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ONTOLOGY REPORT - ANNOTATIONS


Term:beta-catenin destruction complex
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Accession:GO:0030877 term browser browse the term
Definition:A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
Comment:Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
Synonyms:exact_synonym: APC-Axin-1-beta-catenin complex;   Axin-APC-beta-catenin-GSK3B complex;   BDC;   beta-catenin degradation complex
 narrow_synonym: 23S APC complex
 alt_id: GO:0034742;   GO:0034747


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beta-catenin destruction complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apc APC regulator of WNT signaling pathway JBrowse link 18 27,011,710 27,106,323 RGD:1600115
RGD:13792537
RGD:1624291
G Apc2 APC regulator of WNT signaling pathway 2 JBrowse link 7 12,258,468 12,280,459 RGD:13792537
G Axin1 axin 1 RGD:8553327
RGD:1624291
G Cacybp calcyclin binding protein JBrowse link 13 77,948,771 77,959,089 RGD:1624291
G Csnk1a1 casein kinase 1, alpha 1 JBrowse link 18 56,887,722 56,910,610 RGD:1624291
RGD:1600115
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1624291
RGD:1600115
G Ctnnbip1 catenin, beta-interacting protein 1 JBrowse link 5 166,464,170 166,513,030 RGD:1624291
RGD:13792537
G Dact1 dishevelled-binding antagonist of beta-catenin 1 JBrowse link 6 93,740,440 93,751,003 RGD:1624291
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:8553327
RGD:13792537
RGD:1624291
RGD:1600115
G Siah1 siah E3 ubiquitin protein ligase 1 JBrowse link 19 21,372,163 21,395,773 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19843
    protein-containing complex 5779
      beta-catenin destruction complex 10
Path 2
Term Annotations click to browse term
  cellular_component 19843
    intracellular 13806
      cytoplasm 10553
        beta-catenin destruction complex 10
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.