasmic reticulum-associated ubiquitin-dependent protein catabolic process;   endoplasmic reticulum-associated ubiqutin-dependent protein catabolism;   ubiquitin-dependent proteasomal protein catabolism of ER proteins


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ubiquitin-dependent ERAD pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AMFR autocrine motility factor receptor JBrowse link 16 55,780,633 55,843,738 RGD:9068941
G ANKZF1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 JBrowse link 2B 225,078,308 225,085,205 RGD:9068941
G AUP1 AUP1 lipid droplet regulating VLDL assembly factor JBrowse link 2A 76,099,483 76,102,774 RGD:9068941
G BAG6 BAG cochaperone 6 JBrowse link 6 32,190,037 32,204,321 RGD:9068941
G CCDC47 coiled-coil domain containing 47 JBrowse link 17 62,970,109 62,998,465 RGD:9068941
G DERL1 derlin 1 JBrowse link 8 122,463,063 122,492,137 RGD:9068941
G DERL2 derlin 2 JBrowse link 17 5,514,440 5,526,363 RGD:9068941
G DERL3 derlin 3 JBrowse link 22 22,673,908 22,678,451 RGD:9068941
G DNAJB12 DnaJ heat shock protein family (Hsp40) member B12 JBrowse link 10 71,319,836 71,341,876 RGD:9068941
G DNAJB14 DnaJ heat shock protein family (Hsp40) member B14 JBrowse link 4 102,979,885 103,029,857 RGD:9068941
G DNAJB2 DnaJ heat shock protein family (Hsp40) member B2 JBrowse link 2B 225,127,967 225,135,556 RGD:9068941
G DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 JBrowse link 7 113,273,844 113,279,105 RGD:9068941
G DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 JBrowse link 2B 187,799,532 187,864,496 RGD:9068941
G DNAJC18 DnaJ heat shock protein family (Hsp40) member C18 JBrowse link 5 140,903,760 140,938,025 RGD:9068941
G ECPAS Ecm29 proteasome adaptor and scaffold JBrowse link 9 110,662,590 110,774,511 RGD:9068941
G EDEM1 ER degradation enhancing alpha-mannosidase like protein 1 JBrowse link 3 5,234,108 5,266,057 RGD:9068941
G ERLEC1 endoplasmic reticulum lectin 1 JBrowse link 2A 54,842,228 54,874,068 RGD:9068941
G ERLIN1 ER lipid raft associated 1 JBrowse link 10 100,238,320 100,273,971 RGD:9068941
G ERLIN2 ER lipid raft associated 2 JBrowse link 8 34,212,610 34,233,583 RGD:9068941
G FAF2 Fas associated factor family member 2 JBrowse link 5 178,813,998 178,875,208 RGD:9068941
G FBXO17 F-box protein 17 JBrowse link 19 44,590,799 44,624,871 RGD:9068941
G FBXO2 F-box protein 2 JBrowse link 1 11,626,713 11,633,171 RGD:9068941
G FBXO27 F-box protein 27 JBrowse link 19 44,674,775 44,681,873 RGD:9068941
G FBXO44 F-box protein 44 JBrowse link 1 11,632,724 11,641,286 RGD:9068941
G FBXO6 F-box protein 6 JBrowse link 1 11,639,802 11,654,837 RGD:9068941
G FOXRED2 FAD dependent oxidoreductase domain containing 2 JBrowse link 22 35,239,070 35,258,803 RGD:9068941
G HSP90B1 heat shock protein 90 beta family member 1 JBrowse link 12 104,901,997 104,919,592 RGD:9068941
G HSPA5 heat shock protein family A (Hsp70) member 5 JBrowse link 9 124,865,211 124,870,458 RGD:9068941
G JKAMP JNK1/MAPK8 associated membrane protein JBrowse link 14 58,351,807 58,372,653 RGD:9068941
G LOC100989420 SEL1L2, ERAD E3 ligase adaptor subunit JBrowse link 20 13,800,211 13,870,470 RGD:9068941
G MAN1B1 mannosidase alpha class 1B member 1 JBrowse link 9 137,117,150 137,139,066 RGD:9068941
G MARCHF6 membrane associated ring-CH-type finger 6 JBrowse link 5 10,524,958 10,608,046 RGD:9068941
G NCCRP1 NCCRP1, F-box associated domain containing JBrowse link 19 44,844,060 44,849,343 RGD:9068941
G NPLOC4 NPL4 homolog, ubiquitin recognition factor JBrowse link 17 81,713,582 81,785,567 RGD:9068941
