Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:ubiquitin-dependent ERAD pathway
go back to main search page
Accession:GO:0030433 term browser browse the term
Definition:The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
Comment:See also the biological process terms 'ERAD pathway ; GO:0036503', 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'.
Synonyms:exact_synonym: ER-associated ubiquitin-dependent protein breakdown;   ER-associated ubiquitin-dependent protein catabolic process;   ER-associated ubiquitin-dependent protein catabolism;   ER-associated ubiquitin-dependent protein degradation;   ERAD;   endoplasmic reticulum-associated ubiquitin-dependent protein catabolic process;   endoplasmic reticulum-associated ubiqutin-dependent protein catabolism;   ubiquitin-dependent proteasomal protein catabolism of ER proteins


show annotations for term's descendants       view all columns           Sort by:
 
ubiquitin-dependent ERAD pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Amfr autocrine motility factor receptor JBrowse link NW_004936475 8,692,969 8,727,252 RGD:9068941
G Ankzf1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 JBrowse link NW_004936569 1,645,780 1,653,526 RGD:9068941
G Aup1 AUP1 lipid droplet regulating VLDL assembly factor JBrowse link NW_004936556 738,946 742,049 RGD:9068941
G Bag6 BAG cochaperone 6 JBrowse link NW_004936727 1,866,235 1,885,266 RGD:9068941
G Ccdc47 coiled-coil domain containing 47 JBrowse link NW_004936541 4,389,428 4,418,414 RGD:9068941
G Derl1 derlin 1 JBrowse link NW_004936470 24,262,401 24,286,713 RGD:9068941
G Derl2 derlin 2 JBrowse link NW_004936677 2,328,783 2,342,068 RGD:9068941
G Derl3 derlin 3 JBrowse link NW_004936619 1,271,980 1,275,212 RGD:9068941
G Dnajb12 DnaJ heat shock protein family (Hsp40) member B12 JBrowse link NW_004936521 6,583,828 6,605,744 RGD:9068941
G Dnajb14 DnaJ heat shock protein family (Hsp40) member B14 JBrowse link NW_004936520 3,063,250 3,105,610 RGD:9068941
G Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 JBrowse link NW_004936569 1,689,926 1,697,179 RGD:9068941
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 JBrowse link NW_004936653 1,554,534 1,558,832 RGD:9068941
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 JBrowse link NW_004936509 11,334,859 11,383,668 RGD:9068941
G Dnajc18 DnaJ heat shock protein family (Hsp40) member C18 JBrowse link NW_004936531 8,498,714 8,526,803 RGD:9068941
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 JBrowse link NW_004936577 4,486,617 4,516,379 RGD:9068941
G Erlec1 endoplasmic reticulum lectin 1 JBrowse link NW_004936491 351,813 377,978 RGD:9068941
G Erlin1 ER lipid raft associated 1 JBrowse link NW_004936636 80,583 116,027 RGD:9068941
G Erlin2 ER lipid raft associated 2 JBrowse link NW_004936710 1,193,679 1,210,059 RGD:9068941
G Faf2 Fas associated factor family member 2 JBrowse link NW_004936597 710,168 772,455 RGD:9068941
G Fbxo17 F-box protein 17 JBrowse link NW_004936661 1,876,129 1,904,964 RGD:9068941
G Fbxo2 F-box protein 2 JBrowse link NW_004936474 521,235 526,151 RGD:9068941
G Fbxo27 F-box protein 27 JBrowse link NW_004936661 1,931,036 1,936,548 RGD:9068941
G Fbxo44 F-box protein 44 JBrowse link NW_004936474 526,191 531,825 RGD:9068941
G Fbxo6 F-box protein 6 JBrowse link NW_004936474 531,873 538,596 RGD:9068941
G Foxred2 FAD dependent oxidoreductase domain containing 2 JBrowse link NW_004936492 4,272,965 4,292,356 RGD:9068941
G Hsp90b1 heat shock protein 90 beta family member 1 JBrowse link NW_004936492 10,513,908 10,528,281 RGD:9068941
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link NW_004936487 13,348,465 13,352,717 RGD:9068941
G Jkamp JNK1/MAPK8 associated membrane protein JBrowse link NW_004936495 3,839,057 3,849,062 RGD:9068941
G LOC101968642 proteasome-associated protein ECM29 homolog JBrowse link NW_004936559 1,807,768 1,918,529 RGD:9068941
