Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:ubiquitin-dependent ERAD pathway
go back to main search page
Accession:GO:0030433 term browser browse the term
Definition:The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
Comment:See also the biological process terms 'ERAD pathway ; GO:0036503', 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'.
Synonyms:exact_synonym: ER-associated ubiquitin-dependent protein breakdown;   ER-associated ubiquitin-dependent protein catabolic process;   ER-associated ubiquitin-dependent protein catabolism;   ER-associated ubiquitin-dependent protein degradation;   ERAD;   endoplasmic reticulum-associated ubiquitin-dependent protein catabolic process;   endoplasmic reticulum-associated ubiqutin-dependent protein catabolism;   ubiquitin-dependent proteasomal protein catabolism of ER proteins


show annotations for term's descendants       view all columns           Sort by:
 
ubiquitin-dependent ERAD pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AMFR autocrine motility factor receptor JBrowse link 2 59,766,910 59,803,292 RGD:13508589
G ANKZF1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 JBrowse link 37 25,777,665 25,783,892 RGD:13508589
G AUP1 AUP1 lipid droplet regulating VLDL assembly factor JBrowse link 17 48,613,648 48,617,091 RGD:13508589
G BAG6 BAG cochaperone 6 JBrowse link 12 1,126,730 1,141,978 RGD:13508589
G CCDC47 coiled-coil domain containing 47 JBrowse link 9 11,715,793 11,737,055 RGD:13508589
G DERL1 derlin 1 JBrowse link 13 21,423,501 21,452,594 RGD:13508589
G DERL2 derlin 2 JBrowse link 5 31,319,660 31,330,846 RGD:13508589
G DERL3 derlin 3 JBrowse link 26 28,688,307 28,690,400 RGD:13508589
G DNAJB12 DnaJ heat shock protein family (Hsp40) member B12 JBrowse link 4 22,964,098 22,980,291 RGD:13508589
G DNAJB14 DnaJ heat shock protein family (Hsp40) member B14 JBrowse link 32 21,840,790 21,888,400 RGD:13508589
G DNAJB2 DnaJ heat shock protein family (Hsp40) member B2 JBrowse link 37 25,826,496 25,834,011 RGD:13508589
G DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 JBrowse link 36 25,749,855 25,822,117 RGD:13508589
G DNAJC18 DnaJ heat shock protein family (Hsp40) member C18 JBrowse link 2 34,730,877 34,762,234 RGD:13508589
G ERLEC1 endoplasmic reticulum lectin 1 JBrowse link 10 54,815,592 54,845,776 RGD:13508589
G ERLIN1 ER lipid raft associated 1 JBrowse link 28 12,924,942 12,962,016 RGD:13508589
G ERLIN2 ER lipid raft associated 2 JBrowse link 16 27,622,549 27,639,807 RGD:13508589
G FAF2 Fas associated factor family member 2 JBrowse link 4 36,819,754 36,890,901 RGD:13508589
G FBXO17 F-box protein 17 JBrowse link 1 114,161,226 114,188,354 RGD:13508589
G FBXO2 F-box protein 2 JBrowse link 2 84,563,256 84,568,507 RGD:13508589
G FBXO27 F-box protein 27 JBrowse link 1 114,120,617 114,145,295 RGD:13508589
G FBXO6 F-box protein 6 JBrowse link 2 84,549,519 84,554,176 RGD:13508589
G FOXRED2 FAD dependent oxidoreductase domain containing 2 JBrowse link 10 27,908,090 27,923,602 RGD:13508589
G HSP90B1 heat shock protein 90 beta family member 1 JBrowse link 15 42,456,793 42,474,122 RGD:13508589
G HSPA5 heat shock protein family A (Hsp70) member 5 JBrowse link 9 57,850,870 57,855,607 RGD:13508589
G JKAMP JNK1/MAPK8 associated membrane protein JBrowse link 8 34,686,354 34,725,069 RGD:13508589
G LOC100687259 26S proteasome regulatory subunit 10B JBrowse link 32 35,814,756 35,816,311 RGD:13508589
G LOC480667 endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase JBrowse link 9 48,533,962 48,545,514 RGD:13508589
G MARCHF6 membrane associated ring-CH-type finger 6 JBrowse link 34 3,880,988 3,947,127 RGD:13508589
G NCCRP1 NCCRP1, F-box associated domain containing JBrowse link 1 113,989,951 113,993,847 RGD:13508589
G OS9 OS9 endoplasmic reticulum lectin JBrowse link 10 1,757,070 1,787,822 RGD:13508589
G PSMC6 proteasome 26S subunit, ATPase 6 JBrowse link 8 28,914,302 28,947,854 RGD:13508589
G RHBDD2 rhomboid domain containing 2 JBrowse link 6 7,218,796 7,230,949 RGD:13508589
G RNF103 ring finger protein 103 JBrowse link 17 38,549,838 38,566,613 RGD:13508589
G RNF121 ring finger protein 121 JBrowse link 21 26,080,885 26,163,570 RGD:13508589
G RNF5 ring finger protein 5 JBrowse link 12 1,571,277 1,575,151 RGD:13508589
G SEC61B SEC61 translocon subunit beta JBrowse link 11 56,279,564 56,298,593 RGD:13508589
G SEL1L SEL1L adaptor subunit of ERAD E3 ubiquitin ligase JBrowse link 8 53,767,799 53,824,391 RGD:13508589
G SEL1L2 SEL1L2 adaptor subunit of ERAD E3 ligase JBrowse link 24 8,678,528 8,812,373 RGD:13508589
G SELENOS selenoprotein S JBrowse link 3 39,796,711 39,805,654 RGD:13508589
G SGTA small glutamine rich tetratricopeptide repeat containing alpha JBrowse link 20 56,432,688 56,451,438 RGD:13508589
G SGTB small glutamine rich tetratricopeptide repeat containing beta JBrowse link 2 51,397,606 51,446,512 RGD:13508589
G STT3B STT3 oligosaccharyltransferase complex catalytic subunit B JBrowse link 23 13,036,301 13,143,629 RGD:13508589
G STUB1 STIP1 homology and U-box containing protein 1 JBrowse link 6 39,893,492 39,895,385 RGD:13508589
G SYVN1 synoviolin 1 JBrowse link 18 52,061,284 52,068,672 RGD:13508589
G TMEM129 transmembrane protein 129, E3 ubiquitin ligase JBrowse link 3 62,381,240 62,386,381 RGD:13508589
G TMUB1 transmembrane and ubiquitin like domain containing 1 JBrowse link 16 15,131,190 15,134,230 RGD:13508589
G TMUB2 transmembrane and ubiquitin like domain containing 2 JBrowse link 9 19,204,802 19,209,275 RGD:13508589
G TRIM13 tripartite motif containing 13 JBrowse link 22 1,877,672 1,893,097 RGD:13508589
G TRIM25 tripartite motif containing 25 JBrowse link 9 31,703,628 31,725,674 RGD:13508589
G UBE2G2 ubiquitin conjugating enzyme E2 G2 JBrowse link 31 38,432,855 38,470,202 RGD:13508589
G UBE2J1 ubiquitin conjugating enzyme E2 J1 JBrowse link 12 48,542,432 48,570,716 RGD:13508589
G UBE2J2 ubiquitin conjugating enzyme E2 J2 JBrowse link 5 56,440,394 56,455,491 RGD:13508589
G UBE4A ubiquitination factor E4A JBrowse link 5 15,338,279 15,375,722 RGD:13508589
G UBE4B ubiquitination factor E4B JBrowse link 5 63,214,846 63,339,218 RGD:13508589
G UBQLN1 ubiquilin 1 JBrowse link 1 75,767,345 75,812,278 RGD:13508589
G UBXN4 UBX domain protein 4 JBrowse link 19 38,519,778 38,568,760 RGD:13508589
G UBXN8 UBX domain protein 8 JBrowse link 16 33,590,905 33,622,752 RGD:13508589
G USP19 ubiquitin specific peptidase 19 JBrowse link 20 40,062,802 40,074,221 RGD:13508589
G VCP valosin containing protein JBrowse link 11 51,636,986 51,651,749 RGD:13508589
G WFS1 wolframin ER transmembrane glycoprotein JBrowse link 13 38,451,722 38,466,481 RGD:13508589
G YOD1 YOD1 deubiquitinase JBrowse link 7 6,185,650 6,194,005 RGD:13508589
mannose trimming involved in glycoprotein ERAD pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EDEM1 ER degradation enhancing alpha-mannosidase like protein 1 JBrowse link 20 12,444,013 12,473,188 RGD:13508589
G EDEM2 ER degradation enhancing alpha-mannosidase like protein 2 JBrowse link 24 24,137,228 24,165,995 RGD:13508589
G EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 JBrowse link 7 17,918,902 17,991,270 RGD:13508589
negative regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SGTA small glutamine rich tetratricopeptide repeat containing alpha JBrowse link 20 56,432,688 56,451,438 RGD:13508589
G USP14 ubiquitin specific peptidase 14 JBrowse link 7 67,035,774 67,080,082 RGD:13508589
positive regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BCAP31 B cell receptor associated protein 31 JBrowse link X 121,515,417 121,550,373 RGD:13508589
G CAV1 caveolin 1 JBrowse link 14 55,458,934 55,494,563 RGD:13508589
G HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 JBrowse link 2 59,388,492 59,400,028 RGD:13508589
G SGTA small glutamine rich tetratricopeptide repeat containing alpha JBrowse link 20 56,432,688 56,451,438 RGD:13508589
G UBQLN1 ubiquilin 1 JBrowse link 1 75,767,345 75,812,278 RGD:13508589
regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 JBrowse link 2 59,388,492 59,400,028 RGD:13508589