G OS9 OS9 endoplasmic reticulum lectin JBrowse link 12 31,465,836 31,493,076 RGD:9068941
G PSMC6 proteasome 26S subunit, ATPase 6 JBrowse link 14 51,587,467 51,608,044 RGD:9068941
G RHBDD2 rhomboid domain containing 2 JBrowse link 7 82,328,777 82,338,401 RGD:9068941
G RNF121 ring finger protein 121 JBrowse link 11 70,233,723 70,302,576 RGD:9068941
G RNF175 ring finger protein 175 JBrowse link 4 157,874,243 157,923,772 RGD:9068941
G RNF185 ring finger protein 185 JBrowse link 22 30,020,353 30,066,266 RGD:9068941
G RNF5 ring finger protein 5 JBrowse link 6 32,705,674 32,708,076 RGD:9068941
G SEC61B SEC61 translocon beta subunit JBrowse link 9 98,430,774 98,439,105 RGD:9068941
G SEL1L SEL1L adaptor subunit of ERAD E3 ubiquitin ligase JBrowse link 14 81,248,441 81,309,597 RGD:9068941
G SELENOS selenoprotein S JBrowse link 15 99,279,195 99,285,682 RGD:9068941
G SGTA small glutamine rich tetratricopeptide repeat containing alpha JBrowse link 19 2,736,565 2,763,440 RGD:9068941
G SGTB small glutamine rich tetratricopeptide repeat containing beta JBrowse link 5 49,938,579 49,991,778 RGD:9068941
G STT3B STT3 oligosaccharyltransferase complex catalytic subunit B JBrowse link 3 31,771,271 31,873,389 RGD:9068941
G STUB1 STIP1 homology and U-box containing protein 1 JBrowse link 16 694,414 696,682 RGD:9068941
G SYVN1 synoviolin 1 JBrowse link 11 63,828,035 63,835,578 RGD:9068941
G TMEM129 transmembrane protein 129, E3 ubiquitin ligase JBrowse link 4 1,767,517 1,772,643 RGD:9068941
G TMEM67 transmembrane protein 67 JBrowse link 8 92,324,402 92,387,437 RGD:9068941
G TMUB1 transmembrane and ubiquitin like domain containing 1 JBrowse link 7 154,820,388 154,822,511 RGD:9068941
G TMUB2 transmembrane and ubiquitin like domain containing 2 JBrowse link 17 13,369,741 13,374,512 RGD:9068941
G TRIM13 tripartite motif containing 13 JBrowse link 13 49,881,218 49,900,496 RGD:9068941
G TRIM25 tripartite motif containing 25 JBrowse link 17 55,826,458 55,852,422 RGD:9068941
G UBE2G2 ubiquitin conjugating enzyme E2 G2 JBrowse link 21 44,355,235 44,388,373 RGD:9068941
G UBE2J1 ubiquitin conjugating enzyme E2 J1 JBrowse link 6 90,471,136 90,497,320 RGD:9068941
G UBE2J2 ubiquitin conjugating enzyme E2 J2 JBrowse link 1 1,211,502 1,231,813 RGD:9068941
G UBE4A ubiquitination factor E4A JBrowse link 11 117,125,582 117,162,518 RGD:9068941
G UBE4B ubiquitination factor E4B JBrowse link 1 10,033,084 10,178,765 RGD:9068941
G UBQLN1 ubiquilin 1 JBrowse link 9 82,597,507 82,645,587 RGD:9068941
G UBQLN2 ubiquilin 2 JBrowse link X 56,981,696 56,985,979 RGD:9068941
G UBXN4 UBX domain protein 4 JBrowse link 2B 139,809,945 139,852,857 RGD:9068941
G UBXN8 UBX domain protein 8 JBrowse link 8 27,247,044 27,269,348 RGD:9068941
G UFD1 ubiquitin recognition factor in ER associated degradation 1 JBrowse link 22 17,885,073 17,913,506 RGD:9068941
G USP19 ubiquitin specific peptidase 19 JBrowse link 3 50,112,271 50,125,114 RGD:9068941
G VCP valosin containing protein JBrowse link 9 35,712,937 35,729,588 RGD:9068941
G WFS1 wolframin ER transmembrane glycoprotein JBrowse link 4 6,345,960 6,379,094 RGD:9068941
G YOD1 YOD1 deubiquitinase JBrowse link 1 186,925,034 186,932,545 RGD:9068941
mannose trimming involved in glycoprotein ERAD pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EDEM1 ER degradation enhancing alpha-mannosidase like protein 1 JBrowse link 3 5,234,108 5,266,057 RGD:9068941
G EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 JBrowse link 1 164,372,977 164,436,977 RGD:9068941