G Man1b1 mannosidase alpha class 1B member 1 JBrowse link NW_004936669 855,349 867,763 RGD:9068941
G Marchf6 membrane associated ring-CH-type finger 6 JBrowse link NW_004936643 2,455,496 2,507,185 RGD:9068941
G Nccrp1 NCCRP1, F-box associated domain containing JBrowse link NW_004936661 2,057,664 2,060,519 RGD:9068941
G Nploc4 NPL4 homolog, ubiquitin recognition factor JBrowse link NW_004936594 5,206,222 5,251,042 RGD:9068941
G Os9 OS9 endoplasmic reticulum lectin JBrowse link NW_004936646 1,832,434 1,860,200 RGD:9068941
G Psmc6 proteasome 26S subunit, ATPase 6 JBrowse link NW_004936697 2,122,727 2,143,988 RGD:9068941
G Rhbdd2 rhomboid domain containing 2 JBrowse link NW_004936543 2,352,825 2,362,995 RGD:9068941
G Rnf103 ring finger protein 103 JBrowse link NW_004936712 977,650 997,623 RGD:9068941
G Rnf121 ring finger protein 121 JBrowse link NW_004936498 1,291,072 1,353,487 RGD:9068941
G Rnf175 ring finger protein 175 JBrowse link NW_004936576 535,660 573,644 RGD:9068941
G Rnf185 ring finger protein 185 JBrowse link NW_004936755 331,658 367,604 RGD:9068941
G Rnf5 ring finger protein 5 JBrowse link NW_004936727 1,422,207 1,424,808 RGD:9068941
G Sec61b SEC61 translocon beta subunit JBrowse link NW_004936524 7,731,033 7,739,410 RGD:9068941
G Sel1l SEL1L adaptor subunit of ERAD E3 ubiquitin ligase JBrowse link NW_004936488 9,838,092 9,903,780 RGD:9068941
G Sel1l2 SEL1L2 adaptor subunit of ERAD E3 ligase JBrowse link NW_004936485 5,916,463 5,975,844 RGD:9068941
G Selenos selenoprotein S JBrowse link NW_004936483 2,589,773 2,600,837 RGD:9068941
G Sgta small glutamine rich tetratricopeptide repeat containing alpha JBrowse link NW_004936588 1,599,453 1,616,480 RGD:9068941
G Sgtb small glutamine rich tetratricopeptide repeat containing beta JBrowse link NW_004936480 3,481,172 3,524,241 RGD:9068941
G Stt3b STT3 oligosaccharyltransferase complex catalytic subunit B JBrowse link NW_004936473 22,197,625 22,288,941 RGD:9068941
G Stub1 STIP1 homology and U-box containing protein 1 JBrowse link NW_004936501 328,767 330,963 RGD:9068941
G Syvn1 synoviolin 1 JBrowse link NW_004936599 4,235,779 4,243,395 RGD:9068941
G Tmem129 transmembrane protein 129, E3 ubiquitin ligase JBrowse link NW_004936477 21,665,955 21,670,667 RGD:9068941
G Tmem67 transmembrane protein 67 JBrowse link NW_004936544 6,887,867 6,931,669 RGD:9068941
G Tmub1 transmembrane and ubiquitin like domain containing 1 JBrowse link NW_004936527 6,504,471 6,506,572 RGD:9068941
G Tmub2 transmembrane and ubiquitin like domain containing 2 JBrowse link NW_004936541 653,051 657,116 RGD:9068941
G Trim13 tripartite motif containing 13 JBrowse link NW_004936565 2,976,681 2,989,036 RGD:9068941
G Trim25 tripartite motif containing 25 JBrowse link NW_004936490 5,979,320 5,997,632 RGD:9068941
G Ube2g2 ubiquitin conjugating enzyme E2 G2 JBrowse link NW_004936778 1,414,410 1,440,949 RGD:9068941
G Ube2j1 ubiquitin conjugating enzyme E2 J1 JBrowse link NW_004936510 2,864,321 2,887,588 RGD:9068941
G Ube2j2 ubiquitin conjugating enzyme E2 J2 JBrowse link NW_004936737 1,862,577 1,875,216 RGD:9068941
G Ube4b ubiquitination factor E4B JBrowse link NW_004936623 3,934,439 4,051,083 RGD:9068941
G Ubqln1 ubiquilin 1 JBrowse link NW_004936828 543,651 588,673 RGD:9068941
G Ubqln2 ubiquilin 2 JBrowse link NW_004936819 530,833 534,185 RGD:9068941
G Ubxn4 UBX domain protein 4 JBrowse link NW_004936469 40,109,276 40,147,088 RGD:9068941
G Ubxn8 UBX domain protein 8 JBrowse link NW_004936792 588,698 616,288 RGD:9068941
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 JBrowse link NW_004936619 3,395,130 3,419,704 RGD:9068941
G Usp19 ubiquitin specific peptidase 19 JBrowse link NW_004936529 814,649 826,008 RGD:9068941
G Vcp valosin containing protein JBrowse link NW_004936524 3,085,959 3,102,461 RGD:9068941
G Wfs1 wolframin ER transmembrane glycoprotein JBrowse link NW_004936477 18,339,915 18,364,973 RGD:9068941
G Yod1 YOD1 deubiquitinase JBrowse link NW_004936557 5,585,481 5,593,782 RGD:9068941
