Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:ubiquitin-dependent ERAD pathway
go back to main search page
Accession:GO:0030433 term browser browse the term
Definition:The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
Comment:See also the biological process terms 'ERAD pathway ; GO:0036503', 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'.
Synonyms:exact_synonym: ER-associated ubiquitin-dependent protein breakdown;   ER-associated ubiquitin-dependent protein catabolic process;   ER-associated ubiquitin-dependent protein catabolism;   ER-associated ubiquitin-dependent protein degradation;   ERAD;   endoplasmic reticulum-associated ubiquitin-dependent protein catabolic process;   endoplasmic reticulum-associated ubiqutin-dependent protein catabolism;   ubiquitin-dependent proteasomal protein catabolism of ER proteins


GViewer not supported for chinchilla.
show annotations for term's descendants       view all columns           Sort by:
 
ubiquitin-dependent ERAD pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Amfr autocrine motility factor receptor JBrowse link NW_004955433 14,172,871 14,205,484 RGD:9068941
G Ankzf1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 JBrowse link NW_004955453 14,196,728 14,204,344 RGD:9068941
G Aup1 AUP1 lipid droplet regulating VLDL assembly factor JBrowse link NW_004955424 11,259,288 11,262,413 RGD:9068941
G Bag6 BAG cochaperone 6 JBrowse link NW_004955437 176,848 188,243 RGD:9068941
G Ccdc47 coiled-coil domain containing 47 JBrowse link NW_004955478 8,053,057 8,074,530 RGD:9068941
G Derl1 derlin 1 JBrowse link NW_004955540 1,918,230 1,944,186 RGD:9068941
G Derl2 derlin 2 JBrowse link NW_004955467 10,824,922 10,837,408 RGD:9068941
G Derl3 derlin 3 JBrowse link NW_004955455 8,415,868 8,418,753 RGD:9068941
G Dnajb12 DnaJ heat shock protein family (Hsp40) member B12 JBrowse link NW_004955437 19,266,206 19,285,654 RGD:9068941
G Dnajb14 DnaJ heat shock protein family (Hsp40) member B14 JBrowse link NW_004955496 7,746,896 7,782,424 RGD:9068941
G Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 JBrowse link NW_004955453 14,147,286 14,154,396 RGD:9068941
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 JBrowse link NW_004955410 12,814,993 12,820,852 RGD:9068941
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 JBrowse link NW_004955403 14,681,015 14,717,060 RGD:9068941
G Dnajc18 DnaJ heat shock protein family (Hsp40) member C18 JBrowse link NW_004955418 1,119,699 1,149,891 RGD:9068941
G Ecpas Ecm29 proteasome adaptor and scaffold JBrowse link NW_004955419 15,775,208 15,886,101 RGD:9068941
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 JBrowse link NW_004955421 8,196,631 8,225,561 RGD:9068941
G Erlec1 endoplasmic reticulum lectin 1 JBrowse link NW_004955441 19,535,425 19,557,960 RGD:9068941
G Erlin1 ER lipid raft associated 1 JBrowse link NW_004955507 6,029,247 6,062,946 RGD:9068941
G Erlin2 ER lipid raft associated 2 JBrowse link NW_004955463 13,445,468 13,460,370 RGD:9068941
G Faf2 Fas associated factor family member 2 JBrowse link NW_004955408 28,737,597 28,797,143 RGD:9068941
G Fbxo17 F-box protein 17 JBrowse link NW_004955468 591,653 598,370 RGD:9068941
G Fbxo2 F-box protein 2 JBrowse link NW_004955486 2,212,001 2,217,260 RGD:9068941
G Fbxo27 F-box protein 27 JBrowse link NW_004955468 520,321 525,051 RGD:9068941
G Fbxo44 F-box protein 44 JBrowse link NW_004955486 2,204,470 2,210,604 RGD:9068941
G Fbxo6 F-box protein 6 JBrowse link NW_004955486 2,197,296 2,205,947 RGD:9068941
G Foxred2 FAD dependent oxidoreductase domain containing 2 JBrowse link NW_004955413 23,070,715 23,091,402 RGD:9068941
G Hsp90b1 heat shock protein 90 beta family member 1 JBrowse link NW_004955405 38,629,691 38,645,202 RGD:9068941
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link NW_004955419 3,055,420 3,060,208 RGD:9068941
G Jkamp JNK1/MAPK8 associated membrane protein JBrowse link NW_004955466 13,205,424 13,225,573 RGD:9068941