G LOC100980744 ER degradation-enhancing alpha-mannosidase-like protein 2 JBrowse link 20 32,567,799 32,598,998 RGD:9068941
G MAN1B1 mannosidase alpha class 1B member 1 JBrowse link 9 137,117,150 137,139,066 RGD:9068941
negative regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SGTA small glutamine rich tetratricopeptide repeat containing alpha JBrowse link 19 2,736,565 2,763,440 RGD:9068941
G SVIP small VCP interacting protein JBrowse link 11 22,726,818 22,744,558 RGD:9068941
G USP14 ubiquitin specific peptidase 14 JBrowse link 18 17,742,463 17,797,381 RGD:9068941
positive regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BCAP31 B cell receptor associated protein 31 JBrowse link X 153,137,992 153,161,628 RGD:9068941
G CAV1 caveolin 1 JBrowse link 7 121,193,678 121,229,655 RGD:9068941
G HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 JBrowse link 16 56,343,025 56,355,164 RGD:9068941
G NFE2L2 nuclear factor, erythroid 2 like 2 JBrowse link 2B 182,214,116 182,248,282 RGD:9068941
G SGTA small glutamine rich tetratricopeptide repeat containing alpha JBrowse link 19 2,736,565 2,763,440 RGD:9068941
G UBQLN1 ubiquilin 1 JBrowse link 9 82,597,507 82,645,587 RGD:9068941
G UBQLN2 ubiquilin 2 JBrowse link X 56,981,696 56,985,979 RGD:9068941
G XBP1 X-box binding protein 1 JBrowse link 22 27,566,423 27,572,627 RGD:9068941
regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 JBrowse link 16 56,343,025 56,355,164 RGD:9068941
ubiquitin-dependent glycoprotein ERAD pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EDEM1 ER degradation enhancing alpha-mannosidase like protein 1 JBrowse link 3 5,234,108 5,266,057 RGD:9068941
G LOC100980744 ER degradation-enhancing alpha-mannosidase-like protein 2 JBrowse link 20 32,567,799 32,598,998 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15758
    response to stimulus 8304
      response to chemical 4393
        response to organic substance 3161
          response to organonitrogen compound 1035
            ERAD pathway 98
              ubiquitin-dependent ERAD pathway 78
                negative regulation of ER-associated ubiquitin-dependent protein catabolic process 3
                positive regulation of ER-associated ubiquitin-dependent protein catabolic process 8
                regulation of ER-associated ubiquitin-dependent protein catabolic process + 10
                ubiquitin-dependent glycoprotein ERAD pathway + 4
Path 2
Term Annotations click to browse term
  biological_process 15758
    metabolic process 10722
      organic substance metabolic process 10201
        macromolecule metabolic process 8835
          macromolecule catabolic process 1386
            protein catabolic process 913
              cellular protein catabolic process 757
                proteolysis involved in cellular protein catabolic process 703
                  modification-dependent protein catabolic process 617
                    ubiquitin-dependent protein catabolic process 611
                      proteasome-mediated ubiquitin-dependent protein catabolic process 420
                        ubiquitin-dependent ERAD pathway 78
                          negative regulation of ER-associated ubiquitin-dependent protein catabolic process 3
                          positive regulation of ER-associated ubiquitin-dependent protein catabolic process 8
                          regulation of ER-associated ubiquitin-dependent protein catabolic process + 10
                          ubiquitin-dependent glycoprotein ERAD pathway + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.