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14457
    response to stimulus 6260
      response to chemical 3066
        response to organic substance 1744
          response to organonitrogen compound 517
            ERAD pathway 83
              ubiquitin-dependent ERAD pathway 68
                negative regulation of ER-associated ubiquitin-dependent protein catabolic process 2
                positive regulation of ER-associated ubiquitin-dependent protein catabolic process 5
                regulation of ER-associated ubiquitin-dependent protein catabolic process + 6
                ubiquitin-dependent glycoprotein ERAD pathway + 3
Path 2
Term Annotations click to browse term
  biological_process 14457
    metabolic process 9082
      organic substance metabolic process 8574
        macromolecule metabolic process 7351
          macromolecule catabolic process 955
            protein catabolic process 724
              cellular protein catabolic process 614
                proteolysis involved in cellular protein catabolic process 586
                  modification-dependent protein catabolic process 511
                    ubiquitin-dependent protein catabolic process 501
                      proteasome-mediated ubiquitin-dependent protein catabolic process 322
                        ubiquitin-dependent ERAD pathway 68
                          negative regulation of ER-associated ubiquitin-dependent protein catabolic process 2
                          positive regulation of ER-associated ubiquitin-dependent protein catabolic process 5
                          regulation of ER-associated ubiquitin-dependent protein catabolic process + 6
                          ubiquitin-dependent glycoprotein ERAD pathway + 3
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.