G Man1b1 mannosidase alpha class 1B member 1 JBrowse link NW_004955513 5,109,651 5,122,568 RGD:9068941
G Marchf6 membrane associated ring-CH-type finger 6 JBrowse link NW_004955426 228,807 278,888 RGD:9068941
G Nccrp1 NCCRP1, F-box associated domain containing JBrowse link NW_004955468 353,066 356,650 RGD:9068941
G Nploc4 NPL4 homolog, ubiquitin recognition factor JBrowse link NW_004955506 1,451,337 1,513,455 RGD:9068941
G Os9 OS9 endoplasmic reticulum lectin JBrowse link NW_004955458 5,407,709 5,432,646 RGD:9068941
G Psmc6 proteasome 26S subunit, ATPase 6 JBrowse link NW_004955409 10,454,210 10,474,872 RGD:9068941
G Rhbdd2 rhomboid domain containing 2 JBrowse link NW_004955456 14,652,995 14,666,155 RGD:9068941
G Rnf103 ring finger protein 103 JBrowse link NW_004955424 1,097,981 1,161,267 RGD:9068941
G Rnf121 ring finger protein 121 JBrowse link NW_004955414 19,332,670 19,423,711 RGD:9068941
G Rnf175 ring finger protein 175 JBrowse link NW_004955471 8,019,842 8,079,565 RGD:9068941
G Rnf185 ring finger protein 185 JBrowse link NW_004955455 5,351,530 5,394,615 RGD:9068941
G Rnf5 ring finger protein 5 JBrowse link NW_004955437 643,133 645,528 RGD:9068941
G Sec61b SEC61 translocon beta subunit JBrowse link NW_004955419 26,414,891 26,423,260 RGD:9068941
G Sel1l SEL1L adaptor subunit of ERAD E3 ubiquitin ligase JBrowse link NW_004955438 5,030,915 5,082,015 RGD:9068941
G Sel1l2 SEL1L2 adaptor subunit of ERAD E3 ligase JBrowse link NW_004955415 23,290,343 23,392,613 RGD:9068941
G Selenos selenoprotein S JBrowse link NW_004955416 28,152,984 28,162,173 RGD:9068941
G Sgta small glutamine rich tetratricopeptide repeat containing alpha JBrowse link NW_004955495 5,025,038 5,051,810 RGD:9068941
G Sgtb small glutamine rich tetratricopeptide repeat containing beta JBrowse link NW_004955446 3,374,363 3,426,284 RGD:9068941
G Stt3b STT3 oligosaccharyltransferase complex catalytic subunit B JBrowse link NW_004955430 22,986,673 23,070,923 RGD:9068941
G Stub1 STIP1 homology and U-box containing protein 1 JBrowse link NW_004955442 16,521,130 16,523,733 RGD:9068941
G Syvn1 synoviolin 1 JBrowse link NW_004955422 20,067,933 20,074,947 RGD:9068941
G Tmem129 transmembrane protein 129, E3 ubiquitin ligase JBrowse link NW_004955514 968,763 972,918 RGD:9068941
G Tmem67 transmembrane protein 67 JBrowse link NW_004955417 10,097,488 10,137,959 RGD:9068941
G Tmub1 transmembrane and ubiquitin like domain containing 1 JBrowse link NW_004955491 5,518,199 5,520,743 RGD:9068941
G Tmub2 transmembrane and ubiquitin like domain containing 2 JBrowse link NW_004955451 17,277,530 17,280,585 RGD:9068941
G Trim13 tripartite motif containing 13 JBrowse link NW_004955431 3,324,331 3,395,724 RGD:9068941
G Trim25 tripartite motif containing 25 JBrowse link NW_004955451 5,918,287 5,934,252 RGD:9068941
G Ube2g2 ubiquitin conjugating enzyme E2 G2 JBrowse link NW_004955407 41,683,771 41,724,014 RGD:9068941
G Ube2j1 ubiquitin conjugating enzyme E2 J1 JBrowse link NW_004955411 16,076,647 16,091,554 RGD:9068941
G Ube2j2 ubiquitin conjugating enzyme E2 J2 JBrowse link NW_004955486 9,519,467 9,539,666 RGD:9068941
G Ube4a ubiquitination factor E4A JBrowse link NW_004955412 19,517,182 19,551,503 RGD:9068941
G Ube4b ubiquitination factor E4B JBrowse link NW_004955486 3,518,873 3,626,036 RGD:9068941
G Ubqln1 ubiquilin 1 JBrowse link NW_004955432 3,575,034 3,617,029 RGD:9068941
G Ubqln2 ubiquilin 2 JBrowse link NW_004955475 3,260,209 3,263,586 RGD:9068941
G Ubxn4 UBX domain protein 4 JBrowse link NW_004955440 3,106,055 3,143,214 RGD:9068941
G Ubxn8 UBX domain protein 8 JBrowse link NW_004955463 7,189,822 7,213,083 RGD:9068941
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 JBrowse link NW_004955442 18,548,545 18,568,989 RGD:9068941
G Usp19 ubiquitin specific peptidase 19 JBrowse link NW_004955532 1,104,212 1,115,267 RGD:9068941
G Vcp valosin containing protein JBrowse link NW_004955472 1,111,649 1,124,076 RGD:9068941
G Wfs1 wolframin ER transmembrane glycoprotein JBrowse link NW_004955514 3,902,508 3,924,281 RGD:9068941