mannose trimming involved in glycoprotein ERAD pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 JBrowse link NW_004936577 4,486,617 4,516,379 RGD:9068941
G Edem2 ER degradation enhancing alpha-mannosidase like protein 2 JBrowse link NW_004936561 5,578,267 5,605,512 RGD:9068941
G Edem3 ER degradation enhancing alpha-mannosidase like protein 3 JBrowse link NW_004936481 5,352,964 5,424,944 RGD:9068941
G Man1b1 mannosidase alpha class 1B member 1 JBrowse link NW_004936669 855,349 867,763 RGD:9068941
negative regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sgta small glutamine rich tetratricopeptide repeat containing alpha JBrowse link NW_004936588 1,599,453 1,616,480 RGD:9068941
G Svip small VCP interacting protein JBrowse link NW_004936654 3,452,781 3,459,161 RGD:9068941
G Usp14 ubiquitin specific peptidase 14 JBrowse link NW_004936550 640,331 675,703 RGD:9068941
positive regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcap31 B cell receptor associated protein 31 JBrowse link NW_004936809 582,689 614,800 RGD:9068941
G Cav1 caveolin 1 JBrowse link NW_004936589 2,504,235 2,536,778 RGD:9068941
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 JBrowse link NW_004936475 9,091,115 9,102,101 RGD:9068941
G Nfe2l2 nuclear factor, erythroid 2 like 2 JBrowse link NW_004936509 6,589,967 6,621,171 RGD:9068941
G Sgta small glutamine rich tetratricopeptide repeat containing alpha JBrowse link NW_004936588 1,599,453 1,616,480 RGD:9068941
G Ubqln1 ubiquilin 1 JBrowse link NW_004936828 543,651 588,673 RGD:9068941
G Ubqln2 ubiquilin 2 JBrowse link NW_004936819 530,833 534,185 RGD:9068941
G Xbp1 X-box binding protein 1 JBrowse link NW_004936657 2,891,171 2,895,409 RGD:9068941
regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 JBrowse link NW_004936475 9,091,115 9,102,101 RGD:9068941
ubiquitin-dependent glycoprotein ERAD pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 JBrowse link NW_004936577 4,486,617 4,516,379 RGD:9068941
G Edem2 ER degradation enhancing alpha-mannosidase like protein 2 JBrowse link NW_004936561 5,578,267 5,605,512 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14835
    response to stimulus 7845
      response to chemical 4109
        response to organic substance 3064
          response to organonitrogen compound 1009
            ERAD pathway 99
              ubiquitin-dependent ERAD pathway 78
                negative regulation of ER-associated ubiquitin-dependent protein catabolic process 3
                positive regulation of ER-associated ubiquitin-dependent protein catabolic process 8
                regulation of ER-associated ubiquitin-dependent protein catabolic process + 10
                ubiquitin-dependent glycoprotein ERAD pathway + 4
Path 2
Term Annotations click to browse term
  biological_process 14835
    metabolic process 10258
      organic substance metabolic process 9758
        macromolecule metabolic process 8460
          macromolecule catabolic process 1371
            protein catabolic process 914
              cellular protein catabolic process 758
                proteolysis involved in cellular protein catabolic process 703
                  modification-dependent protein catabolic process 615
                    ubiquitin-dependent protein catabolic process 609
                      proteasome-mediated ubiquitin-dependent protein catabolic process 421
                        ubiquitin-dependent ERAD pathway 78
                          negative regulation of ER-associated ubiquitin-dependent protein catabolic process 3
                          positive regulation of ER-associated ubiquitin-dependent protein catabolic process 8
                          regulation of ER-associated ubiquitin-dependent protein catabolic process + 10
                          ubiquitin-dependent glycoprotein ERAD pathway + 4
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.