mannose trimming involved in glycoprotein ERAD pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 JBrowse link NW_004955421 8,196,631 8,225,561 RGD:9068941
G Edem2 ER degradation enhancing alpha-mannosidase like protein 2 JBrowse link NW_004955422 26,243,034 26,271,849 RGD:9068941
G Edem3 ER degradation enhancing alpha-mannosidase like protein 3 JBrowse link NW_004955406 23,329,400 23,401,282 RGD:9068941
G Man1b1 mannosidase alpha class 1B member 1 JBrowse link NW_004955513 5,109,651 5,122,568 RGD:9068941
negative regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sgta small glutamine rich tetratricopeptide repeat containing alpha JBrowse link NW_004955495 5,025,038 5,051,810 RGD:9068941
G Svip small VCP interacting protein JBrowse link NW_004955476 3,231,789 3,236,602 RGD:9068941
G Usp14 ubiquitin specific peptidase 14 JBrowse link NW_004955402 9,710,080 9,737,601 RGD:9068941
positive regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcap31 B cell receptor associated protein 31 JBrowse link NW_004955580 429,223 459,168 RGD:9068941
G Cav1 caveolin 1 JBrowse link NW_004955432 22,258,262 22,292,403 RGD:9068941
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 JBrowse link NW_004955433 14,609,275 14,621,774 RGD:9068941
G Nfe2l2 nuclear factor, erythroid 2 like 2 JBrowse link NW_004955403 19,510,122 19,536,428 RGD:9068941
G Sgta small glutamine rich tetratricopeptide repeat containing alpha JBrowse link NW_004955495 5,025,038 5,051,810 RGD:9068941
G Ubqln1 ubiquilin 1 JBrowse link NW_004955432 3,575,034 3,617,029 RGD:9068941
G Ubqln2 ubiquilin 2 JBrowse link NW_004955475 3,260,209 3,263,586 RGD:9068941
G Xbp1 X-box binding protein 1 JBrowse link NW_004955455 3,037,885 3,041,827 RGD:9068941
regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 JBrowse link NW_004955433 14,609,275 14,621,774 RGD:9068941
ubiquitin-dependent glycoprotein ERAD pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 JBrowse link NW_004955421 8,196,631 8,225,561 RGD:9068941
G Edem2 ER degradation enhancing alpha-mannosidase like protein 2 JBrowse link NW_004955422 26,243,034 26,271,849 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14616
    response to stimulus 7743
      response to chemical 4049
        response to organic substance 3039
          response to organonitrogen compound 1007
            ERAD pathway 99
              ubiquitin-dependent ERAD pathway 78
                negative regulation of ER-associated ubiquitin-dependent protein catabolic process 3
                positive regulation of ER-associated ubiquitin-dependent protein catabolic process 8
                regulation of ER-associated ubiquitin-dependent protein catabolic process + 10
                ubiquitin-dependent glycoprotein ERAD pathway + 4
Path 2
Term Annotations click to browse term
  biological_process 14616
    metabolic process 10124
      organic substance metabolic process 9625
        macromolecule metabolic process 8332
          macromolecule catabolic process 1377
            protein catabolic process 911
              cellular protein catabolic process 753
                proteolysis involved in cellular protein catabolic process 697
                  modification-dependent protein catabolic process 609
                    ubiquitin-dependent protein catabolic process 603
                      proteasome-mediated ubiquitin-dependent protein catabolic process 418
                        ubiquitin-dependent ERAD pathway 78
                          negative regulation of ER-associated ubiquitin-dependent protein catabolic process 3
                          positive regulation of ER-associated ubiquitin-dependent protein catabolic process 8
                          regulation of ER-associated ubiquitin-dependent protein catabolic process + 10
                          ubiquitin-dependent glycoprotein ERAD pathway + 4
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.